Efficacy of trovafloxacin (CP-99,219), a new fluoroquinolone, in an animal model of intraabdominal sepsis

Infectious Diseases in Clinical Practice

Volumn 5, Issue SUPPL. 3, 1996, Pages

  Onderdonk, Andrew B ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b CHANNING LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; GENTAMICIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TROVAFLOXACIN;

ABDOMINAL INFECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTEROIDES FRAGILIS; CONTROLLED STUDY; DRUG EFFICACY; ESCHERICHIA COLI; MALE; NONHUMAN; RAT; SEPSIS;

EID: 0029768777     PISSN: 10569103     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019048-199606001-00007     Document Type: Article

References (12)

1. Cisneros RL, Onderdonk AB. Efficacy of a combination of ciprofloxacin and clindamycin for the treatment of exper-imental intraabdominal sepsis. Curr Ther Res Clin Exp 1989;46:5959-65.
2. Cisneros RL, Bawdon R, Onderdonk AB. Efficacy of ampicillin/sulbactam for the treatment of experimental intraabdominal sepsis. Curr Ther Res Clin Exp 1990;48:1021-9.
3. Girard AE, Faiella JA, Cimochowski CR, et al. In vivo oral activity of CP-99,219 in models of acute and localized infection [abstract 1510]. In: Proceedings and abstracts of the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy; Washington (DC): American Society for Microbiology, 1993.
4. Gootz TD, Brighty KE, Anderson MR, et al. In vivo activity and synthesis of CP-99,219, a novel 7-(3-azabicyclo [3.1.0] hexyl) napthyridone antimicrobial. Diagn Microbiol Infect Dis 1994;19:235-43.
5. Cisneros RL, Onderdonk AB. In vivo efficacy of a new fluoroquinolone, BAYy3118, for the treatment of intraabdominal sepsis due to challenge with a mixed microbial population. Microecology and Therapy 1996;25:368-9.
6. Cisneros RL, Onderdonk AB. In vivo efficacy of temafloxacin hydrochloride in a rat model for experimental intraabdominal sepsis. Proceedings of the Fourth European Congress and Second International Symposium on Anaerobic Bacteria and Infections. Vienna (Austria): 1992.
7. Weinstein WM, Onderdonk AB, Bartlett JG, et al. Experimental intraabdominal abscesses in rats. I. Development of animal model. Infect Immun 1974;10:1250-5.
8. Onderdonk AB, Weinstein WM, Sullivan NM, et al. Experimental intraabdominal abscesses in rats. II. Quantitative bacteriology of infected animals. Infect Immun 1974;10:1256-9.
9. Louie TJ, Tally FP, Bartlett JG, et al. Rapid microbiological assay for chloramphenicol and tetracyclines. Antimicrob Agents Chemother 1976;9:874-8.
10. Louie TJ, Onderdonk AB, Gorbach SL, et al. Therapy of experimental intraabdominal sepsis. A comparison of four cephalosporins with clindamycin and gentamicin. J Infect Dis 1977;135:518-22.
11. Cisneros RL, Onderdonk AB. Efficacy of trospectomycin for the treatment of experimental intraabdominal sepsis. Curr Ther Res Clin Exp 1988;43:16-9.
12. Cisneros RL, Onderdonk AB. Single-dose prophylaxis: efficacy for experimental intraabdominal sepsis. Curr Ther Res Clin Exp 1986;39:745-52.