Somatostatin receptor subtypes: Specific expression and signaling properties

Metabolism: Clinical and Experimental

Volumn 45, Issue SUPPL.1, 1996, Pages 8-11

  Schonbrunn, A ^a   Gu, Y Z ^b   Dournard, P ^b   Beaudet, A ^b   Tannenbaum, G S ^b   Brown, P J ^b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; RECEPTOR ANTIBODY; RECEPTOR SUBTYPE; SOMATOSTATIN; SOMATOSTATIN RECEPTOR;

ANIMAL CELL; ARTICLE; CHO CELL; HORMONE RECEPTOR INTERACTION; IMMUNOPRECIPITATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES; BINDING SITES; BRAIN; HUMANS; RECEPTORS, SOMATOSTATIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SOMATOSTATIN; TISSUE DISTRIBUTION;

EID: 0029786761     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90069-4     Document Type: Article

References (24)

1. Schonbrunn A, Tashjian AH Jr: Characterization of functional receptors for somatostatin in rat pituitary cells in culture. J Biol Chem 253:6473-6783, 1978
2. Hoyer D, Bell GI, Berelowitz M, et al: Classification and nomenclature of somatostatin receptors. Trends Pharmacol Sci 16:86-88, 1995
3. Vanetti M, Kouba M, Wang X, et al: Cloning and expression of a novel mouse somatostatin receptor (SSTR-2B). FEBS Lett 311:290-294, 1992
4. Schonbrunn A: Signal transduction by somatostatin receptors, in Melmed S (ed): Molecular and Clinical Advances in Pituitary Disorders. Los Angeles, CA, Endocrine Research and Education, 1993, pp 305-310
5. Schonbrunn A, Gu Y-Z, Brown PJ, et al: Function and regulation of somatostatin receptor subtypes, in Somatostatin and Its Receptors. Ciba Foundation Symposium 190. New York, NY, Wiley, 1995, pp 204-221
6. 4 pituitary cell membranes. Endocrinology 114:1784-1790, 1984
7. + channels by isolated protein in clonal rat anterior pituitary cell membranes. Mol Endocrinol 1:283-289, 1987
8. + channels through protein dephosphorylation. Nature 351:570-573, 1991
9. Gu Y-Z, Brown PJ, Loose-Mitchell DS, et al: Development and use of a receptor antibody to characterize the interaction between somatostatin receptor SSTR1 and G proteins. Mol Pharmacol 48:1004-1014, 1995
10. Brown PJ, Lee AB, Norman MG, et al: Identification of somatostatin receptors by covalent labeling with a novel, photoreactive somatostatin analog. J Biol Chem 265:17995-18004, 1990
11. Dournaud P, Gu Y-Z, Schonbrunn A, et al: Localization of the somatostatin receptor SSTR2A in rat brain using a specific antipeptide antibody. J Neuroscience (in press)
12. Schonbrunn A: Somatostatin action in pituitary cells involves two independent transduction mechanisms. Metabolism 39 2:96-100, 1990 (suppl)
13. 3 expresses two somatostatin receptor subtypes that inhibit adenylyl cyclase: Functional expression of rat somatostatin receptor subtypes 1 and 2 in human embryonic kidney 293 cells. Mol Pharmacol 45:402-409, 1994
14. Buscail L, Delesque N, Estève J-P, et al: Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: Mediation by human somatostatin receptor subtypes SSTR1 and SSTR2. Proc Natl Acad Sci USA 91:2315-2319, 1994
15. Patel YC, Panetta R, Escher E, et al: Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype. J Biol Chem 269:1506-1509, 1994
16. Hoyer D, Lübbert H, Bruns C: Molecular pharmacology of somatostatin receptors. Naunyn Schmiedebergs Arch Pharmacol 350:441-453, 1994
17. Koch BD, Dorflinger LJ, Schonbrunn A: Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin: Evidence for coupling of Ni to decreases in intracellular free calcium. J Biol Chem 260:13138-13145, 1984
18. Kleuss C, Hescheler J, Ewel C, et al: Assignment of G protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 353:43-48, 1991
19. Pan MG, Florio T, Stork PJS: G protein activation of a hormone-stimulated phosphatase in human tumor cells. Science 256:1215-1217, 1992
20. Viguerie N, Tahiri-Jouti N, Ayral AM, et al: Direct inhibitory effects of a somatostatin analog, SMS201-995, on AR4-2J cell proliferation via pertussis toxin-sensitive guanosine triphosphate-binding protein-independent mechanisms. Endocrinology 124:1017-1025, 1989
21. Brown PJ, Schonbrunn A: Affinity purification of a somatostatin receptor-G protein complex demonstrates specificity in receptor-G protein coupling. J Biol Chem 268:6668-6676, 1993
22. Bell GI, Reisine T: Molecular biology of somatostatin receptors. Trends Neurosci 16:34-38, 1993
23. i2 in GH4C1 pituitary cells. J Biol Chem 269:13880-13886, 1994
24. iα proteins. J Biol Chem 269:23120-23127, 1994