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Volumn 71, Issue 1-2, 1996, Pages 225-252

Saccharin mechanistic data and risk assessment: Urine composition, enhanced cell proliferation, and tumor promotion

Author keywords

neoplasia; promotion; risk assessment; saccharin

Indexed keywords

SACCHARIN;

EID: 0029769328     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(96)00069-1     Document Type: Review
Times cited : (61)

References (168)
  • 1
    • 0017685203 scopus 로고
    • Chromosome aberrations and sister chromatid exchanges in Chinese hamster cells exposed to various chemicals
    • Abe, S. and Sasaki, M. (1977) Chromosome aberrations and sister chromatid exchanges in Chinese hamster cells exposed to various chemicals. J. Natl. Cancer Inst. 58: 1635-1641.
    • (1977) J. Natl. Cancer Inst. , vol.58 , pp. 1635-1641
    • Abe, S.1    Sasaki, M.2
  • 2
    • 0016678587 scopus 로고
    • A chronic study of artificial sweeteners in Syrian golden hamsters
    • Althoff, J., Cardesa, A., Pour, P. and Shubik, P. (1975) A chronic study of artificial sweeteners in Syrian golden hamsters. Cancer Lett. 1: 21-24.
    • (1975) Cancer Lett. , vol.1 , pp. 21-24
    • Althoff, J.1    Cardesa, A.2    Pour, P.3    Shubik, P.4
  • 3
    • 0023712334 scopus 로고
    • An hypothesis of the mechanism of urinary bladder tumorigenesis in rats ingesting sodium saccharin
    • Anderson, R. L. (1988) An hypothesis of the mechanism of urinary bladder tumorigenesis in rats ingesting sodium saccharin. Food Chem. Toxicol. 26: 637-644.
    • (1988) Food Chem. Toxicol. , vol.26 , pp. 637-644
    • Anderson, R.L.1
  • 4
    • 0024211765 scopus 로고
    • Comparison of the responses of male rats to dietary sodium saccharin exposure initiated during nursing with responses to exposure initiated at weaning
    • Anderson, R. L., Lefever, F. R. and Maurer, J. K. (1988a) Comparison of the responses of male rats to dietary sodium saccharin exposure initiated during nursing with responses to exposure initiated at weaning. Food Chem. Toxicol. 26: 899-907.
    • (1988) Food Chem. Toxicol. , vol.26 , pp. 899-907
    • Anderson, R.L.1    Lefever, F.R.2    Maurer, J.K.3
  • 5
    • 0024260771 scopus 로고
    • The effect of various saccharin forms on gastro-intestinal tract, urine and bladder of male rats
    • Anderson, R. L., Lefever, F. R. and Maurer, J. K. (1988b) The effect of various saccharin forms on gastro-intestinal tract, urine and bladder of male rats. Food Chem. Toxicol. 26: 665-669.
    • (1988) Food Chem. Toxicol. , vol.26 , pp. 665-669
    • Anderson, R.L.1    Lefever, F.R.2    Maurer, J.K.3
  • 6
    • 0016285202 scopus 로고
    • Bladder cancer mortality in England and Wales in relation to cigarette smoking and saccharin consumption
    • Armstrong, B. and Doll, R. (1974) Bladder cancer mortality in England and Wales in relation to cigarette smoking and saccharin consumption. Br. J. Prev. Soc. Med. 28: 233-240.
    • (1974) Br. J. Prev. Soc. Med. , vol.28 , pp. 233-240
    • Armstrong, B.1    Doll, R.2
  • 7
    • 0016689575 scopus 로고
    • Bladder cancer mortality in diabetics in relation to saccharin consumption and smoking habits
    • Armstrong, B. and Doll, R. (1975) Bladder cancer mortality in diabetics in relation to saccharin consumption and smoking habits. Br. J. Prev. Soc. Med. 29: 73-81.
    • (1975) Br. J. Prev. Soc. Med. , vol.29 , pp. 73-81
    • Armstrong, B.1    Doll, R.2
  • 10
    • 0022885846 scopus 로고
    • Clastogenicity in vitro of the Na, K, Ca and Mg salts of saccharin; and of magnesium chloride; consideration of significance
    • Ashby, J. and Ishidate, M. (1986) Clastogenicity in vitro of the Na, K, Ca and Mg salts of saccharin; and of magnesium chloride; consideration of significance. Mutat. Res. 163: 63-73.
    • (1986) Mutat. Res. , vol.163 , pp. 63-73
    • Ashby, J.1    Ishidate, M.2
  • 12
    • 0017650251 scopus 로고
    • Saccharin and other sweeteners: Mutagenic properties
    • Batzinger, R. P., Ou, S. Y. L. and Bueding, E. (1977) Saccharin and other sweeteners: mutagenic properties. Science 198: 944-946.
    • (1977) Science , vol.198 , pp. 944-946
    • Batzinger, R.P.1    Ou, S.Y.L.2    Bueding, E.3
  • 14
    • 0018697874 scopus 로고
    • No synergism between caffeine and saccharin in the induction of sister chromatid exchange in human lymphocytes
    • Brøgger, A., Ardito, G. and Waksvik, H. (1979) No synergism between caffeine and saccharin in the induction of sister chromatid exchange in human lymphocytes. Hereditas 91: 135-138.
    • (1979) Hereditas , vol.91 , pp. 135-138
    • Brøgger, A.1    Ardito, G.2    Waksvik, H.3
  • 15
    • 0014954163 scopus 로고
    • Synthetic sweetener consumption and bladder cancer trends in the United States
    • Burbank, F. and Fraumeni, J. F., Jr. (1970) Synthetic sweetener consumption and bladder cancer trends in the United States. Nature 227: 296-297.
    • (1970) Nature , vol.227 , pp. 296-297
    • Burbank, F.1    Fraumeni J.F., Jr.2
  • 16
    • 0019404806 scopus 로고
    • The epidemiology of bladder cancer in West Yorkshire. A preliminary report on non-occupational aetiologies
    • Cartwright, R. A., Adib, R., Glashan, R. and Gray, B. K. (1981) The epidemiology of bladder cancer in West Yorkshire. A preliminary report on non-occupational aetiologies. Carcinogenesis 2: 343-346.
    • (1981) Carcinogenesis , vol.2 , pp. 343-346
    • Cartwright, R.A.1    Adib, R.2    Glashan, R.3    Gray, B.K.4
  • 17
    • 0011785856 scopus 로고
    • Sodium saccharin: Cytogenetic effect on human lymphocytes in vitro
    • Chang, P. and Stacey, T. (1974) Sodium saccharin: cytogenetic effect on human lymphocytes in vitro. Proc. Pa. Acad. Sci. 48: 50-51.
    • (1974) Proc. Pa. Acad. Sci. , vol.48 , pp. 50-51
    • Chang, P.1    Stacey, T.2
  • 18
    • 0018764762 scopus 로고
    • Response of the rat to saccharin with particular reference to the urinary bladder
    • Chowaniec, J. and Hicks, R. M. (1979) Response of the rat to saccharin with particular reference to the urinary bladder. Br. J. Cancer 39: 355-375.
    • (1979) Br. J. Cancer , vol.39 , pp. 355-375
    • Chowaniec, J.1    Hicks, R.M.2
  • 19
    • 0018327785 scopus 로고
    • Validation and characterization of the L5178Y/TK+/-mouse lymphoma mutagen assay system
    • Clive, D., Johnson, K. O., Spector, J. F. S., Batson, A. G. and Brown, M. M. (1979) Validation and characterization of the L5178Y/TK+/-mouse lymphoma mutagen assay system. Mutat. Res. 59: 61-108.
    • (1979) Mutat. Res. , vol.59 , pp. 61-108
    • Clive, D.1    Johnson, K.O.2    Spector, J.F.S.3    Batson, A.G.4    Brown, M.M.5
  • 20
    • 0020972396 scopus 로고
    • Promotion in urinary bladder carcinogenesis
    • Cohen, S. M. (1985) Promotion in urinary bladder carcinogenesis. Environ. Health Perspect. 50: 51-59.
    • (1985) Environ. Health Perspect. , vol.50 , pp. 51-59
    • Cohen, S.M.1
  • 21
    • 0025168534 scopus 로고
    • Cell proliferation in carcinogenesis
    • Cohen, S. M. and Ellwein, L. B. (1990) Cell proliferation in carcinogenesis. Science 249: 1007-1011.
    • (1990) Science , vol.249 , pp. 1007-1011
    • Cohen, S.M.1    Ellwein, L.B.2
  • 22
    • 0026316216 scopus 로고
    • Genetic errors, cell proliferation and carcinogenesis
    • Cohen, S. M. and Ellwein, L. B. (1991) Genetic errors, cell proliferation and carcinogenesis. Cancer Res. 51: 6493-6505.
    • (1991) Cancer Res. , vol.51 , pp. 6493-6505
    • Cohen, S.M.1    Ellwein, L.B.2
  • 23
    • 0027102025 scopus 로고
    • Risk assessment based on high-dose animal exposure experiments
    • Cohen, S. M. and Ellwein, L. B. (1992) Risk assessment based on high-dose animal exposure experiments. Chem. Res. Toxicol. 5: 742-748.
