Synthesis and testosterone 5α-reductase inhibitory activity of 11-substituted 4-aza-5α-androstane compounds

European Journal of Medicinal Chemistry

Volumn 31, Issue 9, 1996, Pages 675-681

  Ishibashi, K ^b   Kurata, H ^b   Hamada, T ^a   Horikoshi, H ^a   Kojima, K ^b  

^a DAIICHI SANKYO CO   (Japan)

^b NONE

Author keywords

4 aza 5 androstane; Prostatic hypertrophy; Steroid; Synthesis; Testosterone 5 reductase inhibitor

Indexed keywords

ANDROSTANE DERIVATIVE; ENZYME INHIBITOR; FINASTERIDE; STEROID 5ALPHA REDUCTASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROSTATE HYPERTROPHY; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0029786953     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/0223-5234(96)85876-4     Document Type: Article

References (8)

1. 1 Ishibashi K, Kurata H, Kojima K, Horikoshi H (1994) Bioorg Med Chem Lett 4, 729-732
2. 2 Hogg JA (1992) Steroids 57, 593-616
3. 3 Ishibashi K, Kojima K, Hamada T, Horikoshi H (1993) Jpn Patent 5-170789; Chem Abstr 120, 107465d
4. 4 Rasmusson GH, Reynolds GF, Utne T et al (1984) J Med Chem 27, 1690-1701
5. 5 Rasmusson GH, Reynolds GF, Steinberg NG et al (1986) J Med Chem 29, 2298-2315
6. 6 Bhattacharya A, DiMichele LM, Dolling UH, Douglas AW, Grabowski EJJ (1988) J Am Chem Soc 110, 3318-3319
7. 7 Anderson S, Berman DM, Jenkins EP, Russell DW (1991) Nature 354, 159-161
8. 8 Normington K, Russell DW (1992) J Biol Chem 267, 19548-19554