Fos expression in grafted gonadotropin-releasing hormone neurons in hypogonadal mouse: Mating and steroid induction

Journal of Neurobiology

Volumn 31, Issue 1, 1996, Pages 67-76

  Wu, T J ^a,b   Silverman, A J ^a   Gibson, M J ^b  

^a College of Physicians and Surgeons ^*  (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

FOS; GnRH; hypogonadal; induced ovulation; mating; progesterone

Indexed keywords

ESTRADIOL BENZOATE; FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE; PROGESTERONE;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EJACULATION; FEMALE; GENE EXPRESSION; HYPOGONADISM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; MALE; MATING; MOUSE; NONHUMAN; ONCOGENE C FOS; OVULATION INDUCTION; PREOPTIC AREA; PRIORITY JOURNAL; SEXUAL BEHAVIOR; STEROID THERAPY; THALAMUS VENTRAL NUCLEUS;

ANIMALS; BRAIN; CERVIX UTERI; FEMALE; GONADOTROPIN-RELEASING HORMONE; HYPOGONADISM; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, MUTANT STRAINS; NEURONS; OVULATION INDUCTION; PREOPTIC AREA; PROGESTERONE; PROTO-ONCOGENE PROTEINS C-FOS; SEXUAL BEHAVIOR, ANIMAL; VAGINA;

EID: 0029783448     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4695(199609)31:1<67::AID-NEU6>3.0.CO;2-D     Document Type: Article

References (55)

