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Volumn 24, Issue 4, 1996, Pages 301-308

Increased serum levels of soluble tumor necrosis factor receptors (sTNF-Rs) in children and adolescents with vertically and horizontally transmitted HIV infection

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 0029783799     PISSN: 03008126     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01743365     Document Type: Article
Times cited : (8)

References (52)
  • 1
    • 0026515551 scopus 로고
    • The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus disease: A review
    • Stein, D. S., Korvick, J. A., Vermund, S. H.: The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus disease: a review. J. Infect. Dis. 165 (1992) 352-363.
    • (1992) J. Infect. Dis. , vol.165 , pp. 352-363
    • Stein, D.S.1    Korvick, J.A.2    Vermund, S.H.3
  • 2
    • 0024512945 scopus 로고
    • Purified blood monocytes from HIV-1-infected patients produce high levels of TNF-α and IL-1
    • Roux-Lombard, P., Modoux, C., Cruchaud, A., Dayer, J.-M.: Purified blood monocytes from HIV-1-infected patients produce high levels of TNF-α and IL-1. Clin. Immunol. Immunopathol. 50 (1989) 374-384.
    • (1989) Clin. Immunol. Immunopathol. , vol.50 , pp. 374-384
    • Roux-Lombard, P.1    Modoux, C.2    Cruchaud, A.3    Dayer, J.-M.4
  • 3
    • 0023852121 scopus 로고
    • The human immunodeficiency virus: Infectivity and mechanisms of pathogenesis
    • Fauci, A. S.: The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science 239 (1988) 617-622.
    • (1988) Science , vol.239 , pp. 617-622
    • Fauci, A.S.1
  • 4
    • 0026333671 scopus 로고
    • Cytokines and HIV infection: Is AIDS a tumor necrosis factor disease?
    • Matsuyama, T., Kobayashi, N., Yamamoto, N.: Cytokines and HIV infection: is AIDS a tumor necrosis factor disease? AIDS 5 (1991) 1405-1417.
    • (1991) AIDS , vol.5 , pp. 1405-1417
    • Matsuyama, T.1    Kobayashi, N.2    Yamamoto, N.3
  • 5
    • 0024370039 scopus 로고
    • Augmentation of in-vitro HIV replication in peripheral blood mononuclear cells of AIDS and ARC patients by tumor necrosis factor
    • Michihiko, S., Yamamoto, N., Shinozaki, F., Shimada, K., Soma, G.-I., Kobayashi, N.: Augmentation of in-vitro HIV replication in peripheral blood mononuclear cells of AIDS and ARC patients by tumor necrosis factor. Lancet i (1989) 1206-1207.
    • (1989) Lancet , vol.1 , pp. 1206-1207
    • Michihiko, S.1    Yamamoto, N.2    Shinozaki, F.3    Shimada, K.4    Soma, G.-I.5    Kobayashi, N.6
  • 6
    • 0010472999 scopus 로고
    • Tumor necrosis factor a induces expression of human immunodeficiency virus in a chronically infected T-cell clone
    • Folks, T. M., Clouse, K. A., Justement, J., Rabson, S., Duh, E., Kehrl, J. H., Fauci, A. S.: Tumor necrosis factor a induces expression of human immunodeficiency virus in a chronically infected T-cell clone. Proc. Natl. Acad. Sci. USA 86 (1989) 2365-2368.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2365-2368
    • Folks, T.M.1    Clouse, K.A.2    Justement, J.3    Rabson, S.4    Duh, E.5    Kehrl, J.H.6    Fauci, A.S.7
  • 7
    • 0027371798 scopus 로고
    • Tumor necrosis factor-dependent proliferation of human immunodeficiency virus 1 in chronically infected HL-60 cells
    • Kitano, K., Rivas, C., Baldwin, G. C., Vera, J. C., Golde, D. W.: Tumor necrosis factor-dependent proliferation of human immunodeficiency virus 1 in chronically infected HL-60 cells. Blood 82 (1993) 2742-2748.
    • (1993) Blood , vol.82 , pp. 2742-2748
    • Kitano, K.1    Rivas, C.2    Baldwin, G.C.3    Vera, J.C.4    Golde, D.W.5
  • 8
    • 0023944339 scopus 로고
    • Tumor necrosis, cachexia, shock, and inflammation: A common mediator
    • Beutler, B., Cerami, A.: Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Annu. Rev. Biochem. 57 (1988) 505-518.
    • (1988) Annu. Rev. Biochem. , vol.57 , pp. 505-518
    • Beutler, B.1    Cerami, A.2
  • 9
    • 0025779160 scopus 로고
    • Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions
    • Vilcek, J., Lee, T. H.: Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions. J. Biol. Chem. 266 (1991) 7313-7316.