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 742-748
    • Cohen, S.M.1    Ellwein, L.B.2
  • 24
    • 0018759473 scopus 로고
    • Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis
    • Cohen, S. M., Arai, M., Jacobs, J. B. and Friedell, G. H. (1979) Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis. Cancer Res. 39: 1207-1217.
    • (1979) Cancer Res. , vol.39 , pp. 1207-1217
    • Cohen, S.M.1    Arai, M.2    Jacobs, J.B.3    Friedell, G.H.4
  • 25
    • 0020081059 scopus 로고
    • Effect of regenerative hyperplasia on the urinary bladder: Carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide
    • Cohen, S. M., Murasaki, G., Fukushima, S. and Greenfield, R. E. (1982) Effect of regenerative hyperplasia on the urinary bladder: carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Cancer Res. 42: 65-71.
    • (1982) Cancer Res. , vol.42 , pp. 65-71
    • Cohen, S.M.1    Murasaki, G.2    Fukushima, S.3    Greenfield, R.E.4
  • 26
    • 0025391221 scopus 로고
    • Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography
    • Cohen, S. M., Fisher, M. J., Sakata, T., Cano, M., Schoenig, G. P., Chappel, C. I. and Garland, E. M. (1990) Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography. Scanning Microsc. 4: 135-142.
    • (1990) Scanning Microsc. , vol.4 , pp. 135-142
    • Cohen, S.M.1    Fisher, M.J.2    Sakata, T.3    Cano, M.4    Schoenig, G.P.5    Chappel, C.I.6    Garland, E.M.7
  • 27
    • 0025767098 scopus 로고
    • A proposed role for silicates and protein in the proliferative effects of saccharin on the male rat urothelium
    • Cohen, S. M., Cano, M., Earl, R. A., Carson, S. D. and Garland, E. M. (1991a) A proposed role for silicates and protein in the proliferative effects of saccharin on the male rat urothelium. Carcinogenesis 12: 1551-1555.
    • (1991) Carcinogenesis , vol.12 , pp. 1551-1555
    • Cohen, S.M.1    Cano, M.2    Earl, R.A.3    Carson, S.D.4    Garland, E.M.5
  • 30
    • 0018562591 scopus 로고
    • Bile as a source of mutagenic metabolites produced in vivo and detected by salmonella typhimurium
    • Connor, T. H., Forti, G. C., Sitra, P. and Legator, M. S. (1979) Bile as a source of mutagenic metabolites produced in vivo and detected by salmonella typhimurium. Environ. Mutagen. 1: 269-276.
    • (1979) Environ. Mutagen. , vol.1 , pp. 269-276
    • Connor, T.H.1    Forti, G.C.2    Sitra, P.3    Legator, M.S.4
  • 31
    • 0016493152 scopus 로고
    • Letters to the editor: Long-term administration of artificial sweeteners to the rhesus monkey (M. Mulatta)
    • Coulston, F., McChesney, E. W. and Goldberg, L. (1975) Letters to the editor: Long-term administration of artificial sweeteners to the rhesus monkey (M. mulatta). Food Cosmet. Toxicol. 13: 297-302.
    • (1975) Food Cosmet. Toxicol. , vol.13 , pp. 297-302
    • Coulston, F.1    McChesney, E.W.2    Goldberg, L.3
  • 32
    • 0025089530 scopus 로고
    • Induction of DNA synthesis by sodium phenobarbital, uracil and sodium saccharin in urinary bladder of the F344 rat
    • Debiec-Rychter, M. and Wang, C. Y. (1990) Induction of DNA synthesis by sodium phenobarbital, uracil and sodium saccharin in urinary bladder of the F344 rat. Toxicol. Appl. Pharmacol. 105: 345-349.
    • (1990) Toxicol. Appl. Pharmacol. , vol.105 , pp. 345-349
    • Debiec-Rychter, M.1    Wang, C.Y.2
  • 33
    • 0019521939 scopus 로고
    • Study of 106 organic and inorganic compounds in the Salmonella/microsome test
    • De Flora, S. (1981) Study of 106 organic and inorganic compounds in the Salmonella/microsome test. Carcinogenesis 2: 283-298.
    • (1981) Carcinogenesis , vol.2 , pp. 283-298
    • De Flora, S.1
  • 34
    • 0019195821 scopus 로고
    • Mutagenicity study of Remsen-Fahlberg saccharin and contaminants
    • Eckhardt, K., King, M. T., Gocke, E. and Wild, D. (1980) Mutagenicity study of Remsen-Fahlberg saccharin and contaminants. Toxicol. Lett. 7: 51-60.
    • (1980) Toxicol. Lett. , vol.7 , pp. 51-60
    • Eckhardt, K.1    King, M.T.2    Gocke, E.3    Wild, D.4
  • 35
    • 0027473632 scopus 로고
    • Update on artificial sweeteners and bladder cancer
    • Elcock, M. and Morgan, R. W. (1993) Update on artificial sweeteners and bladder cancer. Regul. Toxicol. Pharmacol. 17: 35-43.
    • (1993) Regul. Toxicol. Pharmacol. , vol.17 , pp. 35-43
    • Elcock, M.1    Morgan, R.W.2
  • 36
    • 0023719989 scopus 로고
    • A cellular dynamics model of experimental bladder cancer: Analysis of the effect of sodium saccharin in the rat
    • Ellwein, L. B. and Cohen, S. M. (1988) A cellular dynamics model of experimental bladder cancer: analysis of the effect of sodium saccharin in the rat. Risk Anal. 8: 215-221.
    • (1988) Risk Anal. , vol.8 , pp. 215-221
    • Ellwein, L.B.1    Cohen, S.M.2
  • 37
    • 0025296895 scopus 로고
    • The health risks of saccharin revisited
    • Ellwein, L. B. and Cohen, S. M. (1990) The health risks of saccharin revisited. Crit. Rev. Toxicol. 20: 311-326.
    • (1990) Crit. Rev. Toxicol. , vol.20 , pp. 311-326
    • Ellwein, L.B.1    Cohen, S.M.2
  • 38
    • 0020041427 scopus 로고
    • Effects in the mammalian spot test: Cyclamate versus saccharin
    • Fahrig, R. (1982) Effects in the mammalian spot test: cyclamate versus saccharin. Mutat. Res. 103: 43-47.
    • (1982) Mutat. Res. , vol.103 , pp. 43-47
    • Fahrig, R.1
  • 39
    • 0014329251 scopus 로고
    • Biochemistry of carcinogenesis
    • Farber, E. (1968) Biochemistry of carcinogenesis. Cancer Res. 28: 1859-1869.
    • (1968) Cancer Res. , vol.28 , pp. 1859-1869
    • Farber, E.1
  • 41
    • 0024520237 scopus 로고
    • The effect of lifetime sodium saccharin dosing on mice initiated with the carcinogen 2-acetylaminofluorene
    • Frederick, C. B., Dooley, K. L., Kodell, R. L., Sheldon, W. G. and Kadlubar, F. F. (1989) The effect of lifetime sodium saccharin dosing on mice initiated with the carcinogen 2-acetylaminofluorene. Fundam. Appl. Toxicol. 12: 346-357.
    • (1989) Fundam. Appl. Toxicol. , vol.12 , pp. 346-357
    • Frederick, C.B.1    Dooley, K.L.2    Kodell, R.L.3    Sheldon, W.G.4    Kadlubar, F.F.5
  • 42
    • 0018844893 scopus 로고
    • Saccharin-induced hyperplasia of the rat urinary bladder
    • Fukushima, S. and Cohen, S. M. (1980) Saccharin-induced hyperplasia of the rat urinary bladder. Cancer Res. 40: 734-736.
    • (1980) Cancer Res. , vol.40 , pp. 734-736
    • Fukushima, S.1    Cohen, S.M.2
  • 43
    • 0019425262 scopus 로고
    • Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide
    • Fukushima, S., Friedell, G. H., Jacobs, J. B. and Cohen, S. M. (1981) Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Cancer Res. 41: 3100-3103.
    • (1981) Cancer Res. , vol.41 , pp. 3100-3103
    • Fukushima, S.1    Friedell, G.H.2    Jacobs, J.B.3    Cohen, S.M.4
  • 44
    • 0020570251 scopus 로고
    • Differences in susceptibility to sodium saccharin among various strains of rats and other animal species
    • Fukushima, S., Arai, M., Nakanowatari, J., Hibino, T., Okuda, M. and Ito, N. (1983) Differences in susceptibility to sodium saccharin among various strains of rats and other animal species. Gann 74: 8-20.
    • (1983) Gann , vol.74 , pp. 8-20
    • Fukushima, S.1    Arai, M.2    Nakanowatari, J.3    Hibino, T.4    Okuda, M.5    Ito, N.6
  • 45
    • 0022606912 scopus 로고
    • Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats
    • Fukushima, S., Shibata, M. A., Khirai, T., Tamano, S. and Ito, N. (1986a) Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats. Cancer Res. 46: 1623-1626.
