Use of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in the diagnosis of acromegaly and growth hormone deficiency in adults

Growth Regulation

Volumn 6, Issue 4, 1996, Pages 222-229

  Thissen, J P ^a   Ketelslegers, J M ^b   Maiter, D ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Acromegaly; Diagnosis; Gh deficiency; IGF I, IGFBP 3

Indexed keywords

SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ACROMEGALY; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; RADIOIMMUNOASSAY;

ACROMEGALY; ADOLESCENT; ADULT; AGED; AGING; FEMALE; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; RADIOIMMUNOASSAY; SEX CHARACTERISTICS;

EID: 0029768414     PISSN: 0956523X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Blum W F, Ranke M B, Kietzman K, Gauggel E, Zeisel H J, Bierich J R. A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency. J Clin Endocrinol Metab 1990; 70: 1292-1298.
2. Clemmons D R, Van Wyk J J, Ridgway E C, Kliman B, Kjellberg R N, Underwood L E. Evaluation of acromegaly by radioimmunoassay of somatomedin-C. N Engl J Med 1979; 301: 1138-1142.
3. Ho K K Y, Weissberger A J. Characterization of 24-hour growth hormone secretion in acromegaly: implications for diagnosis and therapy. Clin Endocrinol 1994; 41: 75-83.
4. Barkan A L, Beitins I Z, Kelch R P. Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: correlation with the degree of growth hormone hypersecretion. J Clin Endocrinol Metab 1988; 67: 69-73.
5. Oppizzi G, Petroncini M M, Dallabonzana D et al. Relationship between somatomedin-C and growth hormone levels in acromegaly: basal and dynamic evaluation. J Clin Endocrinol Metab 1986; 63: 1348-1353.
6. Grinspoon S, Clemmons D, Swearingen B, Klibanski A. Serum insulin-like growth factor-binding protein-3 levels in the diagnosis of acromegaly. J Clin Endocrinol Metab 1995; 80: 927-932.
7. de Herder W W, Van der Lely A J, Jansesen J A M J L, Uitterlinden P, Hofland L J, Lamberts S W J. IGFBP-3 is a poor parameter for assessment of clinical activity in acromegaly. Clin Endocrinol 1995; 43: 501-505.
8. Cuneo R C, Salomon F, McGauley G A, Sonksen P H. The growth hormone deficiency syndrome in adults. Clin Endocrinol 1992; 37: 387-397.
9. De Boer H, Blok G-J, Van der Veen E A. Clinical aspects of growth hormone deficiency in adults. Endocr Rev 1995; 16: 63-86.
10. Hoffman D M, O'Sullivan A J, Baxter R C, Ho K K Y. Diagnosis of growth hormone deficiency in adults. Lancet 1994; 343: 1064-1068.
11. Smith W J, Nam T J, Underwood L E, Busby W H, Celnicker A, Clemmons D R. Use of insulin-like growth factor-binding protein-2 (IGFBP-2), IGFBP-3, and IGF-I for assessing growth hormone status in short children. J Clin Endocrinol Metab 1993; 77: 1294-1299.
12. Hasegawa Y, Hasegawa T, Aso T et al. Clinical utility of insulin-like growth factor binding protein-3 in the evaluation and treatment of short children with suspected growth hormone deficiency. Acta Endocrinol 1994; 131: 27-32.
13. Furlanetto R W, Underwood L E, Van Wyk J J, D'Ercole A J. Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest 1977; 60: 648-657.
14. Davenport M L, Svoboda M E, Koerber K L, Van Wyk J J, Clemmons D R, Underwood L E. Serum concentrations of insulin-like growth factor II are not changed by short term fasting and refeeding. J Clin Endocrinol Metab 1988; 67: 1231-1236.
15. Blum W F, Breier B H. Radioimmunoassays for IGFs and IGFBPs. Growth Regulation 1994; 4: 11-19.
16. Zweig M H, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 1993; 39: 561-577.
17. Bates A S, Evans A J, Jones P, Clayton R N. Assessment of GH status in acromegaly using serum growth hormone, serum insulin-like growth factor-I and urinary growth hormone excretion. Clin Endocrinol 1995; 42: 417-423.
18. Smith W J, Underwood L E, Clemmons D R. Effects of caloric or protein restriction on insulin-like growth factor-I (IGF-I) and IGF-binding proteins in children and adults. J Clin Endocrinol Metab 1995; 80: 443-449.
19. Baxter R C, Martin J L. Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma. J Clin Invest 1986; 78: 1504-1512.
20. Giudice L C, Farrell E M, Pham H, Lamson G, Rosenfeld R G. Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: effects of a pregnancy-associated serum protease activity. J Clin Endocrinol Metab 1990; 71: 806-816.
21. Lassarre C, Lalou C, Perin L, Binoux M. Protease-induced alteration of insulin-like growth factor-binding protein-3 as detected by radioimmunoassay. Agreement with ligand blotting data. Growth Regulation 1994; 4: 48-55.
22. Coulson V J, Wass J A H, Abdulla A F, Cotterill A M, Holly J M P. Insulin-like growth binding protein (IGFBPs) in acromegaly. Growth Regulation 1991; 1: 119-124.
23. Bang P, Brismar K, Rosenfeld R G. Increased proteolysis of insulin-like growth factor-binding protein-3 (IGFBP-3) in noninsulin-dependent diabetes mellitus serum, with elevation of a 29 kilodalton (kDa) glycosylated IGFBP-3 fragment contained in the approximately 130- to 150-kDa ternary complex. J Clin Endocrinol Metab 1994; 78: 1119-1127.
24. Reutens A T, Hoffman D M, Leung K-C, Ho K K Y. Evaluation and application of a highly sensitive assay for serum growth hormone (GH ) in the study of adult GH deficiency. J Clin Endocrinol Metab 1995; 80: 480-485.
25. Hattori N, Shimatsu A, Kato Y et al. Growth hormone responses to oral glucose loading measured by highly sensitive enzyme immunoassay in normal subjects and patients with glucose intolerance and acromegaly. J Clin Endocrinol Metab 1990; 70: 771-778.
26. Bates A S, Evans A J, Jones P, Clayton R N. Assessment of GH status in adults with GH deficiency using serum growth hormone, serum insulin-like growth factor-I and urinary growth hormone excretion. Clin Endocrinol 1995; 42: 425-430.
27. Adan L, Souberbielle J C, Brauner R. Diagnostic markers of permanent idiopathic growth hormone deficiency. J Clin Endocrinol Metab 1994; 78: 353-358.
28. Powell D R, Rosenfeld R G, Baker B K, Liu F, Hintz R L. Serum somatomedin levels in adults with chronic renal failure: the importance of measuring insulin-like growth factor I (IGF-I) and IGF-II in acid-chromatographed uremic serum. J Clin Endocrinol Metab 1986; 63: 1186-1192.