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Volumn 3, Issue 2, 1996, Pages 99-115

Brain drug delivery and blood-brain barrier transport

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CARMUSTINE; CATION; CHIMERIC PROTEIN; CODEINE; CYCLOSPORIN; CYTARABINE; DIAZEPAM; DOPAMINE; HYDROXYUREA; LEUCINE ENKEPHALIN[2 DEXTRO ALANINE]; LEVODOPA; LIPOSOME; MELPHALAN; MONOCLONAL ANTIBODY; MORPHINE; PEPTIDE DERIVATIVE; PRODRUG; RADIOISOTOPE; SUCROSE; THIOTEPA; UNINDEXED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; ZIDOVUDINE;

EID: 0029786047     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.3109/10717549609031180     Document Type: Review
Times cited : (23)

References (90)
  • 1
    • 0016821989 scopus 로고
    • Complex tight junctions of epithelial and of endothelial cells in early foetal brain
    • Mollgard, K., and Saunders, N. R. (1975) Complex tight junctions of epithelial and of endothelial cells in early foetal brain. J. Neurocytol. 4, 453-468.
    • (1975) J. Neurocytol. , vol.4 , pp. 453-468
    • Mollgard, K.1    Saunders, N.R.2
  • 2
    • 0021041669 scopus 로고
    • The vascularization of the human cerebellar cortex
    • Duvernoy, H., Delon, S., and Vannson, J. L. (1983) The vascularization of the human cerebellar cortex. Brain Res. Bull. 11, 419-480.
    • (1983) Brain Res. Bull. , vol.11 , pp. 419-480
    • Duvernoy, H.1    Delon, S.2    Vannson, J.L.3
  • 4
    • 0022735176 scopus 로고
    • Blood-brain nutrient transport
    • Pardridge, W. M. (1986) Blood-brain nutrient transport. Fed. Proc. 45, 2047-2049.
    • (1986) Fed. Proc. , vol.45 , pp. 2047-2049
    • Pardridge, W.M.1
  • 5
    • 0027427381 scopus 로고
    • Transport of insulin-related peptides and glucose across the blood-brain barrier
    • Pardridge, W. M. (1993) Transport of insulin-related peptides and glucose across the blood-brain barrier. Ann. N.Y. Acad. Sci. 692, 126-137.
    • (1993) Ann. N.Y. Acad. Sci. , vol.692 , pp. 126-137
    • Pardridge, W.M.1
  • 6
    • 0017689969 scopus 로고
    • Morphology of blood-brain interfaces
    • Brightman, M. W. (1977) Morphology of blood-brain interfaces. Exp. Eye Res. 25(Suppl.), 1-25.
    • (1977) Exp. Eye Res. , vol.25 , Issue.SUPPL. , pp. 1-25
    • Brightman, M.W.1
  • 7
    • 0025048342 scopus 로고
    • Electrical resistance across the blood-brain barrier in anaesthetized rats: A developmental study
    • Butt, A. M., Jones, H. C., and Abbott, N. J. (1990) Electrical resistance across the blood-brain barrier in anaesthetized rats: A developmental study. J. Physiol. 429, 47-62.
    • (1990) J. Physiol. , vol.429 , pp. 47-62
    • Butt, A.M.1    Jones, H.C.2    Abbott, N.J.3
  • 9
    • 0022549594 scopus 로고
    • Contractile elements in the regulation of macromolecular permeability
    • Miller, F. N., and Sims, D. E. (1986) Contractile elements in the regulation of macromolecular permeability. Fed. Proc. 45, 84-88.
    • (1986) Fed. Proc. , vol.45 , pp. 84-88
    • Miller, F.N.1    Sims, D.E.2
  • 10
    • 0025778643 scopus 로고
    • Heterogeneity of microvascular pericytes for smooth muscle type alpha-actin
    • Nehls, V., and Drenckhahn, D. (1991) Heterogeneity of microvascular pericytes for smooth muscle type alpha-actin. J. Cell Biol. 113, 147-154.
    • (1991) J. Cell Biol. , vol.113 , pp. 147-154
    • Nehls, V.1    Drenckhahn, D.2
  • 11
    • 0019153446 scopus 로고
    • Permeability and vascularity of the developing brain: Cerebellum vs. cerebral cortex
    • Johanson, C. E. (1980) Permeability and vascularity of the developing brain: Cerebellum vs. cerebral cortex. Brain Res. 190, 3-16.
    • (1980) Brain Res. , vol.190 , pp. 3-16
    • Johanson, C.E.1
  • 12
    • 0019798883 scopus 로고
    • Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimera
    • Stewart, P. A., and Wiley, M. J. (1981) Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimera. Dev. Biol. 84, 183-192.
    • (1981) Dev. Biol. , vol.84 , pp. 183-192
    • Stewart, P.A.1    Wiley, M.J.2
  • 13
    • 0023108382 scopus 로고
    • Astrocytes induce blood-brain barrier properties in endothelial cells
    • Janzer, R. C., and Raff, M. C. (1987) Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 325, 253-257.
