The effects of 5-fluorouracil and interferon-α on early healing of experimental intestinal anastomoses

British Journal of Cancer

Volumn 74, Issue 5, 1996, Pages 711-716

  De Waard, J W D ^a,b   Wobbes, T ^a   De Man, B M ^a   Van Der Linden, C J ^a   Hendriks, T ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Westfries Gasthuis ^*  (Netherlands)

Author keywords

Anastomosis; Collagen; Fluorouracil; Interferon ; Intestine

Indexed keywords

FLUOROURACIL; HYDROXYPROLINE; RECOMBINANT ALPHA INTERFERON;

ADJUVANT CHEMOTHERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER ADJUVANT THERAPY; COLLAGEN SYNTHESIS; CONTROLLED STUDY; INTESTINE ANASTOMOSIS; INTESTINE RESECTION; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029782442     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.426     Document Type: Article

References (35)

1. BHARTIYA D, SKLARSH JW AND MAHESHWARI RK. (1992). Enhanced wound healing in animal models by interferon and interferon inducer. J. Cell. Physiol., 150, 312-319.
2. BURTON KA. (1956). A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J., 62, 15-23.
3. CUNLIFFE WJ AND SUGARBAKER PH. (1989). Gastrointestinal malignancy: rationale for adjuvant therapy using early post-operative intraperitoneal chemotherapy. Br. J. Surg., 76, 1082-1090.
4. DE ROY VAN ZUIDEWIJN DBW, HENDRIKS T, WOBBES T AND DE BOER HHM. (1991). Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses. Br. J. Cancer, 63, 937-941.
5. DE WAARD JWD, WOBBES T AND HENDRIKS T. (1993). Early post-operative 5-fluorouracil does not affect the healing of experimental intestinal anastomoses. Int. J. Colorect. Dis., 8, 175-178.
6. DE WAARD JWD, WOBBES T, VAN DER LINDEN CJ AND HENDRIKS T. (1995a). Retinol may promote 5-fluorouracil-suppressed healing of experimental intestinal anastomoses. Arch. Surg., 130, 959-965.
7. DE WAARD JWD, WOBBES T, DE MAN BM, VAN DER LINDEN CJ AND HENDRIKS T. (1995b). Post-operative levamisole may compromise early healing of experimental intestinal anastomoses. Br. J. Cancer, 72, 456-460.
8. DUNCAN MR AND BERMAN B. (1985). γ Interferon is the lymphokine and β interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation. J. Exp. Med., 162, 516-527.
9. DUNCAN MR AND BERMAN B. (1989). Differential regulation of glycosaminoglycan, fibronectin, and collagenase production in cultured human dermal fibroblasts by interferon-alpha, -beta, and -gamma. Arch. Dermatol. Res., 281, 11-18.
10. DUNCAN MR, HASAN A AND BERMAN B. (1995). Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: evidence for mediation by nuclear factor 1 down regulation. J. Invest. Dermatol., 104, 282-286.
11. FOLKMAN J. (1995). Clinical application of research on angiogenesis. N. Engl. J. Med., 333, 1757-1763.
12. GRAF W, WEIBER S, GLIMELIUS B, JIBORN H, PÅHLMAN L AND ZEDERFELDT B. (1992). Influence of 5-fluorouracil and folinic acid on colonic healing: an experimental study in the rat. Br. J. Surg., 79, 825-828.
13. GRANSTEIN RD, DEAK MR, JACQUES SL, MARGOLIS RJ, FLOTTE TJ, WHITAKER D, LONG FH AND AMENTO EA. (1989). The systemic administration of gamma interferon inhibits collagen synthesis and acute inflammation in a murine skin wounding model. J. Invest. Dermatol., 93, 18-27.
14. GRANSTEIN RD, FLOTTE TJ AND AMENTO EP. (1990). Interferons and collagen production. J. Invest. Dermatol., 95, 75S-80S.
