Minocycline and the thyroid: Antithyroid effects of the drug, and the role of thyroid peroxidase in minocycline-induced black pigmentation of the gland

Thyroid

Volumn 6, Issue 3, 1996, Pages 211-219

  Taurog, Alvin ^a,c   Dorris, Martha L ^a   Doerge, Daniel R ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^c SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHYROID AGENT; MINOCYCLINE; THYROID PEROXIDASE;

ACNE VULGARIS; ARTICLE; CATALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; ENZYME ACTIVITY; HUMAN; IODINATION; LONG TERM CARE; PATIENT MONITORING; PIGMENT DISORDER; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; THYROID FUNCTION; TREATMENT PLANNING;

ANIMALS; ANTI-BACTERIAL AGENTS; GLUCOSE OXIDASE; HUMANS; HYDROGEN PEROXIDE; IODIDE PEROXIDASE; IODINE; KINETICS; MINOCYCLINE; MODELS, BIOLOGICAL; PIGMENTATION; PROPYLTHIOURACIL; THYROID GLAND; THYROXINE; TRIIODOTHYRONINE;

EID: 0029777267     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Basler RSW 1979 Minocycline therapy for acne. Arch Dermatol 115:1391.
2. Jonas M, Burke AC 1982 Minocycline. Therapeutic Drug Monitoring 4:137-145.
3. Kloppenburg M, Breedveld FC, Terwiel JPL, Mallee C, Dijkmans BAC 1994 Minocycline in active rheumatoid arthritis. Arthritis Rheum 37:629-636.
4. Tilley BC, Alarcón GS, Heyse SP, et al. 1995 Minocycline in rheumatoid arthritis; a 48-week, double-blind, placebo-controlled trial. Ann Intern Med 122:81-89.
5. Benitz K-F, Roberts GKS, Yusa A 1967 Morphologic effects of minocycline in laboratory animals. Toxicol Appl Pharmacol 11:150-170.
6. Kurosumi M, Fujita H 1985 Fine structural aspects of the black thyroid induced by minocycline, and the effects of a low iodine diet, propylthiouracil, thyroxine tablet and TSH, on the black discoloration of the rat thyroid. Virchows Arch Cell Pathol 48:219-227.
7. Tajima K, Miyagawa J-I, Nakajima H, et al. 1985 Morphological and biochemical studies on minocycline-induced black thyroid in rats. Toxicol Appl Pharmacol 81:393-400.
8. Attwood HD, Dennett X 1976 A black thyroid and minocycline treatment. Br Med J 2:1109-1110.
9. Saul S, Dekker A, Lee RE, Breitfeld V 1983 The black thyroid. Its relation to minocycline use in man. Arch Pathol Lab Med 107:173-177.
10. Billano RA, Ward WQ, Little WP 1983 Minocycline and black thyroid. J Am Med Assoc 249:1887.
11. Medeiros LJ, Federman M, Silverman ML, Balogh K 1984 Black thyroid associated with minocycline therapy. Arch Pathol Lab Med 108:268-269.
12. Delprado WJ, Carter JJ 1984 Minocycline hydrochloride and thyroid pigmentation. A case report with histological and ultrastructural study. Pathology 16:339-341.
13. Gordon G, Sparano BM, Kramer AW, et al. 1984 Thyroid gland pigmentation and minocycline therapy. Am J Pathol 117:98-109.
14. Alexander CB, Herrara GA, Jaffe K, Yu H 1985 Black thyroid: Clinical manifestations, ultrastructural findings, and possible mechanisms. Human Pathol 16:72-78.
15. Landas SK, Schelper RL, Tio FO, et al. 1986 Black thyroid syndrome. Exaggeration of a normal process? Am J Clin Pathol 85:411-418.
16. Senba M, Toda Y, Yamashita H 1988 Black thyroid associated with minocycline therapy: Histochemical and ultrastructural studies on the brown pigment. Isr J Med Sci 24:51-53.
17. Ohaki Y, Misugi K, Hasegawa H 1986 "Black Thyroid" associated with minocycline therapy. A report of an autopsy case: and review of the literature. Acta Pathol Jpn 36:1367-1375.
18. Noble JG, Christmas TJ, Chapple C, Katz D, Milroy EJG 1989 The black thyroid: An unusual finding during neck exploration. Postgrad Med J 65:34-35.
19. Barsoum GH, Ryley NG, Barros D'Sa AAJ 1990 Minocycline and black thyroid. J Roy Coll Surg Edinb 35:387-388.
20. Purdue B 1992 An incidental autopsy finding of black thyroid associated with minocycline therapy. Med Sci Law 32:148-150.
21. Saito K, Jujio T, Hashizume T, et al. 1972 Studies on goitrogenic action of minocycline and related compounds. Endocrinology 90:1192-1201.
