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A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG
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Sorensen PHB, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT: A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nature Genet 1994, 6:146-151.
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Giovannini M, Biegel JA, Serra M, Wang J-Y, Wei YH, Nycum L, Emanuel BS, Evans GA: EWS-ERG and EWS-FLI1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations. J Clin Invest 1994, 94:489-496.
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Variability of EWS chimaeric transcripts in Ewing tumours: A comparison of clinical and molecular data
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Zoubek A, Pfleiderer C, Salzer-Kuntschik M, Amann G, Windhager R, Fink FM, Koscielniak E, Delattre O, Strehl S, Ambros PF, Gadner H, Kovar H: Variability of EWS chimaeric transcripts in Ewing tumours: a comparison of clinical and molecular data. Br J Cancer 1994, 11:908-913.
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The Ewing family of tumors: A subgroup of small round-cell tumors defined by specific chimeric transcripts
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Delattre O, Zucman J, Melot T, Garau XS, Zucker J, Lenoir M, Ambros PF, Sheer D, Turc-Carel C, Triche TJ, Aurias A, Thomas G: The Ewing family of tumors: a subgroup of small round-cell tumors defined by specific chimeric transcripts. N Engl J Med 1994, 331:294-299.
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Delattre, O.1
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12
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0028237082
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EWS/FLI-1 rearrangement in small round cell sarcomas of bone and soft tissue detected by reverse transcrlptase polymerase chain reaction amplification
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Pellin A, Boix J, Blesa JR, Noguera R, Carda C, Llombart-Bosch A: EWS/FLI-1 rearrangement in small round cell sarcomas of bone and soft tissue detected by reverse transcrlptase polymerase chain reaction amplification. Eur J Cancer 1994, 30:827-831.
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Llombart-Bosch, A.6
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13
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0028888439
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Molecular assays for chromosomal translocations in the diagnosis of pediatric soft tissue sarcomas
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Barr FG, Chatten J, D'Cruz CM, Wilson AE, Nauta LE, Nycum LM, Biegel JA, Womer RA: Molecular assays for chromosomal translocations in the diagnosis of pediatric soft tissue sarcomas. JAMA 1995, 273:553-557. Reverse transcriptase polymerase chain reaction for the EWS-FLI1 and EWS-ERG fusion transcripts and transcripts associated with rhabdomyosarcoma (PAX3-FKHR or PAX7-FKHR) and desmoplastic round cell tumors were applied to 79 soft tissue sarcoma samples and compared with histopathologic slides. Six of eight ES samples were positive for the ES transcript, and one of seven undifferentiated sarcomas was positive.
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JAMA
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Barr, F.G.1
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Nycum, L.M.6
Biegel, J.A.7
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14
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0028959399
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Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma
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Downing JR, Khandekar A, Shurtleff SA, Head DR, Parham DM, Webber BL, Pappo AS, Hulshof MG, Conn WP, Shapiro DN: Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma. Am J Pathol 1995, 146:626-634. Multiplex RT-PCR for the EWS/FL/1 message associated with ES in combination with the PAX3/FKHR message associated with the t(2;13) translocation of alveolar rhabdomyosarcoma was used to develop a rapid test to identify either tumor in a biopsy sample. Forty-four pediatric sarcomas and eight cell lines were examined; zero of eight ES and undifferentiated sarcomas expressed the PAX message. The sensitivity of the assay for rhabdomyosarcoma with the t(2;13) translocation was excellent.
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Am J Pathol
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Downing, J.R.1
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Webber, B.L.6
Pappo, A.S.7
Hulshof, M.G.8
Conn, W.P.9
Shapiro, D.N.10
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0028114385
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Diagnostic value of the molecular genetic detection of the t(11;22) translocation in Ewing's tumours
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Dockhorn-Dworniczak B, Schafer K-L, Dantcheva R, Blasius S, Winkelmann W, Strehl S, Burdach S, van Valen F, Jürgens H, Bocker W: Diagnostic value of the molecular genetic detection of the t(11;22) translocation in Ewing's tumours. Virchows Archiv 1994, 425:107-112.
