Clinical and immunohistochemical comparison of in vivo injected anti-Hu and control IgG in the nervous system of the mouse

European Journal of Neurology

Volumn 3, Issue 4, 1996, Pages 319-323

  Rene R ^a   Ferrer, I ^b   Graus, F ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Autoantibodies; Immunohistochemistry; Paraneoplastic syndrome; Sensory neuronopathy

Indexed keywords

AUTOANTIBODY; AVIDIN; BIOTIN; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFACT; AUTOPSY; CELL NUCLEUS; CHOROID PLEXUS; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOPLASM; ENCEPHALOMYELITIS; EXTRACELLULAR SPACE; FEMALE; IMMERSION; IMMUNOHISTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; LEPTOMENINX; MOUSE; NERVE CELL; NERVOUS SYSTEM; NONHUMAN; PARANEOPLASTIC SYNDROME; PERFUSION; PRIORITY JOURNAL; SENSORY NEUROPATHY; SPINAL GANGLION; TEMPERATURE; TRIGEMINUS GANGLION;

EID: 0029783150     PISSN: 13515101     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1468-1331.1996.tb00224.x     Document Type: Article

References (27)

1. Arvidson B (1979) Distribution of intravenously injected protein tracers in peripheral ganglia of adult mice. Experimental Neurology, 63, 388-410.
2. Brashear HR, Caccamo DV, Heck A and Keeney PM (1991) Localization of antibody in the central nervous system of a patient with paraneoplastic encephalomyeloneuritis. Neurology, 41, 1583-1587.
3. Dalmau J, Furneaux HM, Rosenblum MK, Graus F and Posner JB (1991) Detection of the anti-Hu antibody in specific regions of the nervous system and tumor from patients with paraneoplastic encephalomyelitis/sensory neuronopathy. Neurology, 41, 1757-1764.
4. Dalmau J, Verschuuren J, Hoard R, Posner JB (1995) Anti-Hu serum is cytotoxic for non-Hu-antigen-expressing cell lines. Neurology, 45 (suppl. 4), A229.
5. Dick DJ, Harris JB, Falkous G, Foster JB and Xuereb JH (1988) Neuronal anti-nuclear antibody in paraneoplastic sensory neuronopathy. Journal of Neurological Science, 85, 1-8.
6. Fabian RH (1992) Reliability of immunocytochemical localization of IgG in immersion-fixed tissue from the central nervous system. Journal of Histochemistry and Cytochemistry, 40, 987-991.
7. Farrell MA, Droogan O, Vadims Poukens DLS, Quinn B and Vinters HV (1995) Chronic encephalitis associated with epilepsy: immunohistochemical and ultrastructural studies. Acta Neuropathologica, 89, 313-321.
8. Fukunaga HM, Engel AG, Lang B, Newsom-Davis J and Vincent A (1993) Passive transfer of Lambert-Eaton myasthenic syndrome with IgG from man to mouse depletes the presynaptic membrane active zones. Proceedings of the National Academy of Sciences of the USA, 80, 7636-7640.
9. Furneaux HM, Reich L and Posner JB (1990) Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes. Neurology, 40, 1085-1091.
10. Furneaux HM and Wong E (1994) Incubation of tumor cells with anti-Hu monoclonal results in apoptosis. Neurology, 44 (suppl. 2), A377.
11. Gomez CM and Richman DP (1985) Monoclonal anti-acetylcholine receptor receptor antibodies with differing capacities to induce experimental autoimmune myasthenia gravis. Journal of Immunology, 135, 234-241.
12. Graus F, Elkon KB, Cordon-Cardo C and Posner JB (1986) Sensory neuronopathy and small cell lung cancer. Antineuronal antibody that also reacts with the tumor. American Journal of Medicine, 80, 46-52.
13. Graus F, Ribalta T, Campo E, Monforte R, Urbano A and Rozman C (1990) Immunohistochemical analysis of the immune reaction in the nervous system in paraneoplastic encephalomyelitis. Neurology, 40, 219-222.
14. Graus F, Illa I, Agustí M, Ribalta T, Cruz-Sanchez F and Juarez C (1991) Effect of intraventricular injection of an anti-Purkinje cell antibody (anti-Yo) in a guinea pig model. Journal of Neurological Science, 106, 82-87.
15. Greenlee JE, Parks TN and Jaeckle KA (1993) Type IIa ("anti-Hu") antineuronal antibodies produce destruction of rat cerebellar granule neurons in vitro. Neurology, 43, 2049-2054.
16. Henson RA and Urich H (1982) Encephalomyelitis with carcinoma. In: Cancer and the Nervous System: the Neurological Manifestations of Systemic Malignant Disease (Eds RA Henson and H Urich), pp. 314-345. Oxford, Blackwell Scientific.
17. Hormigo A and Lieberman F (1994) Nuclear localization of anti-Hu antibody is not associated with in vitro cytotoxicity. Journal of Neuroimmunology, 55, 205-212.
18. Jean WC, Dalmau J, Ho A and Posner JB (1994) Analysis of the IgG subclass distribution and inflammatory infiltrates in patients with anti-Hu-associated paraneoplastic encephalomyelitis. Neurology, 44, 140-147.
19. Lang B, Newsom-Davis J, Wray D and Vincent A (1981) Autoimmune aetiology for myasthenic (Eaton-Lambert) syndrome. Lancet, ii, 224-226.
20. Manley GTM, Sillevis Smitt P, Dalmau J and Posner JB (1995) Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites. Annals of Neurology, 38, 101-110.
21. Neumann H, Cavalié A, Jenne DE and Wekerle H (1995) Induction of MHC class I genes in neurons. Science, 269, 549-552.
22. Santos GW (1976) Induction of specific tolerance to soluble and particulate antigens in man and tissue allografts in mice with cyclophosphamide. Experimental Hematology, 14, 32-34.
23. Sillevis-Smitt PAE, Manley GTM and Posner JB (1995). Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice. Neurology, 45, 1873-1878.
24. Szabo A, Dalmau J, Manley G, Rosenfeld M, Wong E, Henson J, Posner JB and Furneaux HM (1991) HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal. Cell, 67, 325-333.
25. Tanaka K, Tanaka M, Onodera O, Igarashi S, Miyatake T and Tsuji S (1994) Passive transfer and active immunization with the recombinant leucine-zipper (Yo) protein as an attempt to establish an animal model of paraneoplastic cerebellar degeneration. Neurological Science, 127, 153-158.
26. Toyka KV, Drachman DB, Griffin DE, Pestronk A, Winkelstein JA, Fischbeck KH and Kao I (1977) Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice. New England Journal of Medicine, 296, 125-131.
27. Vega F, Graus F, Chen QM, Poisson M, Schuller E and Delattre JY (1994) Intrathecal synthesis of the anti-Hu antibody in patients with paraneoplastic encephalomyelitis or sensory neuronopathy: clinical-immunologic correlations. Neurology, 44, 2145-2147.