    • (1987) Nature , vol.325 , pp. 253-257
    • Janzer, R.C.1    Raff, M.C.2
  • 14
    • 0021352170 scopus 로고
    • Immunohistochemical and electron microscopic demonstration of vascular innervation in the mammalian brainstem
    • Kapadia, S. E., and de Lanerolle, N. C. (1984) Immunohistochemical and electron microscopic demonstration of vascular innervation in the mammalian brainstem. Brain Res. 292, 33-39.
    • (1984) Brain Res. , vol.292 , pp. 33-39
    • Kapadia, S.E.1    De Lanerolle, N.C.2
  • 15
    • 0002249910 scopus 로고
    • Molecular cloning and regulation of gene expression of blood-brain barrier glucose transporter
    • (W. M. Pardridge, Ed.), Raven Press, New York
    • Pardridge, W. M., and Boado, R. J. (1993) Molecular cloning and regulation of gene expression of blood-brain barrier glucose transporter. In "The Blood-Brain Barrier: Cellular and Molecular Biology" (W. M. Pardridge, Ed.), pp. 395-440, Raven Press, New York.
    • (1993) The Blood-Brain Barrier: Cellular and Molecular Biology , pp. 395-440
    • Pardridge, W.M.1    Boado, R.J.2
  • 17
    • 0023636719 scopus 로고
    • Blood-brain barrier transcytosis of insulin in developing rabbits
    • Duffy, K. R., and Pardridge, W. M. (1987) Blood-brain barrier transcytosis of insulin in developing rabbits. Brain Res. 420, 32-38.
    • (1987) Brain Res. , vol.420 , pp. 32-38
    • Duffy, K.R.1    Pardridge, W.M.2
  • 18
    • 0021841594 scopus 로고
    • Human blood-brain barrier insulin receptor
    • Pardridge, W. M., Eisenberg, J., and Yang, J. (1985) Human blood-brain barrier insulin receptor. J. Neurochem. 44, 1771-1778.
    • (1985) J. Neurochem. , vol.44 , pp. 1771-1778
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 20
    • 0023227218 scopus 로고
    • Human blood-brain barrier transferrin receptor
    • Pardridge, W. M., Eisenberg, J., and Yang, J. (1987) Human blood-brain barrier transferrin receptor. Metabolism 36, 892-895.
    • (1987) Metabolism , vol.36 , pp. 892-895
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 21
    • 0023547088 scopus 로고
    • Receptor-mediated transcytosis of transferrin across the blood-brain barrier
    • Fishman, J. B., Ruben, J. B., Handrahan, J. V., Connor, J. R., and Fine, R. E. (1987) Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J. Neurosci. Res. 18, 299-304.
    • (1987) J. Neurosci. Res. , vol.18 , pp. 299-304
    • Fishman, J.B.1    Ruben, J.B.2    Handrahan, J.V.3    Connor, J.R.4    Fine, R.E.5
  • 22
    • 0027535206 scopus 로고
    • Receptor-mediated endocytosis of transferrin at the blood-brain barrier
    • Roberts, R. L., Fine, R. E., and Sandra, A. (1993) Receptor-mediated endocytosis of transferrin at the blood-brain barrier. J. Cell Sci. 104, 521-532.
    • (1993) J. Cell Sci. , vol.104 , pp. 521-532
    • Roberts, R.L.1    Fine, R.E.2    Sandra, A.3
  • 23
    • 0026689961 scopus 로고
    • Uptake and distribution of iron and transferrin in the adult rat brain
    • Morris, C. M., Keith, A. B., Edwardson, J. A., and Pullen, R. G. L. (1992) Uptake and distribution of iron and transferrin in the adult rat brain. J. Neurochem. 59, 300-306.
    • (1992) J. Neurochem. , vol.59 , pp. 300-306
    • Morris, C.M.1    Keith, A.B.2    Edwardson, J.A.3    Pullen, R.G.L.4
  • 24
    • 0028979838 scopus 로고
    • 125I]transferrin through the rat blood-brain barrier in vivo
    • 125I]transferrin through the rat blood-brain barrier in vivo. Brain Res. 683, 164-171.
    • (1995) Brain Res. , vol.683 , pp. 164-171
    • Skarlatos, S.1    Pardridge, W.M.2
  • 25
    • 0022978961 scopus 로고
    • Insulin-like growth factor II binding to the type I somatomedin receptor: Evidence for two high affinity binding sites
    • Casella, S. J., Han, V. K., D'Ercole, A. J., et al. (1986) Insulin-like growth factor II binding to the type I somatomedin receptor: Evidence for two high affinity binding sites. J. Biol. Chem. 261, 9268-9272.
