Gene delivery to the heart in vivo and to cardiac myocytes and vascular smooth muscle cells in vitro using herpes virus vectors

Gene Therapy

Volumn 3, Issue 7, 1996, Pages 560-566

  Coffin, R S ^a   Howard, M K ^a   Cumming, D V E ^a,c   Dollery, C M ^b   McEwan, J ^b   Yellon, D M ^b   Marber, M S ^c   MacLean, A R ^d   Brown, S M ^d   Latchman, D S ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b Hatter Institute for Cardiovascular Studies   (United Kingdom)

^c GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^d INSTITUTE OF VIROLOGY   (United Kingdom)

Author keywords

Cardiac myocytes; Gene therapy; Herpes virus vectors; Vascular smooth muscle cells

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CYTOPATHOGENIC EFFECT; EXPRESSION VECTOR; GENE TARGETING; GENE THERAPY; HEART MUSCLE CELL; HERPES VIRUS; IMMEDIATE EARLY GENE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; CELL LINE; CELLS, CULTURED; COLORING AGENTS; GALACTOSIDES; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEART; HERPESVIRUS 1, HUMAN; HUMANS; INDOLES; LAC OPERON; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

ANIMALIA; HERPES; HERPESVIRIDAE; HUMAN HERPESVIRUS 1;

EID: 0029774778     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Nabel EB. Gene therapy for cardiovascular diseases. Circulation 1995; 91: 541-548.
2. Coffin RS, Latchman DS. Herpes simplex virus-based vectors. In: Latchman DS (ed). Genetic Manipulation of the Nervous System. Academic Press: London, 1996, pp 99-111.
3. Huard J, Goins WF, Glorioso JC. Herpes simplex virus type 1 vector mediated gene transfer to muscle. Gene Therapy 1995; 2: 385-392.
4. Chou J, Kern ER, Whitley RJ, Roizman B. Mapping of herpes simplex virus-1 neurovirulence to γ34.5, a gene nonessential for growth in culture. Science 1990; 250: 1262-1266.
5. Balan P et al. An analysis of the in vitro and m vivo phenotypes of mutants of herpes simplex virus type 1 lacking glycoproteins gG, gE, gI or the putative gJ. J Gen Virol 1994; 75: 1245-1258.
6. + between immediate-early gene 1 and the 'a' sequence. J Gen Virol 1991; 72: 632-639.
7. Ace CI et al. Construction and characterisation of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression. J Virol 1989; 63: 2260-2269.
8. Smith IL, Hardwicke MA, Sandri-Goldin RM. Evidence that the herpes simplex virus immediate-early protein ICP27 acts posttranscriptionally during infection to regulate gene expression. Virology 1992; 186: 74-86.
9. Chou J, Roizman B. The γ34.5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells. Proc Natl Acad Sci USA 1992; 89: 3266-3270.
10. Brown SM et al. Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2. J Gen Virol 1994; 75: 2367-2377.
11. Brown SM, MacLean AR, Aitken JD, Harland J. ICP34.5 influences herpes simplex virus type 1 maturation and egress from infected cells in vitro. J Gen Virol 1994; 75: 3679-3686.
12. Marber MS, Walker JM, Latchman DS, Yellon DM. Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein. J Clin Invest 1994; 93: 1087-1094.
13. Marber MS et al. Overexpression of the rat inducible 70 kilodalton heat stress protein in a transgenic mouse increases the resistance of the heart to ischaemic injury. J Clin Invest 1995; 95: 1446-1456.
14. Goldstein D, Weller SK. Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterisation of an ICP6 lacZ insertion mutant. J Virol 1988; 62: 196-205.
15. Cocn DM et al. Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proc Natl Acad Sci USA 1989; 86: 4736-4740.
16. Nabel EG et al. Recombinant FGF-1 promotes intimai hyperplasia and angiogenesis in arteries in vivo Nature 1993; 362-844-846.
17. Qin L et al. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Transplantation 1995; 59: 809-816.
18. Chien KR et al. Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. J Clin Invest 1985; 75: 1770-1780.
19. Buja LM et al. Alterations of ultrastructure and elemental composition in cultured neonatal rat cardiac myocytes after metabolic inhibition with iodoacetic acid. Lab Invest 1988; 53: 397-412.
20. Knowlton KU et al. Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during a adrenergic stimulation of neonatal rat ventricular cells. J Biol Chem 1991; 266: 7759-7768.
21. Rennick RE, Cambell JW, Cambell GR. Vascular smooth muscle phenotype and growth behaviour can be influenced by macrophages in vitro. Atherosclerotion 1988; 71: 35-43.
22. MacLean CAS et al. Investigation of herpes simplex virus type 1 genes encoding multiply inserted membrane proteins. J Gen Virol 1991; 72: 897-906.