Itraconazole cyclodextrin solution for fluconazole-refractory oropharyngeal candidiasis in AIDS: Correlation of clinical response with in vitro susceptibility

AIDS

Volumn 10, Issue 12, 1996, Pages 1369-1376

  Phillips, Peter ^a,b   Zemcov, Janet ^a   Mahmood, Wafeeq ^a   Montaner, Julio S G ^a   Craib, Kevin ^a   Clarke, Alison M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ST PAUL S HOSPITAL   (Canada)

Author keywords

Fluconazole; Fungal disease; In vitro susceptibility; Itraconazole solution; Opportunistic infection; Oropharyngeal candidiasis; Therapy

Indexed keywords

AMPHOTERICIN B; CYCLODEXTRIN; FLUCONAZOLE; ITRACONAZOLE; PYRROLE; RANITIDINE; RIFAMPICIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDIASIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION SENSITIVITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARYNGITIS; PRIORITY JOURNAL; THRUSH;

EID: 0029774381     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199610000-00009     Document Type: Article

References (36)

1. Holt RJ, Azmi A: Miconazole-resistant Candida [letter]. Lancet 1978, i:50-51.
2. Smith KJ, Warnock DW, Kennedy CTC, et al.: Azole resistance in Candida albicans. J Med Vet Mycol 1986, 24:133-144.
3. Leen CLS, Dunbar EM, Ellis ME, Mandai BK: Once-weekly fluconazole to prevent recurrence of oropharyngeal candidiasis in patients with AIDS and AIDS-related complex: a double-blind placebo-controlled study. J Infect 1990, 21:55-60.
4. Fulton P, Phillips P: Fluconazole resistance during suppressive therapy of AIDS-related thrush and esophagitis caused by C. albicans. VI International Conference on AIDS. San Francisco, June 1990 [abstract ThB468].
5. Baily GG, Perry FM, Denning DW, Mandai BK: Fluconazole-resistant candidosis in an HIV cohort. AIDS 1994, 8:787-792.
6. Redding S, Smith J, Farinacci G, et al.: Resistance of Candida albicans to fluconazole during treatment of oropharyngeal candidiasis in a patient with AIDS: documentation by in vitro susceptibility testing and DNA subtype analysis. Clin Infect Dis 1994, 18:240-242.
7. Akova M, Akalin HE, Uzun O, Gur D: Emergence of Candida krusei infections after therapy of oropharyngeal candidiasis with fluconazole [letter]. Eur J Clin Microbiol Infect Dis 1991, 10:598-599.
8. Rex JH, Rinald MG, Pfaller MA: Resistance of Candida species to fluconazole. Antimicrob Agents Chemother 1995, 39:1-8.
9. Ng TTC, Denning DW: Fluconazole resistance in Candida in patients with AIDS: a therapeutic approach. J Infect 1993, 26:117-125.
10. He X, Tiballi RN, Zarins LT, Bradley SF, Sangeorzan JA, Kauffman CA: Azole resistance in oropharyngeal Candida albicans strains isolated from patients infected with human immunodeficiency virus. Antimicrob Agents Chemother 1995, 38:2495-2497.
11. Barchiesi F, Colombo AL, McGough DA, Fothergill A, Rinaldi MG; In vitro activity of itraconazole against fluconazole-susceptible and -resistant Candida albicans isolates from oral cavities of patients infected with human immunodeficiency virus. Antimicrob Agents Chemother 1994, 38:1530-1533.
12. Smith D, Boag F, Midgley J, Gazzard B: Fluconazole resistant Candida in AIDS [letter]. J Infect 1991, 23:345-346.
13. Cartledge JD, Midgley J, Youle M, Gazzard BG: Itraconazole cyclodextrin solution: effective treatment for HIV-related candidosis unresponsive to other azole therapy [letter]. J Antimicrob Chemother 1994, 33:1071-1073.
14. Ganger G, Just-Nubling G, Eichel M, Hoika R, Stille JW: Itraconazole solution in patients with non-response to fluconazole. IX International Conference on AIDS. Berlin, June 1993 [abstract PO-B09-1394].
15. Fothergill AW, McGough DA: In vitro antifungal susceptibility testing of yeasts. In Clinical Microbiology Procedures Handbook. Edited by Isenberg HD. Washington DC: American Society for Microbiology: 1992:5.1.5.1-5.15.16.
