Anesthesia for non-cardiac surgery in patients at high cardiac risk;Anasthesiologische Aspekte des kardialen Risikopatienten bei extrakardialen Eingriffen

Anasthesiologie und Intensivmedizin

Volumn 37, Issue 7-8, 1996, Pages 373-385

  Tonner, P H ^a   Scholz, J ^a   Schulte Am Esch, J ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

anaesthesia; heart diseases; monitoring, physiological; perioperative care; surgery, operative

Indexed keywords

CARDIOVASCULAR DISEASE; DIAGNOSTIC VALUE; ELECTROCARDIOGRAM; GENERAL ANESTHESIA; HIGH RISK POPULATION; HUMAN; PATIENT MONITORING; PERIOPERATIVE PERIOD; REVIEW; RISK ASSESSMENT; SURGICAL TECHNIQUE; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; TREATMENT OUTCOME;

EID: 0029768765     PISSN: 01705334     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (132)

1. Mangano DT: Perioperative cardiac morbidity. Anesthesiology 72 (1990) 153-84.
2. Statistisches Bundesamt: (1996).
3. Beinlich I: Anästhesiebezogene Morbidität und Mortalität. Anästhesiol Intensivmed Notfallmed Schmerzther 26 (1991) 177-85.
4. Mangano DT, Böttiger BW: Kardiovaskuläre Morbidität und Anästhesie. Anästhesiol Intensivmed Notfallmed Schmerzther 30 (1995) 136-40.
5. Knight A A, Hollenberg M, London MJ, Tubaii J, Verrier E, Browner W, Mangano DT: Perioperative myocardial ischemia: importance of the preoperative ischémie pattern. Anesthesiology 68 (1988) 681-8.
6. Huber K, Evans M, Bresnahan J, Gibbons R, Holmes D: Outcome of noncardiac operations in patients with severe coronary artery disease successfully treated with coronary angioplasty. Mayo Clin Proc 67 (1992) 15-21.
7. Mangano DT, Siliciano D, Hollenberg M, Leung JM, Browner WS, Goehner P, Merrick S, Verrier E, The Study of Perioperative Ischemia (SPI) Research Group: Postoperative myocardial ischemia. Therapeutic trials using intensive analgesia following surgery. Anesthesiology 76 (1992) 342-53.
8. Hollenberg M, Mangano DT, Browner WS, London MJ, Tiibau JF, Tateo IM, The Study of Perioperative Ischemia Research Group: Predictors of postoperative myocardial ischemia in patients undergoing noncardiac surgery. Jama 268 (1992) 205-9.
9. Ibrahim Al, Chobanian A, Horan M, Roccella E: Hypertension prevalence and the status of awareness, treatment and conctrol in the United States. Hypertension 7 (1985) 457-68.
10. Shitb C: Stable angina pectoris: 1. Clinical patterns. Mayo Clin Proc 64 (1990) 233-42.
11. Abraham S, Coles N, Coley C, Strauss H, Boucher C, Eagle K: Coronary risk of noncardiac surgery. Prog Cardiovas Dis 34 (1991) 205-34.
12. Sirna S, Biller J, Skorton D, SeaboldJ: Cardiac evaluation of the patient with stroke. Stroke 21 (1990) 14-28.
13. Fretschner R, Klöss T, Kollier B, Müller E, Enz T: Risikoindikatoren in der Koronarchirurgie. Anasthesiol Intensivmed Notfallmed Schmerzther 26 (1991) 246-51.
14. Rabkin S, Home J: Preoperative electrocardiography: Effect of new abnormalities on clinical decisions. Can Med Assoc 1128(1983) 146-47.
15. Fleisher L, Rosenbaum S, Nelson A, Barash P: The predictive value of preoperative silent ischemia for postoperative cardiac events in vascular and nonvascular surgery. Am Heart J 122 (1991) 980-86.
16. Raby K, Goldman L, Creager M, Cook E, Weisberg M, Wliitlemore A, Sehvyn A: Correlation between preoperative ischemia and major cardiac events after peripheral vascular surgery. N Engl J Med 321 (1989) 1296-1300.
17. Cohn P: Silent myocardial ischemia. Ann Intern Med 109 (1988) 312-7.
18. McCatm R, Clements F: Silent myocardial ischemia in patients undergoing peripheral vascular surgery : incidence and association with perioperative cardiac morbidity and mortality. J Vase Surg 9 (1989) 583-87.