    • (1986) Cancer Res. , vol.46 , pp. 1623-1626
    • Fukushima, S.1    Shibata, M.A.2    Khirai, T.3    Tamano, S.4    Ito, N.5
  • 46
    • 0023036548 scopus 로고
    • Changes in the urine and scanning electron microscopically observed appearance of the rat bladder following treatment with tumor promoters
    • Fukushima, S., Shibata, M. A., Kurata, Y., Tamano, S. and Masui, T. (1986b) Changes in the urine and scanning electron microscopically observed appearance of the rat bladder following treatment with tumor promoters. Jpn. J. Cancer Res. 77: 1074-1082.
    • (1986) Jpn. J. Cancer Res. , vol.77 , pp. 1074-1082
    • Fukushima, S.1    Shibata, M.A.2    Kurata, Y.3    Tamano, S.4    Masui, T.5
  • 47
    • 0023925051 scopus 로고
    • The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder
    • Fukushima, S., Tamano, S., Shibata, M. A., Kurata, Y., Hirose, M. and Ito, N. (1988) The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder. Carcinogenesis 9: 1203-1206.
    • (1988) Carcinogenesis , vol.9 , pp. 1203-1206
    • Fukushima, S.1    Tamano, S.2    Shibata, M.A.3    Kurata, Y.4    Hirose, M.5    Ito, N.6
  • 48
    • 0025286984 scopus 로고
    • Synergism by sodium L-ascorbate but inhibition by L-ascorbic acid for sodium saccharin promotion of rat two-stage bladder carcinogenesis
    • Fukushima, S., Uwagawa, S., Shirai, T., Hasegawa, R. and Ogawa, K. (1990) Synergism by sodium L-ascorbate but inhibition by L-ascorbic acid for sodium saccharin promotion of rat two-stage bladder carcinogenesis. Cancer Res. 50: 4195-4198.
    • (1990) Cancer Res. , vol.50 , pp. 4195-4198
    • Fukushima, S.1    Uwagawa, S.2    Shirai, T.3    Hasegawa, R.4    Ogawa, K.5
  • 49
    • 0025930564 scopus 로고
    • The roles of L-ascorbic acid, urinary pH and Na or K ion concentration in rat bladder epithelial cell proliferation with special reference to tumor promotion
    • Butterworth, B. E. (ed.) Wiley-Liss, New York
    • Fukushima, S., Shibata, M. A., Kurata, Y. and Hasegawa, R. (1991) The roles of L-ascorbic acid, urinary pH and Na or K ion concentration in rat bladder epithelial cell proliferation with special reference to tumor promotion. In: Chemically Induced Cell Proliferation: Implications for Risk Assessment, pp. 195-208, Butterworth, B. E. (ed.) Wiley-Liss, New York.
    • (1991) Chemically Induced Cell Proliferation: Implications for Risk Assessment , pp. 195-208
    • Fukushima, S.1    Shibata, M.A.2    Kurata, Y.3    Hasegawa, R.4
  • 50
    • 0024355287 scopus 로고
    • Influences of diet and strain on the proliferative effect on the rat urinary bladder induced by sodium saccharin
    • Garland, E. M., Sakata, T., Fisher, M. J., Masui, T. and Cohen, S. M. (1989) Influences of diet and strain on the proliferative effect on the rat urinary bladder induced by sodium saccharin. Cancer Res. 49: 3789-3794.
    • (1989) Cancer Res. , vol.49 , pp. 3789-3794
    • Garland, E.M.1    Sakata, T.2    Fisher, M.J.3    Masui, T.4    Cohen, S.M.5
  • 51
    • 0026075198 scopus 로고
    • Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. I. Effects at 30 days post-birth
    • Garland, E. M., Kraft, P. L., Shapiro, R., Khachab, M., Patil, K., Ellwein, L. B. and Cohen, S. M. (1991a) Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. I. Effects at 30 days post-birth. Food Chem. Toxicol. 29: 657-667.
    • (1991) Food Chem. Toxicol. , vol.29 , pp. 657-667
    • Garland, E.M.1    Kraft, P.L.2    Shapiro, R.3    Khachab, M.4    Patil, K.5    Ellwein, L.B.6    Cohen, S.M.7
  • 52
    • 0026079455 scopus 로고
    • Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. II. Dose response and reversibility
    • Garland, E. M., Shapiro, R., Kraft, P. L., Mattison, B. J., Parr, J. M. and Cohen, S. M. (1991b) Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. II. Dose response and reversibility. Food Chem. Toxicol. 29: 669-679.
    • (1991) Food Chem. Toxicol. , vol.29 , pp. 669-679
    • Garland, E.M.1    Shapiro, R.2    Kraft, P.L.3    Mattison, B.J.4    Parr, J.M.5    Cohen, S.M.6
  • 53
    • 0027424578 scopus 로고
    • Effects of dietary iron and folate supplementation on the physiological changes produced in weanling rats by sodium saccharin exposure
    • Garland, E. M., Shapiro, R., Wehner, J. M., Johnson, L. S., Mattson, B. J., Khachab, M., Asamoto, M. and Cohen, S. M. (1993) Effects of dietary iron and folate supplementation on the physiological changes produced in weanling rats by sodium saccharin exposure. Food Chem. Toxicol. 31: 689-699.
    • (1993) Food Chem. Toxicol. , vol.31 , pp. 689-699
    • Garland, E.M.1    Shapiro, R.2    Wehner, J.M.3    Johnson, L.S.4    Mattson, B.J.5    Khachab, M.6    Asamoto, M.7    Cohen, S.M.8
  • 55
    • 0022577397 scopus 로고
    • The effect of different salts of saccharin on the rat urinary bladder
    • Hasegawa, R. and Cohen, S. M. (1986) The effect of different salts of saccharin on the rat urinary bladder. Cancer Lett. 30: 261-268.
    • (1986) Cancer Lett. , vol.30 , pp. 261-268
    • Hasegawa, R.1    Cohen, S.M.2
  • 57
    • 0021892933 scopus 로고
    • Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion
    • Hasegawa, R., Greenfield, R. E., Murasaki, G., Suzuki, T. and Cohen, S. M. (1985) Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. Cancer Res. 45: 1469-1473.
    • (1985) Cancer Res. , vol.45 , pp. 1469-1473
    • Hasegawa, R.1    Greenfield, R.E.2    Murasaki, G.3    Suzuki, T.4    Cohen, S.M.5
  • 58
    • 49049151592 scopus 로고
    • Studies to evaluate artificial sweeteners, especially Remsen-Fahlberg saccharin, and their possible impurities, for potential mutagenicity by the salmonella/mammalian liver microsome test
    • Herbold, B. A. (1981) Studies to evaluate artificial sweeteners, especially Remsen-Fahlberg saccharin, and their possible impurities, for potential mutagenicity by the salmonella/mammalian liver microsome test. Mutat. Res. 90: 365-372.
    • (1981) Mutat. Res. , vol.90 , pp. 365-372
    • Herbold, B.A.1
  • 59
    • 0017750317 scopus 로고
    • The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans
    • Hicks, R. M. and Chowaniec, J. (1977) The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans. Cancer Res. 37: 2943-2949.
    • (1977) Cancer Res. , vol.37 , pp. 2943-2949
    • Hicks, R.M.1    Chowaniec, J.2
  • 60
    • 0015917634 scopus 로고
    • Co-carcinogenic action of saccharin in the chemical induction of bladder cancer
    • Hicks, R. M., Wakefield, J. S. J. and Chowaniec, J. (1973) Co-carcinogenic action of saccharin in the chemical induction of bladder cancer. Nature. 243: 347-349.
    • (1973) Nature , vol.243 , pp. 347-349
    • Hicks, R.M.1    Wakefield, J.S.J.2    Chowaniec, J.3
  • 61
    • 0016763876 scopus 로고
    • Evaluation of a new model to detect bladder carcinogens or co-carcinogens; results obtained with saccharin, cyclamate and cyclophosphamide
    • Hicks, R. M., Wakefield, J. S. J. and Chowaniec, J. (1975) Evaluation of a new model to detect bladder carcinogens or co-carcinogens; results obtained with saccharin, cyclamate and cyclophosphamide. Chem. Biol. Interact. 11: 225-233.
    • (1975) Chem. Biol. Interact. , vol.11 , pp. 225-233
    • Hicks, R.M.1    Wakefield, J.S.J.2    Chowaniec, J.3
  • 62
    • 0019351791 scopus 로고
    • Screening of carcinogens with the prophage 2clts857 induction test
    • Ho, Y. L. and Ho, S. K. (1981) Screening of carcinogens with the prophage 2clts857 induction test. Cancer Res. 41: 532-536.
