Studies on the formation of hepatic DNA adducts by the antiandrogenic and gestagenic drug, cyproterone acetate: 1. Adduct levels in various species including man and 2. Persistence and accumulation in the rat

Advances in Experimental Medicine and Biology

Volumn 387, Issue , 1996, Pages 253-258

  Werner, S ^a   Topinka, J ^b   Kunz, S ^a   Beckurts, T ^c   Heidecke, C D ^c   Schwarz, L R ^a   Wolff, T ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b Business School Ostrava plc   (Czech Republic)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYPROTERONE ACETATE;

ANIMAL CELL; CARCINOGENESIS; CONFERENCE PAPER; DNA ADDUCT; DNA REPAIR; DNA SYNTHESIS; DRUG ACCUMULATION; HEALTH HAZARD; HORMONAL REGULATION; LIVER METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR PROMOTION;

EID: 0029769655     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9480-9_33     Document Type: Conference Paper

References (7)

1. Schuppler, J. and Günzel, P., 1979, Liver tumors and steroid hormones in rats and mice. Arch. Toxicol. 2:181-195.
2. Neumann, I., Thierau, D., Andrae, U., Greim, H. and Schwarz, L.R., 1992. Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in gamma-glutamyltranspeptidase-positive cells, Carcinogenesis, 13:373-378.
3. Topinka, J., Andrae, U., Schwarz, L.R. and Wolff, T., 1993, Cyproterone acetate generates DNA adducts in rat liver and in primary hepatocyte cultures, Carcinogenesis, 14:423-427.
4. Strom, S. C., Jirtle, R. L., Jones, R. S., Novicki, D. L., Rosenberg, M. R., Novotny, A., Irons, G., McLain, J. R., Michalopoulos, G., 1982, Isolation, culture, and transplantation of human hepatocytes, J. Natl. Cancer Inst. 68:771-778.
5. Gupta, R.C., 1984, Non-random binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo. Proc. Natl. Acad. Sci. U.S.A., 81:6943-6947.
6. 32P-postlabelling analysis of aromatic carcinogen adducts. Cancer Res., 45:5656-5662.
7. Forth W., Henschler D., Rummel W., 1988, Pharmakologie und Toxikologie, Wissenschaftsverlag Mannheim, 68