In vitro and in vivo binding of trimethoprim and sulphachlorpyridazine to equine food and digesta and their stability in caecal contents

Journal of Veterinary Pharmacology and Therapeutics

Volumn 19, Issue 4, 1996, Pages 281-287

  Van Duijkeren, E ^a   Kessels, B G F ^a   Sloet Van Oldruiten Borgh Oosterbaan, M M ^a   Breukink, H J ^a   Vuloto, A G ^a   Van Miert, A S J P A M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COSUMIX; SULFACHLORPYRIDAZINE; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CECUM; CONTROLLED STUDY; DIGESTION; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DEGRADATION; FEMALE; FOOD DEPRIVATION; FOOD DRUG INTERACTION; GRASS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE; INTESTINE FISTULA; INTESTINE FLORA; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; POWDER; PRIORITY JOURNAL; VETERINARY MEDICINE;

ANIMALIA; EQUIDAE; EQUUS CABALLUS; FISTULA;

EID: 0029770115     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2885.1996.tb00050.x     Document Type: Article

References (22)

1. Argenzio, R.A., Lowe, J.E., Pickard, D.W. & Stevens, C.E. (1974) Digesta passage and water exchange in the equine large intestine. American Journal of Physiology 226, 1035-1042.
2. Bogan, J.A. (1983) Absorption and distribution. In Pharmacological Basis of Large Animal Medicine, Ed. Bogan J.A., Lees P. & Yoxall A.T. pp. 3-22. Blackwell Scientific Publications, Oxford.
3. Ensink, J.M., Klein, W.R., Barneveld, A., van Miert, A.S.J.P.A.M. & Vulto, A.G. (1994) Side-effects of oral antibiotics in the horse: a comparison of pivampicillin and trimethoprim/sulfadiazine. In Proceedings of the Sixth International Congress of the European Association of Veterinary Pharmacology and Toxicology. Ed. Lees, P., p. 199. Edinburgh, 7-11 August. Blackwell Scientific Publications, Oxford.
4. Goodson, J., Tyznik, W.J., Cline, C.H. & Dehority, B.A. (1988) Effects of an abrupt diet change from hay to concentrate on microbial numbers and physical environment in the cecum of the pony. Applied and Environmental Microbiolology, 54, 1946-1950.
5. Lees, P., Taylor, J.B.O., Higgins, A.J. & Sedwick, A.D. (1988) In vitro and in vivo binding of phenylbutazone and related drugs to equine feeds and digesta. Research in Veterinary Science, 44, 50-56.
6. Kern, D.L., Slyter, L.L., Weaver, J.M., Leffel, E.C. & Samuelson, G. (1973) Pony cecum vs. steer rumen: the effect of oats and hay on the microbial ecosystem. Journal of Animal Science, 37, 463-469.
7. Kern, D.L., Slyter, L.L., Leflel, E.C., Weaver, J.M. & Oltjen, R.R. (1974) Ponies vs. steers: microbial and chemical characteristics of intestinal ingesta. Journal of Animal Science, 38, 559-564.
8. McKellar, Q.A. & Horspool, L.J.I. (1995) Stability of penicillin G. ampicillin, amicacin and oxytetracycline and their interactions with food in in vitro simulated equine gastrointestinal contents. Research in Veterinary Science, 58, 227-231.
9. Mackie, R.I. & Wilkins, C.A. (1988) Enumeration of anaerobic bacterial microflora of the equine gastrointestinal tract. Applied and Environmental Microbiology, 54, 2155-2160.
10. Maitho, T.E., Lees, P. & Taylor, J.B. (1986) Absorption and pharmaco-kinetics of phenylbutazone in Welsh Mountain ponies. Journal of Veterinary Pharmacology and Therapeutics, 9, 26-59.
11. Nielsen, P. & Gyrd-Hansen, N. (1994) Oral bioavailability of sulfadiazine and trimethoprim in fed and fasted pigs. Research in Veterinary Science, 56, 48-52.
12. Nielsen, P. & Rasmussen, F. (1978) Sulfadoxine and trimethoprim in goats and cows: absorption fraction, half-lives and the degrading effect of the ruminal flora. Journal of Veterinary Pharmacology and Therapeutics, 1, 37-46.
13. Palmer, J.E. (1992) Diarrhea. In Veterinary Gastroenterology. 2nd Ed. Ed. Anderson, N.V., Sherding, R.G., Merrit, A.M. & Whitlock, R.H. pp.634-670. Lea & Febiger, Philadelphia, USA.
14. Prescott, J.F. & Baggot, J.D. (1993) Principles of antimicrobial drug disposition. In Antimicrobial Therapy In Veterinary Medicine. 2nd Ed. Ed. Prescott, J.F & Baggot, J.D. pp. 37-60. Iowa State University Press, Ames, USA.
15. Sigel, C.W. (1983) Disposition and metabolism of trimethoprim. tetroxoprim, sulfamethoxazole, and sulfadiazine. In Handbook of Experimental Pharmacology, Ed. Hitchings, G.H., pp. 163-184. Springer Verlag, Berlin.
16. Teeter, S.M., Nelson, W.E. & Stillions, M.C. (1968) Cecal fistulation in the horse. Journal of Animal Science, 28, 394-404.
17. van Duijkeren, E., Vulto, A.G., Sloet van Oldruitenborgh Oosterbaan, M.M. et al (1995) Pharmacokinetics of trimethoprim/sulfachlorpyridazine in horses after oral, nasogastric and intravenous administration. Journal of Veterinary Pharmacology and Therapeutics, 18, 47-53.
18. van Miert, A.S.J.P.A.M. (1983) Medicated feed: problems and solutions. In Veterinary Pharmacology and Toxicology; Proceedings from the Second European Association for Veterinary Pharmacology and Toxicology. Ed. Ruckebusch, Y., Toutain, P.-L. & Koritz, G.D. pp.752-757. Toulouse, 13-17 September 1982. MTP Press Ltd, Lancaster, UK.
19. rd EAVPT Congress. Ghent, Belgium, 1985. MTP Press Ltd, Lancaster, UK.
20. Weijkamp, K. Faghihi, S.M., Nijmeijer, S.M., Witkamp, R.F. & van Miert, A.S.J.P.A.M. (1994) Oral bioavailability of sulphamethoxydiazine, sulphathiazole and sulphamoxole in dwarf goats. Veterinary Quarterly, 16, 33-37
21. Welling, P.G. & Tse, F.L.S. (1982) The influence of food on the absorption of antimicrobial agents. Journal of Antimicrobial Chemotherapy, 9, 7-27.
22. Willard, J.G., Willard, J.C., Wolfram, S.A. & Baker, J.P. (1977) Effect of diet on cecal pH and feeding behavior of horses. Journal of Animal Science, 45, 87-93.