    • (1986) J. Biol. Chem. , vol.261 , pp. 9268-9272
    • Casella, S.J.1    Han, V.K.2    D'Ercole, A.J.3
  • 26
    • 0026334912 scopus 로고
    • Human interleukin (IL) 1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism
    • Banks, W. A., Ortiz, L., Plotkin, S. R., and Kastin, A. J. (1991) Human interleukin (IL) 1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 259, 988-996.
    • (1991) J. Pharmacol. Exp. Ther. , vol.259 , pp. 988-996
    • Banks, W.A.1    Ortiz, L.2    Plotkin, S.R.3    Kastin, A.J.4
  • 27
    • 0021683002 scopus 로고
    • Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein
    • Voyta, J. C., Via, D. P., Butterfield, C. E., and Zetter, B. R. (1984) Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. J. Cell Biol. 99, 2034-2040.
    • (1984) J. Cell Biol. , vol.99 , pp. 2034-2040
    • Voyta, J.C.1    Via, D.P.2    Butterfield, C.E.3    Zetter, B.R.4
  • 28
    • 0025295847 scopus 로고
    • Capillary depletion method for quantifying blood-brain barrier transcytosis of circulating peptides and plasma proteins
    • Triguero, D., Buciak, J. B., and Pardridge, W. M. (1990) Capillary depletion method for quantifying blood-brain barrier transcytosis of circulating peptides and plasma proteins. J. Neurochem. 54, 1882-1888.
    • (1990) J. Neurochem. , vol.54 , pp. 1882-1888
    • Triguero, D.1    Buciak, J.B.2    Pardridge, W.M.3
  • 29
    • 1842269785 scopus 로고
    • Transcytotic pathway for blood-borne protein through the blood-brain barrier
    • Broadwell, R. D., Balin, B. J., and Salcman, M. (1988) Transcytotic pathway for blood-borne protein through the blood-brain barrier. Proc. Natl. Acad. Sci. USA 85, 632-636.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 632-636
    • Broadwell, R.D.1    Balin, B.J.2    Salcman, M.3
  • 31
    • 0016816050 scopus 로고
    • Intrathecal chemotherapy: Brain tissue profiles after ventriculocisternal perfusion
    • Blasberg, R. G., Patlak, C., and Fenstermacher, J. D. (1975) Intrathecal chemotherapy: Brain tissue profiles after ventriculocisternal perfusion. J. Pharmacol. Exp. Ther. 195, 73-83.
    • (1975) J. Pharmacol. Exp. Ther. , vol.195 , pp. 73-83
    • Blasberg, R.G.1    Patlak, C.2    Fenstermacher, J.D.3
  • 32
    • 0026038715 scopus 로고
    • Receptor-mediated retrograde transport in CNS neurons after intraventricular administration of NGF and growth factors
    • Ferguson, I. A., Schweitzer, J. B., Barlett, P. F., and Johnson, E. M., Jr. (1991) Receptor-mediated retrograde transport in CNS neurons after intraventricular administration of NGF and growth factors. J. Comp. Neurol. 313, 680-692.
    • (1991) J. Comp. Neurol. , vol.313 , pp. 680-692
    • Ferguson, I.A.1    Schweitzer, J.B.2    Barlett, P.F.3    Johnson Jr., E.M.4
  • 33
    • 0019442388 scopus 로고
    • Tissue distribution of human interferons after exogenous administration in rabbits, monkeys, and mice
    • Billiau, A., Heremans, H., Ververken, D., van Damme, J., Carton, H., and de Somer, P. (1981) Tissue distribution of human interferons after exogenous administration in rabbits, monkeys, and mice. Arch. Virol. 68, 19-25.
    • (1981) Arch. Virol. , vol.68 , pp. 19-25
    • Billiau, A.1    Heremans, H.2    Ververken, D.3    Van Damme, J.4    Carton, H.5    De Somer, P.6
  • 34
    • 0022402795 scopus 로고
    • Plasma and cerebrospinal fluid pharmacokinetics of recombinant interferon alpha a in monkeys: Comparison of intravenous, intramuscular, and intraventricular delivery
    • Collins, J. M., Riccardi, R., Trown, P., O'Neill, D., and Poplack, D. G. (1985) Plasma and cerebrospinal fluid pharmacokinetics of recombinant interferon alpha A in monkeys: Comparison of intravenous, intramuscular, and intraventricular delivery. Cancer Drug Del. 2, 247-253.
    • (1985) Cancer Drug Del. , vol.2 , pp. 247-253
    • Collins, J.M.1    Riccardi, R.2    Trown, P.3    O'Neill, D.4    Poplack, D.G.5
  • 35
    • 0023928939 scopus 로고
    • Delivery of human interferon-alpha to brain by transient osmotic blood-brain barrier modification in the rat
    • Greig, N. H., Fredericks, W. R., Holloway, H. W., Soncrant, T. T., and Rapoport, S. I. (1988) Delivery of human interferon-alpha to brain by transient osmotic blood-brain barrier modification in the rat. J. Pharmacol. Exp. Ther. 245, 581-586.
