-
1
-
-
0027514209
-
Detection of 12 germ-line mutations in the adenomatous polyposis coli gene by polymerase chain reaction
-
ANDO H, MIYOSHI Y, NAGASE H, BABA S AND NAKAMURA Y. (1993). Detection of 12 germ-line mutations in the adenomatous polyposis coli gene by polymerase chain reaction. Gastroenterology, 104, 989-993.
-
(1993)
Gastroenterology
, vol.104
, pp. 989-993
-
-
Ando, H.1
Miyoshi, Y.2
Nagase, H.3
Baba, S.4
Nakamura, Y.5
-
2
-
-
0026591034
-
Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers
-
BOYNTON RF, BLOUNT PL, YIN J, BROWN VL, HUANG Y, TONG Y, MCDANIEL T, NEWKIRK C, RESAU JH, RASKIND WH, HAGGITT RC, REID BJ AND MELTZER SJ. (1992). Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. Proc. Natl Acad. Sci. USA, 89, 3385-3388.
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 3385-3388
-
-
Boynton, R.F.1
Blount, P.L.2
Yin, J.3
Brown, V.L.4
Huang, Y.5
Tong, Y.6
Mcdaniel, T.7
Newkirk, C.8
Resau, J.H.9
Raskind, W.H.10
Haggitt, R.C.11
Reid, B.J.12
Meltzer, S.J.13
-
3
-
-
0028219675
-
Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer
-
CURTIS LJ, BUBB VJ, GLEDHILL S, MORRIS RG, BIRD CC AND WYLLIE AH. (1994). Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer. Hum. Mol. Genet., 3, 443-446.
-
(1994)
Hum. Mol. Genet.
, vol.3
, pp. 443-446
-
-
Curtis, L.J.1
Bubb, V.J.2
Gledhill, S.3
Morris, R.G.4
Bird, C.C.5
Wyllie, A.H.6
-
4
-
-
0026780226
-
Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer
-
D'AMICO D, CARBONE DP, JOHNSON BE, MELTZER SJ AND MINNA JD. (1992). Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer. Cancer Res., 52, 1996-1999.
-
(1992)
Cancer Res.
, vol.52
, pp. 1996-1999
-
-
D'Amico, D.1
Carbone, D.P.2
Johnson, B.E.3
Meltzer, S.J.4
Minna, J.D.5
-
5
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
FEARON ER AND VOGELSTEIN B. (1990). A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
6
-
-
0024390277
-
Clonal allele loss in gastrointestinal cancers
-
FEY MF, HESKETH C, WAINSCOAT JS, GENDLER S AND THEIN SL. (1989). Clonal allele loss in gastrointestinal cancers. Br. J. Cancer. 59, 750-754.
-
(1989)
Br. J. Cancer.
, vol.59
, pp. 750-754
-
-
Fey, M.F.1
Hesketh, C.2
Wainscoat, J.S.3
Gendler, S.4
Thein, S.L.5
-
7
-
-
0028085264
-
Regionally clustered APC mutations are associated with a severe phenotype and occur at high frequency in new mutation cases of adenomatous polyposis coli
-
GAYTHER SA, WELLS D, SENGUPTA SB, CHAPMAN P, NEALE K, TSIOUPRA K AND DELHANTY JDA. (1994). Regionally clustered APC mutations are associated with a severe phenotype and occur at high frequency in new mutation cases of adenomatous polyposis coli. Hum. Mol. Genet., 3, 53 56.
-
(1994)
Hum. Mol. Genet.
, vol.3
, pp. 53-56
-
-
Gayther, S.A.1
Wells, D.2
Sengupta, S.B.3
Chapman, P.4
Neale, K.5
Tsioupra, K.6
Delhanty, J.D.A.7
-
8
-
-
0029131334
-
Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss
-
GAYTHER SA, SUD R, WELLS D, TSIOUPRA K AND DELHANTY JDA. (1995). Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss. J. Med. Genet., 32, 568 571.
-
(1995)
J. Med. Genet.
, vol.32
, pp. 568-571
-
-
Gayther, S.A.1
Sud, R.2
Wells, D.3
Tsioupra, K.4
Delhanty, J.D.A.5
-
9
-
-
0026574906
-
Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumour suppressor gene loci in dysplastic and cancerous ulcerative colitis
-
GREENWALD BD, HARPAZ N, YIN J, HUANG Y, TONG Y, BROWN VL, MCDANIEL T, NEWKIRK C, RESAU JH AND MELTZER SJ. (1992). Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumour suppressor gene loci in dysplastic and cancerous ulcerative colitis. Cancer Res., 52, 741-745.
