Prevalence and diagnostic role of antineutrophil cytoplasmic antibodies in inflammatory bowel disease

European Journal of Gastroenterology and Hepatology

Volumn 8, Issue 9, 1996, Pages 881-885

  Bansi, Devinder S ^a   Chapman, Roger W ^a   Fleming, Kenneth A ^a  

^a OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Antineutrophil cytoplasmic antibodies (ANCA); Diagnostic role; Inflammatory bowel disease

Indexed keywords

ALKALINE PHOSPHATASE; MESALAZINE; NEUTROPHIL CYTOPLASMIC ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT;

ADOLESCENT; ADULT; AGED; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE DURATION; ENTERITIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; SERODIAGNOSIS; ULCERATIVE COLITIS;

ADULT; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; BIOLOGICAL MARKERS; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; INFLAMMATORY BOWEL DISEASES; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; SEROLOGIC TESTS;

EID: 0029781503     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Shanahan F, Targan SR: Immunology of inflammatory bowel disease. In Modern Concepts, in Gasteoenterology. Vol 2. Edited by Schaffer E, Thomson ABR. New York: Plenum: 1989:2-9.
2. Tedesco FJ: Differential diagnosis of ulcerative colitis and Crohn's ileocolitis and other specific inflammatory diseases of the bowel. Med Clin N Am 1980, 64:1173-1188.
3. Strober W, James SR: The immunologic basis of inflammatory bowel disease. J Clin Immunol 1986, 6:415-432.
4. Takahasi F, Shah HS, Wise LS, Das KM: Circulating antibodies against human colonic extract enriched with a 40 kDa protein in patients with ulceralive colitis. Gut 1990, 31:1016-1020.
5. Saxon A, Shanahan F, Landers C, Targan S: A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol 1990, 86:202-210.
6. Duerr RH, Targan SR, Landers CJ, Sutherland LR, Shanahan F: Antineutrophil cytoplasmic antibodies in ulcerative colitis: comparison with other colitides/diarrhoeal illnesses. Gastroenterology 1991, 100:1590-1596.
7. Seibold F, Weber P, Klein R, Berg PA, Wiedman KH: Clinical significance of antibodies against neutrophils in patients with inflammatory bowel disease and primary sclerosing cholangitis. Gut 1992, 33:657-662.
8. Lo SK, Fleming KA, Chapman RW: Prevalence of antineutrophil antibody in primary sclerosing cholangitis and ulcerative colitis using an alkaline phosphatase technique. Gut 1992, 33:1370-1375.
9. Mulder AHL, Broekroelofs J, Horst C, Limhurg PC, Nelis GF, Kallenberg CGM: Antineutrophil cytoplasmic antibodies in inflammatory bowel disease: characterisation and clinical correlates. Clin Exp Immunol 1994, 95:490-497
10. Falk RJ, Jeanette JC: Antineutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988, 318:1651-1657.
11. Ludemann J, Utrecht B, Gross WL: Antineutrophil cytoplasmic antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. J Exp Med 1990, 171:357-362
12. Mecarelli LH, Nusbaum P, Noel LH: Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis. Clin Exp Immunol 1992, 90:79-84.
13. Ellerbroek PM, Oudkerk Pool M, Ridwan BU, Dolman KM, Von Blomberg BME, Kr von dem Borne AEG, et al.: Neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis. J Clin Pathol 1994, 47:257-262.
14. Bansi DS, McWilliams F, Scholey C, Ferry B, Chappel H, Fleming KA, et al: Antigen specificity of antineutrophil antibodies in ulcerative colitis, primary sclerosing cholangitis and autoimmune hepatitis. Hepatology 1995, 22(4):392A.
15. Peen E, Almer S, Bodemar B, Ryden BO, Sjolin T, Teile K, et al.: Antilactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis and Crohn's disease. Gut 1993, 34:56-62.
16. Nassberger L, Ljungh A, Schumacher G, Kollberg B: Beta-glucoronidase antibodies in ulcerative colitis [letter]. Lancet 1992, 340:734-735.
17. Stoffel MP, Csernok E, Herzberg C, Johnston T, Carroll SF, Gross WL: Antineutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders. Clin Exp Immunol 1996, 104:54-59.