    • (1988) J. Pharmacol. Exp. Ther. , vol.245 , pp. 581-586
    • Greig, N.H.1    Fredericks, W.R.2    Holloway, H.W.3    Soncrant, T.T.4    Rapoport, S.I.5
  • 36
    • 0022017514 scopus 로고
    • Kinetic model for disposition of 6-mercaptopurine in monkey plasma and cerebrospinal fluid
    • Covell, D. G., Narang, P. K., and Poplack, D. G. (1985) Kinetic model for disposition of 6-mercaptopurine in monkey plasma and cerebrospinal fluid. Am. J. Physiol. 248, R147-R156.
    • (1985) Am. J. Physiol. , vol.248
    • Covell, D.G.1    Narang, P.K.2    Poplack, D.G.3
  • 37
    • 0021346836 scopus 로고
    • Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors
    • Neuwelt, E. A., and Rapoport, S. I. (1984) Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors. Fed. Proc. 43, 214-219.
    • (1984) Fed. Proc. , vol.43 , pp. 214-219
    • Neuwelt, E.A.1    Rapoport, S.I.2
  • 38
    • 0023705227 scopus 로고
    • Observations on exsudation of fibronectin, fibrinogen, and albumin in the brain after carotid infusion of hyperosmolar solutions
    • Salahuddin, T. S., Kalimo, H., Johansson, B. B., and Olsson, Y. (1988) Observations on exsudation of fibronectin, fibrinogen, and albumin in the brain after carotid infusion of hyperosmolar solutions. Acta Neuropathol. 76, 1-10.
    • (1988) Acta Neuropathol. , vol.76 , pp. 1-10
    • Salahuddin, T.S.1    Kalimo, H.2    Johansson, B.B.3    Olsson, Y.4
  • 41
    • 0026605172 scopus 로고
    • Melphalan penetration of the blood-brain barrier via the neutral amino acid transporter in tumor-bearing brain
    • Cornford, E. M., Young, D., Paxton, J. W., Finlay, G. J., Wilson, W. R., and Pardridge, W. M. (1992) Melphalan penetration of the blood-brain barrier via the neutral amino acid transporter in tumor-bearing brain. Cancer Res. 52, 138-143.
    • (1992) Cancer Res. , vol.52 , pp. 138-143
    • Cornford, E.M.1    Young, D.2    Paxton, J.W.3    Finlay, G.J.4    Wilson, W.R.5    Pardridge, W.M.6
  • 42
    • 0022348641 scopus 로고
    • Blood-brain barrier impairment by low pH buffer perfusion via the internal carotid artery in rat
    • Nagy, Z., Szabo, M., and Huttner, I. (1985) Blood-brain barrier impairment by low pH buffer perfusion via the internal carotid artery in rat. Acta Neuropathol. 68, 160-163.
    • (1985) Acta Neuropathol. , vol.68 , pp. 160-163
    • Nagy, Z.1    Szabo, M.2    Huttner, I.3
  • 43
    • 0019124032 scopus 로고
    • Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
    • Levin, V. A. (1980) Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J. Med. Chem. 23, 682-684.
    • (1980) J. Med. Chem. , vol.23 , pp. 682-684
    • Levin, V.A.1
  • 44
    • 0025316477 scopus 로고
    • Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat
    • Greig, N. H., Soncrant, T. T., Shetty, H. U., Momma, S., Smith, Q. R., and Rapoport, S. I. (1990). Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat. Cancer Chemother. Pharmacol. 26, 263-268.
    • (1990) Cancer Chemother. Pharmacol. , vol.26 , pp. 263-268
    • Greig, N.H.1    Soncrant, T.T.2    Shetty, H.U.3    Momma, S.4    Smith, Q.R.5    Rapoport, S.I.6
  • 45
    • 0004274772 scopus 로고
    • Chemistry of cyclosporin
    • (D. J. G. White, Ed.), Elsevier Biomedical Press, New York
    • Wenger, R. (1982) Chemistry of cyclosporin. In "Cyclosporin A" (D. J. G. White, Ed.), pp. 19-34, Elsevier Biomedical Press, New York.
    • (1982) Cyclosporin A , pp. 19-34
    • Wenger, R.1
  • 46
    • 0017194558 scopus 로고
    • The carrier potential of liposomes in biology and medicine
    • Gregoriadis, G. (1976) The carrier potential of liposomes in biology and medicine. N. Engl. J. Med. 295, 704-710.
    • (1976) N. Engl. J. Med. , vol.295 , pp. 704-710
    • Gregoriadis, G.1
  • 47
    • 51249188620 scopus 로고
    • The movement of molecules across lipid membranes: A molecular theory
    • Trauble, H. (1971) The movement of molecules across lipid membranes: A molecular theory. J. Membr. Biol. 4, 193-208.
