Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling

Advances in Experimental Medicine and Biology

Volumn 387, Issue , 1996, Pages 129-134

  Hissink, Erna ^a   Van Ommen, Ben ^a   Bogaards, Jan J ^a   Van Bladeren, Peter J ^a  

^a TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DICHLOROBENZENE; 1,4 DICHLOROBENZENE; ALANINE AMINOTRANSFERASE; ASCORBIC ACID; CYTOCHROME P450 ISOENZYME; EPOXIDE; GLUTATHIONE; ISONIAZID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BIOTRANSFORMATION; CONFERENCE PAPER; CONTROLLED STUDY; DETOXIFICATION; ENZYME SUBSTRATE; LIVER MICROSOME; LIVER TOXICITY; MALE; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICOKINETICS;

EID: 0029776883     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9480-9_18     Document Type: Conference Paper

References (8)

1. Brodie, B.B., Reid, W.D., Cho, A., Sipes, I.G., Krishna, G., and Gillette, J.R. (1971). Possible mechanism of liver necrosis caused by aromatic organic compounds. Proc. Nat. Acad. Sci. 68, 160-164.
2. Hawley, G.G. (1971). The Condensed Chemical Dictionary, 8th. ed., pp. 283-284. Van Nostrand Reinhold, New York/London.
3. Hissin, P.J. and Hilf, R. (1976). A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74, 214-226.
4. National Toxicology Program (1987). Toxicology and Carcinogenesis studies of 1,4-dichlorobenzene (CAS No. 67-72-1) in F344/N rats and B6C3F1 mice (gavage studies) Abstracts from long-term cancer studies, 1976-1992. Environmental Health Perspectives. National Institute of Health, vol. 101, supplement 1 (1993). 185-186.
5. Ramsey, J.C., and Andersen, M.E. (1984). A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73, 159-175.
6. Ryan, D.E., Ramanathan, L., Iida, S., Thomas, P.E., Haniu, M., Shively, J.E., Lieber, C.S., and Levin, W. (1985). Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid. J. Biol. Chem. 260, 6385-6393.
7. Stine, E.R., Gunawardhana, L., and Sipes, I.G. (1991). The acute hepatotoxicity of the isomers of dichlorobenzene in Fisher-344 and Sprague-Dawley rats: Isomer-specific and strain-specific differential toxicity. Toxicol. Appl. Pharmacol. 109, 472-481.
8. US EPA. (1985). Health assessment document for chlorinated benzenes. Final report. Office of health and environment assessment, Washington D.C., U.S. Environmental Protection Agency. Report EPA/600/8-84/015F.