High postmortem concentrations of hypoxanthine and urate in the vitreous humor of infants are not confined to cases of sudden infant death syndrome

South African Medical Journal

Volumn 86, Issue 7, 1996, Pages 827-828

  Belonje, P C ^a   Wilson, G R ^a   Siroka, S A ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; FREE RADICAL; HALOTHANE; HYPOXANTHINE; URATE;

ARTICLE; AUTOPSY; CAUSE OF DEATH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROLYSIS; HYPOXIA; INFANT; MAJOR CLINICAL STUDY; MALIGNANT HYPERTHERMIA; RESPIRATORY ALKALOSIS; SUDDEN DEATH; SUDDEN INFANT DEATH SYNDROME; SWINE; VITREOUS BODY;

ADENOSINE TRIPHOSPHATE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FREE RADICALS; HUMANS; HYDROLYSIS; HYPOXANTHINES; INFANT; INFANT, NEWBORN; SUDDEN INFANT DEATH; URIC ACID; VITREOUS BODY;

EID: 0029779864     PISSN: 02569574     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Belonje PC, Wilson GR, Berman PA, Human L. Sudden death in laboratory rats induced by acute respiratory alkalosis: Biochemical similarities to malignant hyperthermia in pigs. S Afr J Sci 1995; 91: 18-21.
2. Denborough MA, Galloway GJ, Hopkinson KC. Malignant hyperpyrexia and sudden infant death. Lancet 1982; 2: 1068-1069.
3. Rognum TO, Saugstad OD, Øyasæter S, Olaisen B. Elevated levels of hypoxanthine in vitreous humor indicate prolonged cerebral hypoxia in victims of sudden infant death syndrome. Pediatrics 1988; 82: 615-618.
4. Rognum TO, Saugstad OD. Hypoxanthine levels in vitreous humor: Evidence of hypoxia in most infants who died of sudden infant death syndrome. Pediatrics 1991; 87: 306-310.
5. Saugstad OD, Gluck L. Plasma hypoxanthine levels in newborn infants: A specific indicator of hypoxia. J Perinat Med 1982; 10: 266-272.
6. Saugstad OD, Rognum TO. High postmortem levels of hypoxanthine in the vitreous humor of premature babies with respiratory distress syndrome. Pediatrics 1988; 81: 395-398.
7. Poulson JP, Rognum TO, Hauge S, Øyasæter S, Saugstad OD. Post-mortem concentrations of hypoxanthine in the vitreous humor: A comparison between babies with severe respiratory failure, congenital abnormalities of the heart, and victims of sudden infant death syndrome. J Perinat Med 1993; 21: 153-163.
8. Carpenter KH, Bonham JR, Worthy E, Variend S. Vitreous humor and cerebrospinal fluid hypoxanthine concentrations as a marker of pre-mortem hypoxia in SIDS. J Clin Pathol 1993; 46: 650-653.
9. Saugstad OD. Hypoxanthine as an indicator of hypoxia. Its role in health and disease through free radical production. Pediatr Res 1988; 23: 143-150.