Architecture of the neuronal nicotinic acetylcholine receptor ion channel at the binding site of bis-ammonium blockers

Journal of Membrane Biology

Volumn 152, Issue 1, 1996, Pages 77-87

  Brovtsyna, N B ^a   Tikhonov, D B ^a   Gorbunova, O B ^a   Gmiro, V E ^b   Serduk, S E ^c   Lukomskaya, N Y ^a   Magazanik, L G ^a   Zhorov, B S ^a  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^c Medical Institute of Donetsk

Author keywords

Acetylcholine receptor; Ion channel; Molecular modeling; Open channel blockers; Structure activity relationship

Indexed keywords

CHOLINERGIC RECEPTOR; GANGLION BLOCKING AGENT; ION CHANNEL; NICOTINIC RECEPTOR; PENTAMETHONIUM; QUATERNARY AMMONIUM DERIVATIVE;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING SITE; CAT; CONFORMATION; DRUG POTENCY; DRUG STRUCTURE; GUINEA PIG; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUPERIOR CERVICAL GANGLION; TOPOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BIS-TRIMETHYLAMMONIUM COMPOUNDS; CATS; CHICKENS; GUINEA PIGS; ILEUM; ION CHANNELS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PROTEIN CONFORMATION; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, NICOTINIC; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUPERIOR CERVICAL GANGLION; THREONINE; TORPEDO;

ANIMALIA; CAVIA PORCELLUS; FELIS CATUS; SUS SCROFA;

EID: 0029773384     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002329900087     Document Type: Article

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