    • (1991) J. Biol. Chem. , vol.266 , pp. 7313-7316
    • Vilcek, J.1    Lee, T.H.2
  • 11
    • 0003574039 scopus 로고
    • TNFα. The molecule and the TNF receptors
    • Academic Press, Harcourt Brace & Company, London
    • Callard, R. E., Gearing, A. J. H.: TNFα. The molecule and the TNF receptors. In: The cytokine facts book. Academic Press, Harcourt Brace & Company, London 1994, pp. 241-246.
    • (1994) The Cytokine Facts Book , pp. 241-246
    • Callard, R.E.1    Gearing, A.J.H.2
  • 13
    • 0025463156 scopus 로고
    • Two types of human TNF receptors have similar extracellular domain, but distinct intracellular domain sequences
    • Dembic, Z., Loetscher, H., Gubler, U., Pan, Y.-C. E., Lahm, H.-W., Gentz, R., Brockhaus, M., Lesslauer, W.: Two types of human TNF receptors have similar extracellular domain, but distinct intracellular domain sequences. Cytokine 2 (1990) 231-237.
    • (1990) Cytokine , vol.2 , pp. 231-237
    • Dembic, Z.1    Loetscher, H.2    Gubler, U.3    Pan, Y.-C.E.4    Lahm, H.-W.5    Gentz, R.6    Brockhaus, M.7    Lesslauer, W.8
  • 14
    • 0025238559 scopus 로고
    • Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies
    • Brockhaus, M., Schoenfeld, H. J., Hunziker, W., Lesslauer, W., Loetscher, H.: Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 87 (1990) 3127-3131.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3127-3131
    • Brockhaus, M.1    Schoenfeld, H.J.2    Hunziker, W.3    Lesslauer, W.4    Loetscher, H.5
  • 15
    • 0025113598 scopus 로고
    • Soluble forms of tumor necrosis factor receptors (TNF-Rs). the cDNA for the type 1 TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and the soluble form of the receptor
    • Nophar, Y., Kemper, O., Brakebusch, C., Engelmann, H., Zwang, R., Aderka, D., Holtmann, H., Wallach, D.: Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type 1 TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and the soluble form of the receptor. EMBO J. 9 (1990) 3269-3278.
    • (1990) EMBO J. , vol.9 , pp. 3269-3278
    • Nophar, Y.1    Kemper, O.2    Brakebusch, C.3    Engelmann, H.4    Zwang, R.5    Aderka, D.6    Holtmann, H.7    Wallach, D.8
  • 16
    • 0025165135 scopus 로고
    • Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors
    • Engelmann, H., Novick, D., Wallach, D.: Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors. J. Biol. Chem. 265 (1990) 1531-1536.
    • (1990) J. Biol. Chem. , vol.265 , pp. 1531-1536
    • Engelmann, H.1    Novick, D.2    Wallach, D.3
  • 17
    • 0025054391 scopus 로고
    • Characterization in vitro of a human tumor necrosis factor-binding protein: A soluble form of a tumor necrosis factor receptor
    • Lantz, M., Gullberg, U., Nilsson, E., Olsson, I.: Characterization in vitro of a human tumor necrosis factor-binding protein: a soluble form of a tumor necrosis factor receptor. J. Clin. Invest. 86 (1990) 1196-1202.
    • (1990) J. Clin. Invest. , vol.86 , pp. 1196-1202
    • Lantz, M.1    Gullberg, U.2    Nilsson, E.3    Olsson, I.4
  • 19
    • 0027452462 scopus 로고
    • Mechanism of release of soluble forms of tumor necrosis factor/lymphotoxin receptors by phorbol myristate acetate-stimulated human THP-1 cells in vitro
    • Hwang, C., Gatanaga, M., Granger, G., Gatanaga, T.: Mechanism of release of soluble forms of tumor necrosis factor/lymphotoxin receptors by phorbol myristate acetate-stimulated human THP-1 cells in vitro. J. Immunol. 151 (1993) 5631-5638.
    • (1993) J. Immunol. , vol.151 , pp. 5631-5638
    • Hwang, C.1    Gatanaga, M.2    Granger, G.3    Gatanaga, T.4
  • 20
    • 0028241522 scopus 로고
    • Mechanisms involved in the processing of the p55 and the p75 tumor necrosis factor (TNF) receptors to soluble receptor forms
    • Bjornberg, F., Lantz, M., Olsson, I., Gullberg, U.: Mechanisms involved in the processing of the p55 and the p75 tumor necrosis factor (TNF) receptors to soluble receptor forms. Lymphokine Cytokine Res. 13 (1994) 203-211.