    • (1971) J. Membr. Biol. , vol.4 , pp. 193-208
    • Trauble, H.1
  • 48
    • 0015484902 scopus 로고
    • Blood-brain barrier: Penetration of morphine, codeine, heroin, and methadone after carotid injection
    • Oldendorf, W. H., Hyman, S., Braun, L., and Oldendorf, S. Z. (1972) Blood-brain barrier: Penetration of morphine, codeine, heroin, and methadone after carotid injection. Science 178, 984-986.
    • (1972) Science , vol.178 , pp. 984-986
    • Oldendorf, W.H.1    Hyman, S.2    Braun, L.3    Oldendorf, S.Z.4
  • 49
    • 0025262446 scopus 로고
    • Synthesis and antiretroviral activity of phospholipid analogs of azidothymidine and other antiviral nucleosides
    • Hostetler, K. Y., Stuhmiller, L. M., Lenting, H. B. M., van den Bosch, H., and Richman, D. D. (1990) Synthesis and antiretroviral activity of phospholipid analogs of azidothymidine and other antiviral nucleosides. J. Biol. Chem. 265, 6112-6117.
    • (1990) J. Biol. Chem. , vol.265 , pp. 6112-6117
    • Hostetler, K.Y.1    Stuhmiller, L.M.2    Lenting, H.B.M.3    Van Den Bosch, H.4    Richman, D.D.5
  • 52
    • 0020536543 scopus 로고
    • Evidence for tertiary structure in aqueous solutions of human β-endorphin as shown by difference absorption spectroscopy
    • Bewley, T. A., and Li, C. H. (1983) Evidence for tertiary structure in aqueous solutions of human β-endorphin as shown by difference absorption spectroscopy. Biochemistry 22, 2671-2675.
    • (1983) Biochemistry , vol.22 , pp. 2671-2675
    • Bewley, T.A.1    Li, C.H.2
  • 53
    • 0026783425 scopus 로고
    • A strategy for delivering peptides into the central nervous system by sequential metabolism
    • Bodor, N., Prokai, L., Wu, W.-M., Farag, H., Jonalagadda, S., Kawamura, M., and Simpkins, J. (1992) A strategy for delivering peptides into the central nervous system by sequential metabolism. Science 257, 1698-1700.
    • (1992) Science , vol.257 , pp. 1698-1700
    • Bodor, N.1    Prokai, L.2    Wu, W.-M.3    Farag, H.4    Jonalagadda, S.5    Kawamura, M.6    Simpkins, J.7
  • 54
    • 0015320687 scopus 로고
    • Ethanol enhancement of blood-brain barrier permeability to catecholamines in chicks
    • Hanig, J. P., Morrison, J. M., Jr., and Krop, S. (1972) Ethanol enhancement of blood-brain barrier permeability to catecholamines in chicks. Eur. J. Pharmacol. 18, 79-82.
    • (1972) Eur. J. Pharmacol. , vol.18 , pp. 79-82
    • Hanig, J.P.1    Morrison Jr., J.M.2    Krop, S.3
  • 55
    • 0015056056 scopus 로고
    • Increase of blood-brain barrier permeability to catecholamines by dimethyl sulphoxide in the neonate chick
    • Hanig, J. P., Morrison, J. M., Jr., and Krop, S. (1971) Increase of blood-brain barrier permeability to catecholamines by dimethyl sulphoxide in the neonate chick. J. Pharm. Pharmacol. 23, 386-387.
    • (1971) J. Pharm. Pharmacol. , vol.23 , pp. 386-387
    • Hanig, J.P.1    Morrison Jr., J.M.2    Krop, S.3
  • 56
    • 0016829830 scopus 로고
    • Synthetic amino acids and the nature of L-dopa transport at the blood-brain barrier
    • Wade, L. A., and Katzman, R. (1975) Synthetic amino acids and the nature of L-dopa transport at the blood-brain barrier. J. Neurochem. 25, 837-842.
    • (1975) J. Neurochem. , vol.25 , pp. 837-842
    • Wade, L.A.1    Katzman, R.2
  • 57
    • 0023130976 scopus 로고
    • Facilitated transport of melphalan at the rat blood-brain barrier by the large neutral amino acid carrier system
    • Greig, N. H., Momma, S., Sweeney, D. J., Smith, Q. R., and Rapoport, S. I. (1987) Facilitated transport of melphalan at the rat blood-brain barrier by the large neutral amino acid carrier system. Cancer Res. 47, 1571-1576.
    • (1987) Cancer Res. , vol.47 , pp. 1571-1576
    • Greig, N.H.1    Momma, S.2    Sweeney, D.J.3    Smith, Q.R.4    Rapoport, S.I.5
  • 58
    • 0026708467 scopus 로고
    • Rapid high-affinity transport of a chemotherapeutic amino acid across the blood-brain barrier
    • Takada, Y., Vistica, D. T., Greig, N. H., Purdon, D., Rapoport, S. I., and Smith, Q. R. (1992) Rapid high-affinity transport of a chemotherapeutic amino acid across the blood-brain barrier. Cancer Res. 52, 2191-2196.
