Chronic administration of paraquat produces immunosuppression of T lymphocytes and astrocytosis in rats

Toxic Substance Mechanisms

Volumn 15, Issue 3, 1996, Pages 183-194

  Caroleo, M C ^a   Rispoli, V ^b   Arbitrio, M ^c   Strongoli, C ^c   Rainaldi, G ^d   Rotiroti, D ^b   Nistico G ^d  

^a UNIVERSITY OF CALABRIA   (Italy)

^b UNIVERSITY MEDITERRANEA OF REGGIO CALABRIA   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PARAQUAT;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTOSIS; BRAIN INJURY; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; IMMUNE SYSTEM; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTOXICITY; INTOXICATION; MITOSIS INHIBITION; NONHUMAN; RAT; T LYMPHOCYTE ACTIVATION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALIA; ESCHERICHIA COLI; MAMMALIA;

EID: 0029787811     PISSN: 10769188     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Bagetta, G., Corasaniti, M. T., Iannone, M., Nisticó, G., and Stephenson, J. D. 1992. Production of limbic motor seizures and brain damage by systemic and intracerebral injections of paraquat in rats. Pharmacol. Toxicol. 71:443-448.
2. Berisha, H. I., Pakbaz, H., Absood, A., and Said, S. I. 1994. Nitric oxide as mediator of oxidant lung injury due to paraquat. Proc. Natl. Acad. Sci. USA 91:7445-7449.
3. Bus, J. S., Aust, S. D., and Gibson, J. E. 1974. Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity. Biochem. Biophys. Res. Commun. 58(3):749-755.
4. Bus, J. S., and Gibson, J. E. 1984. Paraquat: Model for oxidant-initiated toxicity. Environ. Health Perspect. 55:37-46.
5. Gagen, S. Z., Janoff, A. F., Bus, J. S., and Gibson, J. E. 1976. Effect of paraquat on liver function in mice. J. Pharmacol. Exp. Ther. 198:222-228.
6. 2 toxicity than T lymphocytes. J. Immunol. 132:2543-2546.
7. Farrington, J. A., Ebert, M., Land, E. J., and Fletcher, K. 1973. Bipyridylium quaternary salts and related compounds. Pulse radiolysis studies of the reaction of paraquat radical with oxygen. Implications for the mode of action of bipyridyl herbicides. Biochem. Biophys. Acta 314:372-381.
8. Fisher, H. K., Clements, J. A., Tierney, D. F., and Wright, R. R. 1975. Pulmonary effects of paraquat in the first day after injection. Am. J. Physiol. 228:1217-1223.
9. Flipo, D., Bernier, J., Girard, D., Krystyniak, K., and Fournier, M. 1992 Combined effects of selected insecticides on humoral immune response in mice. Int. J. Immunopharmacol. 14:747-752.
10. Fontana, A., Fierz, W., and Wekerlee, H. 1984. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature 307:273-278.
11. Fukuda, Y., Farrans, V. J., Schoenberger, C. J., Rennars, S. I., and Crystal, R. G. 1985. Patterns of pulmonary structural remodelling after experimental paraquat toxicity. The morphogenesis of intraalveolar fibrosis. Am. J. Pathol. 118:452-475.
12. Gibson, J. E., and Gagen, S. Z. 1977. Paraquat induced functional changes in kidney and liver. In Biochemical Mechanisms of Paraquat Toxicity, ed. A. P. Antor, pp. 117-136. London: Academic Press.
13. Grant, H. C., Lantos, P. L., and Parkinson, P. 1980. Cerebral damage in paraquat poisoning. Histopathology 4:185-195.
14. Hendricks, L. C., and Heidrick, M. L. 1988. Susceptibility to lipid peroxidation and accumulation of fluorescent products with age is greater in T-cells than in B-cells. Free Radical Biol. Med. 5:145-154.
15. Hughes, J. T. 1988. Brain damage due to paraquat poisoning: A fatal case with neuropathological examination of the brain. Neurotoxicology 9:243-248.
