메뉴 건너뛰기




Volumn 7, Issue 5, 1996, Pages 364-371

How magnesium therapy may influence clinical outcome in acute myocardial infarction: Review of potential mechanisms

Author keywords

acute myocardial infarction; humans; magnesium; mechanisms

Indexed keywords

MAGNESIUM;

EID: 0029788111     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-199605000-00006     Document Type: Review
Times cited : (8)

References (50)
  • 2
    • 0024505252 scopus 로고
    • Magnesium ions in cardiac function: Regulator of ion channels and second messengers
    • White RE, Hartzell HC: Magnesium ions in cardiac function: regulator of ion channels and second messengers. Biochem Pharmacol 1989, 38:859-867.
    • (1989) Biochem Pharmacol , vol.38 , pp. 859-867
    • White, R.E.1    Hartzell, H.C.2
  • 3
    • 0025894889 scopus 로고
    • Possible pharmacologic actions of magnesium in acute myocardial infarction
    • Woods KL: Possible pharmacologic actions of magnesium in acute myocardial infarction. Br J Clin Pharmacol 1991, 32:3-10.
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 3-10
    • Woods, K.L.1
  • 4
    • 0025732885 scopus 로고
    • Clinical correlates of the molecular and cellular actions of magnesium on the cardiovascular system
    • Reinhart RA: Clinical correlates of the molecular and cellular actions of magnesium on the cardiovascular system. Am Heart J 1991, 121:1513-1521.
    • (1991) Am Heart J , vol.121 , pp. 1513-1521
    • Reinhart, R.A.1
  • 5
    • 0021635585 scopus 로고
    • Magnesium: Nature's physiologic calcium blocker
    • Iseri LT, French JH: Magnesium: nature's physiologic calcium blocker. Am Heart J. 1984, 108:188-193.
    • (1984) Am Heart J , vol.108 , pp. 188-193
    • Iseri, L.T.1    French, J.H.2
  • 6
    • 85047676190 scopus 로고
    • Electrophysiologic effects of magnesium and its interaction with potassium
    • Watanabe Y, Dreifus LS: Electrophysiologic effects of magnesium and its interaction with potassium. Cardiovasc Res 1972, 6:79-88.
    • (1972) Cardiovasc Res , vol.6 , pp. 79-88
    • Watanabe, Y.1    Dreifus, L.S.2
  • 8
    • 0024503475 scopus 로고
    • The electrophysiologic effects of intravenous magnesium on human sinus node, atrioventricular node, atrium and ventricle
    • Rasmussen HS, Thomsen PEB: The electrophysiologic effects of intravenous magnesium on human sinus node, atrioventricular node, atrium and ventricle. Clin Cardiol 1989, 12:85-90.
    • (1989) Clin Cardiol , vol.12 , pp. 85-90
    • Rasmussen, H.S.1    Thomsen, P.E.B.2
  • 9
    • 0013660220 scopus 로고
    • Effects of the magnesium ion on heart and on its response to digoxin
    • Stanbury JB, Fara A: Effects of the magnesium ion on heart and on its response to digoxin. J Pharmacol Exp Ther 1950, 100:445-453.
    • (1950) J Pharmacol Exp Ther , vol.100 , pp. 445-453
    • Stanbury, J.B.1    Fara, A.2
  • 11
    • 0026793664 scopus 로고
    • Efficacy of intravenous magnesium in acute myocardial infarction in reducing arrhythmias and mortality
    • Horner SM: Efficacy of intravenous magnesium in acute myocardial infarction in reducing arrhythmias and mortality. Circulation 1992, 86:774-779.
    • (1992) Circulation , vol.86 , pp. 774-779
    • Horner, S.M.1
  • 12
    • 0026748486 scopus 로고
    • Intravenous magnesium sulphate in suspected acute myocardial infarction: Results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2)
    • Woods KL, Fletcher S, Roffe C, Haider Y: Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2) Lancet 1992, 339:1553-1558. This well-conducted and well-designed trial is the most convincing clinical evidence to date that magnesium therapy is useful.
    • (1992) Lancet , vol.339 , pp. 1553-1558
    • Woods, K.L.1    Fletcher, S.2    Roffe, C.3    Haider, Y.4
  • 13
    • 0000237034 scopus 로고