    • (1994) Lymphokine Cytokine Res. , vol.13 , pp. 203-211
    • Bjornberg, F.1    Lantz, M.2    Olsson, I.3    Gullberg, U.4
  • 21
    • 0025519183 scopus 로고
    • Infusion of tumor necrosis factor (TNF) causes an increase in circulating TNF-binding protein in humans
    • Lantz, M., Malik, S., Slevin, M. L., Olsson, I.: Infusion of tumor necrosis factor (TNF) causes an increase in circulating TNF-binding protein in humans. Cytokine 2 (1990) 402-406.
    • (1990) Cytokine , vol.2 , pp. 402-406
    • Lantz, M.1    Malik, S.2    Slevin, M.L.3    Olsson, I.4
  • 22
    • 0026741275 scopus 로고
    • Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor α; in vitro and in vivo
    • van Zee, K. J., Kohno, T., Fischer, E., Rock, C. S., Moldawer, L. L., Lowry, S. F.: Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor α; in vitro and in vivo. Proc. Natl. Acad. Sci. USA 89 (1992) 4845-4849.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4845-4849
    • Van Zee, K.J.1    Kohno, T.2    Fischer, E.3    Rock, C.S.4    Moldawer, L.L.5    Lowry, S.F.6
  • 23
    • 0026737258 scopus 로고
    • Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia
    • Spinas, G. A., Keller, U., Brockhaus, M.: Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia. J. Clin. Invest. 90 (1992) 533-536.
    • (1992) J. Clin. Invest. , vol.90 , pp. 533-536
    • Spinas, G.A.1    Keller, U.2    Brockhaus, M.3
  • 24
    • 0026516744 scopus 로고
    • Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors
    • Aderka, D., Engelmann, H., Maor, Y., Brakebusch, C., Wallach, D.: Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J. Exp. Med. 175 (1992) 323-329.
    • (1992) J. Exp. Med. , vol.175 , pp. 323-329
    • Aderka, D.1    Engelmann, H.2    Maor, Y.3    Brakebusch, C.4    Wallach, D.5
  • 26
    • 0026497573 scopus 로고
    • p55 and p75 tumor necrosis factor receptors in patients with chronic lymphocytic leukemia
    • Waage, A., Liabakk, N.-B., Lien, E., Lamvik, J., Espevik, T.: p55 and p75 tumor necrosis factor receptors in patients with chronic lymphocytic leukemia. Blood 80 (1992) 2577-2583.
    • (1992) Blood , vol.80 , pp. 2577-2583
    • Waage, A.1    Liabakk, N.-B.2    Lien, E.3    Lamvik, J.4    Espevik, T.5
  • 27
    • 0029207178 scopus 로고
    • Soluble tumor necrosis factor receptors in febrile neutropenic cancer patients
    • Kern, W. V., Engel, A., Kern, P.: Soluble tumor necrosis factor receptors in febrile neutropenic cancer patients. Infection 23 (1995) 64-65.
    • (1995) Infection , vol.23 , pp. 64-65
    • Kern, W.V.1    Engel, A.2    Kern, P.3
  • 29
    • 0027306166 scopus 로고
    • Evaluation of soluble tumor necrosis factor (TNF) receptors and TNF receptor antibodies in patients with systemic lupus erythematodes, progressive systemic sclerosis, and mixed connective tissue disease
    • Heilig, B., Fiehn, C., Brockhaus, M., Gallati, H., Pezzutto, A., Hunstein, W.: Evaluation of soluble tumor necrosis factor (TNF) receptors and TNF receptor antibodies in patients with systemic lupus erythematodes, progressive systemic sclerosis, and mixed connective tissue disease. J. Clin. Immunol. 13 (1993) 321-327.
    • (1993) J. Clin. Immunol. , vol.13 , pp. 321-327
    • Heilig, B.1    Fiehn, C.2    Brockhaus, M.3    Gallati, H.4    Pezzutto, A.5    Hunstein, W.6
  • 30
    • 0028342974 scopus 로고
    • Soluble tumor necrosis factor receptors in patients with recurrent hepatitis C infection after liver transplantation
    • Arnold, J. C., Heilig, B., Kallinowski, B., Otto, G., Kommerell, B., Theilmann, L.: Soluble tumor necrosis factor receptors in patients with recurrent hepatitis C infection after liver transplantation. Clin. Invest. 72 (1994) 470.
