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Alm A, Widengárd I, Kjellgren D, Söderström M, Friström B, Heijl A, Stjern• schantz J: Latanoprost administered once daily caused a maintained reduction of intraocular pressure in glaucoma patients treated concomitantly with timolol. Br J Ophthalmol 1995, 1:12-16. This article describes a dose-regimen study performed with 0.006% latanoprost in patients undergoing timolol treatment with IOPs before latanoprost of about 25 mm Hg. Once-daily administration of latanoprost was superior to twice daily.
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Aim A, Stjernschantz J, the Scandinavian Latanoprost Study Group: Ef•• fects on intraocular pressure and side effects of 0.005% latanoprost once daily, evening or morning: a comparison with timolol. Ophthalmology 1995, 102:1743-1752. This article describes a randomized double-masked multicenter trial including a total of 267 patients with open-angle glaucoma or ocular hypertension treated with either 0.005% latanoprost once daily or 0.5% timolol twice daily. Diurnal IOPs were obtained at baseline, 3 months, and 6 months of treatment. Morning versus evening administration was also studied in the latanoprost patients. It is concluded that latanoprost is at least as effective as timolol. Administration of latanoprost in the evening resulted in better diurnal IOP reduction than with timolol. Side effects are discussed in detail.
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Ophthalmology
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Camras CB, the USA Latanoprost Study Group: Comparison of la•• tanoprost and timolol in patients with ocular hypertension and glaucoma-six-month, masked U.S.A. multicenter trial. Ophthalmology 1995, 103:138-147. This article describes a randomized double-masked multicenter trial, including a total of 268 patients with open-angle glaucoma or ocular hypertension treated with either 0.005% latanoprost once daily or 0.5% timolol twice daily. Diurnal IOPs were obtained at baseline and 6 months of treatment. It is concluded that latanoprost was more effective than timolol. Side effects are discussed in detail.
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Watson P, Stjernschantz J, the Latanoprost Study Group in United King•• dom: A six month randomized, double-masked study comparing latanoprost to timolol in open angle glaucoma and ocular hypertension. Ophthalmology 1995, 103:126-137. This article describes a randomized double-masked multicenter trial including a total of 294 patients with open-angle glaucoma or ocular hypertension treated with either 0.005% latanoprost once daily or 0.5% timolol twice daily. Diurnal IOPs were obtained at baseline and 6 months of treatment. It is concluded that latanoprost was at least as effective as timolol. Side effects are discussed in detail.
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Ophthalmology
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