19. Mangano DT, Hollenberg M, Fegert G, Meyer ML, London MJ, Tubaii JF, Kmpski WC, The Study of Perioperative Ischemia (SPI) Research Group: Perioperative myocardial ischemia in patients undergoing noncardiac surgery-I: Incidence and severity during the 4 day perioperative period. J Am Coll Cardiol 17 (1991) 843-50.
20. Epstein S, Qiiyyumi A, Bonow R: Current concepts myocardial ischemia - silent or symptomatic. N Engl J Med 318 (1988) 1038-43.
21. Fleisher L, Barash P: Preoperative cardiac evaluation for noncardiac surgery: A functional approach. Anesth Analg 74 (1992) 586-98.
22. Carliner N, Fisher M, Plotnick G, Garbart H, Rapoport A, Kelemen M, Moran G, Gadacz T, Peters R: Routine preoperative exercise testing in patients undergoing major noncardiac surgery. Am J Cardiol 56 (1985) 51-57.
23. Beller GA: Pharmacologie stress imaging. Jama 265 (1991) 633-8.
24. McPhail N, Ruddy T, Calvin J, Davies R, Barber G: A comparison of dipyridamole-thallium imaging and exercise testing in prediction of postoperative cardiac complications in patients requiring arterial reconstruction. J Vase Surg 10 (1989) 51-6.
25. Mangano DT, London MJ, Tubau JF, Browner VS, Hollenberg M, Kmpski V, Layug EL, Massïe B, Study ofPerioperative Ischemia Research Group: Dipyridamole thallium-201 scintigraphy as a preoperative screening test. A reexamination of its predictive potential. Circulation 84 (1991) 493-502.
26. Fleisher L, Nelson A, Rosenbaum S: Failure of negative dipyriamole-thallium scans to predict perioperative myocardial ischemia and infarction. Can J Anaesth 39 (1992) 17983.
27. Baron J, Mundler O, Bertrand M, Vicaut E, Barre E, Godet G, Sainana C, Codât P, Kieffer E, Viars P: Dipyridamole-thallium scintigraphy and gated radionuclide angiography to assess cardiac risk before abdominal aortic surgery. N Engl J Med 330 (1994) 663-69.
28. Marwick T, Underwood D: Dipyridamole-thallium imaging may not be a reliable screening test for coronary artery disease in patients undergoing vascular surgery. Clin Cardiol 13 (1990) 14-18.
29. Dilsizian V, Rocco T, Freedman N, Leon M, Bonow R: Enhanced detection of ischémic but viable myocardium by the reinjection of thallium after stress redistribution imaging. N Engl J Med 323 (1990) 141-6.
30. Levinson J, Boucher C, Colley C, Gniney T, Strauss H, Eagle K: Usefulness of semiquantitative analysis of dipyridamole-thallium-201 redistribution for improving risk stratifications before valvular surgery. Am J Cardiol 66 (1990) 506-10.
31. Picano E: Stress echocardiography: from pathophysiological toy to diagnostic tool. Circulation 86 (1992) 1604-12.
32. Picano E, Bento de Sonsa MJ, de Moiira Duarte LF, Pingitore A, Sicari R: Detection of viable myocardium by dobutamine and dipyridamole stress echocardiography. Herz 19 (1994) 204-9.
33. Schartl M, Beckmann S, Bocksch V: Stressechokardiographie-eine Standortbestimmung. Z Kardiol 83 (1994) 531-47.
34. Mantha S, Roizen MF, Barnard J, Thisted RA, Ellis JE, Foss J: Relative effectiveness of four preoperative tests for predicting adverse cardiac outcomes after vascular surgery: a meta-analysis. Anesth Analg 79 (1994) 422-33.
35. Cahalan M, Litt L, Botvinick E, Schiller N: Advances in noninvasive cardiovascular imaging: implications for the anesthesiologist. Anesthesiology 66 (1987) 356-72.
36. Scheiben H, Czernin J: Kardiologische Anwendungsbereiche der Positronen-Emissions-Tomographie. Wiener Klinische Wochenschrift 106 (1994) 487-95.