    • (1994) Clin. Invest. , vol.72 , pp. 470
    • Arnold, J.C.1    Heilig, B.2    Kallinowski, B.3    Otto, G.4    Kommerell, B.5    Theilmann, L.6
  • 32
    • 0026708465 scopus 로고
    • Imbalance between tumor necrosis factor-α and soluble TNF receptor concentration in severe meningococcaemia
    • The J5 Study Group
    • Girardin, E., Roux-Lombard, P., Grau, G. E., Suter, P., Gallati, H., Dayer, J.-M.: Imbalance between tumor necrosis factor-α and soluble TNF receptor concentration in severe meningococcaemia. The J5 Study Group. Immunology 76 (1992) 20-23.
    • (1992) Immunology , vol.76 , pp. 20-23
    • Girardin, E.1    Roux-Lombard, P.2    Grau, G.E.3    Suter, P.4    Gallati, H.5    Dayer, J.-M.6
  • 33
    • 0026658217 scopus 로고
    • Increased serum levels of soluble tumor necrosis factor receptors correlate with parasitemia and disease severity in human malaria
    • Kern, P., Hemmer, C. J., Gallati, H., Neifer, S. N., Kremsner, P., Dietrich, D., Porzsolt, F.: Increased serum levels of soluble tumor necrosis factor receptors correlate with parasitemia and disease severity in human malaria. J. Infect. Dis. 166 (1992) 930-934.
    • (1992) J. Infect. Dis. , vol.166 , pp. 930-934
    • Kern, P.1    Hemmer, C.J.2    Gallati, H.3    Neifer, S.N.4    Kremsner, P.5    Dietrich, D.6    Porzsolt, F.7
  • 37
    • 0028140219 scopus 로고
    • Serum levels of tumor necrosis factor-α (TNFα) and soluble TNF receptors in human immunodeficiency virus type 1 infection - Correlations to clinical, immunologic and virologic parameters
    • Aukrust, P., Liabakk, N.-B., Müller, F., Lien, E., Espevik, T., Frøland, S. S.: Serum levels of tumor necrosis factor-α (TNFα) and soluble TNF receptors in human immunodeficiency virus type 1 infection - correlations to clinical, immunologic and virologic parameters. J. Infect. Dis. 169 (1994) 420-424.
    • (1994) J. Infect. Dis. , vol.169 , pp. 420-424
    • Aukrust, P.1    Liabakk, N.-B.2    Müller, F.3    Lien, E.4    Espevik, T.5    Frøland, S.S.6
  • 38
    • 0028963546 scopus 로고
    • Activation of tumor necrosis factor-α system in HIV-1 infection: Association with markers of immune activation
    • Aukrust, P., Liabakk, N.-B., Müller, F., Espevik, T., Frøland, S. S.: Activation of tumor necrosis factor-α system in HIV-1 infection: association with markers of immune activation. Infection 23 (1995) 9-15.
    • (1995) Infection , vol.23 , pp. 9-15
    • Aukrust, P.1    Liabakk, N.-B.2    Müller, F.3    Espevik, T.4    Frøland, S.S.5
  • 39
    • 0028181516 scopus 로고
    • Increased serum concentrations of soluble tumor necrosis factor receptors in HIV-infected individuals are associated with immune activation
    • Zangerle, R., Gallati, H., Sarcletti, M., Weiss, G., Denz, H., Wachter, H., Fuchs, D.: Increased serum concentrations of soluble tumor necrosis factor receptors in HIV-infected individuals are associated with immune activation. J. Acquir. Immune Defic. Syndr. 7 (1994) 79-85.
    • (1994) J. Acquir. Immune Defic. Syndr. , vol.7 , pp. 79-85
    • Zangerle, R.1    Gallati, H.2    Sarcletti, M.3    Weiss, G.4    Denz, H.5    Wachter, H.6    Fuchs, D.7
  • 41
    • 0028344901 scopus 로고
    • Soluble receptors for tumor necrosis factor as predictors of progression to AIDS in asymptomatic human immunodeficiency virus type 1 infection
    • Godfried, M. H., van der Poll, T., Weverling, G. J., Mulder, J. W., Jansen, J., van Deventer, S. J. H., Sauerwein, H. P.: Soluble receptors for tumor necrosis factor as predictors of progression to AIDS in asymptomatic human immunodeficiency virus type 1 infection. J. Infect. Dis. 169 (1994) 739-745.
    • (1994) J. Infect. Dis. , vol.169 , pp. 739-745
    • Godfried, M.H.1    Van Der Poll, T.2    Weverling, G.J.3    Mulder, J.W.4    Jansen, J.5    Van Deventer, S.J.H.6    Sauerwein, H.P.7
  • 42
    • 0030063533 scopus 로고    scopus 로고
    • Soluble cytokine receptors
    • Heaney, M. L., Golde, D. W.: Soluble cytokine receptors. Blood 87 (1996) 847-857.
