Analysis of uncontrolled treatment changes in HIV clinical trials

Statistics in Medicine

Volumn 15, Issue 19, 1996, Pages 2053-2067

  Lin, Hung Mo ^a   Hughes, Michael D ^b  

^a UNITED NETWORK FOR ORGAN SHARING   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CD4 ANTIGEN; ZIDOVUDINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DISEASE COURSE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; METHODOLOGY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS;

ADOLESCENT; ADULT; CD4 LYMPHOCYTE COUNT; CLINICAL TRIALS; CONFIDENCE INTERVALS; CROSS-OVER STUDIES; FEMALE; HIV INFECTIONS; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MODELS, STATISTICAL; PLACEBOS; ZIDOVUDINE;

EID: 0029778276     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0258(19961015)15:19<2053::AID-SIM340>3.0.CO;2-Y     Document Type: Article

References (11)

1. Volberding, P. A., Lagakos, S. W., Koch, M. A., Pettinelli, C. et al. 'Zidovudine in asymptomatic human immunodeficiency virus infection: A controlled trial with persons with fewer than 500 CD4-positive cells per cubic millimeter', New England Journal of Medicine, 322, 941-949 (1990).
2. Fischl, M. A., Richman, D. D., Hansen, N., et al. The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type I (HIV) infection: a double-blind, placebo-controlled trial', Annals of Internal Medicine, 112, 727-737 (1990).
3. + cell count measurement variability on staging HIV-1 infection', Journal of Acquired Immune Deficiency Syndrome, 5, 794-802 (1992).
4. Hughes, M. D., Stein, D. S., Gundacker, H. M., Valentine, F. T., Phair, J. P. and Volberding P. A. 'Within-subject variation in CD4 lymphocyte count in asymptomatic human immunodeficiency virus infection: implications for patient monitoring', Journal of Infectious Diseases, 169, 28-36 (1994).
5. Lin, H. M. 'Assessing the effects of intervention using longitudinal data for samples subject to selection', (dissertation).
6. Burack, J. H., Barrett, D. C., Stall, R. D., Chesney, M. A., Ekstrand, M. L. and Coates, T. J. 'Depressive symptoms and CD4 lymphocyte decline among HIV-infected men', Journal of the American Medical Association, 270, 2568-2573 (1993).
7. Lang, W., Perkins, H., Anderson, R. E., Royce, R., Jewell, N. and Winkelstein, W. Jr. 'Patterns of T lymphocyte changes with human immunodeficiency virus infection: From seroconversion to the development of AIDS', Journal of Acquired Immune Deficiency Syndromes, 2, 63-69 (1989).
8. Lange, N., Carlin, B. P. and Gelfand, A. E. 'Hierarchical Bayes models for the progression of HIV-infection using longitudinal CD4 T-cell numbers', Journal of the American Statistical Association, 87, 615-626 (1992).
9. Taylor, J. M. G., Cumberland, W. G. and Sy, J. P. 'A stochastic model for analysis of longitudinal AIDS data', Journal of the American Statistical Association, 89, 727-736 (1994).
10. DeGruttola, V., Lange, N. and Dafni, U. 'Modeling the progression of HIV infection', Journal of the American Statistical Association, 86, 569-577 (1991).
11. Johnson, R. A. and Wichern, D. W. Applied Multivariate Statistical Analysis, 2nd edn., Prentice-Hall, 1988.