    • ISIS-4: Randomized study of intravenous magnesium in over 50,000 patients with suspected acute myocardial infarction
    • ISIS collaborative group: ISIS-4: randomized study of intravenous magnesium in over 50,000 patients with suspected acute myocardial infarction. Lancet 1995, 345:669-685. This is the most recent and the largest clinical trial of magnesium in AMI.
    • (1995) Lancet , vol.345 , pp. 669-685
  • 14
    • 0025993738 scopus 로고
    • Postischemic free radical production in the venous blood of the regionally ischemic swine heart
    • Mergner G, Weglicki W, Kramer J: Postischemic free radical production in the venous blood of the regionally ischemic swine heart. Circulation 1991, 84:2079-2090.
    • (1991) Circulation , vol.84 , pp. 2079-2090
    • Mergner, G.1    Weglicki, W.2    Kramer, J.3
  • 15
    • 0026664867 scopus 로고
    • Magnesium deficiency in vitro enhances free radical-induced intracellular oxidation and cytotoxicity in endothelial cells
    • Dickens BF, Weglicki WB, Li Y-S, Mak IT: Magnesium deficiency in vitro enhances free radical-induced intracellular oxidation and cytotoxicity in endothelial cells. FEBS Lett 1992, 311:187-191.
    • (1992) FEBS Lett , vol.311 , pp. 187-191
    • Dickens, B.F.1    Weglicki, W.B.2    Li, Y.-S.3    Mak, I.T.4
  • 17
    • 0026541776 scopus 로고
    • Myocardial stunning in man
    • Bolli R: Myocardial stunning in man. Circulation 1992, 86:1671-1691.
    • (1992) Circulation , vol.86 , pp. 1671-1691
    • Bolli, R.1
  • 18
    • 0025061752 scopus 로고
    • Mechanism of myocardial stunning
    • Bolli R: Mechanism of myocardial stunning. Circulation 1990, 82: 723-738.
    • (1990) Circulation , vol.82 , pp. 723-738
    • Bolli, R.1
  • 20
    • 0023257084 scopus 로고
    • Elevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart
    • Steenbergen C, Murphy E, Levy L, London RE: Elevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart. Circ Res 1987, 60:700-707.
    • (1987) Circ Res , vol.60 , pp. 700-707
    • Steenbergen, C.1    Murphy, E.2    Levy, L.3    London, R.E.4
  • 21
    • 0018090906 scopus 로고
    • Calcium efflux from cardiac sarcoplasmic reticulum: Effects of calcium and magnesium
    • Dunnen J, Nayler WG: Calcium efflux from cardiac sarcoplasmic reticulum: effects of calcium and magnesium. J Mol Cell Cardiol 1978, 10:487-498.
    • (1978) J Mol Cell Cardiol , vol.10 , pp. 487-498
    • Dunnen, J.1    Nayler, W.G.2
  • 22
    • 0024320573 scopus 로고
    • Alterations in cardiac sarcoplasmic reticulum transport in the post ischemic 'stunned' myocardium
    • Krause SM, Jacobus WE, Becker LC: Alterations in cardiac sarcoplasmic reticulum transport in the post ischemic 'stunned' myocardium. Circ Res 1989, 65:526-530.
    • (1989) Circ Res , vol.65 , pp. 526-530
    • Krause, S.M.1    Jacobus, W.E.2    Becker, L.C.3
  • 24
    • 0028823029 scopus 로고
    • Paracrine coronary endothetial control of left ventricular function in humans
    • Paulus WJ, Vantrimpont PJ, Shah AM: Paracrine coronary endothetial control of left ventricular function in humans. Circulation 1995, 92:2119-2126.
    • (1995) Circulation , vol.92 , pp. 2119-2126
    • Paulus, W.J.1    Vantrimpont, P.J.2    Shah, A.M.3
  • 25
    • 0023091145 scopus 로고
    • Evidence that prostacyclin mediates the vascular action of magnesium in humans
    • Nadler JL, Goodson S, Rude RK: Evidence that prostacyclin mediates the vascular action of magnesium in humans. Hypertension 1987, 9:379-383.
    • (1987) Hypertension , vol.9 , pp. 379-383
    • Nadler, J.L.1    Goodson, S.2    Rude, R.K.3
  • 26
    • 0026561493 scopus 로고
    • Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at onset of reperfusion
