Alterations of the thymic selection process in transgenic mice expressing SV40 large T antigen

International Journal of Cancer

Volumn 67, Issue 3, 1996, Pages 399-404

  Lee, Won Ha ^a   Seo, Jeong Sun ^a,b  

^a Cancer Research Center   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS LARGE T ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CANCER GROWTH; CARCINOGENESIS; GROWTH STIMULATION; HEMATOPOIETIC STEM CELL; LYMPHOCYTE DIFFERENTIATION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; SIMIAN VIRUS 40; T LYMPHOCYTE; THYMUS CANCER; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; BLOTTING, NORTHERN; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; HEMATOPOIETIC STEM CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; ORGAN SPECIFICITY; STROMAL CELLS; THYMUS GLAND; THYMUS NEOPLASMS;

EID: 0029788131     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960729)67:3<399::AID-IJC14>3.0.CO;2-3     Document Type: Article

References (21)

1. ANDERSON, G., JENKINSON, E.J., MOORE, N.C. and OWEN, J.J., MHC class-II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature (Lond.), 362, 70-73 (1993).
2. + thymocytes in vitro. J. exp. Med., 179, 2027-2031 (1994).
3. BOTTERI, F.M., VAN DER PUTTEN, H., WONG, D.F., SAUVAGE, C.A. and EVANS, R.M., Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. Mol. cell. Biol., 7, 3178-3184 (1987).
4. BOYD, R.L., TUCEK, C.L., GODFREY, D.I., IZON, D.J., WILSON, T.J., DAVIDSON, N.J., BEAN, A.G.D., LADYMAN, H.M., RITTER, M.A. and HUGO, P., The thymic microenvironment. Immunol. Today, 14, 445-459 (1993).
5. BRINSTER, R.L., CHEN, H.Y., MESSING, A., VAN DYKE, T., LEVINE, A.J. and PALMITER, R.D., Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell, 37, 367-379 (1984).
6. CHOI, Y.W., HENRARD. D., LEE, I. and ROSS, S.R., The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice. J. Virol., 61, 3013-3019 (1987).
7. HANAHAN, D., Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature (Lond.), 315, 115-122 (1985).
8. KIMBALL, J.W., Introduction to immunology, 2nd ed., pp. 136-138, Macmillan, New York, NY (1986).
9. LEE, W.H., BANAN, M., HARRISS, J.V., HWANG, I., WOODWARD, E., YOON, H.J. and GOTTLIEB, P.D., Cis-acting DNA elements and cell-type-specific nuclear proteins which may play a role in regulation of mouse CD8α (LYT-2) gene transcription. Int. Immunol., 6, 1307-1321 (1994).
10. MOLL, J., EIBEL, H., BOTTERI, F., SANSIG, G., REGNIER, C. and VAN DER PUTTEN, H., Transgenes encoding mutant simian virus 40 large T antigen unmask phenotypic and functional constraints in thymic epithelial cells. Oncogene, 7, 2175-2187 (1992).
11. NOSSAL, G.J.V., Negative selection of lymphocytes. Cell, 76, 229-239 (1994).
12. PALMITER, R.D., CHEN, H.Y., MESSING, A. and BRINSTER, R.L., SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice. Nature (Lond.), 316, 457-460 (1985).
13. PINKERT, C.A., BRINSTER, R.L., PALMITER, R.D., WONG, C. and BUTEL, J.S., Tumorigenesis in transgenic mice by a nuclear transport-defective SV40 large T-antigen gene. Virology, 160, 169-175 (1987).
14. RHIM, J.S., Neoplastic transformation of human epithelial cells in vivo. Anticancer Res., 9, 1345-1365 (1989).
15. RITTER, M.A. and BOYD, R.L., Development in the thymus: it takes two to tango. Immunol. Today, 14, 462-469 (1993).
16. RUTTER, U., MULLER, W., SUMIDA, T., TOKUHISA, T., RAJEWSKY, K. and WAGNER, E.F., c-fos expression interferes with thymus development in transgenic mice. Cell, 53, 847-856 (1988).
17. VAN DE WIJNGAERT, F.P., RADEMAKERS, L.H.P.M., SCHUURMAN, H.J., WEGER, R.A. and KATER, L., Identification and in situ localization of the "thymic nurse cell" in man. J. Immunol, 130, 2348-2351 (1983).
18. VAN DYKE, T.A., FINLAY, C., MILLER, D., MARKS, J., LOZANO, G. and LEVINE, A.J., Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice. J. Virol., 61, 2029-2032 (1987).
19. VON BOEHMER, H., Positive selection of lymphocytes. Cell, 76, 219-228 (1994).
20. WEISSMAN, I.L., Developmental switches in the immune system. Cell, 76, 207-218 (1994).
21. WIKENHEISER, K.A., CLARK, J.C., LINNOILA, R.I., STAHLMAN, M.T. and WHITSETT, J.A., Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice. Cancer Res., 52, 5342-5352 (1992).