Obesity and cardiovascular disease

Current Opinion in Cardiology

Volumn 11, Issue 5, 1996, Pages 490-495

  Rexrode, Kathryn M ^a   Manson, JoAnn E ^a   Hennekens, Charles H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMEN; ADIPOSE TISSUE; CARDIOVASCULAR DISEASE; DYSLIPIDEMIA; GLUCOSE INTOLERANCE; HUMAN; HYPERTENSION; OBESITY; PRIORITY JOURNAL; RISK FACTOR; SHORT SURVEY; TISSUE DISTRIBUTION; WEIGHT REDUCTION;

EID: 0029767984     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001573-199609000-00007     Document Type: Short Survey

References (51)

1. Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL: Increasing prevalence of overweight among US adults: the National Health and Nutrition Examination Surveys, 1960-1991. JAMA 1994, 272:205-211.
2. McGinnis JM, Foege WH: Actual causes of death in the United States. JAMA 1993, 270:2207-2212.
3. Spiegelman D, Israel RG, Bouchard C, Willett WC: Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? Am J Clin Nutr 1992, 55:1033-1044.
4. Després J-P, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C: Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis 1990, 10:497-511.
5. Stepniakowski K, Egan BM: Additive effects of obesity and hyperten• sion to limit venous volume. Am J Physiol 1995, 268:R562-R568. Obesity and hypertension were independently associated with reduced venous compliance as measured by forearm plethysmography. Although absolute cardiac output was higher among obese subjects, cardiac output indexed for surface area was not significantly different between obese and lean subjects.
6. Stern MP: Do non-insulin dependent diabetes mellitus and cardiovas• cular disease share common antecedents? Ann Intern Med 1996, 124:110-116. A review of the insulin resistance syndrome and its relationship to diabetes mellitus and cardiovascular disease.
7. Intersalt Cooperative Research Group: Intersalt: an international study of electrolyte excretion and blood pressure: results for 24 hour urinary sodium and potassium excretion. BMJ 1988, 297:319-328.
8. Stamler J: Epidemiologic findings on body mass and blood pressure in adults. Ann Epidemiol 1991, 4:347-362.
9. MacMahon S, Cutler J, Brittain E, Higgins M: Obesity and hypertension: epidemiological and clinical issues. Eur Heart J 1987, 8(suppl B):57-70.
10. Paffenbarger RS, Wing AL, Hyde RT, Jung DL: Physical activity and incidence of hypertension in college alumni. Am J Epidemiol 1983, 117:245-257.
11. Wing RR, Bunker CH, Kuller LH, Matthews KA: Insulin, body mass index, and cardiovascular risk factors in perimenopausal women. Arteriosclerosis 1989, 9:479-484.
12. Reisin E, Abel R, Modan M, Silverberg DS, Eliahou H, Modan B: Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. N Engl J Med 1978, 289:1-6.
13. Stevens VJ, Corrigan SA, Obarzanek E, et al.: Weight loss intervention in Phase I of the Trials of Hypertension Prevention. Arch Intern Med 1993, 153:849-858.
14. National High Blood Pressure Education Program Working Group: National High Blood Pressure Education Program Working Group report on primary prevention of hypertension. Arch Intern Med 1993, 153:186-208.
15. Fagerberg B, Berglund A, Andersson OL, Berglund G: Weight reduction versus antihypertensive drug therapy in obese men with high blood pressure: effects upon plasma insulin levels and association with changes in blood pressure and serum lipids. J Hypertens 1992, 10:1053-1061.
16. Wing RR, Bunker CH, Kuller LH, Matthews KA: Insulin, body mass index, and cardiovascular risk factors in premenopausal women. Arteriosclerosis 1989, 9:479-484.
17. Seidell JC, Cigolini M, Charzewska J, Ellsinger B, DiBiases G: Fat distribution in European women: a comparison of anthropometric measurements in relation to cardiovascular risk factors, Int J Epidemiol 1990, 19:303-308.
18. Colditz GA, Willett WC, Rotnitzky A, Manson JE: Weight gain as a risk •• factor for clinical diabetes mellitus in women. Ann Intern Med 1995, 122:481-486. Weight gain from age 18 to middle age was associated with significantly increased risk of developing diabetes mellitus. BMI was the strongest predictor of risk of diabetes, with women of even average weight having increased risk compared with lean women.