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Strehl, S.6
Burdach, S.7
Van Valen, F.8
Jürgens, H.9
Bocker, W.10
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16
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0028903089
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A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1
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Jeon A, Davis NJ, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN: A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene 1995, 10:1229-1234.
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Denny, C.T.6
Shapiro, D.N.7
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17
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0028984788
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Atypical cytogenetic aberrations in two childhood peripheral primitive neuroectodermal tumors
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Murray JC, Langston C, Dreyer ZE, Stephenson CT, Pokorny WJ, Horowitz ME, Cooley LD: Atypical cytogenetic aberrations in two childhood peripheral primitive neuroectodermal tumors. Genes Chromosome Cancer 1995, 12:142-147.
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Murray, J.C.1
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Horowitz, M.E.6
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18
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Characterization of a human endocrine tissue and tumor associated Ewing's sarcoma antigen
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Hamilton, G.1
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Ewing's sarcoma: Routine diagnostic utilization of MIC2 analysis. A Pediatric Oncology Group/Children's Cancer Study Group intergroup study
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Perlman EJ, Dickman PS, Askin FB, Grier HE, Miser JS, Link MP: Ewing's sarcoma: routine diagnostic utilization of MIC2 analysis. A Pediatric Oncology Group/Children's Cancer Study Group intergroup study. Hum Pathol 1994, 25:304-307.
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Perlman, E.J.1
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Miser, J.S.5
Link, M.P.6
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20
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MIC2 and is useful in diagnosing Ewing's sarcoma and peripheral neuroepithelioma
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MIC2 and is useful in diagnosing Ewing's sarcoma and peripheral neuroepithelioma. Am J Surg Pathol 1994, 18:486-494.
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Am J Surg Pathol
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0028050582
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Immunohistochemical detection of p-glycoprotein in Ewing's sarcoma and peripheral primitive neuroectodermal tumors before and after chemotherapy
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Hijazi YM, Axiotis CA, Navarro S, Steinberg SM, Horowitz ME, Tsokos M: Immunohistochemical detection of p-glycoprotein in Ewing's sarcoma and peripheral primitive neuroectodermal tumors before and after chemotherapy. Am J Clin Pathol 1994, 102:61-67.
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Am J Clin Pathol
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Hijazi, Y.M.1
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Navarro, S.3
Steinberg, S.M.4
Horowitz, M.E.5
Tsokos, M.6
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Multiple-drug resistance in Ewing's sarcoma and peripheral primitive neuroectodermal tumors
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Triche TJ: Multiple-drug resistance in Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Am J Clin Pathol 1994, 102:1-2.
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Am J Clin Pathol
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0028907032
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Ewing's sarcoma as a second malignant tumor in a child previously treated for Wilms' tumor
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Fisher R, Kaste SC, Parham DM, Shapiro DN, Pappo AS: Ewing's sarcoma as a second malignant tumor in a child previously treated for Wilms' tumor. J Pediatr Heamatol Oncol 1995, 17:76-80. Five years after the diagnosis and treatment of Wilm's tumor, a 10-year-old girl developed ES, arising from the ribs at the edge of a previously irradiated field.
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J Pediatr Heamatol Oncol
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Fisher, R.1
Kaste, S.C.2
Parham, D.M.3
Shapiro, D.N.4
Pappo, A.S.5
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24
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0029281782
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Second tumors in pediatric oncologic patients: Report of 5 h.cases
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Jimenez M, Leon P, Castro L, Azcona C, Sierrrasesumage L: Second tumors in pediatric oncologic patients: report of 5 h.cases Rev Med Univ Navarra 1995, 40:72-77. In a review of second malignant tumors after treatment of childhood cancer, a case of ES of the fibula after survival of neuroblastoma was noted.
