Risk factors for serious infection during treatment with cyclophosphamide and high-dose corticosteroids for systemic lupus erythematosus

Arthritis and Rheumatism

Volumn 39, Issue 9, 1996, Pages 1475-1482

  Pryor, Betty D ^a   Bologna, Saba G ^a   Kahl, Leslie E ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Box 8045 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CYCLOPHOSPHAMIDE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; HUMAN; INFECTION; INFECTION RISK; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RISK FACTOR; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0029788602     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780390906     Document Type: Article

References (22)

1. Austin HA III, Klippel JH, Balow JE, LeRichie NGH, Stein AD, Plotz PH: Therapy of lupus nephritis: controlled trial of prednisone and cytotoxic drugs. N Engl J Med 314:614-619, 1986
2. Felson DT, Anderson J: Evidence for the superiority of immunosuppressive drugs and prednisone over prednisone alone in lupus nephritis. N Engl J Med 311:1528-1533, 1984
3. McCune WJ, Golbus J, Zeldes W, Bohlke P, Dunne R, Fox D: Clinical and immunologic effects of monthly administration of intravenous cyclophosphamide in severe systemic lupus erythematosus. N Engl J Med 318:1423-1431, 1988
4. Boumpas DT, Barez S, Klippel JN, Balow JE: Intermittent cyclophosphamide for the treatment of autoimmune thrombocytopenia in SLE. Ann Intern Med 112:674-677, 1990
5. Klippel JH: Systemic lupus erythematosus: treatment related complications superimposed on chronic disease. JAMA 263:1812-1815, 1990
6. Karsh J, Klippel JH, Balow JE, Decker JL: Mortality in lupus nephritis. Arthritis Rheum 22:764-769, 1979
7. Rosner S, Ginzler EM, Diamond HS, Weiner M, Schlesinger M, Fries JF, Wasner C, Medsger TA Jr, Ziegler G, Klippel JH, Hadler NM, Albert DA, Hess EV, Spencer-Green G, Grayzel A, Worth D, Hahn BH, Barnett EV: A multicenter study of outcome in systemic lupus erythematosus: II. Causes of death. Arthritis Rheum 25:612-617, 1982
8. Jonsson H, Nived O, Sturfelt G: Outcome of systemic lupus erythematosus: a prospective study of patients from a defined population. Medicine (Baltimore) 68:141-150, 1989
9. Harisdangkul V, Nilganuwonge S, Rockhold L: Cause of death in systemic lupus erythematosus. South Med J 80:1249-1253, 1987
10. Staples PJ, Gerding DN, Decker JL, Gordon RS Jr: Incidence of infection in systemic lupus erythematosus. Arthritis Rheum 17:1-10, 1974
11. Nived O, Sturfelt G, Wollheim F: Systemic lupus erythematosus and infection: a controlled and prospective study including and epidemiological group. QJM 45:271-287, 1985
12. Lee P, Urowitz MB, Bookman AAM, Koehler BE, Smythe HA, Gordon DA. Ogryzlo MA: Systemic lupus erythematosus: a review of 110 cases with reference to nephritis, the nervous system, aseptic necrosis and prognosis. QJM 46:1-32, 1977
13. Ginzler E, Diamond H, Kaplan D, Weiner M, Schlesinger M, Seleznick M: Computer analysis of factors influencing frequency of infection in systemic lupus erythematosus. Arthritis Rheum 21:37-44, 1978
14. Duffy KNW, Duffy C, Gladman DD: Infection and disease activity in systemic lupus erythematosus: a review of hospitalized patients. J Rheumatol 18:1180-1184, 1991
15. Petri M, Genovese M: Incidence of and risk factors for hospitalizations in systemic lupus erythematosus: a prospective study of the Hopkins lupus cohort. J Rheumatol 19:1559-1565, 1992
16. Balow JE, Austin HA II, Tsokos GC, Antonovych TT, Steinberg AD, Klippel JH: Lupus nephritis. Ann Intern Med 106:79-94, 1987
17. Hellmann DB, Petri M, Whiting-O'Keefe Q: Fatal infections in systemic lupus erythematosus: the role of opportunistic organisms. Medicine (Baltimore) 66:341-348, 1987
18. Steinberg AD, Plotz PH, Wolff SM, Wong VG, Agus SG, Decker JL: Cytotoxic drugs in treatment of nonmalignant diseases. Ann Intern Med 76:619-642, 1972
19. Nashel DJ: Mechanism of action and clinical applications of cytotoxic drugs in rheumatic disorders. Med Clin North Am 69:817-840, 1985
20. Morgan MC, Matteson E, Dunne R, Brown M, Fox DA, McCune WJ: Complications of intravenous cyclophosphamide: association of infections with high daily doses of prednisone in lupus patients (abstract). Arthritis Rheum 33 (suppl 5):R27, 1990
21. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271-1277, 1982
22. Liang MH, Socher SA, Larson MG, Schur PH: Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum 32:1107-1118, 1989