Cyclosporine nephrotoxicity in the ischemic kidney and the protective effect of pentoxyfylline - A study in the rat

Transplantation

Volumn 62, Issue 6, 1996, Pages 864-867

  Ates, Ersin ^a   Sharma, Peeyush ^b   Erkasap, Serdar ^a   Talbot, David ^b   Ihtiyar, Enver ^a   Yasar, Bekir ^a   Kiper, Haluk ^a  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

^b FREEMAN HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYCLOSPORIN; CYCLOSPORIN A; PENTOXIFYLLINE; POTASSIUM;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; GRAFT SURVIVAL; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY ISCHEMIA; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029785826     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199609270-00028     Document Type: Article

References (10)

1. Chow SS, Thorner P, Baumal R, Wilson DR. Cyclosporine and experimental renal ischemic injury. Transplantation 1986; 41: 152.
2. Casas A, Hotter G, Rosello-Catafau J, Fernandez-Cruz L, Gelpi E. Prostanoids and cyclosporine-mediated nephrotoxicity in rats. Prostaglandins Leuko Essent Fatty Acids 1995; 52: 49.
3. Petric R, Freeman D, Wallace AC, et al. Modulation of experimental cyclosporine nephrotoxicity by inhibition of thromboxane synthesis. Transplantation 1990; 50: 558.
4. 2 analogue reduces nephrotoxicity and immunosuppression of cyclosporine in rats. Transplant Proc 1986; 18: 626.
5. Wlard A, Clissold SP. Pentoxifylline: a review of its pharmacodynamic and pharmacokinetic properties and its therapeutic efficacy. Drugs 1987; 34: 50.
6. Bennet W, Elzinga LW, Porter GA, Rosen S. The effects of pentoxifylline on experimental chronic cyclosporine nephrotoxicity. Transplantation 1992; 54: 1118.
7. Berty RM, Adler S. In vivo and in vitro rat model for cyclosporine-induced proximal tubuler toxicity. J Lab Clin Med 1991; 118: 17.
8. Ellerman J, Brunner LJ, Luke DR. Effect of pentoxifylline on the ischemic rat kidney monitored by 31P NMR spectroscopy in vivo. Biomed Biochim Acta 1988; 47: 515.
9. Carrier M, Perrault LP, Trone F, Stewart DJ, Pelletier CL. Pentoxifylline decreases cyclosporine-induced renal endothelin release and vasoconstriction. Ann Thorac Surg 1993; 55: 490.
10. Konigsrainer A, Aichberger C, Riedmann B, Steurer W, Ofner D, Margreiter R. Pentoxifylline as an adjunct to cyclosporine-based immunosuppression does not improve the outcome of renal transplantation. Transplant Proc 1995; 27: 1062.