19. Katzel LI, bleeker ER, Colman EG, Rogus EM, Sorkin JD, Goldberg AP: • Effects of weight loss vs aerobic exercise training on risk factors for coronary heart disease to healthy, obese, middle-aged and older men. JAMA 1995, 274:1915-1921. This randomized trial found that weight loss was associated with greater improvements in blood pressure and in lipid and glucose metabolism than was aerobic exercise training.
20. Goldenstein DJ: Beneficial health effects of modest weight loss, Int J Obes 1992, 16:397-415.
21. Denke MA, Sempos CT, Grundy SM: Excess body weight: an underrecognized contributor to high blood cholesterol levels in white American men. Arch Intern Med 1993, 153:1093-1103.
22. Denke MA, Sempos CT, Grundy SM: Excess body weight: an underrecognized contributor to dyslipidemia in white American women. Arch Intern Med 1994, 154:401-410.
23. Larsson B, Svärdsudd K, Welin L, Wilhelmsen L, Björntorp P, Tibblin G: Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. BMJ 1984, 288:1401-1404.
24. Lapidus L, Bengstsson C, Larsson B, Pennert K, Rybo E, Sjoström L: Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. BMJ 1984, 289:1257-1261.
25. Folsom AR, Burke GL, Ballew C, Jacobs DR, Haskell WL, Donahue RP, Liu K, Hilner JE: Relation of body fatness and its distribution to cardiovascular risk factors in young blacks and whites. Am J Epidemiol 1989, 130:911-924.
26. 2 concentrations independent of age and total adiposity in men.
27. Cigolini M, Seidell JC, Targher G, Deslypere JP, Ellsinger BM, Charzewska •• J, Cruz A, Björntorp P: Fasting serum insulin in relation to components of the metabolic syndrome in European healthy men: the European Fat Distribution Study. Metabolism 1995, 44:35-40. Fasting insulin levels were associated with increased total cholesterol, decreased HDL cholesterol, and higher blood pressure in European men from six countries. However, obesity and abdominal adiposity, rather than hyperinsulinemia, appeared to be the main determinants of unfavorable risk profiles.
28. Dattilo AM, Kris-Etherton PM: Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. Am J Clin Nutr 1992, 56:320-328.
29. Wood PD, Stefanick ML, Dreon DM, et al.: Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N Engl J Med 1988, 319:1173-1179.
30. Svenson OL, Hassager C, Christiansen C: Effect of energy-restricted diet, with or without exercise, on lean tissue mass, resting metabolic rate, cardiovascular risk factors, and bone in overweight post-menopausal women. Am J Med 1993, 95:131-140.
31. Wood PD, Stefanick ML, Williams PT, Haskell WL: The effects on plasma Ilpoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women. N Engl J Med 1991, 325:461-466.
32. Willett WC, Manson JE, Stampfer MJ, et al.: Weight, weight change and •• coronary heart disease in women: risk within the normal range. JAMA 1995, 273:461-465. Increased body weight, even within the "normal" range, was associated with significantly increased risk of CHD in middle-aged women. Weight gain of more than 5 kg from age 18 to middle age also appeared to increase risk of CHD.
33. Curb DJ, Marcus EB: Body fat, coronary heart disease, and stroke in Japanese men. Am J Clin Nutr 1991, 53:1612S-1615S.
34. Fraser GE, Strahan TM, Sabaté J, Beeson L, Kissinger D: Effects of traditional coronary risk factors on rates of incident coronary events in a low-risk population: the Adventist Health Study. Circulation 1992, 86:406-413.
35. Rimm EB, Stampfer MJ, Giovanucci E, et al.: Body size and fat distribu•• tion as predictors of coronary heart disease among middle-aged and older US men. Am J Epidemiol 1995, 141:1117-1127. Waist-to-hip ratio was a better predictor of CHD risk than BMI among men older than 65 yeas of age in the Health Professionals' Follow-up Study during 3 years of follow-up. However, among younger men BMI was a better predictor of CHD risk than WHR.
