Efficacy of sulbactam-ampicillin for the treatment of severe diabetic foot infections

Journal of Chemotherapy

Volumn 8, Issue 4, 1996, Pages 284-289

  Akova, M ^a   Ozcebe O ^a   Gullu I ^a   Unal S ^a   Gur D ^a   Akalin, S ^a   Tokgozoglu M ^a   Telatar, F ^a   Akalin, H E ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Diabetes mellitus; Diabetic foot; Osteomyelitis; Sulbactam ampicillin

Indexed keywords

AMPICILLIN; SULBACTAM;

ADULT; AEROBIC BACTERIUM; AMPUTATION; ANAEROBIC BACTERIUM; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; CLINICAL TRIAL; DIABETES MELLITUS; DIABETIC FOOT; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; FEMALE; HOST RESISTANCE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MORBIDITY; OSTEOMYELITIS;

EID: 0029784156     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.1996.8.4.284     Document Type: Article

References (18)

1. Sapico FL. Foot infections. In: Finegold SM, George WL, eds. Anaerobic Infections in Humans. San Diego: Academic Press, 1989: 467-84.
2. Gibbons GW, Eliopoulos GM. Infection of the diabetic foot. In: Kozak GP, Hoar CS Jr, Rowbottam JL, Wheelock FC Jr, Gibbons GW, Campbell D, eds. Management of Diabetic Foot Problems. Philadelphia: Saunders, 1984: 97-102.
3. Joseph WS. Treatment of lower extremity infections in diabetics. Drugs 1991; 42: 984-96.
4. Bush LM, Calmon J, Johnson CC: Newer penicillins and beta-lactamase inhibitors. Infect Dis Clin North Am 1989; 3: 571-94.
5. Caputo GM, Cavanagh PR, Ulbrecht JS, Gibbons GW, Karchmer AW. Assessment and management of foot disease in patients with diabetes. N Engl J Med 1994; 331: 854-60.
6. Gilbert DN, Bennett WM. Use of antimicrobial agents in renal failure. Infect Dis Clin North Am 1989; 3: 517-31.
7. Sahm DF, Washington JA II. Antibacterial susceptibility tests: Dilution methods. In: Balows A, Hausler WJ Jr, Herrmann KL, Isenberg HD, Shadomy HJ.eds. Manual of Clinical Microbiology, 5th ed. Washington DC: American Society for Microbiology, 1985: 1105-16.
8. Murray HJ, Boulton AJ. The pathophysiology of diabetic foot ulceration. Clin Podiatric Med Surg. 1995; 12: 1-17.
9. Mowat A, Baum J. Chemotaxis of polymorphonuclear leucocytes from patients with diabetes mellitus. N Engl J Med1971; 284:621-7.
10. Bybee JD, Rogers DE. The phagocytic activity of polymorphonuclear leucocytes obtained from patients with diabetes mellitus. J Lab Clin Med 1964; 64: 1-13.
11. Tan JS, Anderson JL, Watanakunakorn G, Phair JP. Neutrophil dysfunction in diabetes mellitus. J Lab Clin Med 1975; 85: 26-33.
12. Bessman AN, Sapico FL, Tabatabai M, Montgomerie JZ. Persistence of polymicrobial abscess in the poorly controlled diabetic host. Diabetes 1986; 35: 448-53.
13. Louie TJ, Bartlett JG, Tally FP, Gorbach SL. Aerobic and anaerobic bacteria in diabetic foot ulcers. Ann Int Med 1976; 85: 461-8.
14. Peterson LR, Lissack LM, Canter K, Fasching CE, Clabots C. Therapy of lower extremity infections with ciprofloxacin in patients with diabetes mellitus, peripheral vascular disease, or both. Am J Med 1989; 86: 801-8.
15. Bamberger DM, Daus GP, Gerding DN. Osteomyelitis in the feet of diabetic patients. Am J Med 1987; 83: 653-60.
16. Gozzard DI, Liu YJA, Delamore IW: Clinical usefulness of C-reactive protein measurements. Br J Haematol 1986; 63: 411-4.
17. Akova M, Akalyn HE, Korten V, Özgen T, Erbengi A. Treatment of intracranial abscesses: Experience with sulbactam/ampicillin. J Chemother 1993; 5:181-185.
18. Grayson ML, Gibbons GW, Habershaw GM, et al. Use of ampicillin/sulbactam versus imipenem/cilastatin in the treatment of limb-threatening foot infections in diabetic patients. Clin Infect Dis 1994;18:683-93.