1. ADELMAN, J. P., MASON, A. J., and SEEBURG, P. H. (1986). Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release inhibiting factor in human and rat. Proc. Natl. Acad. Sci. USA 83:179-183.
2. BLAUSTEIN, J. D., KING, J. C., TOFT, D. O., and TURCOTTE, J. (1988). Immunocytochemical localization of estrogen-induced progestin receptors in guinea pig brain. Brain Res. 474:1-15.
3. BLAUSTEIN, J. D. and TURCOTTE, J. C. (1989). Estradiol-induced progestin receptor immunoreactivity is found only in estrogen receptor-immunoreactive cells in guinea pig brain. Neuroendocrinology 49:454-461.
4. BOND, C. T., HAYFLICK, J. S., SEEBURG, P. H., and ADELMAN, J. P. (1989). The rat gonadotropin-releasing hormone: SH locus: structure and hypothalamic expression. Mol. Endocrinol. 3:1257-1262.
5. BRONSON, F. H. and VOMSAAL, F. S. (1979). Control of the preovulatory release of luteinizing hormone by steroids in the mouse. Endocrinology 104:1247-1255.
6. BROWN-GRANT, K., DAVIDSON, J. M., and GREIG, F. (1973). Induced ovulation in albino rats exposed to constant light. J. Endocrinol. 57:7-22.
7. CATTANACH, B. M., IDDON, C. A., CHARLTON, H. M., CHIAPPA, S. A., and FINK, G. (1977). Gonadotropin releasing hormone deficiency in a mutant mouse with hypogonadism. Nature 269:338-340.
8. CONAWAY, H. (1971). Ecological adaptation and mammalian reproduction. Biol. Reprod. 4:239-247.
9. CURRAN, T. and MORGAN, J. I. (1995). Fos: an immediate-early transcription factor in neurons. J. Neurobiol. 26:403-412.
10. DONCARLOS, L. L., GREENE, G. L., and MORRELL, J. I. (1989). Estrogen plus progesterone increases progestin receptor immunoreactivity in the brain of ovariectomized guinea pigs. Neuroendocrinology 50:613-623.
11. DRAGUNOW, M. and FAULL, R. (1989). The use of cfos as a metabolic marker in neuronal pathway tracing. J. Neurosci. Methods 29:261-265.
12. ERSKINE, M. S. (1993). Mating-induced increases in FOS protein in preoptic area and medial amygdala of cycling female rats. Brain. Res. Bull. 32:447-451.
13. FEDER, H. H. and MARRONE, B. L. (1977). Progesterone: its role in the central nervous system as a facilitator and inhibitor of sexual behavior and gonadotropin release. Ann. NY Acad. Sci. 286:331-354.
14. FLANAGAN-CATO, L. M. and MCEWEN, B. S. (1995). Pattern of Fos and Jun expression in the female rat forebrain after sexual behavior. Brain Res. 673:53-60.
15. FOX, S. R., HARLAN, R. E., SHIVERS, B. D., and PFAFF, D. W. (1990). Chemical characterization of neuroendocrine targets for progesterone in the female rat brain and pituitary. Nenroendocrinology 51:276-283.
16. GIBSON, M. J., CHARLTON, H. M., PERLOW, M. J., ZIMMERMA, E. A., SILVERMAN, A. J., and KRIECIER, D. T. (1984a). Preoptic area brain grafts in hypogonadal (hpg) female mice abolish effects of congenital hypothalamic gonadotropin-releasing hormone (GnRH) deficiency. Endocrinology 114:1938-1940.
17. GIBSON, M. J., KOKORIS, G. J., and SILVERMAN, A. J. (1988). Positive feedback in hypogonadal female mice with preoptic area brain transplants. Neuroendocrinoloy 48:112-119.
18. GIBSON, M. J., KRIEGER, D. T., CHARLTON, H. M., ZIMMERMAN, E. A., SILVERMAN, A. J., and PERLOW, M. J. (1984b). Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts. Science 225:949-951.
19. GIBSON, M. J.. MILLER, G. M., and SILVERMAN, A. J. (1991). Pulsatile luteinizing hormone secretion in normal female mice and in hypogonadal female mice with preoptic area implants. Endocrinology 128:965-971.
20. GIBSON, M. J., MOSCOVITZ, H. C., KOKORIS, G. J., and SILVERMAN, A. J. (1987a). Female sexual behavior in hypogonadal mice with GnRH-containing brain grafts. Horm. Behav. 21:211-222.
21. GIBSON, M. J., MOSCOVITZ, H. C., KOKORIS, G. J., and SILVERMAN, A. J. (1987b). Plasma LH rises rapidly following mating in hypogonadal female mice with preoptic area (POA) brain grafts. Brain Res. 424:133-138.
22. GIBSON, M. J., SILVERMAN, A. J., ROSENTHAL, M. F., and MORRELL, J. I. (1989). Estradiol-concentrating cells in the brains of hypogonadal female mice and in their intraventricular preoptic area implants. Exp. Neurol. 105:127-134.
23. HUFFMAN, G. E., LEE, W.-S., ATTARDI, B., YANN, V., and FITZSIMMONS, M. D. (1990). Luteinizing hormone-releasing hormone neurons express c-fos antigen after steroid activation. Endocrinology 126:1736-1741.
24. HUBSCHER, C. H. and BERKLEY, K. J. (1994). Responses of neurons in caudal solitary nucleus of female rats to stimulation of vagina, cervix, uterine horn and colon. Brain Res. 664:1-8.
25. INSEL, T. R. (1990). Regional induction of c-fos-like protein in rat brain after estradiol administration. Endocrinology 126:1849-1853.
26. KING, J. C., TAI, D. W., HANNA, I. K., PFEIFFER, A., HAAS, P., RONSHEIM, P. M., MITCHELL, S. C., TURCOTTE, J. C., and BLAUSTEIN, J. D. (1995). A subgroup of LHRH neurons in guinea pigs with progestin receptors is centrally positioned within the total population of LHRH neurons. Neuroendocrinology 61: 265-275.
27. KRIEGER, D. T., PERLOW, M. J., GIBSON, M. J., DAVIES, T. F., ZIMMERMAN, E. A., FERIN, M., and CHARLTON, H. M. (1982). Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency. Nature 298:468-471.
28. LAMBERT, G. M., RUBIN, B. S., and BAUM, M. J. (1992). Sex difference in the effect of mating on c-fos expression in luteinizing hormone-releasing hormone neurons of the ferret forebrain. Endocrinology 131: 1473-1480.