22. Rawitch AB, Taurog A, Chernoff SB, Dorris ML 1979 Hog thyroid peroxidase: Physical, chemical, and catalytic properties of the highly purified enzyme. Arch Biochem Biophys 194:244-257.
23. Yokoyama N, Taurog A 1988 Porcine thyroid peroxidase: Relationship between the native enzyme and an active, highly purified tryptic fragment. Mol Endocrinol 2:838-844.
24. Taurog A, Dorris M 1992 Myeloperoxidase-catalyzed iodination and coupling. Arch Biochem Biophys 296:239-246.
25. Enochs WS, Nilges MJ, Swartz HM 1993 The minocycline-induced thyroid pigment and several synthetic models: Identification and characterization by electron paramagnetic resonance spectroscopy. J Pharmacol Exp Ther 266:1164-1176.
26. Engler H, Taurog A, Luthy C, Dorris ML 1983 Reversible and irreversible inhibition of thyroid peroxidase-catalyzed iodination by thioureylene drugs. Endocrinol 112:86-95.
27. 14C-labeled l-methyl-2-mercaptoimidazoIe in vitro and in vivo. Endocrinology 124:30-39.
28. 14C-labeled propylthiouracil in a model in vitro system containing thyroid peroxidase. Endocrinology 124:3030-3037.
29. Taurog A, Riesco G, Larsen PR 1976 Formation of 3,3′-diiodothyronine and 3′-5′3-triiodothyronine (reverse T3) by thyroid glands of rats and in enzymatically iodinated thyroglobulin. Endocrinology 99:281-290.
30. Taurog A, Dorris ML, Guziec LJ, Guziec FS Jr 1994 The selenium analog of methimazole: Measurement of its inhibitory effect on type I 5′-deiodinase and of its antithyroid activity. Biochem Pharmacol 40:1447-1453.
31. Lamas L, Dorris ML, Taurog A 1972 Evidence for a catalytic role for thyroid peroxidase in the conversion of diiodotyrosine to thyroxine. Endocrinology 90:1417-1426.
32. Taurog A, Dorris M, Doerge DR 1994 Evidence for a radical mechanism in peroxidase-catalyzed coupling. I. Steady-state experiments with various peroxidases. Arch Biochem Biophys 315:82-89.
33. Engler H, Taurog A, Dorris ML 1982 Preferential inhibition of thyroxine and 3,5,3′-triiodothyronine formation by propylthiouracil and methylmercaptoimidazole in thyroid peroxidase-catalyzed iodination of thyroglobulin. Endocrinology 110:190-197.
34. Kelly RG, Kanegis LA 1967 Metabolism and tissue distribution of radioisotopically labeled minocycline. Toxicol Appl Pharmacol 11:171-183.
35. Taurog A, Dorris ML 1989 A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil. Endocrinology 124:3038-3042.
36. 35S-propylthiouracil by the thyroid gland and its relationship to anion trapping mechanism. Metabolism 20:989-999.
37. 35S-methimazole in the rat. Endocrinology 91:747-756.
38. Nakashima T, Taurog A, Riesco G 1978 Mechanism of action of thioureylene drugs: Factors affecting intrathyroidal metabolism of propylthiouracil and methimazole in rats. Endocrinology 103:2187-2197.
39. Nogimori T, Braverman LE, Taurog A, Fang S, Wright G, Emerson CH 1986 A new class of propylthiouracil analogs: Comparison of 5′-deiodinase inhibition and antithyroid activity. Endocrinology 118:1598-1605.
40. Taurog A, Dorris ML, Hu W, Guziec FS Jr 1995 The selenium analog of propylthiouracil: Measurement of its inhibitory effect on Type I iodothyronine deiodinase and of its antithyroid activity. Biochem Pharmacol 49:701-709.
41. Taurog A 1996 Hormone synthesis: Thyroid iodine metabolism. In: Braverman LS, Utiger RD (eds) Werner and Ingbar's The Thyroid, 7th ed. Lippincott-Raven, Philadelphia, p. 47.
42. Doerge DR, Decker CJ, Takazawa RS 1993 Chemical and enzymatic oxidation of benzimidazoline-2-thiones: A di-chotomy in the mechanism of peroxidase inhibition. Biochemistry 32:58-65.
43. Kohler H, Taurog A, Dunford HB 1988 Spectral studies with lactoperoxidase and thyroid peroxidase: Interconversions between native enzyme, compound II, and compound III. Arch Biochem Biophys 264:438-449.
44. Doerge DR, Taurog A, Dorris M 1994 Evidence for a radical mechanism in peroxidase-catalyzed coupling. II. Single turnover experiments with horseradish peroxidase. Arch Biochem Biophys 315:90-99.