-
(1992)
Cancer Res.
, vol.52
, pp. 741-745
-
-
Greenwald, B.D.1
Harpaz, N.2
Yin, J.3
Huang, Y.4
Tong, Y.5
Brown, V.L.6
Mcdaniel, T.7
Newkirk, C.8
Resau, J.H.9
Meltzer, S.J.10
-
10
-
-
0025938038
-
Identification and characterisation of the familial adenomatous polyposis coli gene
-
GRODEN J, THLIVERIS A, SAMOWITZ W, CARLSON M, GELBERT L, ALBERTSEN H, JOSLYN G, STEVENS J, SPIRIO L, ROBERTSON M, SARGEANT L, KRAPCHO K, WOLFF E, BURT R, HUGHES JP, WARRINGTON J, MCPHERSON J, WASMUTH J, LE PASLIER D, ABDERRAHIM H, COHEN D, LEPPERT M AND WHITE R. (1991). Identification and characterisation of the familial adenomatous polyposis coli gene. Cell, 66, 589 600.
-
(1991)
Cell
, vol.66
, pp. 589-600
-
-
Groden, J.1
Thliveris, A.2
Samowitz, W.3
Carlson, M.4
Gelbert, L.5
Albertsen, H.6
Joslyn, G.7
Stevens, J.8
Spirio, L.9
Robertson, M.10
Sargeant, L.11
Krapcho, K.12
Wolff, E.13
Burt, R.14
Hughes, J.P.15
Warrington, J.16
Mcpherson, J.17
Wasmuth, J.18
Le Paslier, D.19
Abderrahim, H.20
Cohen, D.21
Leppert, M.22
White, R.23
more..
-
11
-
-
0026431865
-
Sspl polymorphism in sequence encoding 3′ untranslated region of the APC gene
-
HEIGHWAY J, HOBAN PR AND WYLLIE AH. (1991). Sspl polymorphism in sequence encoding 3′ untranslated region of the APC gene. Nucleic Acids Res., 19, 6966.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 6966
-
-
Heighway, J.1
Hoban, P.R.2
Wyllie, A.H.3
-
12
-
-
0026470030
-
Frequent somatic mutations of the APC gene in human pancreatic cancer
-
HORII A, NAKATSURU S, MIYOSHI Y, ICHII S, NAGASE H, ANDO H, YANAGISAWA A, TSUCHIYA E, KATO Y AND NAKAMURA Y. (1992). Frequent somatic mutations of the APC gene in human pancreatic cancer. Cancer Res., 52, 6696-6698.
-
(1992)
Cancer Res.
, vol.52
, pp. 6696-6698
-
-
Horii, A.1
Nakatsuru, S.2
Miyoshi, Y.3
Ichii, S.4
Nagase, H.5
Ando, H.6
Yanagisawa, A.7
Tsuchiya, E.8
Kato, Y.9
Nakamura, Y.10
-
13
-
-
0025909734
-
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers
-
KINZLER KW, NILBERT MC, VOGELSTEIN B, BRYAN TM, LEVY DB, SMITH KJ, PREISINGER AC, HAMILTON SR, HEDGE P, MARKHAM A, CARLSON M, JOSLYN G, GRODEN J, WHITE R, MIKI Y, MIYOSHI Y, NISHISHO I AND NAKAMURA Y. (1991). Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science, 251, 1366 1370.
-
(1991)
Science
, vol.251
, pp. 1366-1370
-
-
Kinzler, K.W.1
Nilbert, M.C.2
Vogelstein, B.3
Bryan, T.M.4
Levy, D.B.5
Smith, K.J.6
Preisinger, A.C.7
Hamilton, S.R.8
Hedge, P.9
Markham, A.10
Carlson, M.11
Joslyn, G.12
Groden, J.13
White, R.14
Miki, Y.15
Miyoshi, Y.16
Nishisho, I.17
Nakamura, Y.18
-
14
-
-
0015043748
-
Mutation and cancer: Statistical study of retinoblastoma
-
KNUDSON AG. (1971). Mutation and cancer: statistical study of retinoblastoma. Proc. Natl Acad. Sci. USA, 68, 820 823.
-
(1971)
Proc. Natl Acad. Sci. USA
, vol.68
, pp. 820-823
-
-
Knudson, A.G.1
-
15
-
-
0026518092
-
Two intragenic polymorphisms of the APC-gene detected by PCR and enzymatic digestion
-
KRAUS C AND BALLHAUSEN WG. (1992). Two intragenic polymorphisms of the APC-gene detected by PCR and enzymatic digestion. Hum. Genet., 88, 705 706.