    • du Toit EF, Opie LH: Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at onset of reperfusion. Circ Res 1992, 70:960-967. This research strongly supports the calcium-related hypothesis of reperfusion injury and its relationship to the phenomonon of stunning.
    • (1992) Circ Res , vol.70 , pp. 960-967
    • Du Toit, E.F.1    Opie, L.H.2
  • 28
    • 85074958004 scopus 로고
    • Magnesium and myocardial infarction
    • Herzog WR, Atar D: Magnesium and myocardial infarction [letter]. Lancet 1994, 343:1225.
    • (1994) Lancet , vol.343 , pp. 1225
    • Herzog, W.R.1    Atar, D.2
  • 29
    • 0028331329 scopus 로고
    • Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: The second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2)
    • Woods KL, Fletcher S: Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 1994, 343:816-819.
    • (1994) Lancet , vol.343 , pp. 816-819
    • Woods, K.L.1    Fletcher, S.2
  • 30
    • 0028889872 scopus 로고
    • Magnesium treatment of acute myocardial infarction: Effects on necrosis in an occlusion/ reperfusion dog model
    • Barros LFM, Chagas ACP, da Luz PI, Pileggi F: Magnesium treatment of acute myocardial infarction: effects on necrosis in an occlusion/ reperfusion dog model. Int J Cardiol 1995, 48:3-9.
    • (1995) Int J Cardiol , vol.48 , pp. 3-9
    • Barros, L.F.M.1    Chagas, A.C.P.2    Da Luz, P.I.3    Pileggi, F.4
  • 31
    • 0028862212 scopus 로고
    • Magnesium sulfate reduces myocardial infarct size when administered before but not after coronary reperfusion in a canine model
    • Christensen CW, Rieder MA, Silverstein EL, Genchoff NE: Magnesium sulfate reduces myocardial infarct size when administered before but not after coronary reperfusion in a canine model. Circulation 1995, 92:2617-2621. This article demonstrates the potentially critical importance of the timing of magnesium therapy.
    • (1995) Circulation , vol.92 , pp. 2617-2621
    • Christensen, C.W.1    Rieder, M.A.2    Silverstein, E.L.3    Genchoff, N.E.4
  • 32
    • 0028806531 scopus 로고
    • Timing of magnesium therapy affects experimental infarct size
    • Herzog WR, Schlossberg ML, MacMurdy KS, Edenbum LR, Gerber MJ, Vogel RA, et al.: Timing of magnesium therapy affects experimental infarct size. Circulation 1995, 92:2622-2626. This article demonstrates two important concepts: the effects of timing of administration and the fact that benefit can be achieved by treatment limited to the reperfusion phase.
    • (1995) Circulation , vol.92 , pp. 2622-2626
    • Herzog, W.R.1    Schlossberg, M.L.2    MacMurdy, K.S.3    Edenbum, L.R.4    Gerber, M.J.5    Vogel, R.A.6
  • 33
    • 58149212370 scopus 로고
    • An experimental model examining the role of magnesium in the therapy of acute myocardial infarction
    • Leor J, Kloner RA: An experimental model examining the role of magnesium in the therapy of acute myocardial infarction. Am J Cardiol 1995, 75:1292-1293.
    • (1995) Am J Cardiol , vol.75 , pp. 1292-1293
    • Leor, J.1    Kloner, R.A.2
  • 34
    • 0024432514 scopus 로고
    • +2 overload and depressed recovery of ventricular function of reperfused ischemic rat hearts
    • +2 overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Circ Res 1989, 65:1045-1056.
    • (1989) Circ Res , vol.65 , pp. 1045-1056
    • Tani, M.1    Neely, J.R.2
  • 35
    • 0015350090 scopus 로고
    • Myocardial calcium and magnesium in acute ischemic injury
    • Shen AC, Jennings RB: Myocardial calcium and magnesium in acute ischemic injury. Am J Pathol 1972, 67:417-440.
    • (1972) Am J Pathol , vol.67 , pp. 417-440
    • Shen, A.C.1    Jennings, R.B.2
  • 37
    • 17044454496 scopus 로고
    • Effect of increased magnesium on recovery from ischemia in rat and rabbit hearts
    • Bersohn MM, Shine KI, Sterman WD: Effect of increased magnesium on recovery from ischemia in rat and rabbit hearts. Am J Physiol 1982, 242:H89-H93.
    • (1982) Am J Physiol , vol.242
