Synthesis and cleavage-secretion of enzymatically active rabbit angiotensin-converting enzyme in Pichia pastoris

Journal of Biological Chemistry

Volumn 271, Issue 31, 1996, Pages 18310-18313

  Sadhukhan, Ramkrishna ^a   Sen, Ganes C ^a   Sen, Indira ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; METALLOPROTEINASE INHIBITOR; SIGNAL PEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME RELEASE; ENZYME SYNTHESIS; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; YEAST;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; DNA, RECOMBINANT; ENDOPEPTIDASES; GENE EXPRESSION; GENETIC VECTORS; HELA CELLS; HUMANS; MALE; MICE; MOLECULAR SEQUENCE DATA; PEPTIDYL-DIPEPTIDASE A; PICHIA; RABBITS; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; TESTIS;

EID: 0029780514     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.31.18310     Document Type: Article

References (23)

1. Ehlers, M. R. W., and Riordan, J. F. (1991) Biochemistry 30, 10065-10074
2. Haass, C., and Selkoe, D. J. (1993) Cell 75, 1039-1042
3. Flanagan, J. G., Chen, D. C., and Leder, P. (1991) Cell 64, 1025-1035
4. Sen, I., Samanta, H., Livingston, W., III, and Sen, G. C. (1991) J. Biol. Chem. 266, 21985-21990
5. Ramchandran, R., Sen, G. C., Misono, K., and Sen, I. (1994) J. Biol. Chem. 269, 2125-2130
6. Sen, I., Kasturi, S., Jabbar, M. A., and Sen, G. C. (1993) J Biol. Chem. 268, 25748-25754
7. Ramchandran, R., and Sen, I. (1995) Biochemistry 34, 12645-12652
8. Ramchandran, R., Kasturi, S., Douglas, J. G., and Sen, I. (1996) Am. J. Physiol., in press
9. Mohler, M. M., Sleath, P. R., Fitzner, J. N., Cerretti, D. P., Alderson, M., Kerwar, S. S., Torrance, D. S., Otten-Evans, D., Greenstreet, T., Weerawarke, K., Kronheim, S. R., Petersen, M., Gerhart, M., Kozolsky, C. J., March, C. J., and Black, R. A. (1994) Nature 370, 218-220
10. McGeehan, G. M., Becherer, J. D., Bast, R. C., Jr., Boyer, C. M., Champion, B., Connolly, K. M., Conway, J. G., Furdon, P., Karp, S., Kidao, S., McElroy, A. B., Nichold, J., Pryzwansky, M., Schoenen, F., Sekut, L., Truesdale, A., Verghese, M., Warner, J., and Ways, J. P. (1994) Nature 370, 558-561
11. Gearing, A. J. H., Beckett, P., Christodoulou, M., Churchill, M., Clements, J., Davidson, A. H., Drummond, A. H., Galloway, W. A., Gilbert, R., Gordon, J. L., Leber, T. M., Mangan, M., Miller, K., Nayee, P., Owen, K., Patel, S., Thomas, W., Wells, G., Wood, L. M., and Woolley, K. (1994) Nature 370, 555-557
12. Pandiella, A., Bosenberg, M. W., Huang, E. J., Besmer, P., and Massegue, J. (1992) J. Biol. Chem. 267, 24028-24033
13. Roberts, S. B., Rippellino, J. A., Ingalls, K. M., Robakis, N. K., and Felsenstein, K. M. (1994) J. Biol. Chem. 28, 3111-3116
14. Fuller, R. S., Sterne, R. E., and Thorner, J. (1988) Annu. Rev. Physiol. 50, 345-362
15. Böhni, P. C., Deshaies, R. J., and Schekman, R. W. (1988) J. Cell Biol. 106, 1035-1042
16. Yang, M., Jensen, R. E., Yaffe, M. P., Oppliger, W., and Schatz, G. (1988) EMBO J. 7, 3857-3862
17. Nunnari, J., Fox, T. D., and Walter, P. (1993) Science 262, 1997-2004
18. Zhang, H., Komano, H., Fuller, R. S., Gandy, S. E., and Frail, D. E. (1994) J. Biol. Chem. 269, 27799-27802
19. Kumar, R. S., Kusari, J., Roy, S. N., Soffer, R. L., and Sen, G. C. (1989) J. Biol. Chem. 264, 16754-16758
20. Sadhukhan, R., and Sen, I. (1996) J. Biol. Chem. 271, 6429-6434
21. Ehlers, M. R. W., Chen, P. Y.-N., and Riordon, J. F. (1991) Protein Exp. Purif. 2, 1-9
22. Cushman, D. W., and Cheung, H. S. (1971) Biochem. Pharmacol. 20, 1637-1648
23. El-Dorry, H., Bull, H. G., Iwata, K., Thornberry, N. A., Cordes, E. H., and Soffer, R. L. (1982) J. Biol. Chem. 257, 14128-14133