-
(1992)
Hum. Genet.
, vol.88
, pp. 705-706
-
-
Kraus, C.1
Ballhausen, W.G.2
-
16
-
-
0028037032
-
Frequent loss of heterozygosity of the long arm of chromosome 7 is closely associated with progression of human gastric carcinomas
-
KUNIYASU H, YASUI W, YOKOZAKI H, AKAGI M, AKAMA Y, KITAHARA K, FUJII K AND TAHARA E. (1994). Frequent loss of heterozygosity of the long arm of chromosome 7 is closely associated with progression of human gastric carcinomas. Int. J. Cancer, 59, 597 600.
-
(1994)
Int. J. Cancer
, vol.59
, pp. 597-600
-
-
Kuniyasu, H.1
Yasui, W.2
Yokozaki, H.3
Akagi, M.4
Akama, Y.5
Kitahara, K.6
Fujii, K.7
Tahara, E.8
-
17
-
-
12644292106
-
The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification
-
LAUREN P. (1965). The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol. Microbiol. Scand., 64, 31 49.
-
(1965)
Acta Pathol. Microbiol. Scand.
, vol.64
, pp. 31-49
-
-
Lauren, P.1
-
18
-
-
0029113003
-
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma
-
MAESAWA C, TAMURA G, SUZUKI Y, OGASAWARA S, SAKATA K, KASHIWABA M AND SATODATE R. (1995). The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma. J. Pathol., 176, 249 258.
-
(1995)
J. Pathol.
, vol.176
, pp. 249-258
-
-
Maesawa, C.1
Tamura, G.2
Suzuki, Y.3
Ogasawara, S.4
Sakata, K.5
Kashiwaba, M.6
Satodate, R.7
-
19
-
-
0026894053
-
Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
-
MIYOSHl Y, NAGASE H, ANDO H, HORII A, ICHII S, NAKATSURU S, AOKI T, MIKI Y, MORI T AND NAKAMURA Y. (1992). Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum. Mol. Genet., 1, 229 233.
-
(1992)
Hum. Mol. Genet.
, vol.1
, pp. 229-233
-
-
Miyoshl, Y.1
Nagase, H.2
Ando, H.3
Horii, A.4
Ichii, S.5
Nakatsuru, S.6
Aoki, T.7
Miki, Y.8
Mori, T.9
Nakamura, Y.10
-
20
-
-
0027146559
-
Mutations of the APC (Adenomatous Polyposis Coli) gene
-
NAGASE H AND NAKAMURA Y. (1993). Mutations of the APC (Adenomatous Polyposis Coli) gene. Hum. Mutat., 2, 425 434.
-
(1993)
Hum. Mutat.
, vol.2
, pp. 425-434
-
-
Nagase, H.1
Nakamura, Y.2
-
21
-
-
0026948827
-
Somatic mutation of the APC gene in gastric cancer: Frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma
-
NAKATSURU S, YANAGISAWA A, ICHII S, TAHARA E, KATO Y, NAKAMURA Y AND HORII A. (1992). Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma. Hum. Mol. Genet., 1, 559 563.
-
(1992)
Hum. Mol. Genet.
, vol.1
, pp. 559-563
-
-
Nakatsuru, S.1
Yanagisawa, A.2
Ichii, S.3
Tahara, E.4
Kato, Y.5
Nakamura, Y.6
Horii, A.7
-
22
-
-
0027171301
-
Somatic mutations of the APC gene in precancerous lesion of the stomach
-
NAKATSURU S, YANAGISAWA A, FURUKAWA Y, ICHII S, KATO Y, NAKAMURA Y AND HORII A. (1993). Somatic mutations of the APC gene in precancerous lesion of the stomach. Hum. Mol. Genet., 2, 1463-1465.
-
(1993)
Hum. Mol. Genet.
, vol.2
, pp. 1463-1465
-
-
Nakatsuru, S.1
Yanagisawa, A.2
Furukawa, Y.3
Ichii, S.4
Kato, Y.5
Nakamura, Y.6
Horii, A.7
-
23
-
-
0025899162
-
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
-
NISHISHO I, NAKAMURA Y, MIYOSHI Y, MIKI Y, ANDO H, HORII A, KOYAMA K, UTSONOMIYA J, BABA S, HEDGE P, MARKHAM A, KRUSH AJ, PETERSEN G, HAMILTON SR, NILBERT MC, LEVY DB, BRYAN TM, PREISINGER AC, SMITH KJ, SU L-K, KINZLER KW AND VOGELSTEIN B. (1991). Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science, 253, 665 669.