16. Kindt, M. V., Nickas, W. J., Sonsalle, P. K, and Heikkila, A. E. 1986. Mitochondria and the neurotoxicity of MPTP. Trends Pharmacol. Sci. 7:473-475.
17. Krystyniak, K., Flipo, D., Mansour, S., and Fournier, M. 1989. Suppression of avidin processing and presentation by mouse macrophages after sublethal exposure to dieldrin. Immunopharmacology 18:157-166.
18. Lipton, S. A., and Rosenberg, P. A. 1994. Excitatory amino acid as a final common pathway for neurologic disorders. N. Engl. J. Med. 330(9):613-622.
19. Mollace, V., Colasanti, M., Persichini, T., Bagetta, G., and Lauro, G. 1993a. HIV gp 120 glycoprotein stimulates the inducible isoform of NO synthase in human cultured astrocytoma cells. Biochem. Biophys. Res. Commun. 194:439-445.
20. 2+-calmodulin independent NO synthase. Biochem. Biophys. Res. Commun. 191:327-334.
21. Moncada, S., Palmer, R. M. J., and Higgs, A. 1991. Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43:109-142.
22. Munkres, K. D. 1979. Ageing of Neurospora crassa. IX. Microviscosity properties of mitochondrial membranes during normal and abnormal growth and development of an inositol auxotroph. Mech. Ageing Dev. 10:173-197.
23. Murray, R. E., and Gibson J. E. 1974. Paraquat disposition in rats, guinea pigs and monkeys. Toxicol. Appl. Pharamcol. 27:283-289.
24. Noelle, R. J., and Lawrence, D. A. 1981. Effects of thiol reagents on murine T cell function and biochemistry. Fed. Proc. 39:942.
25. Patten, R. A., and Gordy, W. 1964. Further studies of radiation effects on the protein and their constituents. Radiat. Res. 22:29-44.
26. Rannels, D. E., Pegg, A. E., Clarks, R. S., and Addison, J. C. 1985. Interaction of paraquat and amine uptake by rat lung perfused in situ. Am. J. Physiol. 249:E506-E513.
27. Rose, M. S., and Smith, L. L. 1977. The relevance of paraquat accumulation by tissues. In Biochemical mechanisms of paraquat toxicity, ed. A. P. Autor, pp. 71-79. New York: Academic Press.
28. Rose, M. S., Smith, L. L., and Wyatt, J. 1976. The relevance of pentose phosphate pathway stimulation in rat lung for the mechanism of paraquat toxicity. Biochem. Pharmacol. 25:1763-1767.
29. Schoenberger, C. J., Rennard, S. J., Bitterman, P. B., Fukuda, Y., Ferrants, V. J., and Crystal, R. G. 1984. Paraquat-induced pulmonary fibrosis. Role of the alveolitis in modulation of the development of fibrosis. Am. Rev. Respir. Dis. 129:168-173.
30. Smith, L. L. 1982. The identification of an accumulation system for diamines and polyamines into the lung and its relevance to paraquat toxicity. Arch. Toxicol. Suppl. 5:1-14.
31. Smith, L. L., and Heath, D. 1974. Paraquat lung: A reappraisal. Thorax 29:643-653.
32. Smith, L. L., and Wyatt, J. 1981. The accumulation of putrescine of rat lung and brain and its relationship to the accumulation of paraquat. Biochem. Pharmacol. 30:1053-1058.
33. Tappel, A. 1980. Measurement of and protection from in vivo lipid peroxidation. In Free radicals in biology, ed. W. A. Pryor, pp. 1-47. New York: Academic Press.
34. Westerberg, E., Akesson, B., Rehncrom, S., Smith, D. S., and Siesjo, B. K. 1979. Lipid peroxidation in brain in vitro: Effects on phospholipids and fatty acid. Acta Physiol. Scand. 105:524-526.
35. Wink, D. A., Kasprazak, K. S. Maragos, C. M., Elespuru, R. K., Misra, M., Dunams, T. M., Cebula, T. A., Koch, W. H., Andrews, A. W., Allen, J. S., and Keefer, L. K. 1991. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science 245:1001-1003.