Protective effect of the sodium/hydrogen exchange inhibitors during global low-flow ischemia

Journal of Cardiovascular Pharmacology

Volumn 28, Issue 4, 1996, Pages 540-546

  Khandoudi, Nassirah ^a   Laville, Marie Paule ^a   Bril, Antoine ^a  

^a SmithKline Beecham Laboratoires P   (France)

Author keywords

5 (N ethyl N isopropyl) amiloride; HOE 694; Isolated working rat heart; Low flow ischemia; Na+ H+ exchange; Reperfusion

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; 5 (N ETHYL N ISOPROPYL)AMILORIDE; ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; LACTIC ACID; PROTON; SODIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA FLOW; ARTICLE; CONTROLLED STUDY; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT;

AMILORIDE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CARDIAC OUTPUT; ENERGY METABOLISM; GUANIDINES; HEART; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; RATS; RATS, WISTAR; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 0029769680     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199610000-00010     Document Type: Article

References (37)

1. + exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox. Cardiovasc Res 1993;27:915-24.
2. Lazdunski M, Frelin C, Vigne P. The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol 1985;17:1029-42.
3. Frelin C, Vigne P, Ladoux A, Lazdunski M. The regulation of the intracellular pH in cells from vertebrates. Eur J Biochem 1988;174:3-14.
4. Pucéat M, Clement-Chomienne O, Terzic A, Vassort G. α1-Adrenoceptor and purinoceptor agonists modulate Na-H antiport in single cardiac cells. Am J Physiol 1993;264:H310-9.
5. + exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts. Circ Res 1994;75:369-78.
6. Matsui H, Barry WH, Livsey C, Spitzer KW. Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc Res 1995;29:215-21.
7. Meng HP, Lonsberry BB, Pierce GN. Influence of perfusate pH on the postischemic recovery of cardiac contractile function: involvement of sodium-hydrogen exchange. J Pharmacol Exp Ther 1991;258:772-7.
8. Ibuki C, Hearse DJ, Avkiran M. Mechanisms of antifibrillatory effect of acidic reperfusion: role of perfusate bicarbonate concentration. Am J Physiol 1993;264:H783-90.
9. + exchange. Am J Physiol 1988;255:H608-15.
10. 2+ exchange. Circ Res 1989;65:1045-56.
11. + exchange during ischaemia and reperfusion of normal and diabetic rat hearts. Cardiovasc Res 1990;24:873-8.
12. + exchange. Cir Res 1990;66:1156-9.
13. + exchange is not operative under low-flow ischemic conditions. J Mol Cell Cardiol 1991;23:505-17.
14. + exchange inhibition in ischemic, reperfused porcine hearts. Circulation 1995;92:912-7.
15. Pijl AJ, Pfaffendorf M, Mathy MJ, Van Zwieten PA. Cardioprotection by nifedipine in isolated working hearts: a comparative study on three different types of experimental ischemia. J Cardiovasc Pharmacol 1993;21:70-6.
16. Pijl AJ, Pfaffendord M, Van Zwieten PA. Hemodynamic and antiischemic effects of nifedipine. lacidipine, and nisoldipine in rat isolated working heart, J Cardiovasc Pharmacol 1993;22:381-7.
17. Neely JR, Liebermeister H, Battersby EJ, Morgan HE. Effect of pressure development on oxygen consumption by isolated rat heart. Am J Physiol 1967;212:804-14.
18. Lamprecht W, Trautschold I. Adenine-5′-triphosphate determination with hexokinase and glucose-6-phosphate dehydrogenase. In: Bergmeyer HU, ed. Methods in enzymatic analysis. New York: Academic Press, 1965:543-51.
19. Noll FL. L(+) lactate determination with LDH, GTP and NAD. In: Bergmeyer HU, ed. Methods in enzymatic analysis. New York: Academic Press, 1974:1475.
20. + exchange inhibitor and its effects in cardiac ischemia. Br J Pharmacol 1993;109:562-8.
21. + exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor. Am J Physiol 1994;267:H2430-40.
22. Cross HR, Opie LH, Radda GK, Clarke K, Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved. Circ Res 1996;78:482-91.
23. + exchange inhibitors in cardiac ischemia. J Mol Cell Cardiol 1992;24:731-40.
24. + antiporter inhibitor on postischemic reperfusion in pig heart. J Cardiovasc Pharmacol 1994;23:72-8.
25. + exchanger in reperfusion stunning in isolated perfused rat heart. J Cardiovasc Pharmacol 1993;22:877-83.
26. Piwnica-Worms D, Jacob R, Shigeto N, Russell Horres C, Lieberman M. Na/H exchange in cultured chick heart cells: secondary stimulation of electrogenic transport during recovery from intracellular acidosis. J Mol Cell Cardiol 1986;18:1109-16.
27. Moffat MP, Karmazyn M. Protective effects of the potent Na/H exchange inhibitor methylisobutyl amiloride against post-ischemic contractile dysfunction in rat and guinea-pig hearts. J Mol Cell Cardiol 1993;25:959-71.
28. Duan J, Karmazyn M. Protective effects of amiloride on the ischemic reperfused rat heart. Relation to mitochondrial function. Eur J Pharmacol 1992;210:149-57.
29. 1 recovery after global ischemia in the perfused heart. Circ Res 1993;72:993-1003.
30. Lagadic-Gossmann D, Buckler KJ, Vaughan-Jones RD. Role of bicarbonate in pH recovery from intracellular acidosis in the guinea-pig ventricular myocyte. J Physiol (Lond) 1992;458:361-84.
31. + exchange. Am J Physiol 1993;265:H289-98.
32. Khandoudi N, Bernard M, Cozzone P, Feuvray D. Mechanisms of Intracellular pH regulation during postichemic reperfusion of diabetic rat hearts. Diabetes 1995;44:196-202.
33. 2+ overload in isolated perfused rabbit heart. Circulation 1994;27:2787-98.
34. + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol 1993;44:1041-5.
35. - mechanisms. Cardiovasc Res 1995;29:239-46.
36. Neely JR, Rovetto MJ, Whitmer JT, Morgan HE. Effects of ischemia on function and metabolism of the isolated working rat heart. Am J Physiol 1973;225:651-8.
37. Neely JR, Grotyohann LW. Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts. Circ Res 1984;55:816-24.