    • (1992) Cancer Res. , vol.52 , pp. 2191-2196
    • Takada, Y.1    Vistica, D.T.2    Greig, N.H.3    Purdon, D.4    Rapoport, S.I.5    Smith, Q.R.6
  • 59
    • 0025061636 scopus 로고
    • Direct cerebrospinal fluid delivery of an antiretroviral agent using multivesicular liposomes
    • Kim, S., Scheerer, S., Geyer, M. A., and Howell, S. B. (1990) Direct cerebrospinal fluid delivery of an antiretroviral agent using multivesicular liposomes. J. Infect. Dis. 162, 750-752.
    • (1990) J. Infect. Dis. , vol.162 , pp. 750-752
    • Kim, S.1    Scheerer, S.2    Geyer, M.A.3    Howell, S.B.4
  • 60
    • 0026732781 scopus 로고
    • Cationic lipids direct a viral glycoprotein into the class I major histocompatibility complex antigen-presentation pathway
    • Walker, C., Selby, M., Erickson, A., Cataldo, D., Valensi, J.-P., and Van Nest, G. (1992) Cationic lipids direct a viral glycoprotein into the class I major histocompatibility complex antigen-presentation pathway. Proc. Natl. Acad. Sci. USA 89, 7915-7918.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7915-7918
    • Walker, C.1    Selby, M.2    Erickson, A.3    Cataldo, D.4    Valensi, J.-P.5    Van Nest, G.6
  • 61
    • 0342681721 scopus 로고
    • Targeting of liposomes to the blood-brain barrier in rats
    • Micklus, M. J., Greig, N. H., Tung, J., and Rapoport, S. I. (1993) Targeting of liposomes to the blood-brain barrier in rats. Drug Del. 1, 21-26.
    • (1993) Drug Del. , vol.1 , pp. 21-26
    • Micklus, M.J.1    Greig, N.H.2    Tung, J.3    Rapoport, S.I.4
  • 62
    • 0001120209 scopus 로고
    • Blood-brain barrier transport of cationized immunoglobulin G: Enhanced delivery compared to native protein
    • Triguero, D., Buciak, J. B., Yang, J., and Pardridge, W. M. (1989) Blood-brain barrier transport of cationized immunoglobulin G: Enhanced delivery compared to native protein. Proc. Natl. Acad. Sci. USA 86, 4761-4765.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 4761-4765
    • Triguero, D.1    Buciak, J.B.2    Yang, J.3    Pardridge, W.M.4
  • 63
    • 0024390069 scopus 로고
    • Ultracytochemical characterization of anionic sites in the wall of brain capillaries
    • Vorbrodt, A. W. (1989) Ultracytochemical characterization of anionic sites in the wall of brain capillaries. J. Neurocytol. 18, 359-368.
    • (1989) J. Neurocytol. , vol.18 , pp. 359-368
    • Vorbrodt, A.W.1
  • 65
    • 0029115713 scopus 로고
    • Enhanced cellular uptake and in vivo biodistribution of an anti-ras monoclonal antibody following cationization
    • Pardridge, W. M, Kang, Y.-S., Yang, J., and Buciak, J. L. (1995) Enhanced cellular uptake and in vivo biodistribution of an anti-ras monoclonal antibody following cationization. J. Pharm. Sci. 84, 943-948.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 943-948
    • Pardridge, W.M.1    Kang, Y.-S.2    Yang, J.3    Buciak, J.L.4
  • 67
    • 0028390154 scopus 로고
    • Development and in vitro characterization of a cationized monoclonal antibody against βA4 protein: A potential probe for Alzheimer's disease
    • Bickel, U., Lee, V. M. Y., Trojanowski, J. Q., and Pardridge, W. M. (1994) Development and in vitro characterization of a cationized monoclonal antibody against βA4 protein: A potential probe for Alzheimer's disease. Bioconj. Chem. 5, 119-125.
    • (1994) Bioconj. Chem. , vol.5 , pp. 119-125
    • Bickel, U.1    Lee, V.M.Y.2    Trojanowski, J.Q.3    Pardridge, W.M.4
  • 68
    • 0014848353 scopus 로고
    • Senile plaques and cerebral amyloidosis in aged dogs: A histochemical and ultrastructural study
    • Wisniewski, H., Johnson, A. B., Raine, C. S., Kay, W. J., and Terry, R. D. (1970) Senile plaques and cerebral amyloidosis in aged dogs: A histochemical and ultrastructural study. Lab. Invest. 23, 287-296.