37. Marwick TH, Shan K, Go RT, Maclntyre WJ, Lauer MS: Use of positron emission tomography for prediction of perioperative and late cardiac events before vascular surgery. Am Heart J 130 (1995) 1196-202.
38. Goldman L, Caldera D, Nussbaiim S, Southwick F, Krogstad D, Murray B, Burke D, O'M alley T, Goroll A, Caplan C, Nolan J, Carabello B, Slater E: Multifactorial risk index of cardiac risk in noncardiac surgical procedures. N Engl J Med 297 (1977) 845-50.
39. Eagle K, Coley C, Newell J, Brewster D, Darling R, Strauss H, Guiney T,: Combining clinical and thallium data optimizes preoperative assessment of cardiac risk before major vascular surgery. Ann Intern Med 110 (1989) 85966.
40. London MJ, Hollenberg M, Wong MG, Levenson L, Titban JF, Browner W, Mangano DT: Intraoperative myocardial ischemia: localization by continuous 12-lead electrocardiography. Anesthesiology 69 (1988) 232-41.
41. Haagensen R, Steen P: Perioperative myocardial infarction. Br J Anaesth 61 (1988) 24-37.
42. Rao T, El-Etr A: Myocardial reinfarction following anesthesia in patients with recent infarction. Anesth Analg 60 (1981) 271-72.
43. Fegert G, Hollenberg M, Browner W, Wellington Y, Levenson L, Franks M, Harris D, Mangano D: Perioperative myocardial ischemia in the noncardiac surgical patient. Anesthesiology 69 (1988) A49.
44. Stone JG, Foex P, Sear JV, Johnson LL, Khambalta HJ, Triner L: Myocardial ischemia in untreated hypertensive patients: effect of a single small oral dose of a beta-adrenergic blocking agent. Anesthesiology 68 (1988) 495-500.
45. Häggmark S, Hohner P, Ostmann M, Friedmann A, Diamond G, Lowenstein E, Reiz S: Comparison of hemodynamic, electrocardiographic, mechanical, and metabolic indicators of intraoperative myocardial ischemia in vascular surgery patients with coronary artery disease. Anesthesiology 70 (1989) 19-25.
46. Wong M, Wellington Y, London M, Layug E, Li J, Mangano D: Prolonged postoperative myocardial ischemia in high-risk patients undergoing noncardiac surgery. Anesthesiology 69 (1988) A56.
47. Mangano DT, Browner WS, Hollenberg M, LiJ, Tateo IM, The Study of Perioperative Ischemia Research Group: Long-term cardiac prognosis following noncardiac surgery. Jama 268 (1992) 233-9.
48. Tarhan S, Moffltt EA, Taylor WF, Giuliani ER: Myocardial infarction after general anesthesia. Jama 220 (1972) 1451-4.
49. Roberts S, Tinker J: Cardiovascular disease, risk and outcome in anesthesia. In: D. Brown (Hrsg.). Lippincott, JB, Philadelphia 1988.
50. Rao TL, Jacobs KH, El-Etr AA: Reinfarction following anesthesia in patients with myocardial infarction. Anesthesiology 59 (1983) 499-505.
51. Shah KB, Kleinman BS, Sami II, PatelJ, Rao TL: Reevaluation of perioperative myocardial infarction in patients with prior myocardial infarction undergoing noncardiac operations. Anesth Analg 71 (1990) 231-5.
52. Hertzer N: Myocardial ischemia. Surgery 93 (1983) 97101.
53. Brown O, Hollier L, Pairolero P, Kazmier F, McCready R: Abdominal aortic aneurysm and coronary artery disease. Arch Surg 116 (1981) 1484-88.
54. Kock M, Blomberg S, Emanuelsson H, Lomsky M, Stromblad SO, Ricksten SE: Thoracic epidural anesthesia improves global and regional left ventricular function during stress-induced myocardial ischemia in patients with coronary artery disease. Anesth Analg 71 (1990) 625-30.
55. Breslow M, Jordan D, Christopherson R, Rosenfeld B, Miller C, Hanley D, Beattie C, Traystman R, Rogers M: Epidural morphine decreases postoperative hypertension by attenuating sympathetic nervous system hyperactivity. JAMA 261 (1989) 3577-81.
