Effect of phorbol 12,13-dibutyrate on ligand binding, enzyme activity and translocation of protein kinase C isoforms in the αT3-1 gonadotrope-derived cell line

Molecular and Cellular Biochemistry

Volumn 165, Issue 1, 1996, Pages 65-75

  Johnson, Melanie S ^a   Simpson, James ^a   Mitchell, Rory ^a  

^a ROYAL EDINBURGH HOSPITAL   (United Kingdom)

Author keywords

T3 1 cell; Downregulation; Luteinising hormone releasing hormone; Phorbol 12,13 dibutyrate; Protein kinase C isoforms; Translocation

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; DIETHYLAMINOETHYL CELLULOSE; GONADORELIN; PHORBOL DIBUTYRATE; PROTEIN KINASE C;

ARTICLE; ENZYME ACTIVITY; IMMUNOBLOTTING; LIGAND BINDING;

ANIMALS; CALCIUM; CARCINOGENS; CELL MEMBRANE; CELLS, CULTURED; CHROMATOGRAPHY, DEAE-CELLULOSE; CYTOSOL; DOWN-REGULATION; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; IMMUNOBLOTTING; ISOENZYMES; MEMBRANE PROTEINS; MICE; PHORBOL 12,13-DIBUTYRATE; PROTEIN BINDING; PROTEIN KINASE C;

