A rapid qualitative method to assess in vitro immunobarrier competence of pancreatic islets containing alginate/polyaminoacidic microcapsules

Acta Diabetologica

Volumn 33, Issue 2, 1996, Pages 150-153

  Calafiore, R ^a   Basta, G ^a   Sarchielli, P ^a   Luca, G ^a   Tortoioli, C ^a   Brunetti, P ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Alginate poly L ornithine microcapsules; Immune rejection; Immunobarrier competence; Transplantation

Indexed keywords

ALGINIC ACID; PANCREAS ISLET CELL ANTIBODY; POLYAMINOACID; POLYORNITHINE;

ARTICLE; IMMUNOFLUORESCENCE; IMMUNOGENICITY; LABORATORY TEST; LYMPHOCYTE PROLIFERATION; MICROCAPSULE; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL;

EID: 0029777560     PISSN: 09405429     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00569426     Document Type: Article

References (18)

1. Lim F, Sun AM, Microencapsulated islets as bioartificial endocrine pancreas. Science 210-908-910, 1980
2. Brunetti P, Basta G, Falorni A, Calcinaro F, Pietropaolo M, Calafiore R, Immunoprotection of pancreatic islets grafts within artificial microcapsules. Im J Artif Organs 14:789-791, 1991
3. Zekorn T, Sieberes U, Horcher A, Alginate coating of islets of Langerhans' in vitro studies on a new method for immunoisolated islet transplantation. Acta Diabetol 29:41-45, 1992
4. Soon-Shiong P, Heintz RE, Mendeth N, Yao QZ, Zheng T, Murphy M, Moloney MK, Scmel M, Harris M, Mendez R, Sanford P, Insulin independence in a type I diabetic patient after encapsulated islet transplantation. Lancet 343:950-951, 1994
5. Basta G, Osticioli L, Rossodivita ME, Sarchielli P, Tortoioli C, Brunetti P, Calafiore R, A method for fabrication of coherent microcapsules: a new, potential immunoisolatory barrier for pancreatic islet transplantation. Diabetes Nutr Metab 8:105-112, 1995
6. Calafiore R, Basta G, Falorni A, Calcinaro F, Pietropaolo M, Brunetti P, A method for the large-scale production of microencapsulated islets: in vitro and in vivo results. Diabetes Nutr Metab 5-23-29, 1992
7. Basta G, Falorni A, Osticioli L, Brunetti P, Calafiore R, Method for mass retrieval, morphologic and functional characterization of porcine islets of Langerhans' a potential xenogeneic tissue resource for transplantation in IDDM. J Invest Med 43:555-566, 1995
8. Boyum A, A one stage procedure for isolation of granulocytes and lymphocytes from human blood. Scand J Clin Lab Invest 97:21, 1968
9. Shizuru JA, Ramakrishnan S, Hunt T, Merrell RC, Fathman CG, Inhibition of rat mixed lymphocyte pancreatic islet cultures with anti-la immunotoxins. Transplantation 42:660-666, 1986
10. Maki T, Otsu I, O'Neil JJ, Dunleavy K, Mullon CJP, Salomon BA, Monaco AP, Treatment of diabetes by xenogeneic islets without immunosuppression: use of a vascularized bioartificial pancreas. Diabetes 45:342-347, 1996
11. Calafiore R, Basta G, Falorni A, Brotzu G, Alfani D, Cortesisni R, Brunetti P, Vascular graft of microencapsulated human islets in nonimmunosuppressed diabetic recipient: preliminary results. Diabetes Nutr Metab 4:45-48, 1991
12. Scharp DW, Swanson CJ, Olack BJ, Lacy PE, Protection of encapsulated human islets implanted without immunosuppression in patients with type I or type II diabetes and in nondiabetic control subjects. Diabetes 43:1167-1170, 1994
13. Calafiore R, Koh N, Civantos F, Shienvold FL, Needell SD, Alejandro R, Xenotransplantation of microencapsulated canine islets in diabetic mice. Trans Assoc Am Physicians 99:28-33, 1986
14. Basta G, Rossodivita ME, Osticioli L, Luca G, Brunetti P, Calafiore R, Ultrastructural examination of pancreatic islet containing alginate/polyaminoacidic coherent microcapsules. J Submicrosc Cytol Pathol 28:1-3, 1996
15. Lanza RP, Kuhtreiber W, Ecker D, Beyer AM, Chick WL, Xenotransplantation of porcine and bovine islets without immunosuppression using uncoated alginale microspheres. Transplantation 59:1377-1385, 1995
16. Kaneto H, Fuji J, Seo HG, Suzuki K, Matsuoka T, Nakamura M, Tatsumi H, Yamasaki Y, Yamada T, Taniguchi N, Apoptotic cell death triggered by nitric oxide in pancreatic β-cells. Diabetes 44:733-738, 1995
17. Suarez-Pinzon WL, Strynadka K, Schulz R, Rabinovitch A, Mechanisms of cytokine-induced destruction of rat insulinoma cells: the role of nitric oxide. Endocrinology 134:1006-1010, 1994
18. Dunger A, Cunningham JM, Delaney CA, Lowe JE, Green MHL, Bone AJ, Green IC, Tumor necrosis factor-α and interferon-γ inhibit insulin secretion and cause DNA damage in unweanedrat islets. Extent of nitric oxide involvement Diabetes 45:183- 189, 1996