    • (1981) Cancer Res. , vol.41 , pp. 532-536
    • Ho, Y.L.1    Ho, S.K.2
  • 63
    • 0025866023 scopus 로고
    • Lack of bladder carcinogenicity of dietary sodium saccharin in analbuminaemic rats, which are highly susceptible to N-nitroso-n-butyl-(4-hydroxybutyl)amine
    • Homma, Y., Kondo, Y., Kakizoes, T., Aso, Y. and Nagase, S. (1991) Lack of bladder carcinogenicity of dietary sodium saccharin in analbuminaemic rats, which are highly susceptible to N-nitroso-n-butyl-(4-hydroxybutyl)amine. Food Chem. Toxicol. 29: 373-376.
    • (1991) Food Chem. Toxicol. , vol.29 , pp. 373-376
    • Homma, Y.1    Kondo, Y.2    Kakizoes, T.3    Aso, Y.4    Nagase, S.5
  • 64
    • 0018889467 scopus 로고
    • Ortho-toluene sulphonamide and saccharin in the promotion of bladder cancer in the rat
    • Hooson, J., Hicks, R. M., Grasso, P. and Chowaniec, J. (1980) Ortho-toluene sulphonamide and saccharin in the promotion of bladder cancer in the rat. Br. J. Cancer 42: 129-147.
    • (1980) Br. J. Cancer , vol.42 , pp. 129-147
    • Hooson, J.1    Hicks, R.M.2    Grasso, P.3    Chowaniec, J.4
  • 65
    • 0020122055 scopus 로고
    • Non-nutritive sweeteners and bladder cancer
    • Hoover, R. and Hartge, P. (1982) Non-nutritive sweeteners and bladder cancer. Am. J. Public Health 72: 382-383.
    • (1982) Am. J. Public Health , vol.72 , pp. 382-383
    • Hoover, R.1    Hartge, P.2
  • 66
    • 0018877365 scopus 로고
    • Artificial sweeteners and human bladder cancer
    • Hoover, R. N. and Strasser, P. H. (1980) Artificial sweeteners and human bladder cancer. Lancet i: 837-840.
    • (1980) Lancet , vol.1 , pp. 837-840
    • Hoover, R.N.1    Strasser, P.H.2
  • 68
    • 0022845734 scopus 로고
    • Effect of sodium phenobarbital and sodium saccharin in AIN-76A diet on carcinogenesis initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and N,N-dibutylnitrosamine in male F344 rats
    • Imaida, K. and Wang, C. Y. (1986) Effect of sodium phenobarbital and sodium saccharin in AIN-76A diet on carcinogenesis initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and N,N-dibutylnitrosamine in male F344 rats. Cancer Res. 46: 6160-6164.
    • (1986) Cancer Res. , vol.46 , pp. 6160-6164
    • Imaida, K.1    Wang, C.Y.2
  • 69
    • 0020561474 scopus 로고
    • Classification of compounds by cluster analysis of Ames test data
    • Imamura, A., Kurumi, Y., Danzuka, T., Kodama, M., Kawachi, T. and Nagao, M. (1983) Classification of compounds by cluster analysis of Ames test data. Gann 74: 196-204.
    • (1983) Gann , vol.74 , pp. 196-204
    • Imamura, A.1    Kurumi, Y.2    Danzuka, T.3    Kodama, M.4    Kawachi, T.5    Nagao, M.6
  • 73
    • 0017722987 scopus 로고
    • Chromosome tests with 134 compounds on Chinese hamster cells in vitro - A screening for chemical carcinogens
    • Ishidate, M., Jr. and Odashima, S. (1977) Chromosome tests with 134 compounds on Chinese hamster cells in vitro - a screening for chemical carcinogens. Mutat. Res. 48: 337-354.
    • (1977) Mutat. Res. , vol.48 , pp. 337-354
    • Ishidate M., Jr.1    Odashima, S.2
  • 75
    • 0017185284 scopus 로고
    • Early lesions in experimental bladder cancer: Scanning electron microscopy of cell surface markers
    • Jacobs, J. B., Arai, M., Cohen, S. M. and Friedell, G. H. (1976) Early lesions in experimental bladder cancer: scanning electron microscopy of cell surface markers. Cancer Res. 36: 2512-2517.
    • (1976) Cancer Res. , vol.36 , pp. 2512-2517
    • Jacobs, J.B.1    Arai, M.2    Cohen, S.M.3    Friedell, G.H.4
  • 76
    • 0020038327 scopus 로고
    • Intra-uterine exposure to saccharin and risk of bladder cancer in man
    • Jensen, O. M. and Kamby, C. (1982) Intra-uterine exposure to saccharin and risk of bladder cancer in man. Int. J. Cancer 29: 507-509.
    • (1982) Int. J. Cancer , vol.29 , pp. 507-509
    • Jensen, O.M.1    Kamby, C.2
  • 77
    • 0018956477 scopus 로고
    • Cooperative programme on short-term assays for carcinogenicity in Japan
    • Montesano, R., Bartsch, H. and Tomatis, L. (eds.) International Agency for Research on Cancer (IARC), Lyon
    • Kawachi, T., Yahagi, T., Kada, T., Tazima, Y., Ishidate, M., Sasaki, M. and Sugiyama, T. (1980) Cooperative programme on short-term assays for carcinogenicity in Japan. In: Molecular and Cellular Aspects of Carcinogen Screening Tests, pp. 323-330, Montesano, R., Bartsch, H. and Tomatis, L. (eds.) International Agency for Research on Cancer (IARC), Lyon.
    • (1980) Molecular and Cellular Aspects of Carcinogen Screening Tests , pp. 323-330
    • Kawachi, T.1    Yahagi, T.2    Kada, T.3    Tazima, Y.4    Ishidate, M.5    Sasaki, M.6    Sugiyama, T.7
  • 78
    • 84944656608 scopus 로고
    • Saccharin, cyclamate and human bladder cancer
    • Kessler, I. I. and Clark, J. P. (1978) Saccharin, cyclamate and human bladder cancer. JAMA 240: 349-355.
    • (1978) JAMA , vol.240 , pp. 349-355
    • Kessler, I.I.1    Clark, J.P.2
  • 79
    • 0016693923 scopus 로고
    • The mutagenicity of saccharin
    • Kramers, P. G. N. (1975) The mutagenicity of saccharin. Mutat. Res. .32: 81-92.
    • (1975) Mutat. Res. , vol.32 , pp. 81-92
    • Kramers, P.G.N.1
  • 80
    • 0015436925 scopus 로고
    • The effects of cyclamate and saccharin on the chromosomes of a Chinese hamster cell line
    • Kristoffersson, U. (1972) The effects of cyclamate and saccharin on the chromosomes of a Chinese hamster cell line. Hereditas 70: 271-282.
    • (1972) Hereditas , vol.70 , pp. 271-282
    • Kristoffersson, U.1
  • 81
    • 0017567914 scopus 로고
    • Long-term toxicity and reproduction study (including a teratogenicity study) with cyclamate, saccharin and cyclohexylamine
    • Kroes, R., Peters, P. W. J., Berkvens, M., Verschuuren, H. G., De Vries, T. H. and Van Esch, G. J. (1977) Long-term toxicity and reproduction study (including a teratogenicity study) with cyclamate, saccharin and cyclohexylamine. Toxicol. Appl. Pharmacol. 8: 285-300.
    • (1977) Toxicol. Appl. Pharmacol. , vol.8 , pp. 285-300
    • Kroes, R.1    Peters, P.W.J.2    Berkvens, M.3    Verschuuren, H.G.4    De Vries, T.H.5    Van Esch, G.J.6
  • 82
    • 0021865205 scopus 로고
    • The urinary excretion of bacterial amino-acid metabolites by rats fed saccharin in the diet
    • Lavvrie, C. A., Renwick, A. G. and Sims, J. (1985) The urinary excretion of bacterial amino-acid metabolites by rats fed saccharin in the diet. Food Chem. Toxicol. 23: 445-450.
    • (1985) Food Chem. Toxicol. , vol.23 , pp. 445-450
    • Lavvrie, C.A.1    Renwick, A.G.2    Sims, J.3
  • 83
    • 0018293802 scopus 로고
    • Mutagenicity test with saccharin in the male mouse
    • Léonard, A. and Léonard, E. D. (1979) Mutagenicity test with saccharin in the male mouse. J. Environ. Pathol. Toxicol. 2: 1047-1053.
    • (1979) J. Environ. Pathol. Toxicol. , vol.2 , pp. 1047-1053
    • Léonard, A.1    Léonard, E.D.2
  • 85
    • 0016412870 scopus 로고
    • The metabolism of saccharin in animals
    • Lethco, E. J. and Wallace, W. C. (1975) The metabolism of saccharin in animals. Toxicology 3: 287-300.
    • (1975) Toxicology , vol.3 , pp. 287-300
    • Lethco, E.J.1    Wallace, W.C.2
  • 86
    • 0016423980 scopus 로고
    • Einfluß einer mehrwöchigen behandlung männlicher und weiblicher mäuse mit saccharin, cyclamate oder cyclohexylaminsulfat auf fertilität and dominant-letal-effekte
    • Lorke, D. and Machemer, L. (1975) Einfluß einer mehrwöchigen behandlung männlicher und weiblicher mäuse mit saccharin, cyclamate oder cyclohexylaminsulfat auf fertilität and dominant-letal-effekte. Humangenetik 26: 199-205.