    • Bersohn, M.M.1    Shine, K.I.2    Sterman, W.D.3
  • 38
    • 0017748199 scopus 로고
    • Effect of magnesium sulfate on cardiovascular hemodynamics
    • Mroczek WJ, Lee WR, Davidov ME: Effect of magnesium sulfate on cardiovascular hemodynamics. Angiology 1977, 28:720-724.
    • (1977) Angiology , vol.28 , pp. 720-724
    • Mroczek, W.J.1    Lee, W.R.2    Davidov, M.E.3
  • 40
    • 0017589483 scopus 로고
    • Arteriographic evidence of coronary artery spasm in acute myocardial infarction
    • Oliva PG, Breckenridge JC: Arteriographic evidence of coronary artery spasm in acute myocardial infarction. Circulation 1977, 56:366-374.
    • (1977) Circulation , vol.56 , pp. 366-374
    • Oliva, P.G.1    Breckenridge, J.C.2
  • 41
    • 0023277187 scopus 로고
    • Endothelium dependent relaxation in coronary arteries requires magnesium ions
    • Altura BT, Altura BM: Endothelium dependent relaxation in coronary arteries requires magnesium ions. Br J Pharmacol 1987, 91:449-451.
    • (1987) Br J Pharmacol , vol.91 , pp. 449-451
    • Altura, B.T.1    Altura, B.M.2
  • 44
    • 0028150948 scopus 로고
    • The effects of dihydralazine, labetalol and magnesium sulfate on the isolated, perfused human placental cotyledon
    • Petersen OB, Skajaa K, Svane D, Gregersen H, Forman A: The effects of dihydralazine, labetalol and magnesium sulfate on the isolated, perfused human placental cotyledon. Br J Obst Gynaecol 1994, 101:871-878.
    • (1994) Br J Obst Gynaecol , vol.101 , pp. 871-878
    • Petersen, O.B.1    Skajaa, K.2    Svane, D.3    Gregersen, H.4    Forman, A.5
  • 45
    • 0025737363 scopus 로고
    • Contribution of endogenous endothelin to the extension of myocardial infarct size in rats
    • Watanabe T, Suzuki N, Shimamoto N, Fujino M, Imada A: Contribution of endogenous endothelin to the extension of myocardial infarct size in rats. Circ Res 1991, 69:370-377.
    • (1991) Circ Res , vol.69 , pp. 370-377
    • Watanabe, T.1    Suzuki, N.2    Shimamoto, N.3    Fujino, M.4    Imada, A.5
  • 46
    • 85047675952 scopus 로고
    • Intravenous adenosine suppresses cardiac release of endothelin after myocardial ischemia and reperfusion
    • Velasco CE, Jackson EK, Morrow JA, Vitola JV, Inagmi T, Forman MB: Intravenous adenosine suppresses cardiac release of endothelin after myocardial ischemia and reperfusion. Cardiovasc Res. 1993, 27:121-128.
    • (1993) Cardiovasc Res , vol.27 , pp. 121-128
    • Velasco, C.E.1    Jackson, E.K.2    Morrow, J.A.3    Vitola, J.V.4    Inagmi, T.5    Forman, M.B.6
  • 47
    • 0025202804 scopus 로고
    • Effects of reduced dietary magnesium on platelet production and function in hamsters
    • Rishi M, Ahmad A, Makheja A, Karcher D, Bloom S: Effects of reduced dietary magnesium on platelet production and function in hamsters. Lab Invest 1990, 63:717-721.
    • (1990) Lab Invest , vol.63 , pp. 717-721
    • Rishi, M.1    Ahmad, A.2    Makheja, A.3    Karcher, D.4    Bloom, S.5
  • 48
  • 49
    • 0018693439 scopus 로고
    • The effect of agents which modify platelet behaviour and of magnesium ions on thrombus formation in vivo
    • Adams JH, Mitchell JRA: The effect of agents which modify platelet behaviour and of magnesium ions on thrombus formation in vivo. Thromb Haemost 1979, 42:603-610.
    • (1979) Thromb Haemost , vol.42 , pp. 603-610
    • Adams, J.H.1    Mitchell, J.R.A.2
  • 50
    • 0026446167 scopus 로고
    • Effect of extracellular magnesium on platelet activation and intracellular calcium mobilization
    • Hwang D, Yen C, Nadler J: Effect of extracellular magnesium on platelet activation and intracellular calcium mobilization. Am J Hypertens 1992, 5:700-706.
    • (1992) Am J Hypertens , vol.5 , pp. 700-706
    • Hwang, D.1    Yen, C.2    Nadler, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.