18. Broekroelofs J, Mulder AH, Nelis GF, Westerveld BD, Tervaert IW, Kallenberg CG: Antineutrophil cytoplasmic antibodies (ANCA) in sera from patients with inflammatory bowel disease (IBD). Relation to disease pattern and disease activity. Dig Dis Sci 1994, 3:545-549.
19. Rump JA, Roth M, Scholmerick J, Helfesrieder R, Ludemann J, Gross WL, et al.: A new type of ANCA in sera of patients with ulcerative colitis: effects of therapy and disease severity on serum titre. Immunol Infect 1992, 20:16-18.
20. Jorgensen B, Wiik A, Hoier-Madsen M, Rasmussen N, Haagen-Nielsen O: Serum antibodies to neutrophils in patients with chronic inflammatory bowel disease [abstract]. Gastroenterology 1991, 100:A616.
21. Lennard-Jones JE: Classification of inflammatory bowel disease. Scand J Gastroenterol 1989, 24(suppl. 170):2-6.
22. Truelove SC, Wilts LJ: Cortisone in ulcerative colitis; final report of a therapeutic trial. BMJ 1955, 2:1041-1048.
23. Best WR, Becktel JM, Singleton JW: Rederived values of the eight coefficients of the Crohn's disease activity index (CDAI). Gastroenterology 1979, 77:843-846.
24. Schumacher G: First attack of inflammatory bowel disease and infectious colitis. Scand J Gastroenterol 1993, 28(suppl. 198):1-24.
25. Rump JA, Scholmerich J, Gross V: A new type of perinuclear antineutrophil cytoplasmic antibody (pANCA) in active ulcerative colitis but not in Crohn's disease. Immunobiol 1990, 181:406-413.
26. Oudkerk Pool M, Ellerbroek PM, Ridwan BU, Goldschmeding R, Von Blomberg BME, Pena AS, et al.: Serum antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease are mainly associated with ulcerative colitis. A correlation study between perinuclear antineutrophil cytoplasmic autoantibodies and clinical parameters, medical and surgical treatment. Gut 1993, 34:46-50.
27. Colombel JF, Remaux D, Duthilleul P, Noel LH, Gower Rousseau C, Paris JC, et al.: Antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease. Gastroenterol Clin Biol 1991,16:656-660.
28. Vecchi M, Bianchi M, Torgano G, Meucci G, Omodel P, Levati M: Antineutrophil cytoplasmic antibodies are more prevalent in ulcerative colitis patients with clinical aggressive disease [abstract]. Gastroenterology 1992, 102:A708.
29. Cambridge G, Rampton DS, Stevens TRJ, McCarthy DA, Kamm M, Leaker B: Antineutrophil antibodies in IBD: prevalence and diagnostic role. Gut 1992, 33:668-674.
30. Castellino F, Rosina F, Bansi DS, Bauducci M, Touscoz GA, Giord L, et al.: Antineutrophil cytoplasmic antibodies in inflammatory bowel disease: do they recognize different subsets of an heterogeneous disease? Eur J Gastroenterol Hepatol 1995, 7:859-864.
31. Oudkerk Pool M, Roca M, Remaux D, Bouma G, Pena AS, Colombel JF, et al.: The value of pANCA as a serological marker for ulcerative colitis in different European regions. Eur J Gastroenterol Hepatol 1994, 6:399-403.
32. Shanahan F: Neutrophil autoantibodies in inflammatory bowel disease: are they important? Gastroenterology 1994, 107:586-589.
33. Asakura H, Sugimura K. HLA, Antineutrophil cytoplasmic autoantibody and heterogeneity in ulcerative colitis. Gastroenterology 1995, 108:597-599.
34. Lindgren S, Claes-Henrik F, Lindhagen T, Starck M, Stewenius J, Nassberger L: Low prevalence of antineutrophil cytoplasmic antibodies in ulcerative colitis patients with long-term remission. Eur J Gastroenterol Hepatol 1995, 7:563-568.
35. Targan SR, Landers CJ, Cobb L, MacDermott RP, Vidrich A: Perinuclear anti-neutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells of ulcerative colitis patients. J Immunol 1995, 155(6):3262-3267.
36. Billing P, Tahir S, Calfin B, Gagne G, Cobb C, Targan S, et al.: Nuclear localisation of the antigen detected by ulcerative colitis-associated perinuclear antineutrophil cytoplasmic antibodies. Am J Pathol 1995, 147(4):979-987.