BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells

Molecular Pharmacology

Volumn 50, Issue 3, 1996, Pages 482-492

  Liu, Zhi ^a   Lheureux, Françoise ^a   Pouliot, Jean Francois ^a   Heckel, Armin ^b   Bamberger, Uwe ^b   Georges, Elias ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AZIDOPINE; BIBW 22 BS; COLCHICINE; GLYCOPROTEIN P; PTERIDINE DERIVATIVE; UNCLASSIFIED DRUG; URIDINE; VERAPAMIL; VINBLASTINE;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; DRUG TRANSPORT; HUMAN; HUMAN CELL; LYMPHOMA CELL; MULTIDRUG RESISTANCE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL;

AFFINITY LABELS; ANIMALS; AZIDES; BINDING SITES; CELL LINE; CELL SURVIVAL; CHO CELLS; COLCHICINE; CRICETINAE; DIHYDROPYRIDINES; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; HUMANS; KINETICS; LYMPHOMA; MORPHOLINES; P-GLYCOPROTEIN; PEPTIDE MAPPING; PROTEIN BINDING; TRIAMTERENE; TUMOR CELLS, CULTURED; VERAPAMIL; VINBLASTINE;

EID: 0029786627     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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