Detection of the NPM-ALK genomic rearrangement of Ki-1 lymphoma and isolation of the involved NPM and ALK introns

Diagnostic Molecular Pathology

Volumn 5, Issue 3, 1996, Pages 154-158

  Ladanyi, Marc ^a   Cavalchire, Gina ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

ALK gene; Ki 1 Lymphoma; NPM gene

Indexed keywords

NUCLEOPHOSMIN; PROTEIN TYROSINE KINASE;

ANAPLASTIC CARCINOMA; ARTICLE; DNA DETERMINATION; EXON; GENE AMPLIFICATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; INTRON; LARGE CELL LYMPHOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

GENE REARRANGEMENT; HUMANS; INTRONS; LYMPHOMA, LARGE-CELL, KI-1; NUCLEAR PROTEINS; NUCLEOLUS ORGANIZER REGION; POLYMERASE CHAIN REACTION; PROTEIN-TYROSINE KINASES; TRANSLOCATION, GENETIC;

EID: 0029787532     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-199609000-00002     Document Type: Article

References (28)

1. Barnes WM. PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates. Proc Natl Acad Sci USA 1994;91:2216-20.
2. Bitter MA, Franklin WA, Larson RA, et al. Morphology in Ki-1(CD30)-positive non-Hodgkin's lymphoma is correlated with clinical features and the presence of a unique chromosomal abnormality, t(2;5)(p23;q35). Am J Surg Pathol 1990; 14:305-16.
3. Bullrich F, Morris SW, Hummel M, Pileri S, Stein H, Croce CM. Nucleophosmin (NPM) gene rearrangements in Ki-1 positive lymphomas. Cancer Res 1994;54:2873-7.
4. Chang JH, Olson MOJ. Structure of the gene for rat nucleolar protein B23. J Biol Chem 1990;265:18227-33.
5. Cheng S, Chang SY, Gravitt P, Respess R. Long PCR. Nature 1994;369:684-5.
6. Downing JR, Shurtleff SA, Zielenska M, et al. Molecular detection of the t(2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction. Blood 1995;85:3416-22.
7. Ebrahim SAD, Ladanyi M, Desai SB, et al. Immunohistochemical, molecular, and cytogenetic analysis of a consecutive series of 20 peripheral T cell lymphomas and lymphomas of uncertain lineage, including 12 Ki-1 positive lymphomas. Genes Chromosom Cancer 1990;2:27-35.
8. Falini B, Pileri S, Pizzolo G, et al. CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy. Blood 1995;85:1-14.
9. Herbst H, Anagnostopoulos J, Heinze B, Dürkop H, Hummel M, Stein H. ALK gene products in anaplastic large cell lymphomas and Hodgkin's disease. Blood 1995;86:1694-700.
10. Herbst H, Tippelmann G, Anagnostopoulos I, et al. Immunoglobulin and T cell receptor gene rearrangements in Hodgkin's disease and Ki-1 positive anaplastic large cell lymphoma: dissociation between phenotype and genotype. Leuk Res 1989;13:103-16.
11. Kadin ME. Ki-1/CD30+ (anaplastic) large-cell lymphoma: maturation of a clinicopathologic entity with prospects of effective therapy. J Clin Oncol 1994;12:884-7.
12. Ladanyi M, Cavalchire C. A molecular variant of the NPM-ALK rearrangement of Ki-1 lymphoma involving a cryptic ALK splice site. Genes Chromosom Cancer 1996; 15:173-7.
13. Liu Q-R, Chan PK. Characterization of seven processed pseudogenes of nucleophosmin/B23 in the human genome. DNA Cell Biol 1993;12:149-56.
14. Lopategui JR, Sun LH, Chan JK, et al. Low frequency association of the t(2;5)(p23;q35) chromosomal translocation with CD30+ lymphomas from American and Asian patients. A reverse transcriptase-polymerase chain reaction study. Am J Pathol 1995;146:323-8.
15. Mason DY, Bastard C, Rimokh R, et al. CD30 positive large cell lymphomas ('Ki-1 lymphoma') are associated with a chromosomal translocation involving 5q35. Br J Haematol 1990;74:161-8.
16. Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 1994;263:1281-4.
17. O'Connor NTJ, Stein H, Gatter KC, et al. Genotypic analysis of large cell lymphomas which express the Ki-1 antigen. Histopathology 1987;11:733-40.
18. Offit K, Ladanyi M, Gangi MD, Ebrahim SAD, Filippa DA, Chaganti RSK. Ki-1 antigen expression defines a favorable clinical subset of non-B-cell non-Hodgkin's lymphoma. Leukemia 1990;4:625-30.
19. Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ. The t(5;17) translocation in acute promyelocytic leukemia generates a nucleophosmin-RARα fusion transcript. Blood 1994; 84:375a.
20. Rimokh R, Magaud JP, Berger F, et al. A translocation involving a specific breakpoint (q35) on chromosome 5 is characteristic of anaplastic large cell lymphoma ('Ki-1 lymphoma'). Br J Haematol 1989;71:31-6.
21. Sandlund JT, Pui CH, Roberts WM, et al. Clinicopathologic features and treatment outcome of children with large-cell lymphoma and the t(2;5)(p23;q35). Blood 1994;84:2467-71.
22. Shiota M, Fujimoto J, Takenaga M, et al. Diagnosis of t(2;5)(p23;q35)-associated Ki-1 lymphoma with immunohistochemistry. Blood 1994;84:3648-52.
23. NPM/ALK: a distinct clinicopathologic entity. Blood 1995; 86:1954-60.
24. Stein H. Ki-1 anaplastic large cell lymphoma: is it a discrete entity? Leuk Lymph 1993;10(suppl):81-4.
25. Stein H, Mason DY, Gerdes J, et al. The expression of the Hodgkin's disease-associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 1985;66:848-57.
26. Waggott W, Lo YMD, Bastard C, et al. Detection of NPM-ALK DNA rearrangement in CD30 positive large cell lymphoma. Br J Haematol 1995;89:905-7.
27. Wellmann A, Otsuki T, Vogelbruch M, Clark HM, Jaffe ES, Raffeld M. Analysis of the t(2;5)(p23;q35) translocation by reverse transcription polymerase chain reaction in CD30+ anaplastic large cell lymphomas, in other non-Hodgkin's lymphomas of T-cell phenotype, and in Hodgkin's disease. Blood 1995;86:2321-8.
28. Yoneda-Kato N, Look AT, Kirstein MN, et al. The t(3;5)(q25.1;q34) of myelodysplatic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Oncogene 1996;12:265-75.