    • (1975) Humangenetik , vol.26 , pp. 199-205
    • Lorke, D.1    Machemer, L.2
  • 87
    • 0017719212 scopus 로고
    • Saccharin does not bind to DNA of liver or bladder in the rat
    • Lutz, W. K. and Schlatter, C. H. (1977) Saccharin does not bind to DNA of liver or bladder in the rat. Chem. Biol. Interact. 19: 253-257.
    • (1977) Chem. Biol. Interact. , vol.19 , pp. 253-257
    • Lutz, W.K.1    Schlatter, C.H.2
  • 88
    • 0015802685 scopus 로고
    • Dominant lethal test in the mouse for mutagenic effects of saccharine
    • Machemer, L. and Lorke, D. (1973) Dominant lethal test in the mouse for mutagenic effects of saccharine. Humangenetik 19: 193-198.
    • (1973) Humangenetik , vol.19 , pp. 193-198
    • Machemer, L.1    Lorke, D.2
  • 89
    • 0016749546 scopus 로고
    • Experiences with the dominant lethal test in female mice: Effects of alkylating agents and artificial sweeteners on pre-ovulatory oocyte stages
    • Machemer, L. and Lorke, D. (1975a) Experiences with the dominant lethal test in female mice: effects of alkylating agents and artificial sweeteners on pre-ovulatory oocyte stages. Mutat. Res. 29: 209-214.
    • (1975) Mutat. Res. , vol.29 , pp. 209-214
    • Machemer, L.1    Lorke, D.2
  • 90
    • 0011734131 scopus 로고
    • Method for testing mutagenic effects of chemicals on spermatogonia of the Chinese hamster
    • Machemer, L. and Lorke, D. (1975b) Method for testing mutagenic effects of chemicals on spermatogonia of the Chinese hamster. Drug Res. 25: 1888-1896.
    • (1975) Drug Res. , vol.25 , pp. 1888-1896
    • Machemer, L.1    Lorke, D.2
  • 91
    • 0020081580 scopus 로고
    • Saccharin and the induction of presumed somatic mutations in the mouse
    • Mahon, G. A. T. and Dawson, G. W. P. (1982) Saccharin and the induction of presumed somatic mutations in the mouse. Mutat. Res. 103: 49-52.
    • (1982) Mutat. Res. , vol.103 , pp. 49-52
    • Mahon, G.A.T.1    Dawson, G.W.P.2
  • 92
    • 0022264032 scopus 로고
    • Modification of rat caecal microbial biotransformation activities by dietary saccharin
    • Mallett, A. K., Rowland, I. R. and Bearne, C. A. (1985) Modification of rat caecal microbial biotransformation activities by dietary saccharin. Toxicol. Appl. Pharmacol. 36: 253-262.
    • (1985) Toxicol. Appl. Pharmacol. , vol.36 , pp. 253-262
    • Mallett, A.K.1    Rowland, I.R.2    Bearne, C.A.3
  • 94
    • 0025049290 scopus 로고
    • Point mutation in codons 12 and 61 of the Ha-ras gene in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide
    • Masui, T., Mann, A. M., Garland, E. M., Okamura, T., Johansson, P. L. and Cohen, S. M. (1990) Point mutation in codons 12 and 61 of the Ha-ras gene in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Mol. Carcinog. 3: 210-215.
    • (1990) Mol. Carcinog. , vol.3 , pp. 210-215
    • Masui, T.1    Mann, A.M.2    Garland, E.M.3    Okamura, T.4    Johansson, P.L.5    Cohen, S.M.6
  • 95
    • 0025936057 scopus 로고
    • H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate or related salts
    • Masui, T., Mann, A. M., Macatee, T. L., Okamura, T., Garland, E. M., Fujii, H., Pelling, J. C. and Cohen, S. M. (1991a) H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate or related salts. Cancer Res. 51: 3471-3475.
    • (1991) Cancer Res. , vol.51 , pp. 3471-3475
    • Masui, T.1    Mann, A.M.2    Macatee, T.L.3    Okamura, T.4    Garland, E.M.5    Fujii, H.6    Pelling, J.C.7    Cohen, S.M.8
  • 96
    • 0025808119 scopus 로고
    • Enhanced immunoreactivity of ras oncogene p21 protein in urinary bladder epithelium of rats treated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide
    • Masui, T., Ward, J. M. and Cohen, S. M. (1991b) Enhanced immunoreactivity of ras oncogene p21 protein in urinary bladder epithelium of rats treated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Cancer Lett. 59: 95-102.
    • (1991) Cancer Lett. , vol.59 , pp. 95-102
    • Masui, T.1    Ward, J.M.2    Cohen, S.M.3
  • 97
    • 0027438624 scopus 로고
    • Sequencing analysis of Ha-,Ki-and N-ras genes in rat urinary bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and sodium saccharin
    • Masui, T., Mann, A. M., Borgeson, C. D., Garland, E. M., Okamura, T., Fujii, H., Felling, J. C. and Cohen, S. M. (1993) Sequencing analysis of Ha-,Ki-and N-ras genes in rat urinary bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and sodium saccharin. Teratogenesis Carcinog. Mutagen. 13: 225-233.
    • (1993) Teratogenesis Carcinog. Mutagen. , vol.13 , pp. 225-233
    • Masui, T.1    Mann, A.M.2    Borgeson, C.D.3    Garland, E.M.4    Okamura, T.5    Fujii, H.6    Felling, J.C.7    Cohen, S.M.8
  • 98
    • 0018835873 scopus 로고
    • Effects of caffeine and saccharin on DNA in the bladder epithelium of rats treated with N-butyl-N-(3-carboxypropyl)-nitrosamine
    • Miyata, Y., Hagiwara, A., Nakatsuka, T., Murasaki, G., Arai, M. and Ito, N. (1980) Effects of caffeine and saccharin on DNA in the bladder epithelium of rats treated with N-butyl-N-(3-carboxypropyl)-nitrosamine. Chem. Biol. Interact. 29: 291-302.
    • (1980) Chem. Biol. Interact. , vol.29 , pp. 291-302
    • Miyata, Y.1    Hagiwara, A.2    Nakatsuka, T.3    Murasaki, G.4    Arai, M.5    Ito, N.6
  • 99
    • 0011768229 scopus 로고
    • Syncarcinogenic action of saccharin and sodium-cyclamate in the induction of bladder tumours in MNU-pretreated rats
    • Guggenheim, B. (ed.) Karger, Basel
    • Mohr, U., Green, U., Althoff, J. and Schneider, P. (1978) Syncarcinogenic action of saccharin and sodium-cyclamate in the induction of bladder tumours in MNU-pretreated rats. In: Health and Sugar Substitutes, Proceedings of ERGOB Conference, Geneva, pp. 64-69, Guggenheim, B. (ed.) Karger, Basel.
    • (1978) Health and Sugar Substitutes, Proceedings of Ergob Conference, Geneva , pp. 64-69
    • Mohr, U.1    Green, U.2    Althoff, J.3    Schneider, P.4
  • 100
    • 0020564286 scopus 로고
    • A case control study of female bladder cancer
    • Mommsen, S., Aagaard, J. and Sell, A. (1983) A case control study of female bladder cancer. Eur. J. Cancer 19: 725-729.
    • (1983) Eur. J. Cancer , vol.19 , pp. 725-729
    • Mommsen, S.1    Aagaard, J.2    Sell, A.3
  • 101
    • 0018074980 scopus 로고
    • Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin
    • Mondal, S., Brankow, D. W. and Heidelberger, C. (1978) Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin. Science 201: 1141-1142.
    • (1978) Science , vol.201 , pp. 1141-1142
    • Mondal, S.1    Brankow, D.W.2    Heidelberger, C.3
  • 102
    • 0018580145 scopus 로고
    • Genetic effects of impure and pure saccharin in yeast
    • Moore, C. W. and Schmick, A. (1979) Genetic effects of impure and pure saccharin in yeast. Science 205: 1007-1010.
    • (1979) Science , vol.205 , pp. 1007-1010
    • Moore, C.W.1    Schmick, A.2
  • 103
    • 0023808096 scopus 로고
    • High concentrations of sodium chloride induce a "positive" response at the tk locus of L5178Y/TK-/-mouse lymphoma cells
    • Moore, M. M. and Brock, K. H. (1988) High concentrations of sodium chloride induce a "positive" response at the tk locus of L5178Y/TK-/-mouse lymphoma cells. Environ. Mol. Mutagen. 12: 265-268.
    • (1988) Environ. Mol. Mutagen. , vol.12 , pp. 265-268
    • Moore, M.M.1    Brock, K.H.2
  • 104
    • 0016245187 scopus 로고
    • Bladder cancer: Smoking, beverages and artificial sweeteners
    • Morgan, R. W. and Jain, M. G. (1974) Bladder cancer: smoking, beverages and artificial sweeteners. Can. Med. Assoc. J. 111: 1067-1070.
