Mechanisms of the effects of methotrexate

Bulletin on the Rheumatic Diseases

Volumn 45, Issue 5, 1996, Pages 6-8

  Cronstein, Bruce N ^a   Merrill, Joan T ^b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; HYDROXYCHLOROQUINE; METHOTREXATE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; HUMAN; METHYLATION; RHEUMATOID ARTHRITIS; RHEUMATOID NODULE;

ADENOSINE; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; HUMANS; METHOTREXATE; METHYLATION; RHEUMATOID NODULE;

EID: 0029776349     PISSN: 00075248     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Nesher G, Moore TM: The in vitro effects of methotrexate on peripheral blood mononudear cells: modulation by methyl donors and spermidine. Arthritis Rheum 33:954-959, 1990.
2. Cronstein BN, Eberle MA, Gruber HE, Levin RI: Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells. Proc Natl Acad Sci USA 88:2441-2445, 1991.
3. Cronstein BN, Naime D, Ostad E: The anti-inflammatory mechanism of methotrexate: increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. J Clin Invest 92:2675-2682, 1993.
4. Bernini JC, Fort DW, Griener JC, Kane BJ, Chappell WB, Kamen BA: Aminophylline for methotrexate-induced neurotoxicity. Lancet 345:544-547, 1995.
5. Combe B, Didry C, Gutierrez M, Anaya JM, Sany J: Accelerated nodulosis and systemic manifestations during methotrexate therapy for rheumatoid arthritis. Eur J Med 2: 153-156, 1993.
6. Kerstens PJ, Boerbooms AM, Jeurissen ME, Fast JH, Assmann KJ, van de Putte LB: Accelerated nodulosis during low dose methotrexate therapy for rheumatoid arthritis. An analysis often cases. J Rheumatol 19:867-871, 1992.
7. Merrill JT, Coffey D, Shen C, et al: Mechanisms of rheumatoid nodulosis: methotrexate-enhanced monocyte fusion requires protein synthesis and intact microtubules. Arthritis Rheum 38 (Suppl):S157, 1995.