    • (1996) Blood , vol.87 , pp. 847-857
    • Heaney, M.L.1    Golde, D.W.2
  • 43
    • 0027122957 scopus 로고
    • 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults
    • Centers for Disease Control and Prevention: 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR 41 (No. RR-17) (1992) 1-19.
    • (1992) MMWR , vol.41 , Issue.RR-17 , pp. 1-19
  • 44
    • 0000771140 scopus 로고
    • 1994 revised classification system for human immunodeficiency virus infection in children less than 13 years of age
    • Centers for Disease Control and Prevention: 1994 revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR 43 (No. RR-12) (1994) 1-10.
    • (1994) MMWR , vol.43 , Issue.RR-12 , pp. 1-10
  • 45
    • 0026454728 scopus 로고
    • Age-related standards for T lymphocyte subsets based on uninfected children born to human immunodeficiency virus 1-infected women
    • The European Collaborative Study: Age-related standards for T lymphocyte subsets based on uninfected children born to human immunodeficiency virus 1-infected women. Pediatr. Infect. Dis. J. 11 (1992) 1018-1026.
    • (1992) Pediatr. Infect. Dis. J. , vol.11 , pp. 1018-1026
  • 47
    • 0026722285 scopus 로고
    • Lymphocyte subsets in children younger than 2 years old: Normal values in a population at risk for human immunodeficiency virus infection and diagnostic and prognostic application to infected children
    • McKinney, R. E., Wilfert, C. M.: Lymphocyte subsets in children younger than 2 years old: normal values in a population at risk for human immunodeficiency virus infection and diagnostic and prognostic application to infected children. Pediatr. Infect. Dis. J. 11 (1992) 639-644.
    • (1992) Pediatr. Infect. Dis. J. , vol.11 , pp. 639-644
    • McKinney, R.E.1    Wilfert, C.M.2
  • 48
    • 0028287014 scopus 로고
    • Lipopolysaccharide (LPS)-mediated soluble TNF receptor release and TNF receptor expression by monocytes
    • Leeuwenberg, J. E. M., Dentener, M. A., Buurman, W. A.: Lipopolysaccharide (LPS)-mediated soluble TNF receptor release and TNF receptor expression by monocytes. J. Immunol. 152 (1994) 5070-5076.
    • (1994) J. Immunol. , vol.152 , pp. 5070-5076
    • Leeuwenberg, J.E.M.1    Dentener, M.A.2    Buurman, W.A.3
  • 49
    • 0027934198 scopus 로고
    • Tumor necrosis factor induces a selective shedding of its p75 receptor from human neutrophils
    • Porteu, F., Hieblot, C.: Tumor necrosis factor induces a selective shedding of its p75 receptor from human neutrophils. J. Biol. Chem. 269 (1994) 2834-2840.
    • (1994) J. Biol. Chem. , vol.269 , pp. 2834-2840
    • Porteu, F.1    Hieblot, C.2
  • 50
    • 0024406923 scopus 로고
    • Soluble IL-2 receptor in AIDS. Correlation of its serum level with the classification of HIV-induced diseases and its characterization
    • Honda, M., Kitaniura, K., Matsuda, K., Yokota, Y., Yamamoto, N., Mitsuyasu, R., Chermann, J.-C., Tokunaga, T.: Soluble IL-2 receptor in AIDS. Correlation of its serum level with the classification of HIV-induced diseases and its characterization. J. Immunol. 142 (1989) 4248-4255.
    • (1989) J. Immunol. , vol.142 , pp. 4248-4255
    • Honda, M.1    Kitaniura, K.2    Matsuda, K.3    Yokota, Y.4    Yamamoto, N.5    Mitsuyasu, R.6    Chermann, J.-C.7    Tokunaga, T.8
  • 52
    • 0030071867 scopus 로고    scopus 로고
    • Soluble tumor necrosis factor-α receptor type II (sTNFαRII) correlates with human immunodeficiency virus (HIV) RNA copy number in HIV-infected patients
    • Bilello, J. A., Stellrecht, K., Drusano, G. L., Stein, D. S.: Soluble tumor necrosis factor-α receptor type II (sTNFαRII) correlates with human immunodeficiency virus (HIV) RNA copy number in HIV-infected patients. J. Infect. Dis. 173 (1996) 464-467.
    • (1996) J. Infect. Dis. , vol.173 , pp. 464-467
    • Bilello, J.A.1    Stellrecht, K.2    Drusano, G.L.3    Stein, D.S.4


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