15. GREM JL, MCATEE N, MURPHY RF, BALIS FM, STEINBERG SM, HAMILTON JM, SORENSEN JM, SARTOR O, KRAMER BS, GOLDSTEIN LJ, GAY LM, CAUBO KM, GOLDSPIEL B AND ALLEGRA CJ. (1991). A pilot study of interferon alpha-2a in combination with fluorouracil plus high-dose leucovorin in metastatic gastrointestinal carcinoma. J. Clin. Oncol., 9, 1811-1820.
16. GREM JL, VAN GROENINGEN CJ, ISMAIL AA, JOHNSTON PG, ALEXANDER HR AND ALLEGRA CJ. (1995). The role of interferon-α as a modulator of fluorouracil and leucovorin. Eur. J. Cancer, 31A, 1316-1320.
17. HARRIS DT AND MASTRANGELO MJ. (1991). Theory and application of early systemic therapy. Semin. Oncol., 18, 493-503.
18. HESP FLEM, HENDRIKS T, LUBBERS EJC AND DE BOER HHM. (1984). Wound healing in the intestinal wall: a comparison between experimental ileal and colonic anastomoses. Dis. Colon Rectum, 27, 99-104.
19. r 92,000 type-IV collagenase (gelatinase A and B) gene expression by interferons alpha and gamma in human melanoma. Int. J. Cancer, 58, 582-586.
20. JIMENEZ SA, FREUNDLICH B AND ROSENBLOOM J. (1984). Selective inhibition of human diploid fibroblast collagen synthesis by interferons. J. Clin. Invest., 74, 1112-1116.
21. KEMENY N, LOKICH JJ, ANDERSON N AND AHLGREN J. (1993). Recent advances in the treatment of advanced colorectal cancer. Cancer, 71, 9-18.
22. MALLAT A, PREAUX AM, BLAZEJEWSKI S, ROSENBAUM J, DHUMEAUX D AND MAVIER P. (1995). Interferon alpha and gamma inhibit proliferation and collagen synthesis of human ito cells in culture. Hepatology, 21, 1003-1010.
23. MARTENS MFWC AND HENDRIKS T. (1991). Postoperative changes in collagen synthesis in intestinal anastomoses of the rat. Differences between small and large bowel. Gut, 32, 1482-1487.
24. MARTENS MFWC, DE MAN BM, HENDRIKS T AND GORIS RJA. (1992). Collagen synthesis througout the uninjured and anastomosed intestinal wall. Am. J. Surg., 164, 354-360.
25. MILES RH, PAXTON TP, ZACHEIS D, DRIES DJ AND GAMELLI RL. (1994). Systemic administration of interferon-γ impairs wound healing. J. Surg. Res., 56, 288-294.
26. MOERTEL CG. (1994). Chemotherapy for colorectal cancer. N. Engl. J. Med., 330, 1136-1142.
27. PAHLMAN L. (1995). Open trials in colorectal cancer. Eur. J. Surg. Oncol. 21, 347 351.
28. PAZDUR R. (1991). Fluorouracil and recombinant interferon alfa-2a in advanced gastrointestinal neoplasms. Br. J. Haematol., 79, 56-59.
29. PETERKOFSKY B, CHOIKIER M AND BATEMAN J. (1981). Determination of collagen synthesis in tissue and cell culture systems. In Immunochemistry of the Extracellular Matrix, Vol. 2, Furthmayer H. (ed.) pp. 19-47. CRC Press: Boca Raton, FL.
30. SEN GC AND LENGYEL P. (1992). The interferon system. A bird's eye view of its biochemistry. J. Biol. Chem., 267, 5017-5020.
31. SMITH PK, KROHN RI, HERMANSON GT, MALLIA AK, GARTNER FH, PROVENZANO MD, EUJIMOTO EK, GOEKE NM, OLSON BJ AND KLENK DC. (1985). Measurement of protein using bicinchoninic acid. Anal. Biochem., 150, 76-85.
32. STOUT AJ, GRESSER I AND THOMPSON WD. (1993). Inhibition of wound healing in mice by local interferon α/β injection. Int. J. Exp. Pathol., 74, 79-85.
33. VAN DER MEIDE PH, DIJKEMA R, CASPERS M, VIJVERBERG K AND SCHELLEKENS H. (1986). Cloning, expression, and purification of rat IFN-α1. Methods Enzymol., 119, 441-453.
34. WADLER S, LEMBERSKY B, ATKINS M, KIRKWOOD J AND PETRELLI N. (1991). Phase II trial of fluorouracil and recombinant interferon alpha-2a in patients with advanced colorectal carcinoma: an Eastern Cooperative Oncology Group study. J. Clin. Oncol., 9, 1806-1810.
35. WAHL L AND CORCORAN ML. (1993). Regulation of monocyte/ macrophage metalloproteinase production by cytokines. J. Periodontol., 64, 467-473.