Increased hypodense eosinophils after activation with PAF-acether and calcium ionophore in asthmatic subjects

Journal of Asthma

Volumn 33, Issue 4, 1996, Pages 213-219

  Agrawal, Devendra K ^a   Sarmiento, Emmanuel U ^a   Nabe, Makoto ^a   Miyagawa, Hidefumi ^a   Townley, Robert G ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allergic inflammation; Bronchial asthma; Calcium ionophore; Eosinophils; Platelet activating factor

Indexed keywords

CALCIMYCIN; CALCIUM IONOPHORE; THROMBOCYTE ACTIVATING FACTOR;

ADULT; ALLERGIC ASTHMA; ARTICLE; CELL DENSITY; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; EOSINOPHIL; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; MALE; PATHOGENESIS;

EID: 0029775016     PISSN: 02770903     EISSN: None     Source Type: Journal    
DOI: 10.3109/02770909609055362     Document Type: Article

References (24)

1. DeMonchy JGR, Daufman HF, Venge P, Koeter GH, Jansen HM, Sluiter HJ, deVries K: Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis 131:373-380 (1985).
2. Schats M, Wasserman S, Patterson R: The eosinophil and the lung. Arch Intern Med 142:1515-1519 (1982).
3. Dahl R, Venge P: Role of eosinophil in bronchial asthma. Eur J Respir Dis 122(Suppl):23-28 (1982).
4. Weller PF: The immunobiology of eosinophils. N Engl J Med 324:1110-1116 (1991).
5. 4 production from human eosiniphils in vitro: Role of eosinophil chemotactic factors on eosinophil activation. J Immunol 141:4291-4297 (1988).
6. Agrawal DK: Platelet-activating factor receptors in the airways. In Inflammatory Cells and Mediators in Bronchial Asthma (Agrawal DK, Townley RG, editors), CRC Press, Boca Raton, FL, 1991, 171-206.
7. DeSimone C, Donelli G, Melli D, Rosati F, Sorice F: Human eosinophils and parasitic diseases. II. Characterization of two cell fractions isolated at different densities. Clin Exp Immunol 48:249-255 (1982).
8. Gartner I: Separation of human eosinophils in density gradients of polyvinylpyrrolidone coated silica gel (Percoll). Immunology 40:133-136 (1980).
9. Fukuda T, Dunnette SL, Reed C, Ackerman SJ, Peters MS, Gleich G: Increased number of hypodense eosinophils in the blood of patients with bronchial asthma. Am Rev Respir Dis 132:981-987 (1985).
10. Bass DA, Grove WH, Lewis JC, Szejda P, Chatelet LR, McCall CE: Comparison of human eosinophils from normals and patients with eosinophilia. J Clin Invest 66:1265-1273 (1980).
11. Agrawal DK, Numao T: Transmembrane signaling in eosinophils. In Eosinophils (Makino S, Fukuda T, editors), CRC Press, Boca Raton, FL, 1993, 171-192.
12. 4 from human eosinophils and its relation to the cell density. Int Arch Allergy Appl Immunol 78:406-410 (1985).
13. Cuss FM, Dixon CMS, Barnes PJ: Effect of inhaled platelet-activating factor on pulmonary function and bronchial responsiveness in man. Lancet 2:189-192 (1986).
14. Townley RG, Hopp RJ, Agrawal DK, Bewtra AK: Platelet-activating factor and airway reactivity. J Allergy Clin Immunol 83:997-1012 (1989).
15. Numao T, Agrawal DK: Neuropeptides modulate human eosinophif chemotaxis. J Immunol 149:3309-3315 (1992).
16. Tamura N, Agrawal DK, Suliaman FA, Townley RG: Effects of platelet-activating factor on the chemotaxis of normodense eosinophils from normal subjects. Biochem Biophys Res Commun 142:638-644 (1987).
17. Frick WE, Sedgwick JB, Busse WW: The appearance of hypodense eosinophils (HE) in late phase asthma. J Allergy Clin Immunol 81:208-214 (1988).
18. Fukuda T, Gleich GJ: Heterogeneity of human eosinophils. J Allergy Clin Immunol 83:369-373 (1989).
19. Shult PA, Lega M, Jadidi S, Vrtis R, Warner T, Graziano F, Busse WW: The presence of hypodense eosinophils and diminished chemiluminescence response in asthma. J Allergy Clin Immunol 81:429-437 (1988).
20. Olofsson T, Gartner I, Olsson I: Separation of human bone marrow cells in density gradient of polyvinylpyrrolidone coated silica gel (Percoll). Scand J Haematol 24:254-262 (1980).
21. Peters MS, Gleich GJ, Dunnette SL, Fukuda T: Ultrastructural study of eosinophils from patients with the hypereosinophilic syndrome: A morphological basis of hypodense eosinophils. Blood 71:780-785 (1988).
22. Sedgwick JB, Frick WE, Sondel PM, Busse WW: The appearance of hypodense eosinophils (HE) during interleukin-2 (IL-2) treatment. J Allergy Clin Immunol 81:208-214 (1988).
23. Tai PC Bakes DM, Barkans JR, Spry CJF: Plasma membrane antigens on light density and activated human blood eosinophils. Clin Exp Immunol. 60:427-436 (1985).
24. Kloprogge E, de Leeuw AJ, de Monchy JGR, Kauffman HF: Hypodense eosinophilic granulocytes in normal individuals and patients with asthma: Generation of hypodense cell populations in vitro. J Allergy Clin Immunol 83:393-400 (1989).