56. Bredbacka S, Blomback M, Hagnevik K, Irestedt L, Raabe N: Pre- and postoperative changes in coagulation and fibrinolytic variables during abdominal hysterectomy under epidural or general anesthesia. Acta Anaesthesiol Scand 30 (1986) 204-10.
57. Tiiman K, McCarthy R, March R, DeLaria G, Patel R, Ivankovich A: Effects of epidural anesthesia and analgesia on coagulation and outcome after major vascular surgery. Anesth Analg 73 (1991) 696-704.
58. Erlik D, Valero A, Birkhan J, Gershi I: Prostatic surgery and the cardiovascular patient. Br J Urol 40 (1968) 5361.
59. McGowen S, Smith G: Anesthesia for transurethral prostatectomy: A comparison of spinal intradural anesthesia with two methods of general anesthesia. Anaesthesia 35 (1980) 847-53.
60. Steen PA, Tinker JH, Tarhan S: Myocardial reinfarction after anesthesia and surgery. Jama 239 (1978) 2566-70.
61. Backer CL, Tinker JH, Robertson DM, Vlietstra RE: Myocardial reinfarction following local anesthesia for ophthalmic surgery. Anesth Analg 59 (1980) 257-62.
62. Prough D, Sctideri P, Stullken E, Davis C: Myocardial infarction following regional anesthesia for carotid endarterectomy. Can Anaesth Soc J 31 (1984) 192-6.
63. Rivers SP, Scher LA, Sheehan E, Veith FJ: Epidural versus general anesthesia for infrainguinal arterial reconstruction. J Vase Surg 14 (1991) 764-8.
64. Bode R, Lewis K, Zarich S, Pierce E, Robert M, Kowalchnk G, Satwicz P, Gibbons G, Hunter J, Espanola C, Nesto R: Cardiac outcome after peripheral vascular surgery. Anesthesiology 84 (1996) 3-13.
65. Christopherson R, Beattie C, Frank S, Morris E, Meinen C, Gottlieb S, Yates H, Rock P, Parker S, Perler B, Perioperative Ischemia Randomized Trial Study Group: Perioperative morbidity in patients randomized to epidural or'ge-neral anesthesia for lower extremity vascular surgery. Anesthesiology 79 (1993) 422-34.
66. Go A, Browner V: Cardiac outcomes after regional or general anesthesia: Do ve have the answer? Anesthesiology 84 (1996) 1-2.
67. Bovill JG, Sebel PS, Stanley TH: Opioid analgesics in anesthesia: with special reference to their use in cardiovascular anesthesia. Anesthesiology 61 (1984) 731-55.
68. von Knorring J: Postoperative myocardial infarction: A prospective study in a risk group of surgical patients. Surgery 90 (1981) 55-60.
69. Djokovic JL, Hedley-Whyte J: Prediction of outcome of surgery and anesthesia in patients over 80. Jama 242 (1979) 2301-6.
70. Slogoff S, Keats AS: Randomized trial of primary anesthetic agents on outcome of coronary artery bypass operations. Anesthesiology 70 (1989) 179-88.
71. Timwn K, McCarthy R, Spiess B, Davalle M, Dabir R, Ivankovich A: Does choice of anesthetic agent significantly affect outcome after coronary artery surgery? Anesthesiology 70 (1989) 179-88.
72. Helman JD, Leung JM, Bellows WH, Pinecla N, Roach G\V, Reeves JDil, Howse J, McEnany MT, Mangano DT, Tlie S.P.I. Research Group: The risk of myocardial ischemia in patients receiving desflurane versus sufentanil anesthesia for coronary artery bypass graft surgery. Anesthesiology 77 (1992) 47-62.
73. Hurford WE, Favorito F: Association of myocardial ischemia with failure to wean from mechanical ventilation. Critical Care Medicine 23 (1995) 1475-80.
74. Hannenwn SK, Ingersoll GL, Knebel AR, Shekleton ME, Burns SM, Clochesy JM: Weaning from short-term mechanical ventilation: a review. American Journal Of Critical Care 3 (1994) 421-41.
75. Slogoff S, Keats AS: Does perioperative myocardial ischemia lead to postoperative myocardial infarction? Anesthesiology 62 (1985) 107-14.