29. LEE, W.-S., SMITH, M. S., and HUFFMAN, G. E.(1990a). Progesterone enhances the surge of luteinizing hormone by increasing the activation of luteinizing hormone-releasing hormone neurons. Endocrinology 127:2604-2606.
30. LEE, W.-S., SMITH, M. S., and HUFFMAN, G. E. (1990b). Luteinizing hormone-releasing hormone neurons express Fos protein during the proestrous surge of luteinizing hormone. Proc. Natl. Acad. Sci. USA 87:5163-5167.
31. MASON, A. J., HAYFLICK, J. S., ZOELLER, R. T., YOUNG, W. S., III, PHILLIPS, H. S., NIKOLICS, K., and SEEBURG, P. H. (1986). A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse. Science 234:1366-1371.
32. MILLER, G. M., SILVERMAN, A.-J., ROGERS, M.-C., and GIBSON. M. J. (1995). Neuromodulation of transplanted gonadotropin-releasing hormone neurons in male and female hypogonadal mice with preoptic area brain grafts. Biol Reprod. 52:572-583.
33. PETERS, L. C., KRISTAL, M. B., and KOMISARUK, B. R. (1987). Sensory innervation of the external and internal genitalia of the female rat. Brain Res. 408:199-204.
34. PFAUS, J. G., JAKOB, A., KLEOPOULOS, S. P., GIBBS, R. B., and PFAF, D. W. (1994). Sexual stimulation induces Fos immunoreactivity within GnRH neurons of the female rat preoptic area: interaction with steroid hormones. Neuroendocrinology 60:283-290.
35. RAJENDREN, G., DUDLEY, C. A., and Moss, R. L. (1993). Influence of male rats on the luteinizing hormone-releasing hormone neuronal system in female rats: role of the vomeronasal organ. Neuroendocrinology 57:898-906.
36. RAJENDREN, G. and Moss, R. L. (1993). The role of the medial nucleus of amygdala in the mating-induced enhancement of lordosis in female rats: the interaction with luteinizing hormone-releasing hormone neuronal system. Brain Res. 617:81-86.
37. RAMIREZ, V. D. and BEYER, C. (1988). The ovarian cycle of the rabbit: its neuroendocrine control. In: The Physiology of Reproduction. E. Knobil, J. Neill, L. L. Ewing, G. S. Greenwald, C. L. Markert, and D. W. Pfaff, Eds. Raven Press, New York, pp. 1873-1892.
38. RANSONE, L. J. and VERMA, I. M. (1990). Nuclear proto-oncogenes FOS and JUN. Annu. Rev. Cell Biol. 6:539-557.
39. ROMANO, G. J., KRUST, A., and PFAFF, D. W. (1989). Expression and estrogen regulation of progesterone receptor mRNA in neurons of the mediobasal hypothalamus: an in situ hybridization study. Mol. Endocrinol. 3:1295-1300.
40. ROWE., D. W. and ERSKINE, M. S. (1993). c-Fos protooncogene activity induced by mating in the preoptic area, hypothalamus and amygdala in the female rat: role of afferent input via the pelvic nerve. Brain Res. 621:25-34.
41. SAGAR, S. M., SHARP, F. R., and CURRAN, T. (1988). Expression of c-FOS protein in brain: metabolic mapping at the cellular level. Science 240:1328-1331.
42. SAITOH, Y., SILVERMAN, A. J., and GIBSON, M. J. (1991). Norepinephrine neurons in mouse locus coeruleus express c-fos protein after N-methyl-D,L-aspartic acid (NMDA) treatment: relation to LH release. Brain Res. 561:11-19.
43. 125I] progestin. Endocrinology 124:333-338.
44. SILVERMAN, A. J., KOKORIS, G. J., and GIBSON, M. J. (1988). Quantitative analysis of synaptic input to gonadotropin releasing hormone neurons in normal mice and hpg mice with preoptic area grafts. Brain Res. 443:367-372.
45. SILVERMAN, A. J.,SILVERMAN, R.C.,andGIBSON, M. J. (1990). Repair of reproductive deficits by neural transplantation. Biol. Reprod. 42:29-38.
46. SILVERMAN, A. J., ZIMMERMAN, E. A., GIBSON, M. J., PERLOW, M. J., CHARLTON, H. M., KOKORIS, G. J., and KRIEGER, D. T. (1985). Implantation of normal fetal preoptic area into hypogonadal (hpg) mutant mice: temporal relationships of the growth of GnRH neurons and the development of the pituitary/ testicular axis. Neuroscience 16:69-84.
47. SILVERMAN, A. J., ZIMMERMAN, E. A., KOKORIS, G. J., and GIBSON, M. J. (1986). Ultrastructure of gonadotropin releasing hormone (GnRH) neuronal structures derived from normal fetal preoptic area and transplanted into hypogonadal mutant (hpg) mice. J. Neurosci. 6:2090-2096.
48. SILVERMAN, R. C., GIBSON, M. J., and SILVERMAN, A. J. (1992). Application of a fluorescent dye to study connectivity between third ventricular preoptic area grafts and host hypothalamus. J. Neurosci. Res. 31:156-165.
49. SLOTNICK, B. M. and LEONARD, C. M. (1975). A Stereotaxic Atlas of the Albino Mouse Forebrain. U.S. Department of HEW, Rockville, MD.
50. TETEL, M. J., CELENTANO, D. C., and BLAUSTEIN, J. D. (1994a). Intraneuronal convergence of tactile and hormonal stimuli associated with female reproduction in rats. J. Neuroendocrinol. 6:211-216.
51. TETEL, M. J., GETZINOER, M. J., and BLAUSTEIN, J. D. (1993). Fos stimulation in the rat brain following vaginal-cervical stimulation by mating and manual probing. J. Neuroendocrinol. 5:397-404.
52. TETEL, M. J., GETZINGER, M. J., and BLAUSTEIN, J. D. (1994b). Estradiol and progesterone influence the response of ventromedial hypothalamic neurons to tactile stimuli associated with female reproduction. Brain Res. 646:267-272.
53. WANG, H. J., HOFFMAN, G. E., and SMITH, M. S. (1995). Increased GnRH mRNA in the GnRH neurons expressing cFos during the proestrous LH surge. Endocrinology 136:3673-3676.
54. WU, T. J., SEGAL, A. Z., MILLER, G. M., GIBSON, M. J., and SILVERMAN, A.-J. (1992). FOS expression in gonadotropin-releasing hormone neurons: enhancement by steroid treatment and mating. Endocrinology 131: 2045-2050.
55. ZARROW, M. X. and CLARK, J. H. (1968). Ovulation following vaginal stimulation in a spontaneous ovulator and its implications. J. Endocrinol. 40:343-352.