    • (1974) Can. Med. Assoc. J. , vol.111 , pp. 1067-1070
    • Morgan, R.W.1    Jain, M.G.2
  • 105
    • 0018870175 scopus 로고
    • Artificial sweeteners and cancer of the lower urinary tract
    • Morrison, A. S. and Buring, J. E. (1980) Artificial sweeteners and cancer of the lower urinary tract. N. Engl. J. Med. 302: 537-541.
    • (1980) N. Engl. J. Med. , vol.302 , pp. 537-541
    • Morrison, A.S.1    Buring, J.E.2
  • 106
    • 0020055246 scopus 로고
    • Artificial sweeteners and bladder cancer in Manchester, U.K. And Nagoya, Japan
    • Morrison, A. S., Verhoek, W. G., Leck, I., Aoki, K., Ohno, Y. and Obata, K. (1982) Artificial sweeteners and bladder cancer in Manchester, U.K. and Nagoya, Japan. Br. J. Cancer 45: 332-336.
    • (1982) Br. J. Cancer , vol.45 , pp. 332-336
    • Morrison, A.S.1    Verhoek, W.G.2    Leck, I.3    Aoki, K.4    Ohno, Y.5    Obata, K.6
  • 109
    • 0019430595 scopus 로고
    • Effect of dose of sodium saccharin on the induction of rat urinary bladder proliferation
    • Murasaki, G. and Cohen, S. M. (1981) Effect of dose of sodium saccharin on the induction of rat urinary bladder proliferation. Cancer Res. 41: 942-944.
    • (1981) Cancer Res. , vol.41 , pp. 942-944
    • Murasaki, G.1    Cohen, S.M.2
  • 110
    • 0020663332 scopus 로고
    • Effect of sodium saccharin on urinary bladder epithelial regenerative hyperplasia following freeze ulceration
    • Murasaki, G. and Cohen, S. M. (1983a) Effect of sodium saccharin on urinary bladder epithelial regenerative hyperplasia following freeze ulceration. Cancer Res. 43: 182-187.
    • (1983) Cancer Res. , vol.43 , pp. 182-187
    • Murasaki, G.1    Cohen, S.M.2
  • 111
    • 0020561154 scopus 로고
    • Co-carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for the urinary bladder
    • Murasaki, G. and Cohen, S. M. (1983b) Co-carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for the urinary bladder. Carcinogenesis 4: 97-99.
    • (1983) Carcinogenesis , vol.4 , pp. 97-99
    • Murasaki, G.1    Cohen, S.M.2
  • 113
    • 0019138033 scopus 로고
    • Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine
    • Nakanishi, K., Hagiwara, A., Shibata, M, Imalda, K., Tatematsu, M. and Ito, N. (1980a) Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. J. Natl. Cancer Inst. 65: 1005-1010.
    • (1980) J. Natl. Cancer Inst. , vol.65 , pp. 1005-1010
    • Nakanishi, K.1    Hagiwara, A.2    Shibata, M.3    Imalda, K.4    Tatematsu, M.5    Ito, N.6
  • 114
    • 0018940772 scopus 로고
    • Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine
    • Nakanishi, K., Hirose, M., Ogiso, T., Hasegawa, R., Arai, M. and Ito, N. (1980b) Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann 71: 490-500.
    • (1980) Gann , vol.71 , pp. 490-500
    • Nakanishi, K.1    Hirose, M.2    Ogiso, T.3    Hasegawa, R.4    Arai, M.5    Ito, N.6
  • 115
    • 0020055909 scopus 로고
    • Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats
    • Nakanishi, K., Fukushima, S., Hagiwara, A., Tamano, S. and Ito, N. (1982) Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats. J. Natl. Cancer Inst. 68: 497-500.
    • (1982) J. Natl. Cancer Inst. , vol.68 , pp. 497-500
    • Nakanishi, K.1    Fukushima, S.2    Hagiwara, A.3    Tamano, S.4    Ito, N.5
  • 116
    • 0018216620 scopus 로고
    • Age dependent changes in the excretion of urinary proteins by the rat
    • Neuhaus, O. W. and Flory, W. (1978) Age dependent changes in the excretion of urinary proteins by the rat. Nephron 22: 570-576.
    • (1978) Nephron , vol.22 , pp. 570-576
    • Neuhaus, O.W.1    Flory, W.2
  • 117
    • 0025797192 scopus 로고
    • Lack of bladder tumor promoting activity in rats fed sodium saccharin in AIN-76A diet
    • Okamura, T., Garland, E. M., Masui, T., Sakata, T., St. John, M. and Cohen, S. M. (1991) Lack of bladder tumor promoting activity in rats fed sodium saccharin in AIN-76A diet. Cancer Res. 51: 1778-1782.
    • (1991) Cancer Res. , vol.51 , pp. 1778-1782
    • Okamura, T.1    Garland, E.M.2    Masui, T.3    Sakata, T.4    St. John, M.5    Cohen, S.M.6
  • 118
    • 0019731471 scopus 로고
    • Tumor promoters induce mitotic aneuploidy in yeast
    • Parry, J. M., Parry, E. M. and Barrett, J. C. (1981) Tumor promoters induce mitotic aneuploidy in yeast. Nature 294: 263-265.
    • (1981) Nature , vol.294 , pp. 263-265
    • Parry, J.M.1    Parry, E.M.2    Barrett, J.C.3
  • 119
    • 0022534375 scopus 로고
    • Effect of saccharin on the meiotic division of Saccharomyces cerevisiae
    • Persic, L. (1986) Effect of saccharin on the meiotic division of Saccharomyces cerevisiae. Mutat. Res. 174: 195-197.
    • (1986) Mutat. Res. , vol.174 , pp. 195-197
    • Persic, L.1
  • 121
    • 0018124633 scopus 로고
    • Non-mutagenicity of saccharin
    • Pool, B. (1978) Non-mutagenicity of saccharin. Toxicology 11: 95-97.
    • (1978) Toxicology , vol.11 , pp. 95-97
    • Pool, B.1
  • 122
    • 0023129689 scopus 로고
    • Induction of chromosomal aberrations by prefeeding saccharin in albino mice
    • Prasad, O. and Rai, G. (1987) Induction of chromosomal aberrations by prefeeding saccharin in albino mice. Indian J. Exp. Biol. 25: 124-128.
    • (1987) Indian J. Exp. Biol. , vol.25 , pp. 124-128
    • Prasad, O.1    Rai, G.2
  • 123
    • 0015320048 scopus 로고
    • Induction of dominant lethals in mice by sodium saccharin
    • Rao, M. S. and Qureshi, A. B. (1972) Induction of dominant lethals in mice by sodium saccharin. Indian J. Med. Res. 60: 599-603.
    • (1972) Indian J. Med. Res. , vol.60 , pp. 599-603
    • Rao, M.S.1    Qureshi, A.B.2
  • 124
    • 0020071794 scopus 로고
    • Enhancement of sister-chromatid exchanges by tumor promoters
    • Ray-Chaudhuri, R., Currens, M. and Iype, P. T. (1982) Enhancement of sister-chromatid exchanges by tumor promoters. Cancer 45: 769-777.
    • (1982) Cancer , vol.45 , pp. 769-777
    • Ray-Chaudhuri, R.1    Currens, M.2    Iype, P.T.3
  • 125
    • 0018677918 scopus 로고
    • Possible mutagenic activity of saccharin
    • Renner, H. W. (1979) Possible mutagenic activity of saccharin. Experientia 35: 1364-1365.
    • (1979) Experientia , vol.35 , pp. 1364-1365
    • Renner, H.W.1
  • 126
    • 0021842262 scopus 로고
    • The disposition of saccharin in animals and man - A review
    • Renwick, A. G. (1985) The disposition of saccharin in animals and man - a review. Food Chem. Toxicol. 23: 429-435.
    • (1985) Food Chem. Toxicol. , vol.23 , pp. 429-435
    • Renwick, A.G.1
  • 127
    • 0020966572 scopus 로고
    • Characterization of impurities in commercial lots of sodium saccharin produced by the Sherwin-Williams process
    • Riggin, R. M. and Kinzer, G. W. (1983) Characterization of impurities in commercial lots of sodium saccharin produced by the Sherwin-Williams process. I. Chemistry. Food Chem. Toxicol. 21: 1-10.
    • (1983) I. Chemistry. Food Chem. Toxicol. , vol.21 , pp. 1-10
    • Riggin, R.M.1    Kinzer, G.W.2
  • 128
    • 0020549542 scopus 로고
    • Characterization of impurities in commercial lots of sodium saccharin produced by the Sherwin-Williams process. II. Mutagenicity
    • Riggin, R. M., Margard, W. E. and Kinzer, G. W. (1983) Characterization of impurities in commercial lots of sodium saccharin produced by the Sherwin-Williams process. II. Mutagenicity. Food Chem. Toxicol. 21: 11-17.