76. Mangano DT, Browner WS, Hollenberg M, London A7, Tiiban JF, Tateo IM, The Study of Perioperative Ischemia Research Group: Association of perioperative myocardial ischemia with cardiac morbidity and mortality in men undergoing noncardiac surgery. N Enel J Med 323 (1990) 1781-8.
77. Raby KE, Barry J, Creager MA, Cook EF, Weisberg MC, Goldman L: Detection and significance of intraoperative and postoperative myocardial ischemia in peripheral vascular surgery. Jama 268 (1992) 222-7.
78. Coriat P, Harari A, Daloz M, Viars P: Clinical predictors of intraoperative myocardial ischemia in patients with coronary artery disease undergoing non-cardiac surgery. Acta Anaesthesiol Scand 26 (1982) 287-90.
79. Liebcrman RW, Orkin FK, Jobes DR, Schwanz AJ: Hemodynamic predictors of myocardial ischemia during halothane anesthesia for coronary-artery revascularization. Anesthesiology 59 (1983) 36-41.
80. Thomson IR, Mutch WA, Culligan JD: Failure of intravenous nitroglycerin to prevent intraoperative myocardial ischemia during fentanyl-pancuronium anesthesia. Anesthesiology 61 (1984)385-93.
81. Prys-Roberts C, Melodie R, Foex P: Studies of anaesthesia in relation to hypertension: I. Cardiovascular responses to treated and untreated patients. Br J Anaesth 43 (1971) 122-37.
82. Kolter G, Kotrly K, Kalbfleisch J, Vticins E, Kampine J: Myocardial ischemia during cardiovascular surgery as detected by an ST segment trend monitoring system. J Cardiotho'rac Anesth 1 (1987) 190-7.
83. Plninlce JE, Boettncr Rli: Myocardial infarction during and following anesthesia and operation. South Med J 65 (1972)886-9.
84. Schoeppel L, Wilkinson C, Waters J, Meyers N: Effects of myocardial infarction on perioperative cardiac complications. Anesth Analg 62 (1983) 493-8.
85. Ecrola M, Eerola R, Kaitkinen S, Kaiikinen R: Risk factors in surgical patients with verified preoperative myocardial infarction. Acta Anaesthesiol Scand 24 (1980) 219-23.
86. Riles T, Kopelman I, Imparato A: Myocardial infarction following carotid endarterectomy: A review of 683 operations. Surgery 85 (1979) 249-52.
87. Goldman L, Caldera DL: Risks of general anesthesia and elective operation in the hypertensive patient. Anesthesiology 50 (1979) 285-92.
88. Roy W, Etlclist G, Gilbert B: Myocardial ischemia during noncardiac surgical procedures in patients with coronary artery disease. Anesthesiology 51 (1979) 393-7.
89. Reiz S, Balfors E, Sorensen M, Ariola S, Friedmail A, Tritcdson H: Isoflurane-a powerful coronary vasodilator in patients with coronary artery disease. Anesthesioloay 59 (1983)91-7.
90. Coriat P, Daloz M, Bonssean D, Fnsciardi J, Echter E, Viars P: Prevention of intraoperative myocardial ischemia during noncardiac surgery with intravenous nitroglycerin. Anesthesiology 61 (1984) 193-6.
91. Blackburn H, Taylor H, Okamata N: Standardization of the exercise electrocardiogram: A systemic comparison of chest lead configurations employed for monitoring during exercise. In: Physical activity and the heart. M. Maroven and A. Barry (Hrsg.). Thomas, CC, Springfield 1967.
92. Kaplan J, King S: The precordial electrocardiographic lead (V5) in patients who have coronary disease. Anesthesiology 45 (1976) 570-4.
93. Mnller JG, Barash PG: Automated ST-segment monitoring. Int Anesthesiol Clin 31 (1993) 45-55.
94. Ellis JE, Shall MN, Briller JE, Rotzen MF, Aronson S, Feinstein SB: A comparison of methods for the detection of myocardial ischemia during noncardiac surgery: automated ST-segment analysis systems, electrocardiography, and transesophageal echocardiography. Anesth Analg 75 (1992) 76472.
95. Tennant R, Wiggcrs C: The effect of coronary occlusion on myocardial contraction. J Am Physiol 112 (1985) 351-61.
96. Hanser A, Gangradliaran V, Ranios R, Gordon S, Timmis G, Dndlels P: Sequence of mechanical, electrocardiographic, and clinical effects of repeated coronary artery occlusion in human beings: Echocardiographic observations during coronary angioplasty. J Am Coll Cardiol 5 (1985) 193-7.
