Intra- and extracellular immunization against HIV-1 infection with lymphocytes transduced with an AAV vector expressing a human anti-gp120 antibody

Human Gene Therapy

Volumn 7, Issue 13, 1996, Pages 1515-1525

  Chen, Ji Dai ^a   Yang, Qicheng ^b,d   Yang, An Gang ^a   Marasco, Wayne A ^c   Chen, Si Yi ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Immunsol Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MITOGENIC AGENT; NEUTRALIZING ANTIBODY;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CELL GROWTH; CELL STIMULATION; CELL STRUCTURE; CONTROLLED STUDY; EXPRESSION VECTOR; GENETIC TRANSDUCTION; GROWTH RATE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; LYMPHOCYTE; RIBOSOME; SHUTTLE VECTOR;

EID: 0029785574     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.13-1515     Document Type: Article

References (47)

1. ANDERSON, W.F. (1992). Human gene therapy. Science 256, 808-813.
2. BAGLEY, J., DILLON, P.J., ROSEN, C., ROBINSON, J., SODROSKI, J., and MARASCO, W.A. (1994). Structural characterization of broadly neutralizing human monoclonal antibodies against the CD4 binding site of HIV-1 gp120. Mol. Immunol. 31, 1149-1160.
3. BALTIMORE, D. (1988). Intracellular immunization. Nature 335, 395-396.
4. BUONOCORE, L., and ROSE, J.K. (1990). Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum. Nature 345, 625-628.
5. + T cells by an intracellular CD4 expressed under control of the viral long terminal repeat. Proc. Natl. Acad. Sci. USA 90, 2695-2699.
6. CHATTERJEE, S., JOHNSON, P.R., and WONG, K.K. Jr. (1992). Dual-target inhibition of HIV-1 in vitro by means of an adeno-associated virus antisense vector. Science 258, 1485-1488.
7. CHEN, S.-Y., and COMPANS, R.W. (1991). Oligomerization, transport and Golgi retention of Punta Toro virus glycoproteins. J. Virol. 65, 5902-5909.
8. CHEN, S.-Y., BAGLEY, J., and MARASCO, W.A. (1994a). Intracellular antibodies as a new class of therapeutic molecules for gene therapy. Hum. Gene Ther. 5, 595-601.
9. CHEN, S.-Y., KHOURI, Y., BAGLEY, J., and MARASCO, W.A. (1994b). Combined intra- and extracellular immunization against HIV-1 infection with a human anti-gp120 antibody. Proc. Natl. Acad. Sci. USA 91, 5932-5936.
10. DAAR, E.S., LI, X.L., MOUDGIL, T., and HO, D.D. (1990). High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates. Proc. Natl. Acad. Sci. USA 87, 6574-6578.
11. EARL, P.L., DOMS, R.W., and MOSS, B. (1990). Oligomeric structure of the human immunodeficiency virus type 1 envelope glycoprotein. Proc. Natl. Acad. Sci. USA 87, 648-652.
12. EMBRELSON, J., ZUPAIC, M., RIBAS, J.L., BURKE, A., RACZ, P., TENNER-RACZ, K., and HAASE, A.T. (1993). Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362, 359-362.
13. FAUCI, A.S. (1993). Multifactorial nature of HIV disease: implications for therapy. Science 262, 1011-1018.
14. GALLO, R.C., SALAHUDDIN, S.Z., POPOVIC, M., SHEARER, G.M., KAPLAN, M., HAYNES, B.F., PALKER, T.J., REDFIELD, R., OLESKE, J., SAFAI, B., WHITE, G., FOSTER, P., and MARKHAM, P.D. (1984). Frequent detection and isolation of cytopathic retrovirus (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224, 500-503.
15. GRAHAM, F.L., SMILEY, J., RUSSELL, W.C., and NAIVA, R. (1977). Characterization of a human cell line transformed by DNA from adenovirus type-5. J. Gen. Virol. 36, 59-72.
16. GREEN, M., ISHINO, M., and LOEWENSTEIN, P.M. (1989). Mutational analysis of HIV-1 tat minimal domain peptides: identification of trans-dominant mutants that suppress HIV-LTR-driven gene expression. Cell 58, 215-223.
17. HALBERT, C.L., ALEXANDER, I.E., WOLGAMOT, G.M., and MILLER, A.D. (1995). Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells. J. Virol. 69, 1473-1479.
18. HO, D.D., McKEATING, J.A., LI, X.L., MOUDGIL, T., DAAR, E.S., SUN, N., and ROBINSON, J.E. (1991). Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody. J. Virol. 65, 489-193.
19. KOTIN, R.M. (1994). Prospects for the use of adeno-associated virus as a vector for human gene therapy. Hum. Gene Ther. 5, 793-801.
20. MALIM, M.H., BOHNLEIN, S., HAUBER, J., and CULLEN, B.R. (1989). Functional dissection of the HIV-1 rev trans activator-derivation of a trans-dominant represser of rev function. Cell 58, 205-214.
21. MANIATIS, T., FRITSCH, E.R., and SAMBROOK, J. (1986). Molecular Cloning: A Laboratory Manual. (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY).