-
(1991)
Science
, vol.253
, pp. 665-669
-
-
Nishisho, I.1
Nakamura, Y.2
Miyoshi, Y.3
Miki, Y.4
Ando, H.5
Horii, A.6
Koyama, K.7
Utsonomiya, J.8
Baba, S.9
Hedge, P.10
Markham, A.11
Krush, A.J.12
Petersen, G.13
Hamilton, S.R.14
Nilbert, M.C.15
Levy, D.B.16
Bryan, T.M.17
Preisinger, A.C.18
Smith, K.J.19
Su, L.-K.20
Kinzler, K.W.21
Vogelstein, B.22
more..
-
24
-
-
0027936587
-
Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas
-
OGASAWARA S, MAESAWA C, TAMURA G AND SATODATE R. (1994). Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas. Virchows Arch., 424, 607-611.
-
(1994)
Virchows Arch.
, vol.424
, pp. 607-611
-
-
Ogasawara, S.1
Maesawa, C.2
Tamura, G.3
Satodate, R.4
-
25
-
-
0024308804
-
Amplification, overexpression, and rearrangement of the erB-2 protooncogene in primary human stomach carcinomas
-
PARK JB, RHIM JS, PARK S-C, KIMM S-W AND KRAUS MH. (1989). Amplification, overexpression, and rearrangement of the erB-2 protooncogene in primary human stomach carcinomas. Cancer Res., 49, 6605 6609.
-
(1989)
Cancer Res.
, vol.49
, pp. 6605-6609
-
-
Park, J.B.1
Rhim, J.S.2
Park, S.-C.3
Kimm, S.-W.4
Kraus, M.H.5
-
26
-
-
0026630266
-
APC mutations occur early during colorectal tumorigenesis
-
POWELL SM, ZILZ N, BEAZER-BARCLAY Y, BRYAN TM, HAMILTON SR, THIBODEAU SN, VOGELSTEIN B AND KINZLER KW. (1992). APC mutations occur early during colorectal tumorigenesis. Nature, 359, 235 237.
-
(1992)
Nature
, vol.359
, pp. 235-237
-
-
Powell, S.M.1
Zilz, N.2
Beazer-Barclay, Y.3
Bryan, T.M.4
Hamilton, S.R.5
Thibodeau, S.N.6
Vogelstein, B.7
Kinzler, K.W.8
-
27
-
-
0028099420
-
APC gene mutations in the mutation cluster region are rare in esophageal cancers
-
POWELL SM, PAPADOPOULOS N, KINZLER KW, SMOLINSKI KN AND MELTZER SJ. (1994). APC gene mutations in the mutation cluster region are rare in esophageal cancers. Gastroenterology, 107, 1759 1763.
-
(1994)
Gastroenterology
, vol.107
, pp. 1759-1763
-
-
Powell, S.M.1
Papadopoulos, N.2
Kinzler, K.W.3
Smolinski, K.N.4
Meltzer, S.J.5
-
28
-
-
0027175653
-
Base transitions are the most frequent genetic changes at P53 in gastric cancer
-
RENAULT B, VAN DEN BROEK M, FODDE Rm WIJNEN J, PELLEGATA NS, AMADORI D, MEERA KHAN P AND RANZANI GN. (1993). Base transitions are the most frequent genetic changes at P53 in gastric cancer. Cancer Res., 53, 2614 2617.
-
(1993)
Cancer Res.
, vol.53
, pp. 2614-2617
-
-
Renault, B.1
Van Den Broek, M.2
Fodde, R.3
Wijnen, J.4
Pellegata, N.S.5
Amadori, D.6
Meera Khan, P.7
Ranzani, G.N.8
-
29
-
-
0025807514
-
Frequent loss of heterozygosity on chromosomes 1q, 5q, and 17p in human gastric carcinomas
-
SANO T, TSUJINO T, YOSHIDA K, NAKAYAMA H, HARUMA K, ITO H, NAKAMURA Y, KAJIYAMA G AND TAHARA E. (1991). Frequent loss of heterozygosity on chromosomes 1q, 5q, and 17p in human gastric carcinomas. Cancer Res., 51, 2926-2931.
-
(1991)
Cancer Res.
, vol.51
, pp. 2926-2931
-
-
Sano, T.1
Tsujino, T.2
Yoshida, K.3
Nakayama, H.4
Haruma, K.5
Ito, H.6
Nakamura, Y.7
Kajiyama, G.8
Tahara, E.9
-
30
-
-
0027193630
-
The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions
-
SHEFFIELD VC, BECK JS, KWITEK AE, SANDSTROM DW AND STONE EM. (1993). The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions. Genomics 16, 325-332.