97. Roewcr N, Greim C: Perioperativer Einsatz der transösophagealen Echokardiographie. Anästhesiol Intensivmed Notfallmed Schmerzther 29 (1994) 458-74.
98. Carter J, Fleishcr L, Barash P: Assessment of perioperative ischemia. Adv Anes 9 (1992) 89-120.
99. Apstein C, Grossman W: Opposite initial effects of supply and demand ischemia on left ventricular compliance. The ischemia-diastolic paradox. J Mol Cell Cardiol 19 (1987) 119-28.
100. Braunwald E, Sobcl B: Coronary blood flow and myocardial ischemia. In: A textbook of cardiovascular medicine. E. Braunwald (Hrsg.). Aufl., Saunders, WB, Philadelphia 1992.
101. Mangano DT: Myocardial .stunning: an overview. J Card Surg 8 (1993) 204-13.
102. Hcnsch G, Schulz R: Chronische MyokardischaemieHibernating Myocardium: Merkmale und Grenzen. Z Kardiol41 (1993)
103. Waggoner AD, Perei JE: Ultrasonic tissue characterization and endocardial boundary detection: assessment of myocardial structure and performance. Cor Art Dis 6 (1995) 29-34.
104. Smith J, Calwlan M, Bencfiel D, Dyrd B, Lurz F, Shapiro \V, Rollen M, Bouchard A, Schiller N: Intraoperative detection of myocardial ischemia in high risk patients: Electrocardiography versus two-dimensional transesophageal echocardiography. Circulation 72 (1985) 1015-21.
105. Leiing JM, B OK, Browner WS, Tnbaii J, Hollenberg M, Mangano DT, SPI Research Group: Prognostic importance of postbypass regional wall-motion abnormalities in patients undergoing coronary artery bypass graft surgery. AnesthesiologyVl (1989) 16-25.
106. van Daele ME, Sutherland GR, Mitchell MM, Fraser AG, Prakash O, Rulf EN, RoclandtJR: Do changes in pulmonary capillary wedge pressure adequately reflect myocardial ischemia during anesthesia? A correlative preoperative hemodynamic, electrocardiographic, and transesophageal echocardiographic study. Circulation 81 (1990) 865-71.
107. Rahimtoola S, Loch H, Elisani A, Sinno M, Clniqnimia R, Lal R, Rosen K, Giinnar R: Relationship of pulmonary artery to left ventricular diastolic pressures in acute myocardial infarction. Circulation 46 (1972) 283-90.
108. RoizL'ii M, Beaupré P, Alpen R, Krcnier P, Cahalan M, Schiller N, Sohn Y, Cronelly R, Lnrz F, Ehrenfcld IV, Stoney R: Monitoring with two-dimensional transesophageal echocardiography: Comparison of myocardial function in patients undergoing supraceliac, suprarenal-infraceliac, or infrarenal occlusion. J Vase Surg 1 (1984) 300-5.
109. Kaplan J, Wells P: Early diagnosis of myocardial ischemia using the pulmonary artery catheter. Anesth Analg 60 (1981)789-93.
110. Lee D, Kinnira S, DeQuattro V: Noradrenergic activity and silent ischemia in hypertensive patients with stable angina: effect of metoprolol. Lancet 1 (1989) 403-6.
111. Hcitsch G: Alpha adrenergic mechanisms in myocardial ischemia. Circulation 81 (1990) 1-13.
112. Kiimpmis A, Luchi R, Waildell C, Miller R: Production of circulating platelet aggregates by exercise in coronary patients. Circulation 61 (1980) 61-5.
113. Gibbs N, Crawford G, Michalopoidos N: Postoperative changes in coagulant and anticoagulant factors following abdominal aortic surgery. Anaesth Intensiv Care 20 (1992) 487-90.
114. Tarhan S, Moffltt EA: Anesthesia after myocardial infarction. Minn Med 52 (1969) 1733-6.
115. Landesberg G, Litria Mil, Colev S, Eidelman LA, Anner H, Mosseri M, Schcchter D, AssafJ, Erel J, Berlatzky Y: Importance of long-duration postoperative ST-segment depression in cardiac morbidity after vascular surgery. Lancet 341 (1993) 715-9.