    • (1983) Food Chem. Toxicol. , vol.21 , pp. 11-17
    • Riggin, R.M.1    Margard, W.E.2    Kinzer, G.W.3
  • 130
    • 0021870428 scopus 로고
    • The effect of saccharin on the microbial metabolism of tryptophan in man
    • Roberts, A. and Renwick, A. G. (1985) The effect of saccharin on the microbial metabolism of tryptophan in man. Food Chem. Toxicol. 23: 451-455.
    • (1985) Food Chem. Toxicol. , vol.23 , pp. 451-455
    • Roberts, A.1    Renwick, A.G.2
  • 131
    • 0014772543 scopus 로고
    • Feeding studies on sodium cyclamate, saccharin and sucrose for carcinogenic and tumour-promoting activity
    • Roe, F. J., Levy, L. S. and Carter, R. L. (1970) Feeding studies on sodium cyclamate, saccharin and sucrose for carcinogenic and tumour-promoting activity. Food Cosmet. Toxicol. 8: 135-145.
    • (1970) Food Cosmet. Toxicol. , vol.8 , pp. 135-145
    • Roe, F.J.1    Levy, L.S.2    Carter, R.L.3
  • 132
    • 0022504531 scopus 로고
    • Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide initiation and sodium saccharin promotion of urinary bladder carcinogensis in male F344 rats
    • Sakata, T., Hasegawa, R., Johansson, S. L., Zenser, T. V. and Cohen, S. M. (1986) Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide initiation and sodium saccharin promotion of urinary bladder carcinogensis in male F344 rats. Cancer Res. 46: 3903-3906.
    • (1986) Cancer Res. , vol.46 , pp. 3903-3906
    • Sakata, T.1    Hasegawa, R.2    Johansson, S.L.3    Zenser, T.V.4    Cohen, S.M.5
  • 133
    • 0018778891 scopus 로고
    • Carcinogenesis testing of saccharin. No transformation or increased sister chromatid exchange observed in two mammalian cell systems
    • Saxholm, H. J. K., Iversen, O. H., Reith, A. and Brøgger, A. (1979) Carcinogenesis testing of saccharin. No transformation or increased sister chromatid exchange observed in two mammalian cell systems. Eur. J. Cancer 15: 509-513.
    • (1979) Eur. J. Cancer , vol.15 , pp. 509-513
    • Saxholm, H.J.K.1    Iversen, O.H.2    Reith, A.3    Brøgger, A.4
  • 134
    • 0015848583 scopus 로고
    • Fehlen einer kanzerogenen wirkung von cyclamat, cyclohexylamin und saccharin bei ratten
    • Schmähl, V. D. (1973) Fehlen einer kanzerogenen wirkung von cyclamat, cyclohexylamin und saccharin bei ratten. Arzneimittelforschung 23: 1466-1470.
    • (1973) Arzneimittelforschung , vol.23 , pp. 1466-1470
    • Schmähl, V.D.1
  • 135
    • 0021832629 scopus 로고
    • The effects of high dietary levels of sodium saccharin on mineral and water balance and related parameters in rats
    • Schoenig, G. P. and Anderson, R. L. (1985) The effects of high dietary levels of sodium saccharin on mineral and water balance and related parameters in rats. Food Chem. Toxicol. 23: 465-474.
    • (1985) Food Chem. Toxicol. , vol.23 , pp. 465-474
    • Schoenig, G.P.1    Anderson, R.L.2
  • 137
    • 0028273068 scopus 로고
    • Roles of bladder distension, urinary pH and urinary sodium ion concentration in cell proliferation of urinary bladder epithelium in rats ingesting sodium salts
    • Shioya, S., Nagami-Oguihara, R., Oguihara, S., Kimura, T., Imaida, K. and Fukushima, S. (1994) Roles of bladder distension, urinary pH and urinary sodium ion concentration in cell proliferation of urinary bladder epithelium in rats ingesting sodium salts. Food Chem. Toxicol. 32: 165-171.
    • (1994) Food Chem. Toxicol. , vol.32 , pp. 165-171
    • Shioya, S.1    Nagami-Oguihara, R.2    Oguihara, S.3    Kimura, T.4    Imaida, K.5    Fukushima, S.6
  • 138
    • 0017746001 scopus 로고
    • Early surface changes of the urinary bladder epithelium of different animal species induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine
    • Shirai, T., Murasaki, G., Tatematsu, M., Tsuda, H., Fukushima, S. and Ito, N. (1977) Early surface changes of the urinary bladder epithelium of different animal species induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine. Gann 68: 203-212.
    • (1977) Gann , vol.68 , pp. 203-212
    • Shirai, T.1    Murasaki, G.2    Tatematsu, M.3    Tsuda, H.4    Fukushima, S.5    Ito, N.6
  • 139
    • 0020534031 scopus 로고
    • Artificial sweeteners and lower urinary tract cancer: Hospital vs. Population controls
    • Silverman, D. T., Hoover, R. N. and Swanson, G. M. (1983) Artificial sweeteners and lower urinary tract cancer: hospital vs. population controls. Am. J. Epidemiol. 117: 326-334.
    • (1983) Am. J. Epidemiol. , vol.117 , pp. 326-334
    • Silverman, D.T.1    Hoover, R.N.2    Swanson, G.M.3
  • 140
    • 0016814634 scopus 로고
    • Coffee drinking and cancer of the lower urinary tract
    • Simon, D., Yen, S. and Cole, P. (1975) Coffee drinking and cancer of the lower urinary tract. J. Natl. Cancer Inst. 54: 587-591.
    • (1975) J. Natl. Cancer Inst. , vol.54 , pp. 587-591
    • Simon, D.1    Yen, S.2    Cole, P.3
  • 141
    • 0020674016 scopus 로고
    • The effects of saccharin on the metabolism of dietary tryptophan to indole, a known cocarcinogen for the urinary bladder of the rat
    • Sims, J. and Renwick, A. G. (1983) The effects of saccharin on the metabolism of dietary tryptophan to indole, a known cocarcinogen for the urinary bladder of the rat. Toxicol. Appl. Pharmacol. 67: 132-151.
    • (1983) Toxicol. Appl. Pharmacol. , vol.67 , pp. 132-151
    • Sims, J.1    Renwick, A.G.2
  • 142
    • 0021803672 scopus 로고
    • The microbial metabolism of tryptophan in rats fed a diet containing 7.5% saccharin in a two-generation protocol
    • Sims, J. and Renwick, A. G. (1985) The microbial metabolism of tryptophan in rats fed a diet containing 7.5% saccharin in a two-generation protocol. Food Chem. Toxicol. 23: 437-444.
    • (1985) Food Chem. Toxicol. , vol.23 , pp. 437-444
    • Sims, J.1    Renwick, A.G.2
  • 143
    • 0020554051 scopus 로고
    • Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential
    • Sina, J. F., Bean, C. L., Dysart, G. R., Taylor, V. I. and Bradley, M. O. (1983) Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential. Mutat. Res. 113: 357-391.
    • (1983) Mutat. Res. , vol.113 , pp. 357-391
    • Sina, J.F.1    Bean, C.L.2    Dysart, G.R.3    Taylor, V.I.4    Bradley, M.O.5
  • 144
    • 0018868470 scopus 로고
    • Cell culture tumor promotion experiments with saccharin, phorbol myrisrate acetate and several common food materials
    • Sivak, A. and Tu, A. S. (1980) Cell culture tumor promotion experiments with saccharin, phorbol myrisrate acetate and several common food materials. Cancer Lett. 10: 27-32.
    • (1980) Cancer Lett. , vol.10 , pp. 27-32
    • Sivak, A.1    Tu, A.S.2
  • 145
    • 0021872256 scopus 로고
    • Histopathological evaluation of rat urinary bladders from the IRDC two-generation bioassay of sodium saccharin
    • Squire, R. A. (1985) Histopathological evaluation of rat urinary bladders from the IRDC two-generation bioassay of sodium saccharin. Food Chem. Toxicol. 23: 491-497.
    • (1985) Food Chem. Toxicol. , vol.23 , pp. 491-497
    • Squire, R.A.1
  • 148
    • 0023772570 scopus 로고
    • Mutagenicity of saccharin in a human cell strain
    • Suzuki, H. and Suzuki, N. (1988) Mutagenicity of saccharin in a human cell strain. Mutat. Res. 209: 13-16.
    • (1988) Mutat. Res. , vol.209 , pp. 13-16
    • Suzuki, H.1    Suzuki, N.2
  • 149
    • 0018568169 scopus 로고
    • Saccharin metabolism and tumorigenicity
    • Sweatman, T. W. and Renwick, A. G. (1979) Saccharin metabolism and tumorigenicity. Science 205: 1019-1020.
