Synthesis of β-amino-α,α-dichloro sulfones from vinyl sulfones

Synthetic Communications

Volumn 26, Issue 20, 1996, Pages 3715-3718

  Jung, Jin Hang ^a   Lee, Jae Wook ^b   Lee, Chi Wan ^a   Oh, Dong Young ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Daewoong Pharmaceutical Co Ltd   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

SULFONE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0029776717     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397919608003788     Document Type: Article

References (9)

1. Sympkins, N. S. Sulphones in Organic Synthesis, 1993, Chapter 4, Pergamon Press, Oxford, references cited therein.
2. McDowell, S. T. J. Chem. Soc. (B), 1967, 351.
3. Fedorynski, M.; Klepka, C.; Jonczyk, A. Gazz. Chim. Ital., 1993, 123, 665.
4. Lee, J. W.; Oh, D. Y. Synth. Commun. 1989, 19, 2209. Lee, J. W.; Oh, D. Y. Bull. Korean Chem. Soc., 1989, 10, 39. Lee, J. W.; Oh, D. Y. Synth. Commun. 1990, 20, 273.
5. Lee, J. W.; Oh, D. Y. Synth. Commun. 1989, 19, 2209. Lee, J. W.; Oh, D. Y. Bull. Korean Chem. Soc., 1989, 10, 39. Lee, J. W.; Oh, D. Y. Synth. Commun. 1990, 20, 273.
6. Lee, J. W.; Oh, D. Y. Synth. Commun. 1989, 19, 2209. Lee, J. W.; Oh, D. Y. Bull. Korean Chem. Soc., 1989, 10, 39. Lee, J. W.; Oh, D. Y. Synth. Commun. 1990, 20, 273.
7. Kotake, H.; Inomata, K.; Kinoshita, H.; Sakamoto, Y.; Kaneto, Y. Bull. Chem. Soc. Jpn. 1980, 53, 3027.
8. 4 (10 mmol) and NaH (80% dispersion in mineral oil, 3 mmol) in THF (6 ml) at room temperature was added amine 2 (1.2 mmol). After stirring the mixture for several hours indicated in Table, usual workup was performed. Purification by column chromatography on silica gel was accomplished.
9. Vachor, B.; Samat, A.; Canon, M. Tetrahedron Lett. 1985, 26, 5129.