Myomodulin gene of Lymnaea: Structure, expression, and analysis of neuropeptides

Journal of Neuroscience

Volumn 16, Issue 16, 1996, Pages 4949-4957

  Kellett, Elaine ^a,b   Perry, Stephen J ^a   Santama, Niovi ^a,c   Worster, Belinda M ^a   Benjamin, Paul R ^a   Burke, Julian F ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

gene; Lymnaea; molluscs; myomodulin; neuronal modulation; neuropeptide

Indexed keywords

NEUROPEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; FEEDING BEHAVIOR; GANGLION; GENE EXPRESSION; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC ORGANIZATION; IN SITU HYBRIDIZATION; MASS SPECTROMETRY; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; SNAIL;

EID: 0029776037     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-16-04949.1996     Document Type: Article

References (41)

1. Benjamin PR, Burke JF (1994) Alternative mRNA splicing of the FMRFamide gene and its role in neuropeptidergic signalling in a defined neural network. Bioessays 16:335-342.
2. Birnstiel ML, Busslinger M, Strub K (1985) Transcription termination and 3′ processing: the end is in site! Cell 41:349-359.
3. Bradbury AF, Finnie MDA, Smyth DG (1982) Mechanism of C-terminal amide formation by pituitary enzymes. Nature 298:686-688.
4. Brezina V, Evans CG, Weiss KR (1994a) Enhancement of Ca current in the accessory radula closer muscle of Aplysia californica by neuromodulators that potentiate its contractions. J Neurosci 14:4393-4411.
5. Brezina V, Evans CG, Weiss KR (1994b) Activation of K current in the accessory radula closer muscle of Aplysia californica by neuromodulators that depress its contractions. J Neurosci 14:4412-4432.
6. Brezina V, Bank B, Cropper EC, Rosen S, Vilim FS, Kupfermann I, Weiss KR (1995) Nine members of the myomodulin family of peptide cotransmitters at the B16-ARC neuromuscular junction of Aplysia. J Neurophys 74:54-72.
7. Comb M, Birnberg NC, Seasholtz A, Herbert E, Goodman HM (1986) A cyclic AMP- and phorbol ester-inducible DNA element. Nature 323:353-356.
8. Cropper EC, Tenenbaum R, Kolks MAG, Kupfermann I, Weiss KR (1987) Myomodulin: a bioactive neuropeptide present in an identified cholinergic buccal motor neuron of Aplysia. Proc Natl Acad Sci USA 84:5483-5486.
9. Cropper EC, Vilim FS, Alevizos A, Tenenbaum R, Kolks MAG, Rosen S, Kupfermann I, Weiss KR (1991) Structure, bioactivity and cellular localization of myomodulin B: a novel Aplysia peptide. Peptides 12:683-690.
10. DesGroseillers L, Cowan D, Miles M, Sweet A, Scheller RH (1987) Aplysia californica neurons express microinjected neuropeptide genes. Mol Cell Biol 7:2762-2771.
11. Fugisawa Y, Kubota I, Kanda T, Kuroki Y, Muneoka Y (1990) Neuropeptides isolated from Mytilus edulis (bivalvia) and Fusinus ferrugineous (prosobranchia). In: Comparative pharmacology of neuropeptides (Stefano GB, Florey E, eds). Manchester: Manchester UP.
12. Guntaka RV (1993) Transcription termination and polyadenylation in retroviruses. Microbiol Rev 57:511-521.
13. Hopp TP (1986) Protein surface analysis: methods for identifying antigenic determinants and other interaction sites. J Immunol Methods 88:1-18.
14. Hosaka M, Nagahama M, Kim WS, Watanabe T, Hatsuzawa K, Ikemizu J, Murakami K, Nakayama K (1991) Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalysed by furin within the constitutive secretory pathway. J Biol Chem 266:12127-12130.
15. Imagawa M, Chui R, Karin M (1987) Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell 51:251-260.
16. Jacob M, Gallinar H (1989) The 5′ splice site: phylogenetic evolution and variable geometry of association with U1RNA. Nucleic Acids Res 17:2159-2180.
17. Jackson RJ, Standart N (1990) Do the polyA tail and 3′ untranslated region control messenger-RNA translation. Cell 62:15-24.
18. Klausner RD, Harford JB (1989) Cis-trans models for post-transcriptional gene-regulation. Science 246:870-872.
19. Kozak M (1987) An analysis of 5′-noncoding sequences from 699 vertebrate messenger-RNAs. Nucleic Acids Res 15:8125-8148.
