Comparison of early and late treatment with a recombinant endotoxin neutralizing protein in a rat model of Escherichia coli sepsis

Critical Care Medicine

Volumn 24, Issue 9, 1996, Pages 1514-1517

  Weiner, Debra L ^a   Kuppermann, Nathan ^b   Saladino, Richard A ^a   Thompson, Claudette M ^a   Novitsky, Thomas J ^c   Siber, George R ^a   Fleisher, Gary R ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Associates of Cape Cod Inc   (United States)

Author keywords

animal model; bacterial infection; critical illness; endotoxin; endotoxin neutralizing protein; Escherichia coli; Gram negative bacteria; sepsis; shock; treatment

Indexed keywords

ANTIINFECTIVE AGENT; ANTITOXIN; CEFTRIAXONE; GENTAMICIN; RECOMBINANT ENDOTOXIN NEUTRALIZING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTEREMIA; COLONY FORMING UNIT; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ESCHERICHIA COLI; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; SEPSIS; SURVIVAL RATE;

EID: 0029788248     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199609000-00014     Document Type: Article

References (14)

1. Jafari HS, McCracken GH Jr: Sepsis and septic shock: A review for clinicians. Pediatr Infect Dis J 1992; 11: 739-749
2. Caputo GL, Baldwin G, Alpert G, et al: Effect of meningococcal endotoxin in a rabbit model of shock. Circ Shock 1992; 36:104-112
3. Garcia C, Saladino R, Thompson C, et al: Effect of a recombinant endotoxin neutralizing protein on endotoxin shock in rabbits. Crit Care Med 1994; 22:1211-1218
4. Taveira da Silva AM, Kaulbach HC, Chuidian FS, et al: Brief report: Shock and multiple-organ dysfunction after self-administration of Salmonella endotoxin. N Engl J Med 1993; 328: 1457-1460
5. Michie HR, Manogue KR, Spriggs DR, et al: Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 1988; 318: 1481-1486
6. Nelson DS, Kuppermann N, Fleisher GR, et al: Recombinant endotoxin neutralizing protein improves survival from E. coli sepsis in a rat model. Crit Care Med 1995; 23:92-98
7. Kuppermann N, Nelson D, Saladino R, et al: A comparison of a recombinant endotoxin neutralizing protein with a human monoclonal antibody to endotoxin for the treatment of E. coli sepsis in rats. J Infect Dis 1994; 170:630-635
8. Saladino R, Garcia C, Thompson C, et al: Efficacy of a recombinant endotoxin neutralizing protein in rabbits with Escherichia coli sepsis. Circ Shock 1994; 42:104-110
9. Siber GR, Saladino RA, Kuppermann N, et al: Effect of a recombinant endotoxin neutralizing protein from Limulus polyphemus on Gram-negative sepsis. In: Bacterial Endotoxin Recognition and Effector Mechanisms. Levin J, Alving CR, Munford RS, et al (Eds). Amsterdam, Elsevier Science, 1993, pp 379-387
10. Alpert G, Baldwin G, Thompson C, et al: Limulus antilipopolysaccharide factor protects rabbits from meningococcal endotoxin shock. J Infect Dis 1992; 165:494-500
11. Shenep JL, Morgan KA: Kinetics of endotoxin release during antibiotic therapy for experimental Gram-negative bacterial sepsis. J Infect Dis 1984; 150:380-388
12. Stack A, Saladino R, Marra M, et al: A comparison of a recombinant endotoxin neutralizing protein versus a recombinant bactericidal/permeability increasing protein variant for the treatment of E. coli sepsis in the rat. Crit Care Med, In Press
13. Selye H, Tuchweber B, Bertok L: Effect of lead acetate on the susceptibility of rats to bacterial endotoxins. J Bacteriol 1966; 91:884-890
14. Weinstein WM, Onderdonk AB, Bartlett JG, et al: Experimental intra-abdominal abscesses in rats: Development of an experimental model. Infect Immunol 1974; 10:1250-1255