Constitutive activation of a phosphoinositidase C-linked G protein in murine fibroblasts decreases agonist-stimulated Ca2+ mobilization

Molecular Pharmacology

Volumn 50, Issue 3, 1996, Pages 493-500

  Lobaugh, Leslie Anderson ^a   Eisfelder, Bartholomew ^b   Gibson, Keisha ^a   Johnson, Gary L ^b   Putney Jr , James W ^a,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM 45; CALCIUM ION; FURA 2 ACETOXYMETHYL ESTER; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; INOSITOL; INOSITOL 1,4,5 TRISPHOSPHATE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INOSITOL POLYPHOSPHATE; IONOMYCIN; LITHIUM CHLORIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PLATELET DERIVED GROWTH FACTOR;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL GROWTH; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

3T3 CELLS; ANIMALS; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CHELATING AGENTS; CYTOSOL; EGTAZIC ACID; ENZYME INHIBITORS; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HL-60 CELLS; HUMANS; INOSITOL; INOSITOL PHOSPHATES; IONOMYCIN; KINETICS; LITHIUM CHLORIDE; MICE; MUTAGENESIS, SITE-DIRECTED; PHOSPHORIC DIESTER HYDROLASES; PLATELET-DERIVED GROWTH FACTOR; POINT MUTATION; PROTEIN KINASE C; RECOMBINANT PROTEINS; SEQUENCE DELETION; THAPSIGARGIN; TRANSFECTION;