22. MARASCO, W.A., HASELTINE, W.A., and CHEN, S.-Y. (1993). Design, intracellular expression, and activity of a human anti-HIV-1 gp120 single chain antibody. Proc. Natl. Acad. Sci. USA 90, 7889-7893.
23. MILLER, A.D. (1992). Human gene therapy comes of age. Nature 357, 455-460.
24. MULLIGAN, R.C. (1993). The basic science of gene therapy. Science 260, 926-932.
25. MUZYCZKA, N. (1992). Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr. Top. Microbiol. Immunol. 158, 97-129.
26. PANTALEO, G., GRAZIOSI, C., DEMAREST, J.F., BUTINI, L., MONTGRONI, M., FOX, C.H., ORENSTEIN, J.M., KOTLER, D.P., and FAUCI, A.S. (1993). HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362, 355-358.
27. PODSAKOFF, G., WONG, K.K., JR., and CHATTERJEE, S. (1994). Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors. J. Virol. 68, 5656-5666.
28. POIESZ, B.J., RUSCETTI, F.W., GAZDAR, A.F., BUNN, P.A., MINNA, J.D., and GALLO, R.C. (1980). Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA 77, 7415-7419.
29. POSNER, M.R., HIDESHIMA, T., CANNON, T., MUKHERJEE, M., MAYER, K.H., and BYRN, R.A. (1991). An IgG human monoclonal antibody that reacts with HIV-1/gp120, inhibits virus binding to cells and neutralizes infection. J. Immunol. 146, 4325-4332.
30. POSNER, M.R., CAVACINI, L.A., EMES, C.L., POWER, J., and BYRN, R. (1993). Neutralization of HIV-1 by F105, a human monoclonal antibody to the CD4 binding site of gp120. J. AIDS 6, 7-14.
31. REITZ, JR., M.S., WILSON, C., NAUGLE, C., GALLO, R.C., and ROBERT-GUROFF, M. (1988). Generation of a neutralization-resistant variant of HIV-1 is due to selection for a point mutation in the envelope gene. Cell 54, 57-63.
32. RUSSELL, D.W., MILLER, A.D., and ALEXANDER, I.E. (1994). Adeno-associated virus vectors preferentially transduce cells in S phase. Proc. Natl. Acad. Sci. USA 91, 8915-8919.
33. SAMULSKI, R.J., CHANG, L.S., and SHENK, T. (1987). A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J. Virol. 61, 3096-3101.
34. SAMULSKI, R.J., CHANG, L.S., and SHENK, T. (1989). Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J. Virol. 63, 3822-3828.
35. SARVER, N., and ROSSI, J. (1993). Gene therapy for HIV-1 infection: progress and prospects. J. NIH Res. 5, 63-67.
36. SARVER, N., CANTIN, E.M., CHANG, P.S., ZAIA, J.A., LADNE, P.A., STEPHENS, D.A., and ROSSI, J.J. (1990). Ribozymes as potential anti-HIV-1 therapeutic agents. Science 247, 1222-1225.
37. SCZAKIEL, G., and PAWLITA, M. (1991). Inhibition of human immunodeficiency virus type 1 replication in human T cells stably expressing antisense RNA. J. Virol. 65, 468-472.
38. SUGIMOT, Y., AKSENTIJEVICH, I., GOTTRESMAN, M., and PASTAN, I. (1994). Efficient Expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site. Bio/Technology 12, 694-698.
39. SULLENGER, B.A., GALLARDO, H.F., UNGERS, G.E., and GIBOA, E. (1990). Overexpression of Tar sequences renders cells resistant to human immunodeficiency virus replication. Cell 63, 601-608.
40. THALI, M., OLSHEVSKY, U., FURMAN, C., GABUZDA, D., POSNER, M., and SODROSKI, J. (1991). Characterization of a discontinuous HIV-1 gp120 epitope recognized by a broadly neutralizing human monoclonal antibody. J. Virol. 65, 6188-6193.
41. TRONO, D., FEINBERG, M.B., and BALTIMORE, D. (1989). HIV-1 gag mutants can dominantly interfere with the replication of the wild-type virus. Cell 59, 113-120.
42. TURNER, S., TIZARD, R., DEMARINIS, J., PEPINSKY, R.B., ZULLO, J., SCHOOLEY, R., and FISHER, R. (1992). Resistance of primary isolates of human immunodeficiency virus type-1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoproteins gp120. Proc. Natl. Acad. Sci. USA 89, 1335-1339.
43. YU, M., POESCHLA, E., and WONG-STAAL, F. (1994). Progress toward gene therapy for HIV-1 infection. Gene Ther. 1, 13-26.
44. WALSH, C.E., NIENHUIS, A.W., SAMULSKI, R.J., BROWN, M.G., MILLER, J.L., YOUNG, N.S., and LIU, J.M. (1994). Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector. J. Clin. Invest. 94, 1440-1448.
45. WILLEY, R.L., BONIFACINO, J.S., POTTS, B.J., MARTIN, M.A., and KLAUSNER, R.D. (1988). Biosynthesis, cleavage and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160. Proc. Natl. Acad. Sci. USA 85, 9580-9854.
46. ZACK, J.A., ARRIGO, S.J., WEITSMAN, S.R., GO, A.S., HAISLIP, A., and CHEN, S.Y. (1990). HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61, 213-222.
47. ZHOU, S.Z., BROXMEYER, H.E., COOPER, S., HARRINGTON, M.A., and SRIVASTAVA, A. (1993). Adeno-associated virus-2 mediated gene transfer in murine hematopoietic progenitor cells. Exp. Hematol. 21, 928-933.