Severe outcome of hepatitis B virus (HBV) infection and lack of HBV e antigen-defective virus emergence in patients homozygous for HLA class I alleles

Journal of General Virology

Volumn 77, Issue 8, 1996, Pages 1833-1836

  Pollicino, Teresa ^a   Pernice, Francesco ^a   Campo, Salvatore ^a   Mesiti, Olga ^a   Misefari, Valeric ^b   Pernice, Maurizio ^a   Raimondo, Giovanni ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b Ctro Regionale Tipizzazione T   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS E ANTIGEN; HLA ANTIGEN CLASS 1; VIRUS DNA;

ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; DNA SEQUENCE; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HETEROZYGOSITY; HLA TYPING; HOMOZYGOSITY; HUMAN; LIVER CIRRHOSIS; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029781210     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-77-8-1833     Document Type: Article

References (21)

1. Bertoletti, A., Sette, A., Chisari, F. V., Penna, A., Levrero, M., De Carli, M., Fiaccadori, F. & Ferrari, C. (1994a). Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369, 407-410.
2. Bertoletti, A., Costanzo, A., Chisari, F. V., Levrero, M., Artini, M., Sette, A., Penna, A., Giuberti, T., Fiaccadori, F. & Ferrari, C. (1994b). Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope. Journal of Experimental Medicine 180, 933-943.
3. Bonino, F., Rosina, F., Rizzetto, M., Rizzi, R., Chiaberge, E., Tardanico, R., Callea, F. & Verme, G. (1986). Chronic hepatitis in HBsAg carriers with serum HBV-DNA and anti-HBe. Gastroenterology 90, 1268-1273.
4. Brunetto, M. R., Giarin, E., Oliveri, F., Chiaberge, E., Baldi, M., Alfarano, A., Serra, A., Saraocco, G., Verme, G., Will, H. & Bonino, F. (1991). Wild type and e antigen-deficient hepatitis B viruses and course of chronic hepatitis. Proceedings of the National Academy of Sciences, USA 88, 4186-4190.
5. Brunetto, M. R., Stemler, M., Schodell, F., Will, H., Ottobrelli, A., Rizzetto, M., Verme, G. & Bonino, F. (1989). Identification of HBV variants which cannot produce precore derived HBeAg and may be responsible for severe hepatitis. Italian Journal of Gastroenterology 21, 151-154.
6. Carman, W. F., Jacyna, M. R., Hadziyannis, S., Karayiannis, P., McGarbey, M. J., Makris, A. & Thomas, H. C. (1989). Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet ii, 588-591.
7. Chisari, F. V. & Ferrari, C. (1995). Hepatitis B immunopathogenesis. Annual Review of Immunology 13, 29-60.
8. Galibert, F., Mandart E., Fitoussi, F., Tiollais, P. & Charney, P. (1979). Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature 281, 646-650.
9. Gregorio, G. V., Mieli-Vergani, G. & Mowat, A. P. (1993). Neonatal and pediatric infection. In Viral hepatitis, scientific bases and clinical management, pp. 541-563. Edited by A. J. Zuckerman & H. C. Thomas. London: Churchill Livingstone.
10. Hamasaki, K., Nakata, K., Nagayama, Y., Ohtsuru, A., Daikoku, M., Taniguchi, K., Tzutzumi, T., Sato, Y., Kato, Y. & Nagataki, S. (1994). Changes in the prevalence of HBeAg-negative mutant hepatitis B virus during the course of chronic hepatitis B. Hepatology 20, 8-14.
11. Hoofnagle, J., Dusheiko, G., Seef, L., Jones, E., Waggoner, J. & Bales, Z. B. (1981). Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Annals of Internal Medicine 94, 744-748.
12. Lieberman, H. M., Labrecque, D. R., Kew, M. C., Hadzyiannis, S. J. & Shafritz, D. A. (1983). Detection of hepatitis B virus directly in human serum by a simplified molecular hybridization test. Comparison to HBeAg/anti-HBe status in HBsAg carriers. Hepatology 3, 285-291.
13. Lok, A. S. F., Akarca, U. & Greene, S. (1994). Mutations in the precore region of hepatitis B virus serve to enhance the stability of the secondary structure of the pregenome encapsidation signal. Proceedings of the National Academy of Sciences, USA 91, 4077-4081.
14. Okamoto, H., Yotsumoto, S., Akahane, Y., Yamanaka, T., Miyazaki, Y., Sugai, Y., Tzuda, F., Tanaka, T., Miyakawa, Y. & Mayumi, M. (1990). Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. Virology 64, 1298-1303.
15. Pollicino, T., Campo, S. & Raimondo, G. (1995). Pre-5 and core gene heterogeneity in hepatitis B virus (HBV) genomes isolated from patients with long-lasting HBV chronic infection. Virology 208, 672-677.
16. Raimondo, G., Schneider, R., Stemler, M., Smedile, V., Rodin, G. & Will, H. (1990a). A new hepatitis B virus variant in a chronic carrier with multiple episodes of viral reactivation and acute hepatitis. Virology 179, 64-68.
17. Raimondo, G., Stemler, M., Schneider, R., Wildner, G., Squadrito, G. & Will, H. (1990b). Latency and reactivation of a precore mutant hepatitis B virus in a chronically infected patients. Journal of Hepatology 11, 374-380.
18. Realdi, G., Alberti, A., Rugge, M., Bortolotti, F., Rigoli, A. M., Tremolada, F. & Ruol, A. (1980). Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis virus infection. Gastroenterology 79, 195-199.
19. Takayanagi, M., Kakumu, S., Ishikawa, T., Yasuyuki, H., Yoshioka, K. & Wakita, T. (1993). Comparison of envelop and precore/core variants of hepatitis B virus (HBV) during chronic HBV infection. Virology 196, 138-145.
20. Thursz, M. R., Kwiatkowski, D., Allscop, C. E. M., Greenwood, B. M., Thomas, H. C. & Hill, A. V. S. (1995). Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. New England Journal of Medicine 332, 1065-1069.
21. Tur-Kaspa, R., Keshet, E., Eliakim, M. & Shouval, D. (1984). Detection and characterization of hepatitis B virus DNA in serum of HBeAg-negative HBsAg carriers. Journal of Medical Virology 14, 17-26.