20. Kyte J, Doolittle RF (1982) A simple method for displaying the hydropathic character of a protein. J Mol Biol 157:105-132.
21. Li KW, van Golen FA, van Minnen J, van Veelen PA, van der Greef J, Geraerts WPM (1994) Structural identification, neuronal synthesis, and role in male copulation of myomodulin-A of Lymnaea: a study involving direct peptide profiling of nervous tissue by mass spectrometry. Mol Brain Res 25:355-358.
22. 2 (FMRF-amide) and novel related peptides are encoded in multiple copies by a single gene in the snail Lymnaea stagnalis. J Neurosci 10:412-419.
23. Locker J, Buzzard G (1990) A dictionary of transcription control sequences: DNA sequence. J DNA Sequencing Mapp 1:3-11.
24. Lopez V, Wickham L, DesGroseillers L (1993) Molecular cloning of myomodulin cDNA, a neuropeptide precursor gene expressed in neuron L19 of Aplysia californica. DNA Cell Biol 12:53-61.
25. Miller MW, Beushausen S, Vitek A, Stamm S, Kupfermann I, Brosius J, Weiss KR (1993) The myomodulin-related neuropeptides: characterization of a gene encoding a family of peptide cotransmitters in Aplysia. J Neurosci 13:3358-3367.
26. Montminy MR, Sevarino KA, Wagner JA, Mandel G, Goodman RH (1986) Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc Natl Acad Sci USA 83:6682-6686.
27. Newcomb R, Fisher JM, Scheller RH (1988) Processing of the egg-laying hormone (ELH) precursor in the bag cell neurons of Aplysia. J Biol Chem 263:12514-12521.
28. Pellé R, Murphy NB (1993) Northern hybridization: rapid and simple electrophoretic conditions. Nucleic Acids Res 2:2783-2784.
29. Proudfoot N (1991) Poly(A) signals. Cell 64:671-674.
30. Quinn PG, Wong TW, Magnuson MA, Shabb JB, Granner DK (1988) Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 8:3467-3475.
31. Roesler WJ, Vandenbark GR, Hanson RW (1988) Cyclic AMP and the induction of eukaryotic gene transcription. J Biol Chem 263:9063-9066.
32. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
33. Santama N, Wheeler CH, Burke JF, Benjamin PR (1994a) Neuropeptides myomodulin, small cardioactive peptide, and buccalin in the central nervous system of Lymnaea stagnalis: purification, immunoreactivity and artifacts. J Comp Neurol 342:335-351.
34. Santama N, Brierley M, Burke JF, Benjamin PR (1994b) Neural network controlling feeding in Lymnaea stagnalis: immunocytochemical localization of myomodulin, small cardioactive peptide, buccalin, and FMRFamide-related peptides. J Comp Neurol 342:352-365.
35. Saunders SE, Bright K, Kellett E, Benjamin PR, Burke JF (1991) Neuropeptides Gly-Asp-Pro-Phe-Leu-Arg-Phe-amide (GDPFLRFamide) and Ser-Asp-Pro-Phe-Leu-Arg-Phe-amide (SDPFLRFamide) are encoded by an exon 3′ to Phe-Met-Arg-Phe-amide (FMRFamide) in the snail Lymnaea stagnalis. J Neurosci 11:740-745.
36. Saunders SE, Kellett E, Bright K, Benjamin PR, Burke JF (1992) Cell specific alternative RNA splicing of a FMRFamide gene transcript in the brain. J Neurosci 12:1033-1039.
37. Sossin WS, Sweet-Cordero A, Scheller RH (1990) Dale's hypothesis revisited: different neuropeptides derived from a common prohormone are targeted to different processes. Proc Natl Acad Sci USA 87:4845-4848.
38. Tsukada T, Fink JS, Mandel G, Goodman RH (1987) Identification of a region in the human vasoactive intestinal polypeptide gene responsible for regulation by cyclic-AMP. J Biol Chem 262:8743-8747.
39. van Golen FA, Li KW, Chen S, Jimenez CR, Geraerts WPM (1996) Various isoforms of myomodulin identified from the male copulatory organ of Lymnaea show overlapping yet distinct modulatory effects on the penis muscle. J Neurochem 66:321-329.
40. von Heijne G (1986) A new method for predicting signal sequence cleavage sites. Nucleic Acids Res 14:4683-4690.
41. Vreugdenhil E, Jackson JF, Bouwmeester T, Smit AB, van Minnen J, van Heerikhuizen H, Klootwijk J, Joosse J (1988) Isolation, characterization, and evolutionary aspects of a cDNA clone encoding multiple neuropeptides involved in the stereotyped egg-laying behaviour of the fresh-water snail Lymnaea stagnalis. J Neurosci 8:4184-4191.