    • (1970) Lab. Invest. , vol.23 , pp. 287-296
    • Wisniewski, H.1    Johnson, A.B.2    Raine, C.S.3    Kay, W.J.4    Terry, R.D.5
  • 69
    • 0024349528 scopus 로고
    • Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease β-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system
    • Stern, R. A., Otvos, L., Jr., Trojanowski, J. Q., and Lee, V. M.-Y. (1989) Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease β-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system. Am. J. Pathol. 134, 973-978.
    • (1989) Am. J. Pathol. , vol.134 , pp. 973-978
    • Stern, R.A.1    Otvos Jr., L.2    Trojanowski, J.Q.3    Lee, V.M.-Y.4
  • 70
    • 0020653896 scopus 로고
    • Neuropeptides and the blood-brain barrier
    • Pardridge, W. M. (1983) Neuropeptides and the blood-brain barrier. Ann. Rev. Physiol. 45, 73-82.
    • (1983) Ann. Rev. Physiol. , vol.45 , pp. 73-82
    • Pardridge, W.M.1
  • 71
    • 0025362892 scopus 로고
    • Peptide transport systems for opiates across the blood-brain barrier
    • Banks, W. A., and Kastin, A. J. (1990) Peptide transport systems for opiates across the blood-brain barrier. Am. J. Physiol. 259, E1-E10.
    • (1990) Am. J. Physiol. , vol.259
    • Banks, W.A.1    Kastin, A.J.2
  • 72
    • 0025955822 scopus 로고
    • Delivering peptides to the central nervous system: Dilemmas and strategies
    • Banks, W. A., Kastin, A. J., and Barrera, C. M. (1991) Delivering peptides to the central nervous system: Dilemmas and strategies. Pharm. Res. 8, 1345-1350.
    • (1991) Pharm. Res. , vol.8 , pp. 1345-1350
    • Banks, W.A.1    Kastin, A.J.2    Barrera, C.M.3
  • 73
    • 0027594668 scopus 로고
    • Delivery of peptides and proteins through the blood-brain barrier
    • Bickel, U., Yoshikawa, T., and Pardridge, W. M. (1993) Delivery of peptides and proteins through the blood-brain barrier. Adv. Drug Del. Rev. 10, 205-245.
    • (1993) Adv. Drug Del. Rev. , vol.10 , pp. 205-245
    • Bickel, U.1    Yoshikawa, T.2    Pardridge, W.M.3
  • 74
    • 0027950804 scopus 로고
    • Quantitation of blood-brain barrier transport of neuropeptides with a metabolically stable dermorphin analogue
    • Samii, A., Bickel, U., Stroth, U., and Pardridge, W. M. (1994) Quantitation of blood-brain barrier transport of neuropeptides with a metabolically stable dermorphin analogue. Am. J. Physiol. 267, E124-E131.
    • (1994) Am. J. Physiol. , vol.267
    • Samii, A.1    Bickel, U.2    Stroth, U.3    Pardridge, W.M.4
  • 75
    • 0029265378 scopus 로고
    • In vivo cleavage of a disulfide-based chimeric ooioid peptide in rat brain
    • Bickel, U., Kang, Y.-S., and Pardridge, W. M. (1995). In vivo cleavage of a disulfide-based chimeric ooioid peptide in rat brain. Bioconj. Chem. 6, 211-218.
    • (1995) Bioconj. Chem. , vol.6 , pp. 211-218
    • Bickel, U.1    Kang, Y.-S.2    Pardridge, W.M.3
  • 76
    • 0022764022 scopus 로고
    • Receptor-mediated peptide transport through the blood-brain barrier
    • Pardridge, W. M. (1986) Receptor-mediated peptide transport through the blood-brain barrier. Endocrine Rev. 7, 314-330.
    • (1986) Endocrine Rev. , vol.7 , pp. 314-330
    • Pardridge, W.M.1
  • 77
    • 0009563977 scopus 로고
    • Drug delivery of antisense oligonucleotides or peptides to tissues in vivo using an avidin-biotin system
    • Pardridge, W. M., Boado, R. J., and Buciak, J. L. (1993) Drug delivery of antisense oligonucleotides or peptides to tissues in vivo using an avidin-biotin system. Drug Del. 1, 43-50.
    • (1993) Drug Del. , vol.1 , pp. 43-50
    • Pardridge, W.M.1    Boado, R.J.2    Buciak, J.L.3
  • 79
    • 0025836586 scopus 로고
    • Selective transport of anti-transferrin receptor antibody through the blood-brain barrier in vivo
    • Pardridge, W. M., Buciak, J. L., and Friden, P. M. (1991) Selective transport of anti-transferrin receptor antibody through the blood-brain barrier in vivo. J. Pharmacol. Exp. Ther. 259, 66-70.
    • (1991) J. Pharmacol. Exp. Ther. , vol.259 , pp. 66-70
    • Pardridge, W.M.1    Buciak, J.L.2    Friden, P.M.3
  • 80
    • 0026480374 scopus 로고
    • Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor
    • Yoshikawa, T., and Pardridge, W. M. (1992) Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor. J. Pharmacol. Exp. Ther. 263, 897-903.
