Critical illness is associated with low circulating concentrations of insulin-like growth factors-I and -II, alterations in insulin-like growth factor binding proteins, and induction of an insulin-like growth factor binding protein 3 protease

Critical Care Medicine

Volumn 24, Issue 9, 1996, Pages 1460-1466

  Timmins, Andrew C ^a   Cotterill, Andrew M ^a   Cwyfan Hughes, Sian C ^b   Holly, Jeff M P ^b   Ross, Richard J M ^a   Blum, Werner ^c   Hinds, Charles J ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

carrier protein; catabolism; critical illness; insulin like growth factor I; insulin like growth factor II; liver function; outcome

Indexed keywords

SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 3 PROTEINASE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CRITICAL ILLNESS; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOLOGY; IMMUNOREGULATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0029788739     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199609000-00006     Document Type: Article

References (28)

1. Cerra FB, Siegal JH, Coleman B, et al: Septic autocannibalism - A failure of exogenous nutritional support. Ann Surg 1980; 192:570-580
2. Ross R, Miell J, Freeman E, et al: Critically ill patients have high basal growth hormone levels with attenuated oscillatory activity associated with low levels of insulin-like growth factor-I. Clin Endocrinol (Oxf) 1991; 35:47-54
3. Sara VR, Hall K: Insulin-like growth factors and their binding proteins. Physiol Rev 1990; 70:591-614
4. Cotterill AM, Holly JMP, Wass JAH: The regulation of insulin-like growth factor binding protein (IGFBP)-1 during and following prolonged fasting. Clin Endcrinol (Oxf) 1993; 39:357-362
5. Blum WF, Horn N, Krarzch J, et al: Clinical studies of IGFBP-2 by radioimmunoassay. Growth Regul 1993; 3: 98-102
6. Blum WF, Ranke MB: Plasma IGFBP3 levels as clinical indicators. In: Modern Concepts of Insulin-Like Growth Factors. Spencer EM (Ed). New York, Elsevier Science Publishing, 1991, pp 381-393
7. Blum WF, Ranke MB: Insulin-like growth factor binding proteins (IGFBP's) with special reference to IGFBP-3. Acta Paediatr Suppl 1990; 367:55-62
8. Holly JMP, Wass JAH: Insulin-like growth factors; autocrine, paracrine or endocrine? New perspectives of the somatomedin hypothesis in light of recent developments. J Endocrinol 1989; 122:611-618
9. Davenport M, Isley WL, Pucilowska JB, et al: Insulin-like growth factor binding protein-3 proteolysis is induced after elective surgery. J Clin Endocrinol Metab 1992; 75:590-595
10. Cwyfan Hughes SC, Cotterill AM, Molloy AR, et al: The induction of specific proteases for insulin-like growth factor binding protein following major heart surgery. J Endocrinol 1992; 135:135-145
11. Holly JMP, Biddlecombe RA, Dunger DB, et al: Circadian variation of GH independent IGF-binding protein in diabetes mellitus and its relationship to insulin. A new role for insulin? Clin Endocrinol 1988; 29:667-675
12. Blum WF, Rauke MB, Bierich JR: A specific radioimmunoassay for insulin-like growth factor-II: The interference of IGF binding proteins can be blocked by excess IGF-I. Acta Endocrinologica 1988; 118:374-380
13. Cwyfan Hughes SC, Wass JAH, Holly JMP: Two site specific radioimmunoassays which demonstrate the presence of proteolytically modified insulin-like growth factor binding protein-3 in the circulation. J Endocrinol 1993; 137: 321-328
14. Hawker FH, Stewart PM, Baxter RC, et al: Relationship of somatomedin insulin-like growth factor-I levels to conventional nutritional indices in critically ill patients. Crit Care Med 1987; 15: 732-736
15. Hossenlopp P, Segovia B, Lassarre C, et al: Evidence of enzymatic degradation of insulin-like growth factor binding proteins in the 150 k complex during pregnancy. J Clin Endocrinol Metab 1991; 71:797-805
16. Davies SC, Wass JAH, Ross RJM, et al: The induction of a specific protease for insulin-like growth factor binding protein-3 in the circulation during severe illness. J Endocrinol 1991; 130:469-473
17. Davies SC, Holly JMP, Abdulla AF, et al: The presence of three specific proteases for insulin-like growth factor binding protein in human pregnancy. Abstr. J Endocrinol 1990; 127(Suppl):76
18. Cotterill AM, Mandel P, Timmins AC, et al: The differential regulation of the circulating levels of the insulin-like growth factors and their binding proteins IGFBP1, 2 and 3 after elective surgery. Clin Endocrinol 1996; 44: 91-101
19. Holly JMP, Claffey P, Cwyfan Hughes SC, et al: Proteases acting on IGFBPs: Their occurrence and physiological significance. Growth Regul 1993; 3:88-91
20. Lamson G, Giudice LC, Cohen P, et al: Proteolysis of IGFBP-3 may be a common regulatory mechanism of IGF action in vivo. Growth Regul 1993; 3:91-94
21. Blat C, Villaudy J, Bihoux M: In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells. J Clin Invest 1994; 93:2286-2290
22. Cotterill AM, Holly JMP, Taylor AM, et al: The insulin-like growth factor IGF-binding proteins and IGF bioactivity in Laron-type dwarfism. J Clin Endocrinol Metab 1992; 74:56-63
23. Lassarre C, Bihoux M: Insulin-like growth factor binding protein-3 is functionally altered in pregnancy plasma. Endocrinology 1994; 134:1254-1262
24. Ross RJM, Rodriguez-Amao J, Donaghy A, et al: Expression of IGFBP1 in normal and cirrhotic human livers. J Endocrinol 1994; 141:377-382
25. Jiang ZM, He G-Z, Zhang SY, et al: Low dose growth hormone and hypocaloric nutrition attenuate the protein catabolic response after major operation. Ann Surg 1989; 210:513-524
26. Dahn MS, Lange P, Jacobs LA: Insulin-like growth factor-I production is inhibited in human sepsis. Arch Surg 1988; 123:1409-1414
27. Voerman BJ, Strack van Schijndel RJM, Groeneveld ABJ, et al: Effects of human growth hormone in critically ill nonseptic patients: Results from a prospective, randomized, placebo-controlled trial. Crit Care Med 1995; 23: 665-673
28. Clemmons DR, Smith-Banks A, Underwood LE: Reversal of diet-induced catabolism by infusion of recombinant insulin-like growth factor-I in humans. J Clin Endocrinol Metab 1992; 75:234-238