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Rev Med Univ Navarra
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Jimenez, M.1
Leon, P.2
Castro, L.3
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25
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0028913950
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Detection of (11;22)(q24;q12) translocation-bearing cells in peripheral blood progenitor cells of patients with Ewing's sarcoma family of tumors
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Toresky JA, Neckers L, Wexler LH: Detection of (11;22)(q24;q12) translocation-bearing cells in peripheral blood progenitor cells of patients with Ewing's sarcoma family of tumors. J Natl Cancer Inst 1995, 86:285-286. Granulocyte colony-stimulating factor-mobilized peripheral blood cells were collected for a period of 1 to 3 days after two to four cycles of myelosuppressive induction therapy from 11 previously treated patients with bulky tumors and five newly diagnosed patients (two with localized tumors, three with known metastases) who had negative bone marrow samples before collection. Using RT-PCR assays, 52 samples of peripheral blood, bone marrow, and peripheral blood progenitor cells were examined. Fifty-four percent (13 of 24) of the progenitor collections, 47% of the peripheral blood samples (eight of 17), and 50% (six of 12) of the bone marrow specimens were positive for the t(11;22) translocation.
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J Natl Cancer Inst
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Toresky, J.A.1
Neckers, L.2
Wexler, L.H.3
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26
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0029003049
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Incidence of bone marrow involvement in Ewing's sarcoma: Value of extensive investigation of the bone marrow
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Oberlin O, Bayle C, Hartmann O, Terrier-Lacombe MJ, Lemerle J: Incidence of bone marrow involvement in Ewing's sarcoma: value of extensive investigation of the bone marrow. Med Pediatr Oncol 1995, 24:343-346. Fifty-nine untreated patients and five relapsed ES patients whose condition relapsed underwent multiple-site bone marrow studies under general anesthesia. Standard slides were compared with cytocentrifuged pooled specimens; no difference could be proven based on technique. Sixty-nine percent of patients with bone metastases had positive bone marrow samples, and 30% of patients with lung metastases had positive bone marrow samples. Fever and pelvic site was highly correlated with marrow disease. There was some evidence of focality, but only one patient had marrow disease not discernible by biopsy.
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Med Pediatr Oncol
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Oberlin, O.1
Bayle, C.2
Hartmann, O.3
Terrier-Lacombe, M.J.4
Lemerle, J.5
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27
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0029053870
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Gallium and thallium scintigraphy in pediatric peripheral neuroectodermal tumor (askin tumor) of the chest wall
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Howman-Giles R, Uren RF, Kellie SJ: Gallium and thallium scintigraphy in pediatric peripheral neuroectodermal tumor (askin tumor) of the chest wall. J Nucl Med 1995, 6:814-816. In a case report, a child with a PNET of the chest wall underwent gallium-67 and thallium-201 scanning as part of diagnostic studies and follow up; The thallium scan was more sensitive than gallium in finding a biopsy-positive residual mass.
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J Nucl Med
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Howman-Giles, R.1
Uren, R.F.2
Kellie, S.J.3
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28
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0025992508
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Malignant peripheral neuroectodermal tumor and its necessary distinction from Ewing's sarcoma: A report from the Kiel pediatrictumor registry
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Schmidt D, Hermann C, Jurgens H, Hanns D: Malignant peripheral neuroectodermal tumor and its necessary distinction from Ewing's sarcoma: a report from the Kiel pediatrictumor registry. Cancer 1991, 68:2251-2259.
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Schmidt, D.1
Hermann, C.2
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Hanns, D.4
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0025967283
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Prognostic value of histopathology in Ewing's sarcoma: Long term follow-up of distal extremity primary tumors
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Hartman KR, Triche TJ, Miser JS: Prognostic value of histopathology in Ewing's sarcoma: long term follow-up of distal extremity primary tumors. Cancer 1991, 67:163-171.
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Cancer
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Hartman, K.R.1
Triche, T.J.2
Miser, J.S.3
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30
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0028958378
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Is neuroectodermal differentiation of Ewing's sarcoma of bone associated with an unfavorable prognosis?
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Terrier Ph, Henry-Amar M, Triche TJ, Horowitz ME, Terrier-Lacombe M-J, Miser JS, Kinsella TJ, Contesso G, Llombart-Bosch AL: Is neuroectodermal differentiation of Ewing's sarcoma of bone associated with an unfavorable prognosis? Eur J Cancer 1995, 31A:307-314. The Institut Gustave Roussy, the University of Valencia Medical School, and the National Cancer Institute participated in a retrospective review of the pathology of 315 patients. Five pathologists classified tumors as typical ES (220), atypical ES (48), or ES with neuroectodermal features (47). Multivariate analysis, including histopathological classification, patient age, site, presence of metastases, and treatment ("modern" or "others") demonstrated that the presence of a filigree pattern and dark cells conferred poor prognosis: however, neuroectodermal features did not confer poor prognosis. Clinical factors associated with poor prognosis in the study were treatment, metastases at diagnosis, and proximal tumor location.