EID: 0029769208     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Tsutsumi M, Zhou W, Millar RP, Mellon PL, Roberts JL, Flanagan CA, Dong K, Gillo B, Sealfon SC: Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor. Mol Endocrinol 6: 1163-1169, 1992
2. Schrey MP: Gonadotrophin-releasing hormone stimulates the formation of inositol phosphates in rat anterior pituitary tissue. Biochem J 226: 563-569, 1985
3. Andrews WV, Conn PM: Gonadotropin-releasing hormone stimulates mass changes in phosphoinositides and diacylglycerol accumulation in purified gonadotrope cell cultures. Endocrinology 118: 1148-1158, 1986
4. Huckle WR, Conn PM: Molecular mechanism of gonadotropin-releasing hormone action. 2. The effector system. Endocr Rev 9: 387-395, 1988
5. Conn PM, Hawes BE, Janovick JA: Selection of models for the study of GnRH stimulated gonadotropin release prejudices the assignment of role for mediators and modulators of hormone action. Mol Cell Endocrinol 84: C33-C37, 1992
6. Smith MA, Vale WW: Superfusion of rat anterior pituitary cells attached to cytodex beads: Validation of a technique. Endocrinology 107: 1425-1431, 1980
7. Thomson FJ, Johnson MS, Mitchell R, Wolbers B, Ison AJ, MacEwan DJ: Differential effects of protein kinase C activators and inhibitors on rat anterior pituitary hormone release. Mol Cell Endocrinol 94: 223-234, 1993
8. Johnson MS, Thomson FJ, MacEwan DJ, Mitchell R: The involvement of dihydropyridine-sensitive calcium channels in phorbol ester-induced luteinizing hormone and growth hormone release. Mol Cell Endocrinol 95: 31-41, 1993
9. Johnson MS, Mitchell R, Thomson FJ: The priming effect of luteinizing hormone-releasing hormone (LHRH), but not LHRH-induced gonadotropin release, can be prevented by certain PKC inhibitors. Mol Cell Endocrinol 85: 183-193, 1992
10. Denef C, Swennen L, Andries M: Separated anterior pituitary cells and their response to hypophysiotropic hormones. Int Rev Cytol 76: 225-244, 1982
11. Windle JJ, Weiner RI, Mellon PL: Cell lines of the pituitary gonadotrope lineage derived by target oncogenesis in transgenic mice. Mol Endocrinol 4: 597-603, 1990
12. Johnson MS, MacEwan DJ, Simpson J, Mitchell R: Characterisation of protein kinase C isoforms and enzymic activity from the αT3-1 gonadotroph-derived cell line. FEBS Lett 333: 67-72, 1993
13. Naor Z, Dan-Cohen H, Hermon J, Limor R: Induction of exocytosis in permeabilized pituitary cells by α and β-type protein kinase C. Proc Natl Acad Sci USA 86: 4501-4504, 1989
14. Hug H, Sarre TF: Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291: 329-343, 1993
15. 2+-dependent protein kinase from heart. II Substrate specificity and inhibition by various agents. J Biol Chem 257: 8489-8495, 1982
16. Huang K-P, Huang FL, Nakabayashi H, Yoshida Y: Biochemical characterisation of rat brain protein kinase C isozymes. J Biol Chem 263: 14839-14845, 1988
17. Johnson MS, Simpson J, MacEwan DJ, Ison A, Clegg RA, Connor K, Mitchell R: Phorbol ester and diacylglycerol activation of native protein kinase C species from various tissues. Mol Cell Biochem 146: 127-137, 1995
18. MacEwan DJ, Johnson MS, Mitchell R, Thomson FJ, Lutz EM, Clegg RA, Connor K: Evidence that protein kinase C α has reduced affinity towards 1,2-dioctanoyl-sn-glycerol: the effects of lipid activators on phorbol ester binding and kinase activity. Eur J Pharmacol Mol Pharmacol Section 246: 9-18, 1993
19. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, Dukamel D, Charan D, Kirilovsky J: The bisindoylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266: 15771-15781, 1991
20. Hidaka H, Hagiwara M: Pharmacology of the isoquinoline sulfonamide Protein Kinase C inhibitors. Trends Pharmacol Sci 8: 162-164, 1987
21. Limatola C, Schaap D, Moolenaar WH, van Blitterswijk WJ: Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids. Biochem J 304: 1001 1008, 1994
22. Netiv E, Liscovitch M, Naor Z: Delayed activation of phospholipase D by gonadotropin-releasing-hormone in a clonal pituitary gonadotrope cell-line (αT3-1). FEBS Lett 295: 107-109, 1991
23. Billah MM, Pai J-K, Mullmann TJ, Egan RW, Siegel MI: Regulation of phospholipase D in HL-60 granulocytes. J Biol Chem 264: 9069-9076, 1989
24. Chen Z-P, Kratzmeier M, Poch A, Xu S, McArdle CA, Levy A, Mukhopadhyay AK, Lightman SL: Effects of extracellular nucleotides in the pituitary: adenosine triphosphate receptor-mediated intracellular responses in gonadotrope-derived αT3- 1 cells. Endocrinology 137: 248-256, 1996
25. 1 rat pituitary cells. J Biol Chem 265: 15704-15712, 1990
