Elevated serotonin levels in autism: Association with the major histocompatibility complex

Neuropsychobiology

Volumn 34, Issue 2, 1996, Pages 72-75

  Warren, R P ^a   Singh, V K ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

Autism; Autoimmune disorders; C4B gene; Major histocompatibility complex; Null allele; Serotonin

Indexed keywords

SEROTONIN;

ARTICLE; AUTISM; CENTRAL NERVOUS SYSTEM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOCOMPATIBILITY COMPLEX; HUMAN; IMMUNE SYSTEM; IMMUNOPATHOLOGY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SEROTONIN BLOOD LEVEL;

AUTISTIC DISORDER; CHILD; FEMALE; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; SEROTONIN;

EID: 0029781224     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000119295     Document Type: Article

References (22)

1. Gillberg C, Coleman M: The Biology of the Autistic Syndromes, ed 2, Oxford, MacKeith Press, London, Blackwell Scientific, 1992:pp 96-114.
2. Warren RP, Yonk U, Burger RA, Cole P, Odell JD, Warren WL, White E, Singh VK: Deficiency of suppressor-induccr (CD4+CD45R+) T cells in autism, Immunol Invest 1990:19:245-251.
3. Yonk IJ, Warren RP, Burger RA, Cole P, Odell JD, Warren WL, White E, Singh VK: CD4+ helper T cell depression in autism, Immunol Lett 1990:25:341-346.
4. Abramason RK, Self S, Gcnco P, Smith N, Pendleton A, Valentine J, Wright HH, Cuccaro M, Powell D: (abstract), Am J Hum Genet 1990:47:A45.
5. Wood Frei B, Denny D, Gaffney GR, O'Donnell T: Scientific Proceedings of the Annual Meeting of the American Academy of Child and Adolescent Psychiatry (abstract 26), 1991, vol 7, p 53.
6. Plioplys AV, Greaves A, Kazenti K, Silverman E: Lymphocyte function in autism and Rett syndrome, Ncuropsychobiologv 1994;7:12-16.
7. Stubbs EG, Crawford ML, Burger DR, Vandcr-bark AA: Depressed lymphocyte responsiveness in autistic children, J Autism Child Schi-zophr 1977:7:49-55.
8. Warren RP, Margarctten NC, Pace NC, Foster A: Immune abnormalities in patients with autism, J Aut Dev Disord 1986:16:189-197.
9. Singh VK, Fudcnberg HH, Emerson D, Coleman M: Immunodiagnosis and immunotherapy in autistic children, Ann NY Acad Sci 1988; 540:602-604.
10. Ferrari P, Marescot MR, Moulias R, Burszlejn C, Devillc-Chabrolle A, Thiollct M, Lesourd B, Braconnier A, Dreux C, Zarifian E: Immune status in infantile autism: Correlation between the immune status, autistic symptoms and levels of serotonin, Encéphale 1988:14:339-344.
11. Warren RP, Foster A, Margaretten NC: Reduced natural killer cell activity in autism, J Am Acad Child Adolesc Psychiatry 1987:26: 333-335.
12. Warren RP, Yonk J, Burger RA, Odell D, Warren WL: DR-positive T cells in autism: Association with decreased plasma levels of the complement C4B protein, Ncuropsvchobiolo-gy 1995:31:53-57.
13. Wcizman A, Wcizman R, Szckelv GA, Wijsen-bcck H, Livini E: Abnormal immune response to brain tissue antigen in the syndrome of autism, Am J Psychiatry 1982; 139:1462-1465.
14. Plioplys AV, Greaves A, Kazemi K, Silverman E: Immunoglobulin reactivity in autism and Rett's syndrome, Dev Brain Dysfunct 1994:7: 12-16.
15. Singh VK, Warren RP, Odell JD, Warren WL, Cole P: Antibodies to myelin basic protein in children with autistic behavior, Brain Bchav Immun 1993:7:97-103.
16. Warren RP, Singh VK, Cole P, Odell JD, Pin-gree CB, Warren WL, White E: Increased frequency of the null allele at the complement C4B locus in autism, Clin Exp Immunol 1991; 83:438-440.
17. Warren RP, Singh VK, Cole P, Odell JD, Pin-gree CB, Warren WL, DeWitt CW, McCullough M: Possible association of the extended MHC haplotype B44-SC30-DR4 with autism, Immunogenctics 1992;36:203-207.
18. Daniels WW, Warren RP, Odell JD, Maciulis A, Burger RA, Warren WL, Torres AR: Increased frequency of the extended or ancestral haplotype B44-SC30-DR4 in autism, Neuro-psychobiology 1995;32:120-123.
19. Alpcr CA, Awdch ZL, Yunis EJ: Complotypes and extended haplotypcs in laboratory medicine: Complement in laboratory medicine, Inflammation 1989:6:8-18.
20. Degli-Esposli M, Leaver AL, Christiansen FT, Witt CS, Abraham L, Dawkins RL: Ancestral haplotypes: Conserved population MHC haplotypcs, Hum Immunol 1992;34:242-252.
21. Field EJ, Caspary EA, Carnegie PR: Lymphocyte sensitization to basic protein of brain in malignant neoplasia: Experiments with serotonin and related compounds, Nature 1971; 233:284-286.
22. Waksman BH: Multiple sclerosis: in Cohen 1R (ed): Perspectives on Autoimmunity, Boca Raton, CRC Press, 1988, pp 59-109.