16. Bennett JV, Brodie JL, Benner EJ, Kirby WM: Simplified accurate method for antibiotic assay of clinical specimens. Appl Microbiol 1966, 14:170-177.
17. Fan-Harvard P, Capano D, Smith SM, Mangia A, Eng RHK: Development of resistance in Candida isolates from patients receiving prolonged antifungal therapy. Antimicrob Agents Chemother 1991, 35:2302-2305.
18. Vanden Bossche H, Marichal P, Gorrens J, Bellens D, Moereels H, Janssen PAJ: Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals. Biochem Soc Trans 1990, 18:56-59.
19. Vanden Bossche H, Marichal P, Odds FC, Le Jeune L, Coone MC: Characterization of an azole-resistant Candida glabrata isolate. Antimicrob Agents Chemother 1992, 36:2602-2610.
20. Parkinson T, Falconer DJ, Hitchcock CA: Fluconazole resistance due to energy-dependent drug efflux in Candida glabrata. Antimicrob Agents Chemother 1995, 39:1696-1699.
21. Sanglard D, Kuchler K, Ischer F, Pagani J-L, Monod M, Bille J: Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob Agents Chemother 1995, 39:2378-2386.
22. Ansari AM, Gould IM, Douglas JG: High dose oral fluconazole for oropharyngeal candidosis in AIDS [letter]. J Antimicrob Chemother 1990, 25:720-721.
23. Grant SM, Clissold SP: Itraconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and systemic mycoses. Drugs 1989, 37:310-344.
24. Smith DE, Midgley J, Allan M, Connolly GM, Gazzard BG: Itraconazole versus ketaconazole in the treatment of oral and oesophageal candidosis in patients infected with HIV. AIDS 1991, 5:1367-1371.
25. Barone JA, Koh JG, Bierman RH, et al.: Food interaction and steady state pharmacokinetics of itraconazole capsules in healthy volunteers. Antimicrob Agents Chemother 1993, 37:778-784.
26. Janssen Research Foundation: Itraconazole Oral Solution (R 51 211). Investigator's Brochure, 2nd Edn. Beerse: Janssen Research Foundation; 1993.
27. Levron JC, Reynes J, Bazin C, et al.: Bioavailability of itraconazole oral solution (IOS) during treatment of oropharyngeal candidosis in HIV+ patients. 19th International Congress on Chemotherapy. Montreal, July 1995 [abstract 2131].
28. Dupont B, Drouhet E: Fluconazole in the treatment of oropharyngeal candidiasis in a predominantly HIV antibody-positive group of patients. Sabouraudia 1988, 26:67-71.
29. National Committee for Clinical Laboratory Standards: Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Proposed Standard. [Document M27-P, Vol 12, No 25]. Villanova, PA: National Committee for Clinical Laboratory Standards; 1992.
30. Galgiani IN: Susceptibility testing of fungi: current status of the standardization process. Antimicrob Agents Chemother 1993, 37:2517-2521.
31. Fromtling RA, Galgiani JN, Pfaller MA, et al.: Multicenter evaluation of a broth macrodilution antifungal susceptibility test for yeasts. Antimicrob Agents Chemother 1993, 37:39-45.
32. Sandven P, Bjorneklett A, Maeland A, the Norwegian Yeast Study Group: Susceptibilities of Norwegian Candida albicans strains to fluconazole: emergence of resistance. Antimicrob Agents Chemother 1993, 37:2443-2448.
33. Cameron ML, Schell WA, Bruch S, Bartlet JA, Waskin HA, Perfect JR: Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1. Antimicrob Agents Chemother 1993, 37:2449-2453.
34. Pfaller MA, Rhine-Chalberg J, Redding SW, et al.: Variations in fluconazole susceptibility and electrophoretic karyotype among oral isolates of Candida albicans from patients with AIDS and oral candidiasis. J Clin Microbiol 1994, 32:59-64.
35. Chryssanthou E, Torssander J, Petrini B: Oral Candida albicans isolates with reduced susceptibility to fluconazole in Swedish HIV-infected patients. Scand J Infect Dis 1995, 27:391-395.
36. Dupont B, Improvisi L, Eliaszewicz M, Pialoux G: Resistance of Candida albicans to fluconazole in AIDS patients. 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy. Anaheim, October 1992 [abstract 1203].