    • (1979) Science , vol.205 , pp. 1019-1020
    • Sweatman, T.W.1    Renwick, A.G.2
  • 150
    • 0018885675 scopus 로고
    • Chronic toxicity and carcinogenicity to the urinary bladder of sodium saccharin in the in utero-exposed rat
    • Taylor, J. M., Weinberger, M. A. and Friedman, L. (1980) Chronic toxicity and carcinogenicity to the urinary bladder of sodium saccharin in the in utero-exposed rat. Toxicol. Appl. Pharmacol. 54: 57-75.
    • (1980) Toxicol. Appl. Pharmacol. , vol.54 , pp. 57-75
    • Taylor, J.M.1    Weinberger, M.A.2    Friedman, L.3
  • 151
    • 0017655384 scopus 로고
    • Preliminary studies on mutagenicity of saccharin by induction of dominant lethals
    • Tezabwala, B. U. and Gothoskar, S. V. (1977) Preliminary studies on mutagenicity of saccharin by induction of dominant lethals. Indian J. Cancer 14: 232-234.
    • (1977) Indian J. Cancer , vol.14 , pp. 232-234
    • Tezabwala, B.U.1    Gothoskar, S.V.2
  • 153
    • 0011870739 scopus 로고
    • Long-term feeding of saccharin in rats
    • Inglett, G. E. (ed.) Avi Publishing, Westport
    • Tisdel, M. O., Nees, P. O., Harris, D. L. and Derse, P. H. (1974) Long-term feeding of saccharin in rats. In: Symposium: Sweeteners, pp. 145-158, Inglett, G. E. (ed.) Avi Publishing, Westport.
    • (1974) Symposium: Sweeteners , pp. 145-158
    • Tisdel, M.O.1    Nees, P.O.2    Harris, D.L.3    Derse, P.H.4
  • 154
    • 0018879891 scopus 로고
    • Do induced sperm-head abnormalities in mice specifically identify mammalian mutagens rather than carcinogens?
    • Topham, J. C. (1980) Do induced sperm-head abnormalities in mice specifically identify mammalian mutagens rather than carcinogens? Mutat. Res. 74: 379-387.
    • (1980) Mutat. Res. , vol.74 , pp. 379-387
    • Topham, J.C.1
  • 155
    • 0019434873 scopus 로고
    • Two-stage carcinogenesis in vitro: Transformation of 3-methylcholanthrene-initiated Rauscher murine leukemia virus-infected rat embryo cells by diverse tumor promoters
    • Traul, K. A., Hink, R. J., Kachevsky, V. and Wolf, J. S. (1981) Two-stage carcinogenesis in vitro: transformation of 3-methylcholanthrene-initiated Rauscher murine leukemia virus-infected rat embryo cells by diverse tumor promoters. J. Natl. Cancer Inst. 66: 171-176.
    • (1981) J. Natl. Cancer Inst. , vol.66 , pp. 171-176
    • Traul, K.A.1    Hink, R.J.2    Kachevsky, V.3    Wolf, J.S.4
  • 156
    • 0019309325 scopus 로고
    • Saccharin may act as a tumour promoter by inhibiting metabolic cooperation between cells
    • Trosko, J. E., Dawson, B., Yotti, L. P. and Chang, C. C. (1980) Saccharin may act as a tumour promoter by inhibiting metabolic cooperation between cells. Nature 285: 109-110.
    • (1980) Nature , vol.285 , pp. 109-110
    • Trosko, J.E.1    Dawson, B.2    Yotti, L.P.3    Chang, C.C.4
  • 157
    • 0028142604 scopus 로고
    • Lack of induction of epithelial cell proliferation by sodium saccharin and sodium L-ascorbate in the urinary bladder of NCI-Black-Reiter (NBR) male rats
    • Uwagawa, S., Saito, K., Okuno, Y., Kawasaki, H. Yoshitake, A., Yamada, H. and Fukushima, S. (1994) Lack of induction of epithelial cell proliferation by sodium saccharin and sodium L-ascorbate in the urinary bladder of NCI-Black-Reiter (NBR) male rats. Toxicol. Appl. Pharmacol. 127: 182-186.
    • (1994) Toxicol. Appl. Pharmacol. , vol.127 , pp. 182-186
    • Uwagawa, S.1    Saito, K.2    Okuno, Y.3    Kawasaki, H.4    Yoshitake, A.5    Yamada, H.6    Fukushima, S.7
  • 158
    • 0016492764 scopus 로고
    • Saccharin: Lack of chromosome-damaging activity in Chinese hamsters in vivo
    • van Went-de Vries, G. F. and Kragten, M. C. T. (1975) Saccharin: lack of chromosome-damaging activity in Chinese hamsters in vivo. Food Cosmet. Toxicol. 13: 177-183.
    • (1975) Food Cosmet. Toxicol. , vol.13 , pp. 177-183
    • Van Went-De Vries, G.F.1    Kragten, M.C.T.2
  • 159
    • 0020122546 scopus 로고
    • An independent analysis of the National Cancer Institute study on non-nutritive sweeteners and bladder cancer
    • Walker, A. M., Dreyer, N. A., Friedlander, E., Loughlin, J., Rothman, K. J. and Kohn, H. I. (1982) An independent analysis of the National Cancer Institute study on non-nutritive sweeteners and bladder cancer. Am. J. Public Health 72: 376-383.
    • (1982) Am. J. Public Health , vol.72 , pp. 376-383
    • Walker, A.M.1    Dreyer, N.A.2    Friedlander, E.3    Loughlin, J.4    Rothman, K.J.5    Kohn, H.I.6
  • 160
    • 0011795383 scopus 로고
    • Carcinogenesis Bioassays of Natural and Artificial Sweeteners
    • Williams, G. M. (ed.) Princeton Scientific Publishing Co., Inc., Princeton
    • Weisburger, J. H. (1988) Carcinogenesis Bioassays of Natural and Artificial Sweeteners. In: Sweeteners: Health Effects, pp. 193-224, Williams, G. M. (ed.) Princeton Scientific Publishing Co., Inc., Princeton.
    • (1988) Sweeteners: Health Effects , pp. 193-224
    • Weisburger, J.H.1
  • 161
    • 0022999881 scopus 로고
    • The effects of saccharin on the development of neoplastic lesions initiated with N-methyl-N-nitrosourea in the rat urothelium
    • West, R. W., Sheldon, W. G., Gaylor, D. W., Haskin, M. G., Delongchamp, R. R. and Kadlubar, F. F. (1986) The effects of saccharin on the development of neoplastic lesions initiated with N-methyl-N-nitrosourea in the rat urothelium. Fundam. Appl. Toxicol. 7: 585-600.
    • (1986) Fundam. Appl. Toxicol. , vol.7 , pp. 585-600
    • West, R.W.1    Sheldon, W.G.2    Gaylor, D.W.3    Haskin, M.G.4    Delongchamp, R.R.5    Kadlubar, F.F.6
  • 163
  • 164
    • 0018261005 scopus 로고
    • Saccharin-induced sister chromatid exchanges in Chinese hamster and human cells
    • Wolff, S. and Rodin, B. (1978) Saccharin-induced sister chromatid exchanges in Chinese hamster and human cells. Science 200: 543-545.
    • (1978) Science , vol.200 , pp. 543-545
    • Wolff, S.1    Rodin, B.2
  • 165
    • 0017720484 scopus 로고
    • The epidemiology of bladder cancer
    • Wynder, E. L. and Goldsmith, R. (1977) The epidemiology of bladder cancer. Cancer 40: 1246-1268.
    • (1977) Cancer , vol.40 , pp. 1246-1268
    • Wynder, E.L.1    Goldsmith, R.2
  • 166
    • 0018892819 scopus 로고
    • Artificial sweetener use and bladder cancer: A case-control study
    • Wynder, E. L. and Stellman, S. D. (1980) Artificial sweetener use and bladder cancer: a case-control study. Science 207: 1214-1216.
    • (1980) Science , vol.207 , pp. 1214-1216
    • Wynder, E.L.1    Stellman, S.D.2
  • 167
    • 0018083080 scopus 로고
    • Induced chromosome aberrations by artificial sweeteners in CHO-K1 cells
    • Yoshida, S., Masubuchi, M. and Hiraga, K. (1985) Induced chromosome aberrations by artificial sweeteners in CHO-K1 cells. Mutat. Res. 54: 262.
    • (1985) Mutat. Res. , vol.54 , pp. 262
    • Yoshida, S.1    Masubuchi, M.2    Hiraga, K.3
  • 168
    • 0026738069 scopus 로고
    • Anti-promoting effect of nordihydroguaiaretic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine and sodium saccharin-induced rat urinary bladder carcinogenesis
    • Yu, A., Hashimura, T., Nishio, Y., Kanamaru, H., Fukuzawa, S. and Yoshida, O. (1992) Anti-promoting effect of nordihydroguaiaretic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine and sodium saccharin-induced rat urinary bladder carcinogenesis. Jpn. J. Cancer Res. 83: 944-948.
    • (1992) Jpn. J. Cancer Res. , vol.83 , pp. 944-948
    • Yu, A.1    Hashimura, T.2    Nishio, Y.3    Kanamaru, H.4    Fukuzawa, S.5    Yoshida, O.6


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