36. Hubert HB, Feinleib M, McNamara PM, Castelli WP: Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 1983, 67:969-977.
37. Williamson DF, Pamuk E, Thun M, Flanders D, Byers T, Heath C: • Prospective study of intentional weight loss and mortality in never-smoking overweight US white women aged 40-64. Am J Epidemiol 1995, 141:1128-1141. Long-term mortality follow-up from the Cancer Prevention Study found that intentional weight loss was associated with a 19% risk reduction in cardiovascular mortality among women with obesity-related health conditions. Among women without preexisting illness there was no clear benefit.
38. Freedman DS, Williamson DF, Croft JB, Ballew C, Byers T: Relation of •• body fat distribution to ischemic heart disease: the National Health and Nutrition Examination Survey I (NHANES I) Epidemiologic Follow-up Study. Am J Epidemiol 1995, 142:53-63. Central obesity measured by skinfold thicknesses was associated with increased risk of CHD in both men and women. Results were similar for black and white men, but black women appeared to have less risk than white women.
39. Donaue RP, Abbott RD, Bloom E, Reed DM, Yano K: Central obesity and coronary heart disease in men. Lancet 1987, i:821-824.
40. Prineas RJ, Folsom AR, Kaye SA: Central adiposity and increased risk of coronary artery mortality in older women. Ann Epidemiol 1993, 3:35-41.
41. Manson JE, Willett WC, Stampfer MJ, et al.: Body weight and mortality •• among women. N Engl J Med 1995, 333:677-685. All-cause mortality and cardiovascular mortality were directly related to body weight in middle-aged women. Lean women had no increase in mortality. In fact, the lowest mortality was seen among women weighing 15% less than the current US average weight for women.
42. Terry RB, Page WF, Haskell WL: Waist/hip ratio, body mass index and premature cardiovascular mortality in US Army veterans during a twenty-three year follow-up study. Int J Obes 1992, 16:417-423.
43. Young TK, Geleskey DE: Is noncentral obesity metabolically benign? •• Implications for prevention from a population survey. JAMA 1995, 274:1939-1941. Although both BMI and WHR were significant predictors of blood pressure, fasting glucose, lipids, and lipoproteins in men and women, BMI was the stronger predictor for each of the metabolic variables. Noncentral obesity is not metabolically benign.
44. Stamler R, Stamler J, Gosch FC, Civinelli J, Fishman J, McKeever P, McDonald A, Dyer AR: Primary Prevention of Hypertension by Nutritional-Hygienic Means: final report of a randomized, controlled trial. JAMA 1989, 262:1801-1807.
45. Hypertension Prevention Trial Research Group: The Hypertension Prevention Trial: three-year effects of dietary changes on blood pressure. Arch Intern Med 1990, 150:153-162.
46. The Trials of Hypertension Prevention Collaborative Research Group: The effects of nonpharmacologic interventions on blood pressure of persons with high normal levels: results of the Trials of Hypertension Prevention, Phase I. JAMA 1992, 267:1213-1220.
47. National Heart Lung and Blood Institute: Press statement. Washington DC: November 15, 1995.
48. Langford HG, Blaufox MD, Oberman A, et al.: Dietary therapy slows the return of hypertension after stopping prolonged medication. JAMA 1985, 253:657-664.
49. Davis BR, Blaufox MD, Oberman A, Wassertheil-Smoller S, Zimbaldi N, Cutler JA, Kirchner K, Langford HG: Reduction in long-term antihypertensive medication requirements: effects of weight reduction by dietary intervention in overweight persons with mild hypertension. Arch Intern Med 1993, 153:1773-1782.
50. Stamler R, Stamler J, Grimm R, et al.: Nutritional therapy for high blood pressure: final report of a four year randomized controlled trial: the Hypertension Control Program. JAMA 1987, 257:1484-1491.
51. The Treatment of Mild Hypertension Research Group: The Treatment of Mild Hypertension Study: a randomized, placebo-controlled trial of a nutritional-hygienic regimen along with various drug monotherapies. Arch Intern Med 1991, 151:1413-1423.