A newly identified immunodominant membrane protein (pMB67) involved in Mycoplasma bovis surface antigenic variation

Microbiology

Volumn 142, Issue 9, 1996, Pages 2463-2470

  Behrens, Annett ^a,f   Poumarat, François ^b   Le Grand, Dominique ^c   Heller, Martin ^d   Rosengarten, Renate ^a,e  

^a Institut fur Mikrobiologie und Tierseuchen   (Germany)

^b Healthy Pigs Production and Experimentation Section   (France)

^c VETAGRO SUP   (France)

^d Inst F Veterinarmedizin G   (Germany)

^e UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^f UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

Author keywords

Immunodominant antigens; Mycoplasma bovis; Phase variation; Surface antigenic variation; Variable membrane proteins

Indexed keywords

CYSTEINE; EPITOPE; LIPID; LIPOPROTEIN; MEMBRANE ANTIGEN; MEMBRANE PROTEIN;

ANTIGENIC VARIATION; ARTICLE; MOLECULAR WEIGHT; MYCOPLASMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

BOVINAE; MYCOPLASMA BOVIS;

EID: 0029786053     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-142-9-2463     Document Type: Article

References (29)

1. Behrens, A., Heller, M., Kirchhoff, H., Yogev, D. & Rosengarten, R. (1994). A family of phase- and size-variant membrane surface lipoprotein antigens (Vsps) of Mycoplasma bovis. Infect Immun 62, 5075-5084.
2. Bhugra, B., Voelker, L. L., Zou, N., Yu, H. & Dybvig, K. (1995). Mechanisms of antigenic variation in Mycoplasma pulmonis: interwoven, site-specific DNA inversions. Mol Microbiol 18, 703-714.
3. Brown, M. B., Shearer, J. K. & Elvinger, F. (1990). Mycoplasmal mastitis in a dairy herd. J Am Vet Med Assoc 196, 1097-1101.
4. Cleavinger, C. M., Kim, M. F. & Wise, K. S. (1994). Processing and surface presentation of the Mycoplasma hyorhinis variant lipoprotein VlpC. J Bacteriol 176, 2463-2467.
5. Dallo, S. F., Chavoya, A. & Baseman, J. B. (1990). Characterization of the gene for a 30-kilodalton adhesin-related protein of Mycoplasma pneumoniae. Infect Immun 58, 4163-4165.
6. Droesse, M., Tangen, G., Gummelt I., Kirchhoff, H., Washburn, L. R. & Rosengarten, R. (1995). Major membrane proteins and lipoproteins as highly variable immunogenic surface components and strain-specific antigenic markers of Mycoplasma arthritidis. Microbiology 141, 3207-3219.
7. Gourlay, R. N., Thomas, L. H. & Wyld, S. G. (1989). Increased severity of calf pneumonia associated with the appearance of Mycoplasma bovis in a rearing herd. Vet Rec 124, 420-422.
8. Hjerpe, C. A. & Knight H. D. (1972). Polyarthritis and synovitis associated with Mycoplasma bovimastitidis in feetlot cattle. J Am Vet Med Assoc 160, 1414-1418.
9. Howard, C. J., Thomas, L. H. & Parsons, K. R. (1987). Comparative pathogenicity of Mycoplasma bovis and Mycoplasma dispar for the respiratory tract of calves. Isr J Med Sci 23, 621-624.
10. Kinde, H., Daft, B. M., Walker, R. L., Charlton, B. R. & Petty, R. (1993). Mycoplasma bovis associated with decubital abscesses in Holstein calves. J Vet Diagn Invest 5, 194-197.
11. ter Laak, E. A., Wentink, G. H. & Zimmer, G. M. (1992). Increased prevalence of Mycoplasma bovis in the Netherlands. Vet Q 15, 100-104.
12. Markham, P. F., Glew, M. D., Whithear, K. G. & Walker, I. D. (1993). Molecular cloning of a member of the gene family that encodes pMGA, a hemagglutinin of Mycoplasma gallisepticum. Infect Immun 61, 903-909.