116. Godet G, Coriat P, Baron J, Bertrand M, Diqiiet B, Sebag C, Viars P: Prevention of intraoperative myocardial ischemia during noncardiac surgery with intravenous diltiazem: a randomized trial versus placebo. Anesthesiology 66 (1987)241-5.
117. Pasternack P, Grossi E, Bnitmann F, Riles T, Lainparello P, Giangiola G, Priinis L, Mintzcr R, Imparato A: Betablockade to decrease silent myocardial ischemia during peripheral vascular surgery. Am J Surg 158 (1989) 113-6.
118. Lischke V, Probst S, Belme'M, Dietcrich HA: Zur Prophylaxe myokardialer Ischaemien. Untersuchung während aortokoronarer Bypassoperation mit dem Kalziumantagonisten Diltiazem. Anaesthesist 44 (1995) 92-100.
119. Dodds TM, Stone JG, CoroinilasJ, Weinberger M, Levy DG: Prophylactic nitroglycerin infusion during noncardiac surgery does not reduce perioperative ischemia. Anesth Analg 76 (1993) 705-13.
120. Hermans WR, Reusing BJ, Strauss BH, Serrnys PW: Prevention of restenosis after percutaneous transluminal coronary aneioplasty: the search for a masic bullet". Am Heart J 122 0991) 171-87.
121. McGarry TF, Jr., Göttlich RS, Morganroth J, Zelenkofske SL, Kasparian H, Dnca PR, Lester RM, Kreulen TH: The relationship of anticoagulation level and complications after successful percutaneous transluminal coronary ansioplasty. Am Heart J 123 (1992) 1445-51.
122. Sclm-cirtz L, Seidelin PH: Antithrombotic and thrombolytic therapy in patients undergoing coronary artery interventions: a review. Prog Cardiovasc Dis 38 (1995) 67-86.
123. Barry \VL, Sarcmbock U: Antiplatelet and anticoagulant therapy in patients undergoing percutaneous transluminal coronary angioplasty. Cardiol Clin 12 (1994) 517-35.
124. Zlwo ZQ, Williams MV, Sato H, Huclspetli DA, McGee DS, Vintcii-Joliaiisen J, Van Wylcn DC: Acadesine reduces myocardial infarct size by an adenosine mediated mechanism. Cardiovasc Res 29 (1995) 495-505.
125. Lenng JM, Stanley Tr, Mathew J, Curling P, Barasli P, Salnienpera M, Reves JG, Hollcnberg M, Mangano DT, S PI Research Group: An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. Anesth Analg 78 (1994) 420-34.
126. Englcnian E, Lipszyc M, Gilbart E, Van der Linden P, Bcllens B, Van Roinplicy A, de Rood M: Effects of clonidine on anesthetic drug requirements and hemodynamic response during aortic surgery. Anesthesiology 71 (1989) 178-87.
127. Rosenfeld B, Faraday N, Campbell D, Dornian T, Clarkson K, Siedler A, Breslow M, Bell W: Perioperative platelet reactivity and the effects of clonidine. Anesthesiology 79(1993)255-61.
128. Wright R A, Dccroly P, Kharkevitch T, Oliver MF: Exercise tolerance in angina is improved by mivazerol-an alpha 2-adrenoceptor agonist. Cardiovasc Drugs Ther 7 (1993) 929-34.
129. Dyck JB, Maze M, Haack C, Vnorilelito L, Shafcr SL: The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidinehidrocRloride in adult human volunteers. Anesthesiology 78(1993) 813-20.
130. Aantaa RE, Kanto JH, Scheinin M, Kallio AM, Scheinin H: Dexmedetomidine premedication for minor gynecologic surgery. Anesth Analg 70 (1990) 407-13.
131. Scheinin H, Karhuvaara S, Olkkola KT, Kallio A, Anttila M, Vnorilelito L, Scheinin M: Pharmacodynamics and pharmacokinetics of intramuscular dexmedetomidine. Clin Pharm Ther 52 (1992) 537-46.
132. Talke P, Li J, Jain U, Lenng J, Drasner K, Hollenberg M, Mangano DT, The Study of Perioperative Ischemia Research Group: Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. Anesthesiology 82 (1995) 620-33.