EID: 0029786461     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Berridge, M. J. Inositol trisphosphate and calcium signalling. Nature (Lond.) 361:315-325 (1993).
2. Rozengurt, E. Early signals in the mitogenic response. Science (Washington D. C.) 234:161-166 (1986).
3. Julius, D., T. J. Livelli, T. M. Jessell, and R. Axel. Ectopic expression of the serotonin 1C receptor and the triggering of malignant transformation. Science (Washington D. C.) 244:1057-1062 (1989).
4. Gutkind, J. S., E. A. Novotny, M. R. Brann, and K. C. Robbins. Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc. Nat. Acad. Sci. USA 88:4703-4708 (1991).
5. q-α-subunits. J. Biol. Chem. 267:18263-18266 (1992).
6. q protein induces malignant transformation in NIH-3T3 cells. Mol. Cell. Biol. 12:4687-4693 (1992).
7. Bourne, H. R., D. A. Sanders, and F. McCormick. The GTPase superfamily: conserved structure and molecular mechanism. Nature (Lond.) 349:117-127 (1991).
8. sα designed to alter the reactivity of the protein with bacterial toxins. J. Biol. Chem. 264:21907-21914 (1990).
9. i2 protein have opposite effects on proliferation of NIH-3T3 cells. Proc. Nat. Acad. Sci. USA 88: 10455-10459 (1991).
10. i2 inhibit cyclic AMP accumulation. Nature (Lond.) 351:63-65 (1991).
11. 0-α subunit expressed in NIH-3T3 cells induces transformation. J. Biol. Chem. 267:23183-23188 (1992).
12. qα: mutational activation and coupling to receptors and phospholipase C. J. Biol. Chem. 267:31-34 (1992).
13. 11 proteins in transfected Cos-7 cells. J. Biol. Chem. 267:1811-1817 (1992).
14. 16 subunit. Biochem. Biophys. Res. Commun. 188:1018-1023 (1992).
15. Amatruda, D., III, A. Steele, V. Z. Slepak, and M. I. Simon. G alpha 16, a G protein alpha subunit specifically expressed hematopoietic cells. Proc. Nat. Acad. Sci. USA 88:5587-5591 (1991).
16. 16 inhibits Swiss 3T3 cell growth. J. Biol. Chem. 269:17417-17423 (1994).
17. Downes, C. P., P. T. Hawkins, and R. F. Irvine. Inositol 1:3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland. Biochem. J. 238:501-506 (1986).
18. Shears, S. B., D. J. Storey, A. J. Morris, A. B. Cubitt, J. B. Parry, R. H. Michell, and C. J. Kirk. Dephosphorylation of myo-inositol 1:4,5-trisphosphate and myo-inositol 1,3,4-trisphosphate. Biochem. J. 242:393-402 (1987).
19. Menniti, F. S., K. G. Oliver, K. Nogimori, J. F. Obie, S. B. Shears, and J. W. Putney, Jr. Origins of myoinositol tetrakisphosphates in agonist-stimulated rat pancreatoma cells: stimulation by bombesin of myoinositol (1,3,4,5,6)pentakisphosphate breakdown to myoinositol (3,4,5,6)tetrakisphosphate. J. Biol. Chem. 265:11167-11176 (1990).
20. Sugiya, H., K. A. Tennes, and J. W. Putney, Jr. Homologous desensitization of substance-P-induced inositol polyphosphate formation in rat parotid acinar cells. Biochem. J. 244:647-653 (1987).
21. Sharp, A. H., S. H. Snyder, and S. K. Nigam. Inositol 1:4,5-trisphosphate receptors: localization in epithelial tissue. J. Biol. Chem. 267:7444-7449 (1992).
22. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450 (1986).
23. 2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane. Biochem. J. 300:665-672 (1994).
24. Bird, G. S. J., K. G. Oliver, D. A. Horstman, J. F. Obie, and J. W. Putney, Jr. Relationship between the calcium-mobilizing action of inositol 1:4,5-trisphosphate in permeable AR4-2J cells and the estimated levels of inositol 1,4,5-trisphosphate in intact AR4-2J cells. Biochem. J. 273:541-546 (1991).
25. Challiss, R. A., I. H. Batty, and S. R. Nahorski. Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: effects of neurotransmitters and depolarization. Biochem. Biophys. Res. Commun. 157:684-691 (1988).
26. Shears, S. B. Metabolism of inositol phosphates. Adv. Second Messenger Phosphoprotein Res. 26:63-92 (1992).
27. 6. Trends Biochem. Sci. 18:53-56 (1993).
28. Rhee, S. G., and K. D. Choi. Regulation of inositol phospholipid-specific phospholipase C isozymes. J. Biol. Chem. 267:12393-12396 (1992).
29. Wojcikiewicz, R. J., and S. R. Nahorski. Chronic muscarinic stimulation of SH-SY5Y neuroblastoma cells suppresses inositol 1,4,5-trisphosphate action. J. Biol. Chem. 266:22234-22241 (1991).
30. Dieter, P., and E. Fitzke. Ro 31-8220 and Ro 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages. Biochem. Biophys. Res. Commun. 181:396-401 (1991).
31. 1. J. Biol. Chem. 269:21699-21708 (1994).
32. 2. Science (Washington D. C.) 247:1074-1077 (1990).
33. Smith, M. R., Y. -L. Liu, H. Kim, S. G. Rhee, and H.-F. Kung. Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C. Science (Washington D. C.) 247:1074-1077 (1990).
34. De Vivo, M. and R. Iyengar. Activated Gq-α potentiates platelet-derived growth factor-stimulated mitogenesis in confluent cell cultures. J. Biol. Chem. 269:19671-19674 (1994).
35. Ghosh, T. K., J. Bian, A. D. Short, S. L. Rybak, and D. L. Gill. Persistent intracellular calcium pool depletion by thapsigargin and its influence on cell growth. J. Biol. Chem. 266:24690-24697 (1991).
36. 2+ pool content is linked to control of cell growth. Proc. Nat. Acad. Sci. USA 90:4986-4990 (1993).
37. Waldron, R. T., A. D. Short, J. J. Meadows, T. K. Ghosh, and D. L. Gill. Endoplasmic reticulum calcium pump expression and control of cell growth. J. Biol. Chem. 269:11927-11933 (1994).
38. Villereal, M. L., and K. L. Byron. Calcium signals in growth factor signal transduction. Rev. Physiol. Biochem. Pharmacol. 119:67-121 (1992).
39. Missiaen, L., J. B. Parys, H. DeSmedt, M. Oike, and R. Casteels. Partial calcium release in response to submaximal inositol 1:4,5-trisphosphate receptor activation. Mol. Cell. Endocrinol. 98:147-156 (1994).
40. 2+ influx in human neutrophils is secondary to the emptying of intracellular calcium stores. Biochem. J. 277:73-79 (1991).
41. Wojcikiewicz, R. J. H., T. Furuichi, S. Nakade, K. Mikoshiba, and S. Nahorski. Muscarinic receptor activation down-regulates the type I inositol 1:4,5-trisphosphate receptor by accelerating its degradation. J. Biol. Chem. 269:7963-7969 (1994).
42. Wojcikiewicz, R. J. H. Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types. J. Biol. Chem. 270:11678-11683 (1995).
43. q pathway desensitizes chemotactic receptor-induced calcium signaling via inositol trisphosphate receptor down-regulation. J. Biol. Chem. 270:4840-4844 (1995).