Conformation of lipid A, the endotoxic center of bacterial lipopolysaccharide

Journal of Endotoxin Research

Volumn 3, Issue 3, 1996, Pages 173-178

  Brandenburg, Klaus ^a   Seydel, Ulrich ^a   Schromm, Andra B ^a   Loppnow, Harald ^a   Koch, Michel H J ^b   Rietschel, Ernst Th ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; LIPID A;

CONFERENCE PAPER; GRAM NEGATIVE BACTERIUM; NONHUMAN; STRUCTURE ANALYSIS;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 0029782024     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1177/096805199600300302     Document Type: Conference Paper

References (31)

1. Rietschel E.T., Kirikae T., Schade F.U. et al. Bacterial endotoxin: Molecular relationships of structure to activity and function. FASEB J 1994; 8: 217-225.
2. Galanos C., Lüderitz O., Westphal O. A new method for the extraction of R lipopolysaccharides. Eur J Biochem 1969; 9: 245-249.
3. Rietschel E.T., Brade H., Holst O. et al. Bacterial endotoxin: chemical constitution, biological recognition, host response, and immunological detoxification. Curr Top Microbiol Immunol 1996; 216: 39-81.
4. Leeson M.C., Fujihara Y., Morrison D.C. Evidence for lipopolysaccharide as the predominant proinflammatory mediator in supernatants of antibiotic-treated bacteria. Infect Immun 1994; 62: 4975-4980.
5. Johnston C.A., Greisman S.E. Endotoxemia induced by antibiotic therapy: a mechanism for adrenal corticosteroid protection in gram-negative sepsis. Trans Assoc Am Phys 1984; 97: 172-181.
6. Shenep J.L., Barton R.P., Morgan K.A. Role of antibiotic class in the rate of liberation of endotoxin during therapy for experimental gram-negative sepsis. J Infect Dis 1985; 151: 1012-1018.
7. Israelachvili J.N., Marcelja S., Horm R.G. Physical principles of membrane organisation. Q Rev Biophys 1980; 13: 121-200.
8. Seydel U., Brandenburg K. Conformations of endotoxin and their relationship to biological activity. In: Novotny A., Spitzer J.J., Ziegler E.J. Eds. Cellular and Molecular Aspects of Endotoxin Reactions. Amsterdam: Elsevier, 1990; 61-71.
9. Seydel U., Brandenburg K. Supramolecular structure of lipopolysaccharides and lipid A. In: Morrison D.C., Ryan J. Eds. Bacterial Endotoxic Lipopolysaccharides. Bota Racon: CRC Press, 1992; 225-250.
10. Brandenburg K., Seydel U. Investigations into the fluidity of lipopolysaccharide and free lipid A membrane systems by Fourier-transform infrared spectroscopy and differential scanning calorimetry. Eur J Biochem 1990; 191: 229-236.
11. Seydel U., Labischinski H., Kastowsky M., Brandenburg K. Phase behaviour, supramolecular structure, and molecular conformation of lipopolysaccharide. Immunobiology 1993; 187: 191-211.
12. Brandenburg K., Mayer H., Koch M.H.J., Weckesser J., Rietschel E.T., Seydel U. Influence of the supramolecular structure of free lipid A on its biological activity. Eur J Biochem 1993; 218: 555-563.
13. Seydel U., Brandenburg K., Koch M.H.J., Rietschel E.T. Supramolecular structure of lipopolysaccharide and free lipid A under physiological conditions as determined by synchrotron small-angle X-ray diffraction. Eur J Biochem 1989; 186: 325-332.
14. Brandenburg K., Koch M.H.J., Seydel U. Phase diagram of lipid A from Salmonella minnesota and Escherichia coli rough mutant lipopolysaccharide. J Struct Biol 1990; 105: 11-21.
15. Brandenburg K., Koch M.H.J., Seydel U. Phase diagram of deep rough mutant lipopolysaccharide from Salmonella minnesota R595. J Struct Biol 1992; 108: 93-106.
16. Seydel U., Koch M.H.J., Brandenburg K. Structural polymorphisms of rough mutant lipopolysaccharides Rd to Ra from Salmonella minnesota. J Struct Biol 1993; 110: 232-243.
17. Rietschel E.T., Brade L., Holst O. et al. Molecular structure of bacterial endotoxin in relation to bioactivity. In: Nowotny A., Spitzer J.J., Ziegler E.J. Eds. Cellular and Molecular Aspects of Endotoxin Reactions. Amsterdam: Elsevier, 1990; 15-32.
18. Rietschel E.T., Kirikae T., Loppnow H. et al. Molecular aspects of the chemistry and biology of endotoxin. In: Sies H., Flohé L., Zimmer G. Eds. Molecular Aspects of Inflammation. Berlin: Springer-Verlag, 1991; 207-231.
19. Brandenburg K., Schromm A.B., Koch M.H.J. et al. Conformation and fluidity of endotoxins as determinants of biological activity. In: Levin J., Alving C.R., Munford R.S., Redl H. Eds. Bacterial Endotoxins: Lipopolysaccharides from Genes to Therapy. New York: John Wiley, 1995; 167-182.
20. Seydel U., Brandenburg K., Rietschel E.T. A case for an endotoxic conformation. Prog Clin Biol Res 1994; 388: 17-30.
21. Ramadas Bhat. U., Carlson R.W., Busch M., Mayer H. Distribution and phylogenetic significance of 27-hydroxyoctacosanoic acid in lipopolysaccharides from bacteria belonging to the alpha-2 subgroup of Proteobacteria. Int J Syst Bacteriol 1991; 41: 213-217.
22. Mayer H., Krauss J.H., Yokota A. et al. Natural variants of lipid A. In: Friedman H., Klein T.W., Nakano M., Nowotny A. Eds. Endotoxin. New York: Plenum, 1990; 45-70.
23. Takayama K., Qureshi N., Ribi E., Cantrell J.L. Separation and characterization of toxic and nontoxic forms of lipid A. Rev Infect Dis 1984; 6: 439-443.
24. Alving C.R. Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologic adjuvants. Immunobiology 1993; 187: 430-446.
25. Kiener P.A., Marek F., Rodgers G., Lin P-F., Warr G., Desiderio J. Induction of tumor necrosis factor, IFN-gamma, and acute lethality of mice by toxic and non-toxic forms of lipid A. J Immunol 1988; 141: 870-874.
26. Loppnow H., Libby P., Freudenberg M., Krauss J.H., Weckesser J., Mayer H. Cytokine induction by lipopolysaccharide (LPS) corresponds to lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS. Infect Immun 1990; 58: 3743-3750.
27. Moran A.P. Biological and serological characterization of Campylobacter jejuni lipopolysaccharides with deviating core and lipid A structures. FEMS Immunol Med Microbiol 1995; 11: 121-130.
28. Schromm A.B., Brandenburg K., Rietschel E.T, Seydel U. Do endotoxin aggregates intercalate into phospholipid membranes in a nonspecific, hydrophobic manner? J Endotoxin Res 1995; 2: 313-323
29. Takayama K., Mitchell D.H., Din Z.Z., Mukerjee P., Li C., Coleman D.L. Monomeric Re lipopolysaccharide from Escherichia coli is more active than the aggregated form in the Limulus amebocyte lysate assay and in inducing Egr-1 mRNA in murine peritoneal macrophages. J Biol Chem 1994; 269: 2241-2244.
30. Gegner J.A., Ulevitch R.J., Tobias P.S. Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD 14. J Biol Chem 1995; 270: 5320-5326.
31. Lynn W.A., Liu Y., Golenbock D.T. Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide. Infect Immun 1993; 61:4452-4461.