-
(1993)
Genomics
, vol.16
, pp. 325-332
-
-
Sheffield, V.C.1
Beck, J.S.2
Kwitek, A.E.3
Sandstrom, D.W.4
Stone, E.M.5
-
31
-
-
0026008884
-
A CA repeat 30-70 KB downstream from the adenomatous polyposis coli (APC) gene
-
SPIRIO L, JOSLYN G, NELSON L, LEPPERT M AND WHITE R. (1991). A CA repeat 30-70 KB downstream from the adenomatous polyposis coli (APC) gene. Nucleic Acids Res., 19, 6348.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 6348
-
-
Spirio, L.1
Joslyn, G.2
Nelson, L.3
Leppert, M.4
White, R.5
-
32
-
-
0027381316
-
Primary gastric carcinoma cells frequently lose heterozygosity at the APC and MCC genetic loci
-
TAMURA G, MAESAWA C, SUZUKI Y, OGASAWARA S, TERASHIMA M, SAITO K AND SATODATE R. (1993). Primary gastric carcinoma cells frequently lose heterozygosity at the APC and MCC genetic loci. Jpn J. Cancer Res., 84, 1015 1018.
-
(1993)
Jpn J. Cancer Res.
, vol.84
, pp. 1015-1018
-
-
Tamura, G.1
Maesawa, C.2
Suzuki, Y.3
Ogasawara, S.4
Terashima, M.5
Saito, K.6
Satodate, R.7
-
33
-
-
0028222940
-
Mutations of the APC gene occur during early stages of gastric adenoma development
-
TAMURA G, MAESAWA C, SUZUKI Y, TAMADA H, SATOH M, OGASAWARA S, KASHIWABA M AND SATODATE R. (1994). Mutations of the APC gene occur during early stages of gastric adenoma development. Cancer Res., 54, 1149-1151.
-
(1994)
Cancer Res.
, vol.54
, pp. 1149-1151
-
-
Tamura, G.1
Maesawa, C.2
Suzuki, Y.3
Tamada, H.4
Satoh, M.5
Ogasawara, S.6
Kashiwaba, M.7
Satodate, R.8
-
34
-
-
0026642513
-
Frequent loss of heterozygosity at the DCC locus in gastric cancer
-
UCHINO S, TSUDA H, NOGUCHI M, YOKOTA J, TERADA M, SAITO T, KOBAYASHI M, SUGIMURA T AND HIROHASHI S. (1992). Frequent loss of heterozygosity at the DCC locus in gastric cancer. Cancer Res., 52, 3099-3102.
-
(1992)
Cancer Res.
, vol.52
, pp. 3099-3102
-
-
Uchino, S.1
Tsuda, H.2
Noguchi, M.3
Yokota, J.4
Terada, M.5
Saito, T.6
Kobayashi, M.7
Sugimura, T.8
Hirohashi, S.9
-
35
-
-
0028024941
-
Abnormalities of the adenomatous polyposis coli gene in human oral squamous-cell carcinoma
-
UZAWA K, YOSHIDA H, SUZUKI H, TANZAWA H, SHIMAZAKI J, SEINO S AND SATO K. (1994). Abnormalities of the adenomatous polyposis coli gene in human oral squamous-cell carcinoma. Int. J. Cancer, 58, 814 817.
-
(1994)
Int. J. Cancer
, vol.58
, pp. 814-817
-
-
Uzawa, K.1
Yoshida, H.2
Suzuki, H.3
Tanzawa, H.4
Shimazaki, J.5
Seino, S.6
Sato, K.7
-
36
-
-
0028289053
-
Rapid detection of translation-terminating mutations at the adenomatous polyposis coli (APC) gene by direct protein truncation test
-
VAN DER LUIJT R, MEERA KHAN P, VASEN H, VAN LEEUWEN C, TOPS C, ROEST P, DEN DUNNEN J AND FODDE R. (1994). Rapid detection of translation-terminating mutations at the adenomatous polyposis coli (APC) gene by direct protein truncation test. Genomics, 20, 1 4.
-
(1994)
Genomics
, vol.20
, pp. 1-4
-
-
Van Der Luijt, R.1
Meera Khan, P.2
Vasen, H.3
Van Leeuwen, C.4
Tops, C.5
Roest, P.6
Den Dunnen, J.7
Fodde, R.8
|