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 897-903
    • Yoshikawa, T.1    Pardridge, W.M.2
  • 81
    • 0028211211 scopus 로고
    • Use of neutral-avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate
    • Kang, Y.-S., and Pardridge, W. M. (1994) Use of neutral-avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate. J. Pharmacol. Exp. Ther. 269, 344-350.
    • (1994) J. Pharmacol. Exp. Ther. , vol.269 , pp. 344-350
    • Kang, Y.-S.1    Pardridge, W.M.2
  • 83
    • 0025921895 scopus 로고
    • The preparation of biotinyl-∈-aminocaproylated forms of the vasoactive intestinal polypeptide (VIP) as probes for the VIP receptor
    • Andersson, M., Marie, J.-C., Carlquist, M., and Mutt, V. (1991) The preparation of biotinyl-∈-aminocaproylated forms of the vasoactive intestinal polypeptide (VIP) as probes for the VIP receptor. FEBS Lett. 282, 35-40.
    • (1991) FEBS Lett. , vol.282 , pp. 35-40
    • Andersson, M.1    Marie, J.-C.2    Carlquist, M.3    Mutt, V.4
  • 85
    • 0017068975 scopus 로고
    • Excessive increase in oxygen uptake and blood flow in the brain during amphetamine intoxication
    • Berntman, L., Carlsson, C., Hagerdal, M., and Siesjo, B. K. (1976) Excessive increase in oxygen uptake and blood flow in the brain during amphetamine intoxication. Acta Physiol. Scand. 97, 264-266.
    • (1976) Acta Physiol. Scand. , vol.97 , pp. 264-266
    • Berntman, L.1    Carlsson, C.2    Hagerdal, M.3    Siesjo, B.K.4
  • 86
    • 0022601210 scopus 로고
    • Effects of vasoactive intestinal peptide on thyroid blood flow and circulating thyroid hormone levels in the rat
    • Huffman, L., and Hedge, G. A. (1986) Effects of vasoactive intestinal peptide on thyroid blood flow and circulating thyroid hormone levels in the rat. Endocrinology 118, 550-557.
    • (1986) Endocrinology , vol.118 , pp. 550-557
    • Huffman, L.1    Hedge, G.A.2
  • 87
    • 0021592651 scopus 로고
    • A light and electron microscopic immunohistochemical study of vasoactive intestinal polypeptide - and substance p - containing nerve fibers along the cerebral blood vessels: Comparison with aminergic and cholinergic nerve fibers
    • Itakura, T., Okuno, T., Nakakita, K., Kamei, I., Naka, Y., Nakai, K., Imai, H., Komai, N., Kimura, H., and Maeda, T. (1984) A light and electron microscopic immunohistochemical study of vasoactive intestinal polypeptide - and substance p - containing nerve fibers along the cerebral blood vessels: Comparison with aminergic and cholinergic nerve fibers. J. Cerebral Blood Flow Metab. 4, 407-414.
    • (1984) J. Cerebral Blood Flow Metab. , vol.4 , pp. 407-414
    • Itakura, T.1    Okuno, T.2    Nakakita, K.3    Kamei, I.4    Naka, Y.5    Nakai, K.6    Imai, H.7    Komai, N.8    Kimura, H.9    Maeda, T.10
  • 88
    • 0023214752 scopus 로고
    • Cortical vasodilatation produced by vasoactive intestinal polypeptide (VIP) and by physiological stimuli in the cat
    • Yaksh, T. L., Wang, J.-Y., Go, V. L. W., and Harty, G. J. (1987) Cortical vasodilatation produced by vasoactive intestinal polypeptide (VIP) and by physiological stimuli in the cat. J. Cerebral Blood Flow Metab. 7, 315-326.
    • (1987) J. Cerebral Blood Flow Metab. , vol.7 , pp. 315-326
    • Yaksh, T.L.1    Wang, J.-Y.2    Go, V.L.W.3    Harty, G.J.4
  • 89
    • 0028279458 scopus 로고
    • Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery
    • Pardridge, W. M., Kang, Y.-S., and Buciak, J. L. (1994) Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery. Pharm. Res. 11, 738-746.
    • (1994) Pharm. Res. , vol.11 , pp. 738-746
    • Pardridge, W.M.1    Kang, Y.-S.2    Buciak, J.L.3
  • 90
    • 0017701219 scopus 로고
    • Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
    • Abuchowski, A., van Es, T., Palczuk, N. C., and Davis, F. F. (1977) Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. J. Biol. Chem. 252, 3578-3581.
    • (1977) J. Biol. Chem. , vol.252 , pp. 3578-3581
    • Abuchowski, A.1    Van Es, T.2    Palczuk, N.C.3    Davis, F.F.4


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