13. Nicolet, J. (1994). Mycoplasma bovis. Ausbreitung eines neuen pathogenen Erregers beim Rindvieh in der Schweiz? Schweiz Arch Tierheilkd 136, 81-82.
14. Pfützner, H. (1990). Epizootiology of the Mycoplasma bovis infection in cattle. Zentralbl Bakteriol Suppl 20, 394-399.
15. Poumarat, F., Solsona, M. & Boldini, M. (1994). Genomic, protein and antigenic variability of Mycoplasma bovis. Vet Microbiol 40, 305-321.
16. Rosengarten, R. & Wise, K. S. (1990). Phenotypic switching in mycoplasmas: phase variation of diverse surface lipoproteins. Science 247, 315-318.
17. Rosengarten, R., Behrens, A., Stetefeld, A., Heller, M., Ahrens, M., Sachse, K., Yogev, D. & Kirchhoff, H. (1994). Antigen heterogeneity among isolates of Mycoplasma bovis is generated by high-frequency variation of diverse membrane surface proteins. Infect Immun 62, 5066-5074.
18. Ross, R. F. (1985). Mycoplasmas of cattle. In Handbuch der Bakteriellen Infektionen bei Tieren, vol. 5, pp. 314-344. Edited by H. Blobel & T. Schliesser. Stuttgart: Gustav Fischer Verlag.
19. Ruhnke, H. L. (1994). Mycoplasmas associated with bovine genital tract infections. In Mycoplasmosis in Animals: Laboratory Diagnosis, pp. 56-62. Edited by H. W. Whitford, R. F. Rosenbusch & L. H. Lauerman. Ames, IA: Iowa State University Press.
20. Sachse, K., Grajetzki, C., Rosengarten, R., Hänel, I., Heller, M. & Pfützner, H. (1996). Mechanisms and factors involved in Mycoplasma bovis adhesion to host cells. Zentralbl Bakteriol (in press).
21. Simmons, W. L., Zuhua, C., Glass, J. I., Simecka, J. W., Cassell, G. H. & Watson, H. L. (1996). Sequence analysis of the chromosomal region around and within the V-1-encoding gene of Mycoplasma pulmonis: evidence for DNA inversion as a mechanism for V-1 variation. Infect Immun 64, 472-479.
22. Stipkovits, L., Rady, M. & Glavits, R. (1993). Mycoplasmal arthritis and meningitis in calves. Acta Vet Hung 41, 73-88.
23. Theiss, P. M., Kim, M. F. & Wise, K. S. (1993). Differential protein expression and surface presentation generate high-frequency antigenic variation in Mycoplasma fermentans. Infect Immun 61, 5123-5128.
24. Wise, K. S. (1993). Adaptive surface variation in mycoplasmas. Trends Microbiol 1, 59-63.
25. Wise, K. S., Kim, M. F., Theiss, P. M. & Lo, S.-C. (1993). A family of strain variant surface lipoproteins of Mycoplasma fermentans. Infect Immun 61, 3327-3333.
26. Wu, H. (1987). Post-translational modification and processing of membrane proteins in bacteria. In Bacterial Outer Membranes as Model Systems, pp. 37-71. Edited by M. Inouye. New York: Wiley.
27. Yogev, D., Rosengarten, R., Watson-McKown, R. & Wise, K. S. (1991). Molecular basis of Mycoplasma surface antigenic variation: a novel set of divergent genes undergo spontaneous mutation of periodic coding regions and 5′ regulatory sequences. EMBO J 10, 4069-4079.
28. Yogev, D., Menaker, D., Strutzberg, K., Levisohn, S., Kirchhoff, H., Hinz, K.-H. & Rosengarten, R. (1994). A surface epitope undergoing phase variation is shared by Mycoplasma gallisepticum and Mycoplasma bovis. Infect Immun 62, 4962-4968.
29. Zheng, X., Teng, L.-J., Watson, H. L., Glass, J. I., Blanchard, A. & Cassell, G. H. (1995). Small repeating units within the Ureaplasma urealyticum MB antigen gene encode serovar specificity and are associated with antigen size variation. Infect Immun 63, 891-898.