26. 6 glioma cells. FEBS Lett 332: 169-173, 1993
27. Olivier AR, Parker PJ: Bombesin, platelet-derived growth factor, and diacylglycerol induce selective membrane association and down-regulation of protein kinase C isotypes in Swiss 3T3 cells. J Biol Chem 269: 2758-2763, 1994
28. Bogoyevitch MA, Parker PJ, Sugden PH: Characterization of protein kinase C isotype expression in adult rat heart. Circ Res 72: 757-767, 1993
29. Standaert ML, Cooper DR, Hernandez H, Arnold TP, Farese RV: Differential down-regulation of insulin-sensitive protein kinase C isoforms by 12-0-tetradecanoyl phorbol-13-acetate in rat adipocytes and BC3H-1 myocytes. Endocrinology 132: 689-692, 1993
30. Heidenreich KA, Toledo SP, Brunton LL, Watson MJ, Daniel-Issakani S, Strulovici B: Insulin stimulates the activity of a novel protein kinase C, PKC ε, in cultured fetal chick neurons. J Biol Chem 265: 15076-15082, 1990
31. Szallasi Z, Kosa K, Smith CB, Dlugosz AA, Williams EK, Yuspa SH, Blumberg PM: Differential regulation of anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes. Mol Pharmacol 47: 258-265, 1995
32. Fujihara M, Connolly N, Ito N, Suzuki T: Properties of protein kinase C isoforms (βII, ε and ζ) in a macrophage cell line (J774) and their roles in LPS-induced nitric oxide production. J Immunol 152: 1898-1906, 1994
33. Zhou G, Wooten MW, Coleman ES: Regulation of atypical ζ-protein kinase C in cellular signalling. Exp Cell Res 214: 1-11, 1994
34. Ono Y, Fujii T, Ogita K, Kikkawa U, Igarashi K, Nishizuka Y: Protein kinase C ζ subspecies from rat brain: Its structure, expression, and properties. Proc Natl Acad Sci USA 86: 3099-3103, 1989
35. Huwiler A, Fabbro D, Stabel S, Pfeilschifter J: Immunocharacterization of δ- and ζ-isotrizymes of protein kinase C in rat mesangial cells. FEBS Lett 300: 259-262, 1992
36. Ways DK, Cook PP, Webster C, Parker PJ: Effect of phorbol esters on protein kinase C-ζ. J Biol Chem 267: 4799-4805, 1992
37. Gschwendt M, Leibersperger H, Kittstein W, Marks F: Protein kinase C ζ and η in murine epidermis (TPA induces down-regulation of PKCη but not PKCζ). FEBS Lett 307: 151-155, 1992
38. Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF, Mischak H: The cDNA sequence expression pattern and protein characteristics of mouse protein kinase C-ζ. Gene 122: 305-311, 1992
39. Crabos M, Fabbro D, Stabel S, Erne P: Effect of tumour-promoting phorbol ester, thrombin and vasopressin on translocation of three distinct protein kinase C isoforms in human platelets and regulation by calcium. Biochem J 288: 891-896, 1992
40. Borner C, Guadagno SN, Fabbro D, Weinstein IB: Expression of 4 protein kinase C isoforms in rat fibroblasts - distinct subcellular distribution and regulation by calcium and phorbol esters. J Biol Chem 267: 12892-12899, 1992
41. Wooten MW, Zhou G, Seibenhener ML, Coleman ES: A role for ζ-protein kinase C in nerve growth factor-induced differentiation of PC12 cells. Cell Growth Differ 5: 395-403, 1994
42. Allen BG, Andrea JE, Walsh MP: Identification and characterization of protein kinase C ζ-immunoreactive proteins. J Biol Chem 269: 29288-29298, 1994
43. Nishikawa K, Yamamoto S, Nagumo H, Maruyama K, Kato R: The presence of phorbol ester responsive and non-responsive forms of ζ isozyme of protein kinase C in mouse epidermal cells. Cell Signal 7: 491-504, 1995
44. Mau SE, Saermark T, Vihardt H: Translocation of protein kinase C isozymes in lactotroph-enriched rat anterior pituitary cell cultures: differential effects of substance P and phorbol ester. J Mol Endocrinol 12: 293-302, 1994
45. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marmé D, Schächtele C: Selective inhibition of protein kinase C isozymes by the indolocarbazole Go6976. J Biol Chem 268: 9194-9197, 1993
46. Leach KL, Raben DM: Nuclear location of protein kinase C. Biochem Soc Trans 21: 879-883, 1993
47. Ha KS, Exton JH: Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor - a possible function for phosphatidylcholine-derived diacylglycerol. J Biol Chem 268: 10534-10539, 1993
48. Davidson JS, Wakefield IK, Millar RP: Absence of rapid desensitization of the mouse gonadotropin-releasing hormone receptor. Biochem J 300: 299-302, 1994
49. 2+-independent isoforms of protein kinase C differentially translocate in smooth muscle. Am J Physiol 263: C714-719, 1992
50. Berti L, Mosthaf L, Kroder G, Kellerer M, Tippmer S, Mushak J, Seffer E, Seedorf K, Häring H: Glucose-induced translocation of protein kinase C isoforms in Rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase. J Biol Chem 269: 3381-3386, 1994