Crystal forms, improvements of dissolution and absorption of poorly water- soluble (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022)

Yakugaku Zasshi

Volumn 116, Issue 8, 1996, Pages 639-646

  Yano, Katsuhiko ^a   Takamatsu, Narushi ^a   Yamazaki, Shigeru ^a   Sako, Kazuhiro ^a   Nagura, Satsuki ^a   Tomizawa, Sakiko ^a   Shimaya, Jun ^a   Yamamoto, Keiji ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

bioavailability; dissolution behavior; polymorph; poorly water soluble drug; solid dispersion; water soluble polymer

Indexed keywords

1 [2,3 DIHYDRO 1 (2' METHYLPHENACYL) 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL] 3 (3 METHYLPHENYL)UREA;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG SOLUBILITY; DRUG STRUCTURE; X RAY DIFFRACTION;

EID: 0029782943     PISSN: 00316903     EISSN: None     Source Type: Journal    
DOI: 10.1248/yakushi1947.116.8_639     Document Type: Article

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