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Eur J Cancer
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Terrier, Ph.1
Henry-Amar, M.2
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Horowitz, M.E.4
Terrier-Lacombe, M.-J.5
Miser, J.S.6
Kinsella, T.J.7
Contesso, G.8
Llombart-Bosch, A.L.9
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31
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0028349831
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Percutaneous biopsy of peripheral primitive neuroectodermal tumors and Ewing's sarcomas for cytogenetic analysis
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Hoffer FA, Gianturco LE, Fletcher JA, Grier HE: Percutaneous biopsy of peripheral primitive neuroectodermal tumors and Ewing's sarcomas for cytogenetic analysis. Am J Roent 1994, 162:1141-1142.
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Am J Roent
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Hoffer, F.A.1
Gianturco, L.E.2
Fletcher, J.A.3
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0029131437
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Role of surgical resection in pelvic Ewing's sarcoma
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Scully SP, Temple HT, O'Keefe RJ, Scarborough MT, Mankin HJ, Gebhardt MC: Role of surgical resection in pelvic Ewing's sarcoma. J Clin Oncol 1995, 13:2336-2341. Retrospective evaluation of 39 patients with ES of the pelvis was undertaken. Twenty patients were treated with radiation only and 19 with surgery with or without radiation. Local radiation failed three patients in each group. Disease-free survival was not significantly different between patients who underwent surgery and those who did not (16 vs 22 months median disease-free interval). These patients were treated with a variety of regimens over a 16-year period; however, the time of treatment did not appear to effect the outcome.
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J Clin Oncol
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Scully, S.P.1
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Radiation therapy in Ewing's sarcoma: An update of the CESS 86 Trial
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Dunst J, Jurgens H, Sauer R, Hildegard P, Paulussen M, Winkelmann W, Rube C: Radiation therapy in Ewing's sarcoma: an update of the CESS 86 Trial. Int J Radiat Oncol Biol Phys 1995, 32:919-930. Analysis of the German cooperative ES trial conducted between 1986 and 1991 showed that among 177 patients with ES of bone treated on standardized chemotherapy, overall survival and relapse-free survival (69%) did not differ according to local control method. Although there was a better local control rate after radical surgery, there were also more metastases in this group. Patients were selected for local treatment regimen by clinical status and clinician preference.
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Int J Radiat Oncol Biol Phys
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Dunst, J.1
Jurgens, H.2
Sauer, R.3
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Paulussen, M.5
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34
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0025008189
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Multimodal therapy for the management of primary nonmetastatic Ewing's sarcoma of bone: A long-term follow-up of the first intergroup study
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Nesbit ME, Gehan EA, Burgert O, Vietti TJ, Cangir A, Tefft M, Evans R, Thomas P, Askin F, Kissane JM, Pritchard DJ, Hermann J, Neff J, Makley JT, Gilula T: Multimodal therapy for the management of primary nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the first intergroup study. J Clin Oncol 1990, 8:1664-1674.
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Askin, F.9
Kissane, J.M.10
Pritchard, D.J.11
Hermann, J.12
Neff, J.13
Makley, J.T.14
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35
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0025126798
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Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: Intergroup study IESS-II
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Burgert OE, Nesbitt ME, Garnsey LA, Gehan EA, Hermann J, Vietti TJ, Cangir A, Tefft M, Evans R, Thomas P, Askin F, Kissane JM, Pritchard DJ, Neff J, Makley JT, Gilula L: Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: intergroup study IESS-II. J Clin Oncol 1990, 8:1514-1524.
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36
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The impact of doxorubicin dose intensity on survival of patients with Ewing's sarcoma
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Smith MA: The impact of doxorubicin dose intensity on survival of patients with Ewing's sarcoma. J Clin Oncol 1991, 9:889-891.
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